未登录 Identification of Diarylurea Inhibitors of the Cardiac-Specific Kinase TNNI3K by Designing Selectivity Against VEGFR2, p38α, and B-Raf Patterson, Jaclyn R.; Graves, Alan P.; Stoy, Patrick; Cheung, Mui; Desai, Tina A.; Fries, Harvey; Gatto, Gregory J., Jr.; Holt, Dennis A.; Shewchuk, Lisa; Totoritis, Rachel; Wang, Liping; Kallander, Lara S. 分享 收藏
Identification, Synthesis, and Characterization of a Major Circulating Human Metabolite of TRPV4 Antagonist GSK2798745 Pero, Joseph E.; McAtee, John J.; Behm, David J.; Briand, Jacques; Graczyk-Millbrandt, Grazyna; Erhard, Karl; Roberts, Andrew D.; Rivero, Ralph A.; Holt, Dennis A.; Lawhorn, Brian G. 分享 收藏
In Vivo Half-Life Extension of BMP1/TLL Metalloproteinase Inhibitors Using Small-Molecule Human Serum Albumin Binders Vantourout, Julien C.; Mason, Andrew M.; Yuen, Josephine; Simpson, Graham L.; Evindar, Ghotas; Kuai, Letian; Hobbs, Michael; Edgar, Emma; Needle, Saul; Bai, Xiaopeng; Wilson, Steve; Scott-Stevens, Paul; Traylen, William; Lambert, Kim; Young, Neil; Bunally, Shenaz; Summerfield, Scott G.; Snell, Richard; Lad, Rakesh; Shi, Eric; Skinner, Steven; Shewchuk, Lisa; Watson, Allan J. B.; Chung, Chun-Wa; Pal, Sandeep; Holt, Dennis A.; Kallander, Lara S.; Prendergast, Joanne; Rivera, Katrina; Washburn, David G.; Harpel, Mark R.; Arico-Muendel, Christopher; Isidro-Llobet, Albert 分享 收藏
Design and Optimization of an Acyclic Amine Series of TRPV4 Antagonists by Electronic Modulation of Hydrogen Bond Interactions Patterson, Jaclyn R.; Terrell, Lamont R.; Donatelli, Carla A.; Holt, Dennis A.; Jolivette, Larry J.; Rivero, Ralph A.; Roethke, Theresa J.; Shu, Arthur; Stoy, Patrick; Ye, Guosen; Youngman, Mark; Lawhorn, Brian G. 分享 收藏
Discovery of GSK3527497: A Candidate for the Inhibition of Transient Receptor Potential Vanilloid-4 (TRPV4) Brooks, Carl A.; Barton, Linda S.; Behm, David J.; Brnardic, Edward J.; Costell, Melissa H.; Holt, Dennis A.; Jolivette, Larry J.; Matthews, Jay M.; McAtee, John J.; McCleland, Brent W.; Patterson, Jaclyn R.; Pero, Joseph E.; Rivero, Ralph A.; Roethke, Theresa J.; Sanchez, Robert M.; Shenje, Raynold; Terrell, Lamont R.; Lawhorn, Brian G. 分享 收藏
Discovery of GSK2798745: A Clinical Candidate for Inhibition of Transient Receptor Potential Vanilloid 4 (TRPV4) GSK2798745的发现: 抑制瞬时受体电位香草素4 (TRPV4) 的临床候选物 Brooks, Carl A.; Barton, Linda S.; Behm, David J.; Eidam, Hilary S.; Fox, Ryan M.; Hammond, Marlys; Hoang, Tram H.; Holt, Dennis A.; Hilfiker, Mark A.; Lawhorn, Brian G.; Patterson, Jaclyn R.; Stoy, Patrick; Roethke, Theresa J.; Ye, Guosen; Zhao, Steve; Thorneloe, Kevin S.; Goodman, Krista B.; Cheung, Mui 分享 收藏
Design and Optimization of Sulfone Pyrrolidine Sulfonamide Antagonists of Transient Receptor Potential Vanilloid-4 with in Vivo Activity in a Pulmonary Edema Model Pero, Joseph E.; Matthews, Jay M.; Behm, David J.; Brnardic, Edward J.; Brooks, Carl; Budzik, Brian W.; Costell, Melissa H.; Donatelli, Carla A.; Eisennagel, Stephen H.; Erhard, Karl; Fischer, Michael C.; Holt, Dennis A.; Jolivette, Larry J.; Li, Huijie; Li, Peng; McAtee, John J.; McCleland, Brent W.; Pendrak, Israil; Posobiec, Lorraine M.; Rivera, Katrina L. K.; Rivero, Ralph A.; Roethke, Theresa J.; Sender, Matthew R.; Shu, Arthur; Terrell, Lamont R.; Vaidya, Kalindi; Xu, Xiaoping; Lawhorn, Brian G. 分享 收藏
