未登录 Spatial transcriptomic validation of a biomimetic model of fibrosis enables re-evaluation of a therapeutic antibody targeting LOXL2 纤维化仿生模型的空间转录组验证可以重新评估靶向LOXL2的治疗性抗体 Bell, Joseph A.; Davies, Elizabeth R.; Brereton, Christopher J.; Vukmirovic, Milica; Roberts, James J. W.; Lunn, Kerry; Wickens, Leanne; Conforti, Franco; Ridley, Robert A.; Ceccato, Jessica; Sayer, Lucy N.; Johnston, David A.; Vallejo, Andres F.; Alzetani, Aiman; Jogai, Sanjay; Marshall, Ben G.; Fabre, Aurelie; Richeldi, Luca; Monk, Phillip D.; Skipp, Paul; Kaminski, Naftali; Offer, Emily; Wang, Yihua; Davies, Donna E.; Jones, Mark G. 分享 收藏
Safety and efficacy of inhaled interferon-β1a (SNG001) in adults with mild-to-moderate COVID-19: a randomized, controlled, phase II trial 轻中度新型冠状病毒肺炎成人吸入干扰素-β1a (SNG001) 的安全性和有效性: 一项随机，对照，II期试验 Jagannathan, Prasanna; Chew, Kara W.; Giganti, Mark J.; Hughes, Michael D.; Moser, Carlee; Main, Mark J.; Monk, Phillip D.; Javan, Arzhang Cyrus; Li, Jonathan Z.; Fletcher, Courtney V.; McCarthy, Caitlyn; Wohl, David A.; Daar, Eric S.; Eron, Joseph J.; Currier, Judith S.; Singh, Upinder; Smith, Davey M.; Fischer, William 分享 收藏
Clinical trials of inhaled interferon beta-1a (SNG001) in COVID-19 patients in the home and hospital Monk, Phillip D.; Brookes, Jody; Tear, Victoria; Batten, Toby; Mankowski, Marcin; Gabbay, Felicity; Davies, Donna; Brightling, Chris; Kraft, Monica; Djukanovic, Ratko; Holgate, Stephen; Wilkinson, Tom 分享 收藏
Safety and efficacy of inhaled nebulised interferon beta-1a (SNG001) for treatment of SARS-CoV-2 infection: a randomised, double-blind, placebo-controlled, phase 2 trial Monk, Phillip D.; Marsden, Richard J.; Tear, Victoria J.; Brookes, Jody; Batten, Toby N.; Mankowski, Marcin; Gabbay, Felicity J.; Davies, Donna E.; Holgate, Stephen T.; Ho, Ling-Pei; Clark, Tristan; Djukanovic, Ratko; Wilkinson, Tom M. A. 分享 收藏
INEXAS: A Phase 2 Randomized Trial of On-demand Inhaled Interferon Beta-1a in Severe Asthmatics McCrae, Christopher; Olsson, Marita; Gustafson, Per; Malmgren, Anna; Aurell, Malin; Fageras, Malin; Da Silva, Carla A.; Cavallin, Anders; Paraskos, Jonathan; Karlsson, Karin; Wingren, Cecilia; Monk, Phillip; Marsden, Richard; Harrison, Tim 分享 收藏
The epigenetic modulator 5-aza-2′-deoxycytidine reduces the fibrotic response of human lung fibroblasts to TGFβ1 in a novel, long term, 3D cell culture system Ward, Mark; Smart, David E.; Roberts, James; Monk, Phillip; Davies, Donna E.; Jones, Mark G.; O'Reilly, Katherine M. A.; Baugh, John Andrew 分享 收藏
TGFβ1 induces collagen deposition and increased tissue stiffness in sarcoidosis fibroblasts grown in a novel, long term, 3D culture system Ward, Mark; Smart, David; Roberts, James; Monk, Phillip; Baugh, John Andrew; Jones, Mark Glynne; Davies, Donna E.; O'Reilly, Katherine M. A. 分享 收藏
Nanoscale dysregulation of collagen structure-function disrupts mechano-homeostasis and mediates pulmonary fibrosis Jones, Mark G.; Andriotis, Orestis G.; Roberts, James J. W.; Lunn, Kerry; Tear, Victoria J.; Cao, Lucy; Ask, Kjetil; Smart, David E.; Bonfanti, Alessandra; Johnson, Peter; Alzetani, Aiman; Conforti, Franco; Doherty, Regan; Lai, Chester Y.; Johnson, Benjamin; Bourdakos, Konstantinos N.; Fletcher, Sophie, V; Marshall, Ben G.; Jogai, Sanjay; Brereton, Christopher J.; Chee, Serena J.; Ottensmeier, Christian H.; Sime, Patricia; Gauldie, Jack; Kolb, Martin; Mahajan, Sumeet; Fabre, Aurelie; Bhaskar, Atul; Jarolimek, Wolfgang; Richeldi, Luca; O'Reilly, Katherine M. A.; Monk, Phillip D.; Thurner, Philipp J.; Davies, Donna E. 分享 收藏
