未登录 A Phase Ib/II study of IGF-neutralising antibody xentuzumab with enzalutamide in metastatic castration-resistant prostate cancer Macaulay, Valentine M.; Lord, Simon; Hussain, Syed; Maroto, Jose Pablo; Jones, Robert Hugh; Climent, Miguel Angel; Cook, Natalie; Lin, Chia-Chi; Wang, Shian-Shiang; Bianchini, Diletta; Bailey, Mark; Schlieker, Laura; Bogenrieder, Thomas; de Bono, Johann 分享 收藏
Phase 1b Open-Label Trial of Afatinib Plus Xentuzumab (BI 836845) in Patients With EGFR Mutation-Positive NSCLC After Progression on EGFR Tyrosine Kinase Inhibitors Afatinib联合xtuzumab (BI 836845) 在EGFR酪氨酸激酶抑制剂治疗进展后EGFR突变阳性NSCLC患者中的1b期开放标签试验 Park, Keunchil; Tan, Daniel Shao Weng; Su, Wu-Chou; Cho, Byoung Chul; Kim, Sang-We; Lee, Ki Hyeong; Wang, Chin-Chou; Seto, Takashi; Huang, Dennis Chin-Lun; Jung, Helen Hayoun; Hsu, Ming-Chi; Bogenrieder, Thomas; Lin, Chia-Chi 分享 收藏
分享 收藏
Targeting IGF Perturbs Global Replication through Ribonucleotide Reductase Dysfunction Rieunier, Guillaume; Wu, Xiaoning; Harris, Letitia E.; Mills, Jack, V; Nandakumar, Ashwin; Colling, Laura; Seraia, Elena; Hatch, Stephanie B.; Ebner, Daniel, V; Folkes, Lisa K.; Weyer-Czernilofsky, Ulrike; Bogenrieder, Thomas; Ryan, Anderson J.; Macaulay, Valentine M. 分享 收藏
A phase Ib/II study of xentuzumab, an IGF-neutralising antibody, combined with exemestane and everolimus in hormone receptor-positive, HER2-negative locally advanced/metastatic breast cancer IGF中和抗体xentuzumab与依西美坦和依维莫司联合治疗激素受体阳性，HER2-negative局部晚期/转移性乳腺癌的Ib/II期研究 Schmid, Peter; Sablin, Marie-Paule; Bergh, Jonas; Im, Seock-Ah; Lu, Yen-Shen; Martinez, Noelia; Neven, Patrick; Lee, Keun Seok; Morales, Serafin; Perez-Fidalgo, J. Alejandro; Adamson, Douglas; Goncalves, Anthony; Prat, Aleix; Jerusalem, Guy; Schlieker, Laura; Espadero, Rosa-Maria; Bogenrieder, Thomas; Huang, Dennis Chin-Lun; Crown, John; Cortes, Javier 分享 收藏
Antitumor Activity of the IGF-1/IGF-2-Neutralizing Antibody Xentuzumab (BI 836845) in Combination with Enzalutamide in Prostate Cancer Models IGF-1/IGF-2-Neutralizing抗体Xentuzumab (BI 836845) 联合恩扎鲁他胺在前列腺癌模型中的抗肿瘤活性 Weyer-Czernilofsky, Ulrike; Hofmann, Marco H.; Friedbichler, Katrin; Baumgartinger, Rosa; Adam, Paul J.; Solca, Flavio; Kraut, Norbert; Nguyen, Holly M.; Corey, Eva; Liu, Gang; Sprenger, Cynthia C.; Plymate, Stephen R.; Bogenrieder, Thomas 分享 收藏
Two first-in-human studies of xentuzumab, a humanised insulin-like growth factor (IGF)-neutralising antibody, in patients with advanced solid tumours de Bono, Johann; Lin, Chia-Chi; Chen, Li-Tzong; Corral, Jesus; Michalarea, Vasiliki; Rihawi, Karim; Ong, Michael; Lee, Jih-Hsiang; Hsu, Chih-Hung; Yang, James Chih-Hsin; Shiah, Her-Shyong; Yen, Chia-Jui; Anthoney, Alan; Jove, Maria; Buschke, Susanne; Fuertig, Rene; Schmid, Ulrike; Goeldner, Rainer-Georg; Strelkowa, Natalja; Huang, Dennis Chin-Lun; Bogenrieder, Thomas; Twelves, Chris; Cheng, Ann-Lii 分享 收藏
分享 收藏
