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M

Martin Hentemann

Bayer AG
H指数:14
被引数:1,146

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Discovery of FHD-286, a First-in-Class, Orally Bioavailable, Allosteric Dual Inhibitor of the Brahma Homologue (BRM) and Brahma-Related Gene 1 (BRG1) ATPase Activity for the Treatment of SWItch/Sucrose Non-Fermentable (SWI/SNF) Dependent Cancers

发现FHD-286，一种首创、口服生物利用的别构双抑制剂，可抑制Brahma同源物(BRM)和Brahma相关基因1(BRG1)的ATP酶活性，用于治疗SWItch/Sucrose Non-Fermentable(SWI/SNF)依赖性癌症。

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2025-01-133
PRE
Vaswani, Rishi G.; Huang, David S.; Anthony, Neville; Xu, Lan; Centore, Richard; Schiller, Shawn; Li, Zhifang; Fan, Hong; Setser, Jeremy; Zawadzke, Laura E.; Davenport, Yunji; Chen, Xueying; Barnash, Kimberly; Adam, Ammar; Ichikawa, Kana; Huang, Liyue; Gu, Chong-Hui; Voigt, Johannes; Millan, David; Chan, Ho Man; Decicco, Carl; Hentemann, Martin; Bellon, Steven F.; Wilson, Kevin J.
Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2020-09-10131
PREAI
LaMarche, Matthew J.; Acker, Michael; Argintaru, Andreea; Bauer, Daniel; Boisclair, Julie; Chan, Homan; Chen, Christine Hiu-Tung; Chen, Ying-Nan; Chen, Zhouliang; Deng, Zhan; Dore, Michael; Dunstan, David; Fan, Jianmei; Fekkes, Peter; Firestone, Brant; Fodor, Michelle; Garcia-Fortanet, Jorge; Fortin, Pascal D.; Fridrich, Cary; Giraldes, John; Glick, Meir; Grunenfelder, Denise; Hao, Huia-Xiang; Hentemann, Martin; Ho, Samuel; Jouk, Andriana; Kang, Zhao B.; Karki, Rajesh; Kato, Mitsunori; Keen, Nick; Koenig, Robert; LaBonte, Laura R.; Larrow, Jay; Liu, Gang; Liu, Shumei; Majumdar, Dyuti; Mathieu, Simon; Meyer, Matthew J.; Mohseni, Morvarid; Ntaganda, Rukundo; Palermo, Mark; Perez, Lawrence; Pu, Minying; Ramsey, Timothy; Reilly, John; Sarver, Patrick; Sellers, William R.; Sendzik, Martin; Shultz, Michael D.; Slisz, Joanna; Slocum, Kelly; Smith, Troy; Spence, Stanley; Stams, Travis; Straub, Christopher; Tamez, Victoriano, Jr.; Toure, Bakary-Barry; Towler, Christopher; Wang, Ping; Wang, Hongyun; Williams, Sarah L.; Yang, Fan; Yu, Bing; Zhang, Ji-Hu; Zhu, Suzanne
Discovery and SAR of Novel 2,3-Dihydroimidazo[1,2-c]-quinazoline PI3K Inhibitors: Identification of Copanlisib (BAY 80-6946)

新型2，3-二氢咪唑并 [1，2-c]-喹唑啉PI3K抑制剂的发现和SAR: Copanlisib (BAY 80-6946) 的鉴定

CHEMMEDCHEM
IF3.4
2016-06-1698
OAAI
Scott, William J.; Hentemann, Martin F.; Rowley, R. Bruce; Bull, Cathy O.; Jenkins, Susan; Bullion, Ann M.; Johnson, Jeffrey; Redman, Aniko; Robbins, Arthur H.; Esler, William; Fracasso, R. Paul; Garrison, Timothy; Hamilton, Mark; Michels, Martin; Wood, Jill E.; Wilkie, Dean P.; Xiao, Hong; Levy, Joan; Stasik, Enrico; Liu, Ningshu; Schaefer, Martina; Brands, Michael; Lefranc, Julien
BAY 80-6946 Is a Highly Selective Intravenous PI3K Inhibitor with Potent p110α and p110δ Activities in Tumor Cell Lines and Xenograft Models

BAY 80-6946是一种高度选择性的静脉内PI3K抑制剂，在肿瘤细胞系和异种移植模型中具有有效的p110α 和p110δ 活性

MOLECULAR CANCER THERAPEUTICS
IF5.5
2013-11-06237
OAAI
Liu, Ningshu; Rowley, Bruce R.; Bull, Cathy O.; Schneider, Claudia; Haegebarth, Andrea; Schatz, Christoph A.; Fracasso, Paul R.; Wilkie, Dean P.; Hentemann, Martin; Wilhelm, Scott M.; Scott, William J.; Mumberg, Dominik; Ziegelbauer, Karl
Discovery of Selective and Potent Inhibitors of Gram-Positive Bacterial Thymidylate Kinase (TMK)
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2012-10-2439
PREAI
Martinez-Botella, Gabriel; Breen, John N.; Duffy, James E. S.; Dumas, Jacques; Geng, Bolin; Gowers, Ian K.; Green, Oluyinka M.; Guler, Satenig; Hentemann, Martin F.; Hernandez-Juan, Felix A.; Joseph-McCarthy, Diane; Kawatkar, Sameer; Larsen, Nicholas A.; Lazari, Ovadia; Loch, James T.; Macritchie, Jacqueline A.; McKenzie, Andrew R.; Newman, Joseph V.; Olivier, Nelson B.; Otterson, Linda G.; Owens, Andrew P.; Read, Jon; Sheppard, David W.; Keating, Thomas A.
In Vivo Validation of Thymidylate Kinase (TMK) with a Rationally Designed, Selective Antibacterial Compound
ACS CHEMICAL BIOLOGY
IF3.8
2012-08-2838
PREAI
Keating, Thomas A.; Newman, Joseph V.; Olivier, Nelson B.; Otterson, Linda G.; Andrews, Beth; Boriack-Sjodin, P. Ann; Breen, John N.; Doig, Peter; Dumas, Jacques; Gangl, Eric; Green, Oluyinka M.; Guler, Satenig Y.; Hentemann, Martin F.; Joseph-McCarthy, Diane; Kawatkar, Sameer; Kutschke, Amy; Loch, James T.; McKenzie, Andrew R.; Pradeepan, Selvi; Prasad, Swati; Martinez-Botella, Gabriel

研究方向

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