未登录 Neither agouti-related protein nor neuropeptide Y is critically required for the regulation of energy homeostasis in mice Qian, S; Chen, H; Weingarth, D; Trumbauer, ME; Novi, DE; Guan, XM; Yu, H; Shen, Z; Feng, Y; Frazier, E; Chen, AR; Camacho, RE; Shearman, LP; Gopal-Truter, S; MacNeil, DJ; Van der Ploeg, LHT; Marsh, DJ 分享 收藏
Discovery of MK-1462: GLP-1 and Glucagon Receptor Dual Agonist for the Treatment of and Diabetes MK-1462的发现: GLP-1和胰高血糖素受体双激动剂治疗糖尿病 Palani, Anandan; Nawrocki, Andrea R.; Orvieto, Federica; Bianchi, Elisabetta; Mandic, Emanuela; Pessi, Antonello; Huang, Chunhui; Deng, Qiaolin; Toussaint, Nathalie; Walsh, Erika; Reddy, Vijay; Ashley, Eric; He, Huaibing; Mumick, Sheena; Hawes, Brian; Marsh, Donald; Erion, Mark; Nargund, Ravi; Carrington, Paul E. 分享 收藏
A PEGylated analog of the gut hormone oxyntomodulin with long-lasting antihyperglycemic, insulinotropic and anorexigenic activity Bianchi, Elisabetta; Carrington, Paul E.; Ingallinella, Paolo; Finotto, Marco; Santoprete, Alessia; Petrov, Aleksandr; Eiermann, George; Kosinski, Jennifer; Marsh, Donald J.; Pocai, Alessandro; SinhaRoy, Ranabir; Pessi, Antonello 分享 收藏
Pharmacological Inhibition of Diacylglycerol Acyltransferase 1 Reduces Body Weight and Modulates Gut Peptide Release-Potential Insight into Mechanism of Action Liu, Jinqi; Gorski, Judith N.; Gold, Stephen J.; Chen, Dunlu; Chen, Shirley; Forrest, Gail; Itoh, Yoshiki; Marsh, Donald J.; McLaren, David G.; Shen, Zhu; Sonatore, Lisa; Carballo-Jane, Ester; Craw, Stephanie; Guan, Xiaoming; Karanam, Bindhu; Sakaki, Junichi; Szeto, Daphne; Tong, Xinchun; Xiao, Jianying; Yoshimoto, Ryo; Yu, Hong; Roddy, Thomas P.; Balkovec, James; Pinto, Shirly 分享 收藏
The Glucagon Receptor Is Involved in Mediating the Body Weight-Lowering Effects of Oxyntomodulin Kosinski, Jennifer R.; Hubert, James; Carrington, Paul E.; Chicchi, Gary G.; Mu, James; Miller, Corey; Cao, Jin; Bianchi, Elisabetta; Pessi, Antonello; SinhaRoy, Ranabir; Marsh, Donald J.; Pocai, Alessandro 分享 收藏
Optimization of co-agonism at GLP-1 and glucagon receptors to safely maximize weight reduction in DIO-rodents 优化GLP-1和胰高血糖素受体的共激动作用，以安全地最大程度地减轻啮齿动物的体重 Day, Jonathan W.; Gelfanov, Vasily; Smiley, David; Carrington, Paul E.; Eiermann, George; Chicchi, Gary; Erion, Mark D.; Gidda, Jas; Thornberry, Nancy A.; Tschoep, Matthias H.; Marsh, Donald J.; SinhaRoy, Ranabir; DiMarchi, Richard; Pocai, Alessandro 分享 收藏
PEGylation of Neuromedin U yields a promising candidate for the treatment of obesity and diabetes Ingallinella, Paolo; Peier, Andrea M.; Pocai, Alessandro; Di Marco, Annalise; Desai, Kunal; Zytko, Karolina; Qian, Ying; Du, Xiaobing; Cellucci, Antonella; Monteagudo, Edith; Laufer, Ralph; Bianchi, Elisabetta; Marsh, Donald J.; Pessi, Antonello 分享 收藏
