未登录Transcriptomic analysis of hepatocellular carcinoma reveals molecular features of disease progression and tumor immune biology
Okrah, K.; Tarighat, S.; Liu, B.; Koeppen, H.; Wagle, M. C.; Cheng, G.; Sun, C.; Dey, A.; Chang, M. T.; Sumiyoshi, T.; Mounir, Z.; Cummings, C.; Hampton, G.; Amler, L.; Fridlyand, J.; Hegde, P. S.; Turley, S. J.; Lackner, M. R.; Huang, S. M. .png)
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收藏Differential regulation of PD-L1 expression by immune and tumor cells in NSCLC and the response to treatment with atezolizumab (anti-PD-L1)NSCLC中免疫细胞和肿瘤细胞对PD-L1表达的差异调节以及对阿特珠单抗治疗的反应 (anti-PD-L1)Kowanetz, Marcin; Zou, Wei; Gettinger, Scott N.; Koeppen, Hartmut; Kockx, Mark; Schmid, Peter; Kadel, Edward E., III; Wistuba, Ignacio; Chaft, Jamie; Rizvi, Naiyer A.; Spigel, David R.; Spira, Alexander; Hirsch, Fred R.; Cohen, Victor; Smith, Dustin; Boyd, Zach; Miley, Natasha; Flynn, Susan; Leveque, Vincent; Shames, David S.; Ballinger, Marcus; Mocci, Simonetta; Shankar, Geetha; Funke, Roel; Hampton, Garret; Sandler, Alan; Amler, Lukas; Mellman, Ira; Chen, Daniel S.; Hegde, Priti S. 分享 收藏 A transcriptional MAPK Pathway Activity Score (MPAS) is a clinically relevant biomarker in multiple cancer typesWagle, Marie-Claire; Kirouac, Daniel; Klijn, Christiaan; Liu, Bonnie; Mahajan, Shilpi; Junttila, Melissa; Moffat, John; Merchant, Mark; Huw, Ling; Wongchenko, Matthew; Okrah, Kwame; Srinivasan, Shrividhya; Mounir, Zineb; Sumiyoshi, Teiko; Haverty, Peter M.; Yauch, Robert L.; Yan, Yibing; Kabbarah, Omar; Hampton, Garret; Amler, Lukas; Ramanujan, Saroja; Lackner, Mark R.; Huang, Shih-Min A. 分享 收藏 A custom gene expression panel for consensus molecular subtype classification of archival primary and metastatic colorectal cancersHuw, Ling-Yuh; Piskol, Robert; de Sosa e Melo, Felipe; Kim, Doris; Qu, Xueping; Koeppen, Hartmut; Lackner, Mark; Hampton, Garret; Kabbarah, Omar; Tam, Rachel 分享 收藏 Analysis of non-metastatic HCC patient tumors revealed the significance of cell cycle regulation and tumor immunity in association with overall survival and identified clinically relevant druggable targetsMiao, Pei-Zhen; Cheng, Jeff; Okrah, Kwame; Liu, Bonnie; Sun, Charlie; Cao, Grace; Guo, Tony; Fu, Shijing; Wagle, Marie-Claire; Blackwood, Elizabeth; Shames, David; Hampton, Garret; Amler, Lukas; Kiermaier, Astrid; Fridlyand, Yevgeniya; Lackner, Mark; Huang, Shih-Min; Zhou, Jian; Dai, Zhi 分享 收藏 Tumor mutation load assessed by FoundationOne (FM1) is associated with improved efficacy of atezolizumab (atezo) in patients with advanced NSCLCKowanetz, M.; Zou, W.; Shames, D. S.; Cummings, C.; Rizvi, N.; Spira, A. I.; Frampton, G. M.; Leveque, V.; Flynn, S.; Mocci, S.; Shankar, G.; Funke, R.; Ballinger, M.; Waterkamp, D.; Sandler, A.; Hampton, G.; Amler, L.; Hegde, P. S.; Hellmann, M. 分享 收藏 Comprehensive RNA-seq transcriptome interrogation of paired hepatocellular carcinoma and cirrhosis tissues revealed significant molecular features of disease evolution and modulation of tumor immunityLiu, Bonnie P.; Okrah, Kwame; Cheng, Jeff; Motlhabi, Maipelo; Sun, Charlie; Sumiyoshi, Teiko; Ikeda, Shoji; Koeppen, Hartmut; Mounir, Zineb; Cummings, Craig; Hague, Nadia; Hampton, Garret; Amler, Lukas; Lackner, Mark; Huang, Shih-Min A. 分享 收藏 Whole transcriptome and exome targeted RNA sequencing for FFPE tumor samples from clinical trialsSchleifman, Erica B.; Kiialainen, Anna; Roller, Andreas; Bader, Sabine; Motlhabi, Maipelo; Hegde, Priti; McCaffery, Ian; Hampton, Garret; Cannarile, Michael; Cummings, Craig; Spleiss, Olivia; Peters, Eric 分享 收藏 A novel predictive biomarker model for MEK sensitivityWagle, Marie; Klijn, Christiaan; Liu, Bonnie; Mahajan, Shilpi; Haverty, Peter; Moffat, John; Merchant, Mark; Yauch, Bob; Hampton, Garret; Amler, Lukas; Lackner, Mark; Huang, Shih-Min A. 