Discovery of Pyrrolidine Sulfonamides as Selective and Orally Bioavailable Antagonists of Transient Receptor Potential Vanilloid-4 (TRPV4) Brnardic, Edward J.; Ye, Guosen; Brooks, Carl; Donatelli, Carla; Barton, Linda; McAtee, Jeff; Sanchez, Robert M.; Shu, Arthur; Erhard, Karl; Terrell, Lamont; Graczyk-Millbrandt, Grazyna; He, Yanan; Costell, Melissa H.; Behm, David J.; Roethke, Theresa; Stoy, Patrick; Holt, Dennis A.; Lawhorn, Brian G. 分享 收藏
Reverse Hydroxamate Inhibitors of Bone Morphogenetic Protein 1 Kallander, Lara S.; Washburn, David; Hilfiker, Mark A.; Eidam, Hilary Schenck; Lawhorn, Brian G.; Prendergast, Joanne; Fox, Ryan; Dowdell, Sarah; Manns, Sharada; Hoang, Tram; Zhao, Steve; Ye, Guosen; Hammond, Marlys; Holt, Dennis A.; Roethke, Theresa; Hong, Xuan; Reid, Robert A.; Gampe, Robert; Zhang, Hong; Diaz, Elsie; Rendina, Alan R.; Quinn, Amy M.; Willette, Bob 分享 收藏
4,6-Diaminopyrimidines as Highly Preferred Troponin I-Interacting Kinase (TNNI3K) Inhibitors Philp, Joanne; Lawhorn, Brian G.; Graves, Alan P.; Shewchuk, Lisa; Rivera, Katrina L.; Jolivette, Larry J.; Holt, Dennis A.; Gatto, Gregory J., Jr.; Kallander, Lara S. 分享 收藏
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Discovery of GSK2193874: An Orally Active, Potent, and Selective Blocker of Transient Receptor Potential Vanilloid 4 Cheung, Mui; Bao, Weike; Behm, David J.; Brooks, Carl A.; Bury, Michael J.; Dowdell, Sarah E.; Eidam, Hilary S.; Fox, Ryan M.; Goodman, Krista B.; Holt, Dennis A.; Lee, Dennis; Roethke, Theresa J.; Willette, Robert N.; Xu, Xiaoping; Ye, Guosen; Thorneloe, Kevin S. 分享 收藏
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Identification of Purines and 7-Deazapurines as Potent and Selective Type I Inhibitors of Troponin I-Interacting Kinase (TNNI3K) Lawhorn, Brian G.; Philp, Joanne; Zhao, Yongdong; Louer, Christopher; Hammond, Marlys; Cheung, Mui; Fries, Harvey; Graves, Alan P.; Shewchuk, Lisa; Wang, Liping; Cottom, Joshua E.; Qi, Hongwei; Zhao, Huizhen; Totoritis, Rachel; Zhang, Guofeng; Schwartz, Benjamin; Li, Hu; Sweitzer, Sharon; Holt, Dennis A.; Gatto, Gregory J., Jr.; Kallander, Lara S. 分享 收藏
Novel 3-Oxazolidinedione-6-aryl-pyridinones as Potent, Selective, and Orally Active EP3 Receptor Antagonists Jin, Jian; Morales-Ramos, Angel; Eidam, Patrick; Mecom, John; Li, Yue; Brooks, Carl; Hilfiker, Mark; Zhang, David; Wang, Ning; Shi, Dongchuan; Tseng, Pei-San; Wheless, Karen; Budzik, Brian; Evans, Karen; Jaworski, Jon-Paul; Jugus, Jack; Leon, Lisa; Wu, Charlene; Pullen, Mark; Karamshi, Bhumika; Rao, Parvathi; Ward, Emma; Laping, Nicholas; Evans, Christopher; Leach, Colin; Holt, Dennis; Su, Xin; Morrow, Dwight; Fries, Harvey; Thorneloe, Kevin; Edwards, Richard 分享 收藏
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DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS AND THE X-RAY CRYSTAL-STRUCTURES OF THEIR COMPLEXES WITH FKBP12 HOLT, DA; LUENGO, JI; YAMASHITA, DS; OH, HJ; KONIALIAN, AL; YEN, HK; ROZAMUS, LW; BRANDT, M; BOSSARD, MJ; LEVY, MA; EGGLESTON, DS; LIANG, J; SCHULTZ, LW; STOUT, TJ; CLARDY, J 分享 收藏
A ligand-reversible dimerization system for controlling protein-protein interactions 用于控制蛋白质-蛋白质相互作用的配体可逆二聚化系统 Rollins, CT; Rivera, VM; Woolfson, DN; Keenan, T; Hatada, M; Adams, SE; Andrade, LJ; Yaeger, D; van Schravendijk, MR; Holt, DA; Gilman, M; Clackson, T 分享 收藏
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