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The case for regulatory approval of amyloid-lowering immunotherapies in Alzheimer's disease based on clearcut biomarker evidence 基于明确的生物标志物证据的阿尔茨海默氏病降低淀粉样蛋白免疫疗法的监管批准案例 Aisen, Paul; Bateman, Randall J.; Crowther, Damian; Cummings, Jeff; Dwyer, John; Iwatsubo, Takeshi; Kosco-Vilbois, Marie; Mcdade, Eric; Mohs, Richard; Scheltens, Philip; Sperling, Reisa; Selkoe, Dennis 分享 收藏
Targeting the TDP-43 low complexity domain blocks spreading of pathology in a mouse model of ALS/FTD Chevalier, Elodie; Audrain, Mickael; Ratnam, Monisha; Ollier, Romain; Fuchs, Aline; Piorkowska, Kasia; Pfeifer, Andrea; Kosco-Vilbois, Marie; Seredenina, Tamara; Afroz, Tariq 分享 收藏
Targeting amyotrophic lateral sclerosis by neutralizing seeding-competent TDP-43 in CSF Audrain, Mickael; Egesipe, Anne-Laure; Tentillier, Noemie; Font, Laure; Ratnam, Monisha; Mottier, Lorene; Clavel, Mathieu; Le Roux-Bourdieu, Morgan; Fenyi, Alexis; Ollier, Romain; Chevalier, Elodie; Guilhot, Florence; Fuchs, Aline; Piorkowska, Kasia; Carlyle, Becky; Arnold, Steven E.; Berry, James D.; Luthi-Carter, Ruth; Adolfsson, Oskar; Pfeifer, Andrea; Kosco-Vilbois, Marie; Seredenina, Tamara; Afroz, Tariq 分享 收藏
The α-synuclein PET tracer [18F] ACI-12589 distinguishes multiple system atrophy from other neurodegenerative diseases Smith, Ruben; Capotosti, Francesca; Schain, Martin; Ohlsson, Tomas; Vokali, Efthymia; Molette, Jerome; Touilloux, Tanja; Hliva, Valerie; Dimitrakopoulos, Ioannis K.; Puschmann, Andreas; Jogi, Jonas; Svenningsson, Per; Andreasson, Mattias; Sandiego, Christine; Russell, David S.; Miranda-Azpiazu, Patricia; Halldin, Christer; Stomrud, Erik; Hall, Sara; Bratteby, Klas; Tampio L'Estrade, Elina; Luthi-Carter, Ruth; Pfeifer, Andrea; Kosco-Vilbois, Marie; Streffer, Johannes; Hansson, Oskar 分享 收藏
Improved antibody pharmacokinetics by disruption of contiguous positive surface potential and charge reduction using alternate human framework Ollier, Romain; Fuchs, Aline; Gauye, Florence; Piorkowska, Katarzyna; Menant, Sebastien; Ratnam, Monisha; Montanari, Paolo; Guilhot, Florence; Phillipe, Didier; Audrain, Mickael; Egesipe, Anne-Laure; Nevoltris, Damien; Seredenina, Tamara; Pfeifer, Andrea; Kosco-Vilbois, Marie; Afroz, Tariq 分享 收藏
Modeling Alzheimer's disease related phenotypes in the Ts65Dn mouse: impact of age on Aβ, Tau, pTau, NfL, and behavior Overk, Cassia; Fiorini, Emma; Babolin, Chiara; Vukicevic, Marija; Morici, Catherine; Madani, Rime; Eligert, Valerie; Kosco-Vilbois, Marie; Roberts, Amanda; Becker, Ann; Pfeifer, Andrea; Mobley, William C. 分享 收藏
Immunotherapy targeting the C-terminal domain of TDP-43 decreases neuropathology and confers neuroprotection in mouse models of ALS/FTD Afroz, Tariq; Chevalier, Elodie; Audrain, Mickael; Dumayne, Christopher; Ziehm, Tamar; Moser, Roger; Egesipe, Anne-Laure; Mottier, Lorene; Ratnam, Monisha; Neumann, Manuela; Havas, Daniel; Ollier, Romain; Piorkowska, Kasia; Chauhan, Mayank; Silva, Alberto B.; Thapa, Samjhana; Stohr, Jan; Bavdek, Andrej; Eligert, Valerie; Adolfsson, Oskar; Nelson, Peter T.; Porta, Silvia; Lee, Virginia M. -Y.; Pfeifer, Andrea; Kosco-Vilbois, Marie; Seredenina, Tamara 分享 收藏
Beneficial Effect of ACI-24 Vaccination on Aβ Plaque Pathology and Microglial Phenotypes in an Amyloidosis Mouse Model Njavro, Jasenka Rudan; Vukicevic, Marija; Fiorini, Emma; Dinkel, Lina; Mueller, Stephan A.; Berghofer, Anna; Bordier, Chiara; Kozlov, Stanislav; Halle, Annett; Buschmann, Katrin; Capell, Anja; Giudici, Camilla; Willem, Michael; Feederle, Regina; Lichtenthaler, Stefan F.; Babolin, Chiara; Montanari, Paolo; Pfeifer, Andrea; Kosco-Vilbois, Marie; Tahirovic, Sabina 分享 收藏