The design and synthesis of potent, selective benzodiazepine sulfonamide bombesin receptor subtype 3 (BRS-3) agonists with an increased barrier of atropisomerization Chobanian, Harry R.; Guo, Yan; Liu, Ping; Lanza, Thomas J., Jr.; Chioda, Marc; Chang, Linda; Kelly, Theresa M.; Kan, Yanqing; Palyha, Oksana; Guan, Xiao-Ming; Marsh, Donald J.; Metzger, Joseph M.; Raustad, Katie; Wang, Sheng-Ping; Strack, Alison M.; Gorski, Judith N.; Miller, Randy; Pang, Jianmei; Lyons, Kathy; Dragovic, Jasminka; Ning, Jian G.; Schafer, Wes A.; Welch, Christopher J.; Gong, Xiaoyi; Gao, Ying-Duo; Hornak, Viktor; Reitman, Marc L.; Nargund, Ravi P.; Lin, Linus S. 分享 收藏
Discovery of MK-7725, A Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity Chobanian, Harry R.; Guo, Yan; Liu, Ping; Chioda, Marc; Lanza, Thomas J., Jr.; Chang, Linda; Kelly, Theresa M.; Kan, Yanqing; Palyha, Oksana; Guan, Xiao-Ming; Marsh, Donald J.; Metzger, Joseph M.; Gorski, Judith N.; Raustad, Kate; Wang, Sheng-Ping; Strack, Alison M.; Miller, Randy; Pang, Jianmei; Madeira, Maria; Lyons, Kathy; Dragovic, Jasminka; Reitman, Marc L.; Nargund, Ravi P.; Lin, Linus S. 分享 收藏
Discovery of Benzodiazepine Sulfonamide-Based Bombesin Receptor Subtype 3 Agonists and Their Unusual Chirality Liu, Ping; Lanza, Thomas J., Jr.; Chioda, Marc; Jones, Carrie; Chobanian, Harry R.; Guo, Yan; Chang, Linda; Kelly, Theresa M.; Kan, Yanqing; Palyha, Oksana; Guan, Xiao-Ming; Marsh, Donald J.; Metzger, Joseph M.; Ramsay, Katie; Wang, Sheng-Ping; Strack, Alison M.; Miller, Randy; Pang, Jianmei; Lyons, Kathy; Dragovic, Jasminka; Ning, Jian G.; Schafer, Wes A.; Welch, Christopher J.; Gong, Xiaoyi; Gao, Ying-Duo; Hornak, Viktor; Ball, Richard G.; Tsou, Nancy; Reitman, Marc L.; Wyvratt, Matthew J.; Nargund, Ravi P.; Lin, Linus S. 分享 收藏
The use of stable-isotopically labeled oleic acid to interrogate lipid assembly in vivo: assessing pharmacological effects in preclinical species McLaren, David G.; He, Timothy; Wang, Sheng-Ping; Mendoza, Vivienne; Rosa, Raymond; Gagen, Karen; Bhat, Gowri; Herath, Kithsiri; Miller, Paul L.; Stribling, Sloan; Taggart, Andrew; Imbriglio, Jason; Liu, Jinqi; Chen, Dunlu; Pinto, Shirly; Balkovec, James M.; DeVita, Robert J.; Marsh, Donald J.; Castro-Perez, Jose M.; Strack, Alison; Johns, Douglas G.; Previs, Stephen F.; Hubbard, Brian K.; Roddy, Thomas P. 分享 收藏
Effects of Peripherally Administered Neuromedin U on Energy and Glucose Homeostasis Peier, Andrea M.; Desai, Kunal; Hubert, James; Du, Xiaobing; Yang, Liming; Qian, Ying; Kosinski, Jennifer R.; Metzger, Joseph M.; Pocai, Alessandro; Nawrocki, Andrea R.; Langdon, Ronald B.; Marsh, Donald J. 分享 收藏
Antiobesity Effect of MK-5046, a Novel Bombesin Receptor Subtype-3 Agonist Guan, Xiao-Ming; Metzger, Joseph M.; Yang, Liming; Raustad, Kate A.; Wang, Sheng-Ping; Spann, Stephanie K.; Kosinski, Jennifer A.; Yu, Hong; Shearman, Lauren P.; Faidley, Terry D.; Palyha, Oksana; Kan, Yanqing; Kelly, Theresa M.; Sebhat, Iyassu; Lin, Linus S.; Dragovic, Jasminka; Lyons, Kathy A.; Craw, Stephanie; Nargund, Ravi P.; Marsh, Donald J.; Strack, Alison M.; Reitman, Marc L. 分享 收藏
