徐涌 (Yong Xu)

Central South University教授

H指数:8

被引数:300

个人简介

"徐涌作者：基础医学院日期：2015-03-23 点击：20256 徐涌，教授，博士，博士生导师科学研究方向重大疾病的转录调控联系方式地址：江苏省南京市江宁区龙眠大道101号学海楼，邮编211166 电邮：yjxu@njmu.edu.cn简介江苏省第五期“333高层次人才培养工程”培养对象，江苏特聘教授。先后主持了国家自然科学基金、教育部新世纪优秀人才基金、江苏省杰出青年基金，杰出青年基金等科研项目。相关研究成果在Circulation、Circ Res、Hepatology、Nat Commun、Nucleic Acids Res等国际期刊发表研究论文或特邀综述100余篇，累计影响因子超过500。奖项及荣誉“心血管病炎症调控关键节点的靶向学研究”获2015年教育部自然科学一等奖，徐涌排名第三“心血管疾病的表观遗传学研究”获2019年江苏省科学技术奖二等奖，徐涌排名第一承担科研课题1. HIC1调控CIITA转录机制研究及其在B细胞分化中的意义（2013-2016）国家自然科学基金面上项目（31270805）80万元2. 蛋白质翻译后修饰与心血管系统病理生理学（2012-2014）教育部“新世纪优秀人才”基金（DG216D5049） 50万元3. 重大疾病过程中的转录调控（2012-2015）江苏省杰出青年基金（BK2012043）100万元4. Brg1调控血管内皮细胞稳态的机制研究（2014-2017）江苏省高校自然科学研究重大项目(江苏省教育厅）（14KJA310001）15万元5. Brg1调控血管内皮细胞稳态的机制及其在心肌肥大中的作用研究（2015-2017）国家自然科学基金重大研究计划培育项目（91439106）100万元6. H3K9甲基转移酶SUV39H1调控血管平滑肌表型转化的表观遗传机制研究（2013-2016）国家自然科学基金面上项目（81670223）93万元7. 心血管系统稳态失衡的转录调控（2018-2022）国家杰出青年科学基金（81725001） 350万元近五年代表性论文、专利1. Yu L, Yang G, Weng X, Liang P, Li L, Li J, Fan Z, Tian W, Wu X, Xu H, Fang M, Ji Y, Li Y, Chen Q, Xu Y*.Histone Methyltransferase SET1 Mediates Angiotensin II-Induced Endothelin-1 Transcription and Cardiac Hypertrophy in Mice.ArteriosclerThrombVasc Biol. 2015 May;35(5):1207-17.2. Weng X, Yu L, Liang P, Li L, Dai X, Zhou B, Wu X, Xu H, Fang M, Chen Q, Xu Y*. A crosstalk between chromatin remodeling and histone H3K4 methyltransferase complexes in endothelial cells regulates angiotensin II-induced cardiac hypertrophy. J Mol Cell Cardiol. 2015 May;82:48-58.3. Chen D, Yang Y, Cheng X, Fang F, Xu G, Yuan Z, Xia J, Kong H, Xie W, Wang H, Fang M, Gao Y, Xu Y*. Megakaryocytic leukemia 1 directs a histone H3 lysine 4 methyltransferase complex to regulate hypoxic pulmonary hypertension. Hypertension. 2015 Apr; 65(4): 821-33.4. Weng X, Yu L, Liang P, Chen D, Cheng X, Yang Y, Li L, Zhang T, Zhou B, Wu X, Xu H, Fang M, Gao Y, Chen Q, Xu Y*.Endothelial MRTF-A mediates angiotensin II induced cardiac hypertrophy. J Mol Cell Cardiol. 2015 Mar;80:23-33. doi: 10.1016/j.yjmcc.2014.11.009.5. Xu H, Wu X, Qin H, Tian W, Chen J, Sun L, Fang M, Xu Y*.Myocardin-Related Transcription Factor A Epigenetically Regulates Renal Fibrosis in Diabetic Nephropathy. J Am SocNephrol. 2015 Jul;26(7):1648-60.6. Tian W, Hao C, Fan Z, Weng X, Qin H, Wu X, Fang M, Chen Q, Shen A, Xu Y*. Myocardin related transcription factor A programs epigenetic activation of hepatic stellate cells. J Hepatol. 2015 Jan;62(1):165-74.7. Fang MM, Fan ZW, Tian WF, Zhao YH, Li P, Xu HH, Zhou BS, Zhang LP, Wu XY, Xu Y*: HDAC4 mediates IFN- induced disruption of energy expenditure-related gene expression by repressing SIRT1 transcription in skeletal muscle cells. BBA-Gene Regul Mech. 2016 Feb 2; 1859(2): 294-305.8. Tian WF, Fan ZW, Li JF, Hao CZ, Li M, Xu HH, Wu XY, Zhou BS, Zhang LP, Fang MM, Xu Y*: Myocardin-related transcription factor A (MRTF-A) plays an essential role in hepatic stellate cell activation by epigenetically modulating TGF-β signaling. Int J Biochem Cell Biol. 2016 Feb; 71(2):35-43.9. Fan ZW, Kong XC, Xia