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Adjuvant Pembrolizumab in Stage II Melanoma: Outcomes by Primary Tumor Location in the Randomized, Double-Blind, Phase III KEYNOTE-716 Trial Pembrolizumab在II期黑色素瘤中的辅助治疗: 随机，双盲，III期KEYNOTE-716试验中原发性肿瘤位置的结果 Yoon, Charles H.; Ross, Merrick I.; Gastman, Brian R.; Luke, Jason J.; Ascierto, Paolo A.; Long, Georgina V.; Rutkowski, Piotr; Khattak, Muhammad; Del Vecchio, Michele; de la Cruz Merino, Luis; Mackiewicz, Jacek; Chiarion-Sileni, Vanna; Schadendorf, Dirk; Carlino, Matteo S.; Zhao, Yujie; Fukunaga-Kalabis, Mizuho; Krepler, Clemens; Eggermont, Alexander M. M.; Gershenwald, Jeffrey E.; Sondak, Vernon K. 分享 收藏
Neoadjuvant anti-PD-1 alone or in combination with anti-TIGIT or an oncolytic virus in resectable stage IIIB-D melanoma: a phase 1/2 trial 新辅助抗PD-1单药或联合抗TIGIT或溶瘤病毒在可切除的III B-D期黑色素瘤中的应用：一项I/II期临床试验 Dummer, Reinhard; Robert, Caroline; Scolyer, Richard A.; Taube, Janis M.; Tetzlaff, Michael T.; Menzies, Alexander M.; Hill, Andrew; Grob, Jean-Jacques; Portnoy, David C.; Lebbe, Celeste; Khattak, Muhammad A.; Cohen, Jonathan; Bar-Sela, Gil; Mehmi, Inderjit; Shapira-Frommer, Ronnie; Meyer, Nicolas; Webber, Andrea L.; Ren, Yixin; Fukunaga-Kalabis, Mizuho; Krepler, Clemens; Long, Georgina V. 分享 收藏
Pembrolizumab for the First-Line Treatment of Recurrent Locally Advanced or Metastatic Merkel Cell Carcinoma: Results from the Single-Arm, Open-Label, Phase III KEYNOTE-913 Study Mortier, Laurent; Villabona, Lisa; Lawrence, Ben; Arance, Ana; Butler, Marcus O.; Beylot-Barry, Marie; Saiag, Philippe; Samimi, Mahtab; Ascierto, Paolo A.; Spada, Francesca; De Pontville, Michel; Maio, Michele; Berrocal, Alfonso; Espinosa, Enrique; Capdevila, Jaume; Levin, Max; Das, Debasmita; Krepler, Clemens; Grebennik, Dmitri; Chiarion-Sileni, Vanna 分享 收藏
Pembrolizumab versus placebo as adjuvant therapy in resected stage IIB or IIC melanoma: Outcomes in histopathologic subgroups from the randomized, double-blind, phase 3 KEYNOTE-716 trial Pembrolizumab与安慰剂作为切除的IIB或IIC期黑色素瘤的辅助治疗: 来自随机，双盲，3期KEYNOTE-716试验的组织病理学亚组的结果 Schadendorf, Dirk; Luke, Jason John; Ascierto, Paolo A.; Long, Georgina, V; Rutkowski, Piotr; Khattak, Adnan; Del Vecchio, Michele; de la Cruz-Merino, Luis; Mackiewicz, Jacek; Sileni, Vanna Chiarion; Kirkwood, John M.; Robert, Caroline; Grob, Jean-Jacques; Dummer, Reinhard; Carlino, Matteo S.; Zhao, Yujie; Kalabis, Mizuho; Krepler, Clemens; Eggermont, Alexander; Scolyer, Richard A. 分享 收藏
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KEYMAKER-U02 substudy 02C: neoadjuvant pembrolizumab (pembro) plus vibostolimab (vibo) or gebasaxturev (geba) or pembro alone followed by adjuvant pembro for stage IIIB-D melanoma Dummer, Reinhard; Robert, Caroline; Scolyer, Richard A.; Taube, Janis M.; Tetzlaff, Michael T.; Hill, Andrew; Grob, Jean-Jacques; Portnoy, David C.; Lebbe, Celeste; Khattak, Muhammad A.; Cohen, Jonathan; Bar-Sela, Gil; Mehmi, Inderjit; Frommer, Ronnie Shapira; Meyer, Nicolas; Ren, Yixin; Fukunaga-Kalabis, Mizuho; Krepler, Clemens; Long, Georgina V. 分享 收藏