Xentuzumab (BI 836845), an insulin-like growth factor (IGF)-neutralizing antibody (Ab), combined with exemestane and everolimus in hormone receptor-positive (HR plus ) locally advanced/metastatic breast cancer (LA/mBC): Randomized phase 2 results Crown, J.; Sablin, M-P; Cortes, J.; Bergh, J.; Im, S-A; Lu, Y-S; Martinez, N.; Neven, P.; Lee, K. S.; Morales, S.; Perez-Fidalgo, J. A.; Adamson, D.; Goncalves, A.; Prat, A.; Jerusalem, G.; Schlieker, L.; Espadero, R-M; Bogenrieder, T.; Huang, D. Chin-Lun; Schmid, P. 分享 收藏
Nuclear IGF1R Interacts with Regulatory Regions of Chromatin to Promote RNA Polymerase II Recruitment and Gene Expression Associated with Advanced Tumor Stage Aleksic, Tamara; Gray, Nicki; Wu, Xiaoning; Rieunier, Guillaume; Osher, Eliot; Mills, Jack; Verrill, Clare; Bryant, Richard J.; Han, Cheng; Hutchinson, Kathryn; Lambert, Adam G.; Kumar, Rajeev; Hamdy, Freddie C.; Weyer-Czernilofsky, Ulrike; Sanderson, Michael P.; Bogenrieder, Thomas; Taylor, Stephen; Macaulay, Valentine M. 分享 收藏
Combination of the CDK4/6 inhibitor abemaciclib with xentuzumab, a humanized IGF-1 and IGF-2 ligand co-neutralizing monoclonal antibody, results in synergistic antineoplastic effects in human breast cancer cell lines Weyer-Czernilofsky, Ulrike; Baumgartinger, Rosa; Schmittner, Susanne; Gong, Xueqian; Buchanan, Sean; Beckmann, Richard P.; Marugan, Carlos; Torres, Raquel; Boehnke, Karsten; Lallena, Maria Jose; Solca, Flavio; Kraut, Norbert; Bogenrieder, Thomas 分享 收藏
Blockade of insulin-like growth factors increases efficacy of paclitaxel in metastatic breast cancer Ireland, Lucy; Santos, Almudena; Campbell, Fiona; Figueiredo, Carlos; Hammond, Dean; Ellies, Lesley G.; Weyer-Czernilofsky, Ulrike; Bogenrieder, Thomas; Schmid, Michael; Mielgo, Ainhoa 分享 收藏
分享 收藏
Xentuzumab, a humanized IGF1 and IGF-2 ligand neutralizing antibody, improves the antitumor efficacy of enzalutamide in preclinical models of prostate cancer Weyer-Czernilofsky, Ulrike; Hofmann, Marco H.; Adam, Paul J.; Solca, Flavio; Friedbichler, Katrin; Kraut, Norbert; Corey, Eva; Bogenrieder, Thomas 分享 收藏
Chemoresistance in Pancreatic Cancer Is Driven by Stroma-Derived Insulin-Like Growth Factors Ireland, Lucy; Santos, Almudena; Ahmed, Muhammad S.; Rainer, Carolyn; Nielsen, Sebastian R.; Quaranta, Valeria; Weyer-Czernilofsky, Ulrike; Engle, Danielle D.; Perez-Mancera, Pedro A.; Coupland, Sarah E.; Taktak, Azzam; Bogenrieder, Thomas; Tuveson, David A.; Campbell, Fiona; Schmid, Michael C.; Mielgo, Ainhoa 分享 收藏
Phase I dose escalation (esc) trial of weekly intravenous (i.v.) BI 836845 in Japanese patients (pts) with advanced solid tumors Doi, T.; Shitara, K.; Naito, Y.; Kuboki, Y.; Kojima, T.; Hosono, A.; Yoshino, T.; Kawamoto, H.; Tadayasu, Y.; Ugai, H.; Takeuchi, Y.; Bogenrieder, T.; Yoh, K. 分享 收藏
分享 收藏
分享 收藏
分享 收藏
分享 收藏
.png){kind=icon}
未登录.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