分享 收藏 Gene expression and genomic drift comparative analysis between patient-derived conditionally reprogrammed cells and original tumorsLi, Jessica; Liu, Bonnie; Nakamura, Rin; Savage, Heidi; Ikeda, Shoji; Wilson, Timothy; Sumiyoshi, Teiko; Hampton, Garret; Amler, Lukas; Lackner, Mark; Huang, Shih-Min A.; Darbonne, Walter C. 分享 收藏 Integrated genomic analysis of colorectal cancer progression reveals activation of EGFR through demethylation of the EREG promoterQu, Xueping; Sandmann, Thomas; Frierson, Henry; Fu, Ling; Fuentes, Eloise; Walter, Kimberly; Okrah, Kwame; Rumpel, Craig; Moskaluk, Christopher; Lu, Shan; Wang, Yulei; Bourgon, Richard; Penuel, Elicia; Pirzkall, Andrea; Amler, Lukas; Lackner, Mark; Tabenero, Josep; Hampton, Garret; Kabbarah, Omar 分享 收藏 Integrated genomic analysis of colorectal cancer progression reveals activation of EGFR through demethylation of the EREG promoterQu, X.; Sandmann, T.; Frierson, H., Jr.; Fu, L.; Fuentes, E.; Walter, K.; Okrah, K.; Rumpel, C.; Moskaluk, C.; Lu, S.; Wang, Y.; Bourgon, R.; Penuel, E.; Pirzkall, A.; Amler, L.; Lackner, M. R.; Tabernero, J.; Hampton, G. M.; Kabbarah, O. 分享 收藏 Heterogeneity and clinical significance of ESR1 mutations in ER-positive metastatic breast cancer patients receiving fulvestrantSpoerke, Jill M.; Gendreau, Steven; Walter, Kimberly; Qiu, Jiaheng; Wilson, Timothy R.; Savage, Heidi; Aimi, Junko; Derynck, Mika K.; Chen, Meng; Chan, Iris T.; Amler, Lukas C.; Hampton, Garret M.; Johnston, Stephen; Krop, Ian; Schmid, Peter; Lackner, Mark R. 分享 收藏 A role for FOXO1 in BCR-ABL1-independent tyrosine kinase inhibitor resistance in chronic myeloid leukemiaWagle, M.; Eiring, A. M.; Wongchenko, M.; Lu, S.; Guan, Y.; Wang, Y.; Lackner, M.; Amler, L.; Hampton, G.; Deininger, M. W.; O'Hare, T.; Yan, Y. 分享 收藏 分享 收藏 High prevalence and clonal heterogeneity of ESR1 mutations (mt) in circulating tumor DNA (ctDNA) from patients (pts) enrolled in FERGI, a randomized phase II study testing pictilisib (GDC-0941) in combination with fulvestrant (F) in pts that failed a prior aromatase inhibitor (AI)Spoerke, J.; Gendreau, S.; Johnston, S.; Schmid, P.; Krop, I.; Qui, J.; Derynck, M.; Chan, I.; Walter, K.; Amler, L.; Hampton, G.; Lackner, M. 分享 收藏 Pharmacodynamic biomarker evaluation in phase I clinical trials of selective PI3K and PI3K/mTOR inhibitorsNakanishi, Yoshito; Spoerke, Jill M.; Derynck, Mika; Lauchle, Jennifer O.; Koeppen, Hartmut; Fredrickson, Jill; Ware, Joseph; Hampton, Garret; Yan, Yibing; Lackner, Mark R. 分享 收藏 Comprehensive predictive biomarker evaluation in two phase II clinical trials of the PI3K/mTOR inhibitor GDC-0980 in metastatic renal cell carcinoma and advanced endometrial cancerSpoerke, Jill M.; Makker, Vicky; Aghajanian, Carol; Thomas, Powles; Motzer, Robert J.; Lauchle, Jennifer O.; Parmar, Hema; Gilbert, Houston; Lin, Wei; O'Keeffe, Bridget; Byrtek, Michelle; Koeppen, Hartmut; Wang, Yulei; Lu, Shan; Huw, Ling-Yuh; Hampton, Garret M.; Lackner, Mark R. 分享 收藏 Development of a robust RNA-based classifier to accurately determine ER, PR, and HER2 status in breast cancer clinical samples开发基于RNA的强大分类器，以准确确定乳腺癌临床样本中的ER，PR和HER2状态Wilson, Timothy R.; Xiao, Yuanyuan; Spoerke, Jill M.; Fridlyand, Jane; Koeppen, Hartmut; Fuentes, Eloisa; Huw, Ling Y.; Abbas, Ilma; Gower, Arjan; Schleifman, Erica B.; Desai, Rupal; Fu, Ling; Sumiyoshi, Teiko; O'Shaughnessy, Joyce A.; Hampton, Garret M.; Lackner, Mark R. 分享 收藏 Comprehensive biomarker profiling of matched primary and metastatic estrogen receptor positive breast cancersSpoerke, Jill M.; Schleifman, Erica B.; Desai, Rupal; Xiao, Yuanyuan; Wong, Cheryl; Abbas, Ilma; O'Brien, Carol; Patel, Rajesh; Sumiyoshi, Teiko; Fu, Ling; Tam, Rachel; Koeppen, Hartmut; Wilson, Timothy; Raja, Rajiv; Hampton, Garret M.; Lackner, Mark R. 分享 收藏 
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