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Adjuvant pembrolizumab versus placebo in resected high- risk stage II melanoma: Health-related quality of life from the randomized phase 3 KEYNOTE-716 study 帕博利珠单抗与安慰剂在切除的高风险II期黑色素瘤中的辅助治疗: 来自随机3期KEYNOTE-716研究的健康相关生活质量 Khattak, Muhammad A.; Luke, Jason J.; Long, Georgina V.; Ascierto, Paolo A.; Rutkowski, Piotr; Schadendorf, Dirk; Robert, Caroline; Grob, Jean-Jacques; Merino, Luis de la Cruz; Del Vecchio, Michele; Spagnolo, Francesco; Mackiewicz, Jacek; Chiarion-Sileni, Vanna; Carlino, Matteo S.; Mohr, Peter; De Galitiis, Federica; Ross, Merrick I.; Eroglu, Zeynep; Chen, Ke; Jiang, Ruixuan; Fukunaga-Kalabis, Mizuho; Krepler, Clemens; Eggermont, Alexander M. M.; Kirkwood, John M. 分享 收藏
A distinct pattern of growth and RAC1 signaling in melanoma brain metastasis cells 黑色素瘤脑转移细胞的生长和RAC1信号传导的独特模式 Stejerean-Todoran, Ioana; Gimotty, Phyllis A.; Watters, Andrea; Brafford, Patricia; Krepler, Clemens; Godok, Tetiana; Li, Haiyin; del Rio, Zurine Bonilla; Zieseniss, Anke; Katschinski, Dorthe M.; Sertel, Sinem M.; Rizzoli, Silvio O.; Garman, Bradley; Nathanson, Katherine L.; Xu, Xiaowei; Chen, Qing; Oswald, Jack H.; Lotem, Michal; Mills, Gordon B.; Davies, Michael A.; Schon, Michael P.; Bogeski, Ivan; Herlyn, Meenhard; Vultur, Adina 分享 收藏
Baseline and post-treatment biomarkers of resistance to anti-PD-1 therapy in acral and mucosal melanoma: an observational study Shui, Irene M.; Liu, Xiao Qiao; Zhao, Qing; Kim, Seung Tae; Sun, Yuan; Yearley, Jennifer H.; Choudhury, Tasmiah; Webber, Andrea L.; Krepler, Clemens; Cristescu, Razvan; Lee, Jeeyun 分享 收藏
Persister state-directed transitioning and vulnerability in melanoma Chauvistre, Heike; Shannan, Batool; Daignault-Mill, Sheena M.; Ju, Robert J.; Picard, Daniel; Egetemaier, Stefanie; Varaljai, Renata; Gibhardt, Christine S.; Sechi, Antonio; Kaschani, Farnusch; Keminer, Oliver; Stehbens, Samantha J.; Liu, Qin; Yin, Xiangfan; Jeyakumar, Kirujan; Vogel, Felix C. E.; Krepler, Clemens; Rebecca, Vito W.; Kubat, Linda; Lueong, Smiths S.; Forster, Jan; Horn, Susanne; Remke, Marc; Ehrmann, Michael; Paschen, Annette; Becker, Juergen C.; Helfrich, Iris; Rauh, Daniel; Kaiser, Markus; Gul, Sheraz; Herlyn, Meenhard; Bogeski, Ivan; Rodriguez-Lopez, Jose Neptuno; Haass, Nikolas K.; Schadendorf, Dirk; Roesch, Alexander 分享 收藏
Crossover and rechallenge with pembrolizumab in recurrent patients from the EORTC 1325-MG/Keynote-054 phase III trial, pembrolizumab versus placebo after complete resection of high-risk stage III melanoma pembrolizumab在EORTC 1325 MG/Keynote-054 III期试验的复发患者中的交叉和再激发，高危III期黑色素瘤完全切除后pembrolizumab与安慰剂的比较 Eggermont, Alexander M. M.; Meshcheryakov, Andrey; Atkinson, Victoria; Blank, Christian U.; Mandala, Mario; Long, Georgina, V; Barrow, Catherine; Di Giacomo, Anna Maria; Fisher, Rosalie; Sandhu, Shahneen; Kudchadkar, Ragini; Romero, Pablo Luis Ortiz; Svane, Inge Marie; Larkin, James; Puig, Susana; Hersey, Peter; Quaglino, Pietro; Queirolo, Paola; Stroyakovskiy, Daniil; Bastholt, Lars; Mohr, Peter; Hernberg, Micaela; Chiarion-Sileni, Vanna; Strother, Matthew; Hauschild, Axel; Yamazaki, Naoya; van Akkooi, Alexander Cj; Lorigan, Paul; Krepler, Clemens; Ibrahim, Nageatte; Marreaud, Sandrine; Kicinski, Michal; Suciu, Stefan; Robert, Caroline 分享 收藏
Baseline and post-treatment biomarkers of resistance to anti-PD-1 (aPD1) therapy in acral and mucosal melanoma Lee, J.; Liu, X. Q.; Zhao, Q.; Kim, K-M.; Kim, S. T.; Sun, Y.; Yearley, J.; Choudhury, T.; Webber, A.; Krepler, C.; Cristescu, R.; Shui, I. 分享 收藏