Evaluation of novel LOXL2-selective inhibitors in models of pulmonary fibrosis Roberts, James; Tear, Victoria; Lunn, Kerry; Cao, Lucy; Murphy, James; Shimbori, Chiko; Imani, Jewel; Tandon, Karun; Ayaub, Ehab; Jones, Mark; Davies, Donna; Jarolimek, Wolfgang; Ask, Kjetil; Gauldie, Jack; Kolb, Martin; Monk, Phillip 分享 收藏
Susceptibility to influenza virus infection of bronchial biopsies in asthma Nicholas, Ben; Dudley, Sarah; Tariq, Kamran; Howarth, Peter; Lunn, Kerry; Pink, Sandy; Sterk, Peter J.; Adcock, Ian M.; Monk, Phillip; Djukanovic, Ratko 分享 收藏
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The Effect of Inhaled IFN-β on Worsening of Asthma Symptoms Caused by Viral Infections A Randomized Trial Djukanovic, Ratko; Harrison, Tim; Johnston, Sebastian L.; Gabbay, Flic; Wark, Peter; Thomson, Neil C.; Niven, Robert; Singh, Dave; Reddel, Helen K.; Davies, Donna E.; Marsden, Richard; Boxall, Christine; Dudley, Sarah; Plagnol, Vincent; Holgate, Stephen T.; Monk, Phillip 分享 收藏
Experimental rhinovirus 16 infection in moderate asthmatics on inhaled corticosteroids Adura, Peter T.; Reed, Eleanor; Macintyre, Jonathan; del Rosario, Ajerico; Roberts, James; Pestridge, Rachel; Beegan, Rona; Boxall, Christine B.; Xiao, Chang; Kebadze, Tatiana; Aniscenko, Juliya; Cornelius, Victoria; Gern, James E.; Monk, Phillip D.; Johnston, Sebastian L.; Djukanovic, Ratko 分享 收藏
Protein engineering and preclinical development of a GM-CSF receptor antibody for the treatment of rheumatoid arthritis Minter, R. R.; Cohen, E. S.; Wang, B.; Liang, M.; Vainshtein, I.; Rees, G.; Eghobamien, L.; Harrison, P.; Sims, D. A.; Matthews, C.; Wilkinson, T.; Monk, P.; Drinkwater, C.; Fabri, L.; Nash, A.; McCourt, M.; Jermutus, L.; Roskos, L.; Anderson, I. K.; Sleeman, M. A. 分享 收藏
ADAPTIVE AND INNATE-LIKE T CELL PHENOTYPES IN ASTHMA IN RELATIONSHIP TO COMPARTMENT AND SEVERITY Hinks, T. S. C.; Staples, K. J.; Smith, C.; Ward, J.; Mansour, S.; Monk, P.; Howarth, P. H.; Virgin, H. W.; Gadola, S.; Djukanovic, R. 分享 收藏
Barrier responses of human bronchial epithelial cells to grass pollen exposure Blume, Cornelia; Swindle, Emily J.; Dennison, Patrick; Jayasekera, Nivenka P.; Dudley, Sarah; Monk, Phillip; Behrendt, Heidrun; Schmidt-Weber, Carsten B.; Holgate, Stephen T.; Howarth, Peter H.; Traidl-Hoffmann, Claudia; Davies, Donna E. 分享 收藏
Defective epithelial barrier function in asthma Xiao, Chang; Puddicombe, Sarah M.; Field, Sarah; Haywood, Joel; Broughton-Head, Victoria; Puxeddu, Ilaria; Haitchi, Hans Michael; Vernon-Wilson, Elizabeth; Sammut, David; Bedke, Nicole; Cremin, Catherine; Sones, Jody; Djukanovic, Ratko; Howarth, Peter H.; Collins, Jane E.; Holgate, Stephen T.; Monk, Phillip; Davies, Donna E. 分享 收藏
Increased sputum and bronchial biopsy IL-13 expression in severe asthma Saha, Shironjit K.; Berry, Mike A.; Parker, Deborah; Siddiqui, Salman; Morgan, Angela; May, Richard; Monk, Phillip; Bradding, Peter; Wardlaw, Andrew J.; Pavord, Ian D.; Brightling, Christopher E. 分享 收藏
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