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Development of a succinyl CoA:3-ketoacid CoA transferase inhibitor selective for peripheral tissues that improves glycemia in obesity 开发一种选择性作用于外周组织的琥珀酰辅酶A:3-酮酸辅酶A转移酶抑制剂，以改善肥胖患者的血糖水平 Dakhili, Seyed Amirhossein Tabatabaei; Yang, Kunyan; Al Nebaihi, Hamdah; Greenwell, Amanda A.; Wuest, Melinda; Woodfield, Jenilee; Abou Farraj, Rabih; Saed, Christina T.; Chan, Jordan S. F.; Bhat, Rakesh K.; Mangra-Bala, Indiresh A.; Shafaati, Tanin; Gopal, Keshav; Eaton, Farah; Ferrari, Sally R.; Wagg, Cory S.; Capozzi, Megan E.; Campbell, Jonathan E.; Overduin, Michael; Velazquez-Martinez, Carlos A.; Glover, J. N. Mark; Wuest, Frank; Brocks, Dion R. 分享 收藏
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The ketogenic diet does not improve cardiac function and blunts glucose oxidation in ischaemic heart failure 生酮饮食不能改善心脏功能，也不能降低缺血性心力衰竭的葡萄糖氧化 Ho, Kim L.; Karwi, Qutuba G.; Wang, Faqi; Wagg, Cory; Zhang, Liyan; Panidarapu, Sai; Chen, Brandon; Pherwani, Simran; Greenwell, Amanda A.; Oudit, Gavin Y.; Ussher, John R.; Lopaschuk, Gary D. 分享 收藏
Ketones provide an extra source of fuel for the failing heart without impairing glucose oxidation Pherwani, Simran; Connolly, David; Sun, Qiuyu; Karwi, Qutuba G.; Carr, Michael; Ho, Kim L.; Wagg, Cory S.; Zhang, Liyan; Levasseur, Jody; Silver, Heidi; Dyck, Jason R. B.; Lopaschuk, Gary D. 分享 收藏
Pharmacological Inhibition of Succinyl Coenzyme A:3-Ketoacid Coenzyme A Transferase Alleviates the Progression of Diabetic Cardiomyopathy Greenwell, Amanda A.; Tabatabaei Dakhili, Seyed Amirhossein; Wagg, Cory S.; Saed, Christina T.; Chan, Jordan S. F.; Yang, Kunyan; Mangra-Bala, Indiresh A.; Stenlund, Magnus J.; Eaton, Farah; Gopal, Keshav; Dyck, Jason R. B.; Lopaschuk, Gary D.; Ussher, John R. 分享 收藏
Mitochondrial fatty acid oxidation is the major source of cardiac adenosine triphosphate production in heart failure with preserved ejection fraction Sun, Qiuyu; Guven, Berna; Wagg, Cory S.; de Oliveira, Amanda Almeida; Silver, Heidi; Zhang, Liyan; Chen, Brandon; Wei, Kaleigh; Ketema, Ezra B.; Karwi, Qutuba G.; Persad, Kaya L.; Vu, Jennie; Wang, Faqi; Dyck, Jason R. B.; Oudit, Gavin Y.; Lopaschuk, Gary D. 分享 收藏
Obesity Is a Major Determinant of Impaired Cardiac Energy Metabolism in Heart Failure with Preserved Ejection FractionS Guven, Berna; Sun, Qiuyu; Wagg, Cory S.; de Oliveira, Amanda Almeida; Silver, Heidi; Persad, Kaya L.; Onay-Besikci, Arzu; Vu, Jennie; Oudit, Gavin Y.; Lopaschuk, Gary D. 分享 收藏
Stimulating cardiac glucose oxidation lessens the severity of heart failure in aged female mice Sun, Qiuyu; Wagg, Cory S.; Guven, Berna; Wei, Kaleigh; de Oliveira, Amanda A.; Silver, Heidi; Zhang, Liyan; Vergara, Ander; Chen, Brandon; Wong, Nathan; Wang, Faqi; Dyck, Jason R. B.; Oudit, Gavin Y.; Lopaschuk, Gary D. 分享 收藏
Aldose reductase inhibition alleviates diabetic cardiomyopathy and is associated with a decrease in myocardial fatty acid oxidation Gopal, Keshav; Karwi, Qutuba G.; Dakhili, Seyed Amirhossein Tabatabaei; Wagg, Cory S.; Zhang, Liyan; Sun, Qiuyu; Saed, Christina T.; Panidarapu, Sai; Perfetti, Riccardo; Ramasamy, Ravichandran; Ussher, John R.; Lopaschuk, Gary D. 分享 收藏
Targeting systolic heart failure: A newly developed troponin activator RPI-194 increases striated muscle contraction by acting as a calcium sensitizer Mahmud, Zabed; Tikunova, Svetlana; Belevych, Natalya Belevych; Wagg, Cory; Zhabyeyev, Pavel; Liu, Philip; Rasicci, David; Schulz, Richard; Yengo, Christopher; Oudit, Gavin; Lopaschuk, Gary; Reiser, Peter; Davis, Jonathan; Hwang, Peter 分享 收藏
The ketogenic diet blunts insulin-stimulated glucose oxidation in the failing heart Ho, Kim; Karwi, Qutuba; Chen, Brandon; Wang, Faqi; Wagg, Cory; Zhang, Liyan; Panidarapu, Sai; Pherwani, Simran; Greenwell, Amanda; Oudit, Gavin; Ussher, John; Lopaschuk, Gary 分享 收藏
Inhibition of branched-chain amino acid oxidation aggravates adverse remodeling in the failing heart Karwi, Qutuba; Zhang, Liyan; Wagg, Cory; Gopal, Keshav; Ho, Kim; Levasseur, Jody; Sun, Qiuyu; Panidarapu, Sai; Ussher, John; Dyck, Jason; Lopaschuk, Gary 分享 收藏
Small Molecule RPI-194 Stabilizes Activated Troponin to Increase the Calcium Sensitivity of Striated Muscle Contraction 小分子RPI-194稳定活化肌钙蛋白增加横纹肌收缩的钙敏感性 Mahmud, Zabed; Tikunova, Svetlana; Belevych, Natalya; Wagg, Cory S.; Zhabyeyev, Pavel; Liu, Philip B.; Rasicci, David V.; Yengo, Christopher M.; Oudit, Gavin Y.; Lopaschuk, Gary D.; Reiser, Peter J.; Davis, Jonathan P.; Hwang, Peter M. 分享 收藏
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Deletion of BCATm increases insulin-stimulated glucose oxidation in the heart Uddin, Golam M.; Karwi, Qutuba G.; Pherwani, Simran; Gopal, Keshav; Wagg, Cory S.; Biswas, Dipsikha; Atnasious, Mariam; Wu, Yikuan; Wu, Guoqing; Zhang, Liyan; Ho, Kim L.; Pulinilkunnil, Thomas; Ussher, John R.; Lopaschuk, Gary D. 分享 收藏
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p53-Mediated Repression of the PGC1A (PPARG Coactivator 1α) and APLNR (Apelin Receptor) Signaling Pathways Limits Fatty Acid Oxidation Energetics: Implications for Cardio-oncology Saleme, Bruno; Das, Subhash K.; Zhang, Yongneng; Boukouris, Aristeidis E.; Carrillo, Maria Areli Lorenzana; Jovel, Juan; Wagg, Cory S.; Lopaschuk, Gary D.; Michelakis, Evangelos D.; Sutendra, Gopinath 分享 收藏
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