J, Wu XY, Li H, Xu HH, Fang MM, Xu Y*: The arginine methyltransferase PRMT5 regulates CIITA-dependent MHC II transcription. BBA-Gene Regul Mech. 2016 May 2; 1859(5): 687-96.10. Zhou BS, Zeng S, Li LY, Fan ZW, Tian WF, Li M, Xu HH, Wu XY, Fang MM, Xu Y*: Angiogenic factor with G patch and FHA domains 1 (Aggf1) regulates liver fibrosis by modulating TGF- signaling. BBA-Mol Basis Dis. 2016 June 2; 1862(6): 1203-13.11. Sun LN, Fan ZW Chen JL, Tian WF, Li M, Xu HH, Wu XY, Shao J, Bian YY, Fang MM, Xu Y*: Transcriptional repression of SIRT1 by protein inhibitor of activated STAT 4 (PIAS4) in hepatic stellate cells contributes to liver fibrosis. Sci Rep. 2016 Jun 21;6:28432.12. Sun LN, Fan ZW, Chen JL, Tian WF, Li M, Xu HH, Wu XY, Fang MM, Xia J, Xu Y*: Protein inhibitor of activated STAT 4 (PIAS4) regulates pro-inflammatory transcription in hepatocyte by repressing SIRT1. Oncotarget. 2016 July 12; 7(28): 42892-903.13. Xu HH, Fan ZW, Tian WF, Xu Y*: Protein inhibitor of activated STAT 4 (PIAS4) regulates liver fibrosis through modulating SMAD3 activity. J Biomed Res. Dec 1; 30(6): 496-501.14. Zeng S, Yang YY, Cheng X, Zhou BS, Li P, Zhao YH, Kong XC, Xu Y*: HIC1 epigenetically represses CIITA transcription in B lymphocytes. BBA-Gene Regul Mech. Dec 2; 1859(12): 1841-9.15. Guang Yang, XinyuWeng, Yuhao Zhao, Xinjian Zhang, Yuanping Hu, Xin Dai, Peng Liang, PengWang,LeiLei Ma, Xiaolei Sun, Lei Hou, HuihuiXu, Mingming Fang, Yuehua Li, Thomas Jenuwein, Yong Xu*&Aijun Sun*：The histone H3K9 methyltransferase SUV39H linksSIRT1 repression to myocardial infarction.Nat Commun.2017 Mar 31;8:1494116. Fan Z, Li L, Li M, Zhang X, Hao C, Yu L, Zeng S, Xu H, Fang M, Shen A, Jenuwein T, Xu Y*. The histone methyltransferase Suv39h2 contributes to nonalcoholic steatohepatitis in mice. Hepatology. 2017; 65(6):1904-1919. 17. Fan Z, Li Z, Yang Y, Liu S, Guo J, Xu Y*. HIF-1α coordinates epigenetic activation of SIAH1 in hepatocytes in response to nutritional stress. Biochim Biophys Acta Gene Regul Mech. 2017; 1860(10):1037-1046.18. Yu L, Fang F, Dai X, Xu H, Qi X, Fang M, Xu Y*. MKL1 defines the H3K4Me3 landscape for NF-κB dependent inflammatory response. Sci Rep. 2017; 7(1):191.19. Song M, Fang F, Dai X, Yu L, Fang M, Xu Y*. MKL is an epigenetic mediator of TNF-α-induced proinflammatory transcription in macrophages by interacting with ASH2. FEBS Lett. 2017; 591(6):934-945.20. Yang G, Zhang X, Weng X, Liang P, Dai X, Zeng S, Xu H, Huan H, Fang M, Li Y, Xu D, Xu Y*. SUV39H1 mediated SIRT1 trans-repression contributes to cardiac ischemia-reperfusion injury. Basic Res Cardiol. 2017; 112(3):22.21. Liming Y, Guang Y, Xinjian Z, Peng W, Xinyu W, Yuyu Y, Zilong L, Mingming F, Xu Y* ,Aijun S*, Junbo G*.Megakaryocytic Leukemia 1 Bridges Epigenetic Activation of NADPH Oxidase in Macrophages to Cardiac Ischemia-Reperfusion Injury.Circulation. 2018;138(24): 2820-2836.22. Zhang X, Liu S, Weng X, Zeng S, Yu L, Guo J, Xu Y*. Brg1 deficiency in vascular endothelial cells blocks neutrophil recruitment and ameliorates "