Neural Crest-Like Stem Cell Transcriptome Analysis Identifies LPAR1 in Melanoma Progression and Therapy Resistance Liu, Jianglan; Rebecca, Vito W.; Kossenkov, Andrew, V; Connelly, Thomas; Liu, Qin; Gutierrez, Alexis; Xiao, Min; Li, Ling; Zhang, Gao; Samarkina, Anastasia; Zayasbazan, Delaine; Zhang, Jie; Cheng, Chaoran; Wei, Zhi; Alicea, Gretchen M.; Fukunaga-Kalabis, Mizuho; Krepler, Clemens; Aza-Blanc, Pedro; Yang, Chih-Cheng; Delvadia, Bela; Tong, Cynthia; Huang, Ye; Delvadia, Maya; Morias, Alice S.; Sproesser, Katrin; Brafford, Patricia; Wang, Joshua X.; Beqiri, Marilda; Somasundaram, Rajasekharan; Vultur, Adina; Hristova, Denitsa M.; Wu, Lawrence W.; Lu, Yiling; Mills, Gordon B.; Xu, Wei; Karakousis, Giorgos C.; Xu, Xiaowei; Schuchter, Lynn M.; Mitchell, Tara C.; Amaravadi, Ravi K.; Kwong, Lawrence N.; Frederick, Dennie T.; Boland, Genevieve M.; Salvino, Joseph M.; Speicher, David W.; Flaherty, Keith T.; Ronai, Ze'ev A.; Herlyn, Meenhard 分享 收藏
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Inhibition of endothelin-B receptor signaling synergizes with MAPK pathway inhibitors in BRAF mutated melanoma Schaefer, Alexander; Haenig, Benedicte; Erupathil, Julie; Strickner, Panja; Sabato, Daniela; Welford, Richard W. D.; Klaeyle, Lheanna; Simon, Elise; Krepler, Clemens; Brafford, Patricia; Xiao, Min; Herlyn, Meenhard; Gstaiger, Matthias; Lehembre, Francois; Renz, Imke 分享 收藏
Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy Somasundaram, Rajasekharan; Connelly, Thomas; Choi, Robin; Choi, Hyeree; Samarkina, Anastasia; Ling Li; Gregorio, Elizabeth; Chen, Yeqing; Thakur, Rohit; Abdel-Mohsen, Mohamed; Beqiri, Marilda; Kiernan, Meaghan; Perego, Michela; Fang Wang; Min Xiao; Brafford, Patricia; Xue Yang; Xu, Xiaowei; Secreto, Anthony; Danet-Desnoyers, Gwenn; Traum, Daniel; Kaestner, Klaus H.; Huang, Alexander C.; Hristova, Denitsa; Wang, Joshua; Fukunaga-Kalabis, Mizuho; Krepler, Clemens; Fang Ping-Chen; Zhou, Xiangyang; Gutierrez, Alexis; Rebecca, Vito W.; Vonteddu, Prashanthi; Dotiwala, Farokh; Bala, Shashi; Majumdar, Sonali; Dweep, Harsh; Wickramasinghe, Jayamanna; Kossenkov, Andrew, V; Reyes-Arbujas, Jorge; Santiago, Kenisha; Nguyen, Tran; Griss, Johannes; Keeney, Frederick; Hayden, James; Gavin, Brian J.; Weiner, David; Montaner, Luis J.; Qin Liu; Peiffer, Lukas; Becker, Juergen; Burton, Elizabeth M.; Davies, Michael A.; Tetzlaff, Michael T.; Muthumani, Kar; Wargo, Jennifer A.; Gabrilovich, Dmitry; Herlyn, Meenhard 分享 收藏
DURABLE RESPONSES AND IMMUNE ACTIVATION WITH INTRATUMORAL ELECTROPORATION OF PIL-12 PLUS PEMBROLIZUMAB IN ACTIVELY PROGRESSING ANTI-PD-1 REFRACTORY ADVANCED MELANOMA: KEYNOTE 695 INTERIM DATA Fernandez-Penas, Pablo; Carlino, Matteo; Tsai, Katy; Atkinson, Victoria; Shaheen, Monaster; Thomas, Sajeve; Mihalcioiu, Catalin; Van Hagen, Tom; Roberts-Thomson, Rachel; Haydon, Andrew; Mant, Andrew; Butler, Marcus; Daniels, Gregory; Buchbinder, Elizabeth; Hyngstrom, John; Moller, Mecker; Puzanov, Igor; Cowey, C. Lance; Whitman, Eric; Ballesteros-Merino, Carmen; Jensen, Shawn; Fox, Bernard; Schmidt, Emmett; Krepler, Clemens; Diede, Scott; Browning, Erica; Hermiz, Reneta; Svenson, Lauren; Salazar, Jon; Lee, Jack; Baker, Christopher; Bannavong, Donna; Sell, Jendy; Foerter, Kellie Malloy; Canton, David; Aung, Sandra; Twitty, Christopher; Algazi, Alain; Daud, Adil 分享 收藏
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