Discovery of MK-5046, a Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity Sebhat, Iyassu K.; Franklin, Christopher; Lo, Michael M. -C.; Chen, David; Jewell, James P.; Miller, Randy; Pang, Jianmei; Palyha, Oksana; Kan, Yanqing; Kelly, Theresa M.; Guan, Xiao-Ming; Marsh, Donald J.; Kosinski, Jennifer A.; Metzger, Joseph M.; Lyons, Kathryn; Dragovic, Jasminka; Guzzo, Peter R.; Henderson, Alan J.; Reitman, Marc L.; Nargund, Ravi P.; Wyvratt, Matthew J.; Lin, Linus S. 分享 收藏
Glucagon-Like Peptide 1/Glucagon Receptor Dual Agonism Reverses Obesity in Mice Pocai, Alessandro; Carrington, Paul E.; Adams, Jennifer R.; Wright, Michael; Eiermann, George; Zhu, Lan; Du, Xiaobing; Petrov, Aleksandr; Lassman, Michael E.; Jiang, Guoqiang; Liu, Franklin; Miller, Corey; Tota, Laurie M.; Zhou, Gaochao; Zhang, Xiaoping; Sountis, Michael M.; Santoprete, Alessia; Capito, Elena; Chicchi, Gary G.; Thornberry, Nancy; Bianchi, Elisabetta; Pessi, Antonello; Marsh, Donald J.; SinhaRoy, Ranabir 分享 收藏
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Characterization of a novel and selective cannabinoid CB1 receptor inverse agonist, Imidazole 24b, in rodents Shearman, Lauren P.; Stribling, D. Sloan; Camacho, Ramon E.; Rosko, Kimberly M.; Wang, Junying; Tong, Sharon; Feng, Yue; Marsh, Donald J.; Yu, Hong; Guan, Xiaoming; Spann, Stephanie K.; MacNeil, Douglas J.; Fong, Tung M.; Metzger, Joseph M.; Goulet, Mark T.; Hagmann, William K.; Plummer, Christopher W.; Finke, Paul E.; Mills, Sander G.; Shah, Shrenik K.; Truong, Quang; Van der Ploeg, L. H. T.; Maclntyre, D. Euan; Strack, Alison M. 分享 收藏
Antiobesity efficacy of a novel cannabinoid-1 receptor inverse agonist, N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), in rodents Fong, Tung M.; Guan, Xiao-Ming; Marsh, Donald J.; Shen, Chun-Pyn; Sloan Stribling, D.; Rosko, Kim M.; Lao, Julie; Yu, Hong; Feng, Yue; Xiao, Jing C.; Van der Ploeg, Lex H. T.; Goulet, Mark T.; Hagmann, Williams K.; Lin, Linus S.; Lanza, Thomas J., Jr.; Jewell, James P.; Liu, Ping; Shah, Shrenik K.; Qi, Hongbo; Tong, Xinchun; Wang, Junying; Xu, Suoyu S.; Francis, Barbara; Strack, Alison M.; MacIntyre, D. Euan; Shearman, Lauren P. 分享 收藏
Antiobesity effect of a melanin-concentrating hormone 1 receptor antagonist in diet-induced obese mice Mashiko, S; Ishihara, A; Gomori, A; Moriya, R; Ito, M; Iwaasa, H; Matsuda, M; Feng, Y; Shen, Z; Marsh, DJ; Bednarek, MA; MacNeil, DJ; Kanatani, A 分享 收藏
Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein Chen, HY; Trumbauer, ME; Chen, AS; Weingarth, DT; Adams, JR; Frazier, EG; Shen, Z; Marsh, DJ; Feighner, SD; Guan, XM; Ye, Z; Nargund, RP; Smith, RG; Van Der Ploeg, LHT; Howard, AD; Macneil, DJ; Qian, S 分享 收藏
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