An amyloid beta vaccine that safely drives immunity to a key pathological species in Alzheimer's disease: pyroglutamate amyloid beta 一种淀粉样蛋白 β 疫苗，可安全地对阿尔茨海默氏病的关键病理物种产生免疫力: 焦谷氨酸淀粉样蛋白 β Vukicevic, M.; Fiorini, E.; Siegert, S.; Carpintero, R.; Rincon-Restrepo, M.; Lopez-Deber, P.; Piot, N.; Ayer, M.; Rentero, I.; Babolin, C.; Bravo-Veyrat, S.; Giriens, V.; Morici, C.; Beuzelin, M.; Gesbert, A.; Rivot, S.; Depretti, S.; Donati, P.; Streffer, J.; Pfeifer, A.; Kosco-Vilbois, M. H. 分享 收藏
Targeting a membrane-proximal epitope on mesothelin increases the tumoricidal activity of a bispecific antibody blocking CD47 on tumor cells Hatterer, E.; Chauchet, X.; Barba, L.; Richard, F.; Moine, V.; Chatel, L.; Cons, L.; Ravn, U.; Masternak, K.; Fischer, N.; Kosco-Vilbois, M.; Ferlin, W.; Buatois, V.; Shang, L. 分享 收藏
Co-engaging CD47 and CD19 with a bispecific antibody abrogates B-cell receptor/CD19 association leading to impaired B-cell proliferation 将CD47和CD19与双特异性抗体共同结合可消除导致b细胞增殖受损的b细胞受体/CD19关联 Hatterer, Eric; Barba, Leticia; Noraz, Nelly; Daubeuf, Bruno; Aubry-Lachainaye, Jean-Pierre; von der Weid, Benoit; Richard, Francoise; Kosco-Vilbois, Marie; Ferlin, Walter; Shang, Limin; Buatois, Vanessa 分享 收藏
Preclinical Development of a Bispecific Antibody that Safely and Effectively Targets CD19 and CD47 for the Treatment of B-Cell Lymphoma and Leukemia 安全有效靶向CD19和CD47的双特异性抗体的临床前开发，用于治疗b细胞淋巴瘤和白血病 Buatois, Vanessa; Johnson, Zoe; Salgado-Pires, Susana; Papaioannou, Anne; Hatterer, Eric; Chauchet, Xavier; Richard, Francoise; Barba, Leticia; Daubeuf, Bruno; Cons, Laura; Broyer, Lucile; D'Asaro, Matilde; Matthes, Thomas; LeGallou, Simon; Fest, Thierry; Tarte, Karin; Hinojosa, Robert K. Clarke; Ferrer, Eulalia Genesca; Ribera, Jose Maria; Dey, Aditi; Bailey, Katharine; Fielding, Adele K.; Eissenberg, Linda; Ritchey, Julie; Rettig, Michael; DiPersio, John F.; Kosco-Vilbois, Marie H.; Masternak, Krzysztof; Fischer, Nicolas; Shang, Limin; Ferlin, Walter G. 分享 收藏
Dual-targeting mesothelin/CD47 bispecific antibodies for tumor-directed blockade of CD47 in solid cancer Moine, Valery; Broyer, Lucile; Chauchet, Xavier; Hatterer, Eric; Majocchi, Stefano; Buatois, Vanessa; Shang, Limin; Didelot, Gerard; Magistrelli, Giovanni; Poitevin, Yves; Ravn, Ulla; Kosco-Vilbois, Marie H.; Fiischer, Nicolas; Ferlin, Walter G.; Masternak, Krzysztof 分享 收藏
Antibody Neutralization of CXCL10 in Vivo Is Dependent on Binding to Free and Not Endothelial-bound Chemokine IMPLICATIONS FOR THE DESIGN OF A NEW GENERATION OF ANTI-CHEMOKINE THERAPEUTIC ANTIBODIES Bonvin, Pauline; Gueneau, Franck; Buatois, Vanessa; Charreton-Galby, Maud; Lasch, Stanley; Messmer, Marie; Christen, Urs; Luster, Andrew D.; Johnson, Zoe; Ferlin, Walter; Kosco-Vilbois, Marie; Proudfoot, Amanda; Fischer, Nicolas 分享 收藏
Selective Blockade of the Ubiquitous Checkpoint Receptor CD47 Is Enabled by Dual-Targeting Bispecific Antibodies Dheilly, Elie; Moine, Valery; Broyer, Lucile; Salgado-Pires, Susana; Johnson, Zoe; Papaioannou, Anne; Cons, Laura; Calloud, Sebastien; Majocchi, Stefano; Nelson, Robert; Rousseau, Francois; Ferlin, Walter; Kosco-Vilbois, Marie; Fischer, Nicolas; Masternak, Krzysztof 分享 收藏
Use of a mouse model to identify a blood biomarker for IFNγ activity in pediatric secondary hemophagocytic lymphohistiocytosis Buatois, Vanessa; Chatel, Laurence; Cons, Laura; Lory, Sabrina; Richard, Francoise; Guilhot, Florence; Johnson, Zoe; Bracaglia, Claudia; De Benedetti, Fabrizio; de Min, Cristina; Kosco-Vilbois, Marie H.; Ferlin, Walter G. 分享 收藏
Neutralization of CD47 in cancer cells with bispecific antibodies harnesses the phagocytic potential of tumor -infiltrating macrophages Masternak, Krzysztof; Moine, Valery; Broyer, Lucile; Chauchet, Xavier; Buatois, Vanessa; Dheilly, Elie; Majocchi, Stefano; Magistrelli, Giovanni; Poitevin, Yves; Ravn, Ulla; Hatterer, Eric; Pires, Susana Salgado; Shang, Limin; Johnson, Zoe; Ferlin, Walter; Kosco-Vilbois, Marie; Fischer, Nicolas 分享 收藏
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