Timothy L. Macdonald - Publications, H-index & Citations

Timothy L. Macdonald

University of Virginia

61H指数

323论文数

1.2W被引数

收录论文 79

发表时间

Synthesis and Antimicrobial Evaluation of Amixicile-Based Inhibitors of the Pyruvate-Ferredoxin Oxidoreductases of Anaerobic Bacteria and Epsilonproteobacteria

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2016-07-01

OAAI

Kennedy, Andrew J.; Bruce, Alexandra M.; Gineste, Catherine; Ballard, T. Eric; Olekhnovich, Igor N.; Macdonald, Timothy L.; Hoffman, Paul S.

Structural Requirements and Docking Analysis of Amidine-Based Sphingosine Kinase 1 Inhibitors Containing Oxadiazoles

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2016-03-09

OAAI

Houck, Joseph D.; Dawson, Thomas K.; Kennedy, Andrew J.; Kharel, Yugesh; Naimon, Niels D.; Field, Saundra D.; Lynch, Kevin R.; Macdonald, Timothy L.

Preclinical Studies of Amixicile, a Systemic Therapeutic Developed for Treatment of Clostridium difficile Infections That Also Shows Efficacy against Helicobacter pylori

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2014-08-01

OAAI

Hoffman, Paul S.; Bruce, Alexandra M.; Olekhnovich, Igor; Warren, Cirle A.; Burgess, Stacey L.; Hontecillas, Raquel; Viladomiu, Monica; Bassaganya-Riera, Josep; Guerrant, Richard L.; Macdonald, Timothy L.

Amixicile, a Novel Inhibitor of Pyruvate:Ferredoxin Oxidoreductase, Shows Efficacy against Clostridium difficile in a Mouse Infection Model

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2012-08-01

OAAI

Warren, Cirle A.; van Opstal, Edward; Ballard, T. Eric; Kennedy, Andrew; Wang, Xia; Riggins, Mary; Olekhnovich, Igor; Warthan, Michelle; Kolling, Glynis L.; Guerrant, Richard L.; Macdonald, Timothy L.; Hoffman, Paul S.

Sphingosine kinase type 1 inhibition reveals rapid turnover of circulating sphingosine 1-phosphate

BIOCHEMICAL JOURNAL

IF4.3

2011-11-28

OAAI

Kharel, Yugesh; Mathews, Thomas P.; Gellett, Amanda M.; Tomsig, Jose L.; Kennedy, Perry C.; Moyer, Morgan L.; Macdonald, Timothy L.; Lynch, Kevin R.

Characterization of a Sphingosine 1-Phosphate Receptor Antagonist Prodrug

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2011-09-01

OAAI

Kennedy, Perry C.; Zhu, Ran; Huang, Tao; Tomsig, Jose L.; Mathews, Thomas P.; David, Marion; Peyruchaud, Olivier; Macdonald, Timothy L.; Lynch, Kevin R.

Development of Amidine-Based Sphingosine Kinase 1 Nanomolar Inhibitors and Reduction of Sphingosine 1-Phosphate in Human Leukemia Cells

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2011-05-02

OAAI

Kennedy, Andrew J.; Mathews, Thomas P.; Kharel, Yugesh; Field, Saundra D.; Moyer, Morgan L.; East, James E.; Houck, Joseph D.; Lynch, Kevin R.; Macdonald, Timothy L.

Selective Activation of Sphingosine 1-Phosphate Receptors 1 and 3 Promotes Local Microvascular Network Growth

TISSUE ENGINEERING PART A

IF2.9

2011-03-01

OAAI

Sefcik, Lauren S.; Aronin, Caren E. Petrie; Awojoodu, Anthony O.; Shin, Soo J.; Mac Gabhann, Feilim; MacDonald, Timothy L.; Wamhoff, Brian R.; Lynch, Kevin R.; Peirce, Shayn M.; Botchwey, Edward A.

Synthesis and Antimicrobial Evaluation of Nitazoxanide-Based Analogues: Identification of Selective and Broad Spectrum Activity

CHEMMEDCHEM

IF3.4

2010-12-29

OAAI

Ballard, T. Eric; Wang, Xia; Olekhnovich, Igor; Koerner, Taylor; Seymour, Craig; Salamoun, Joseph; Warthan, Michelle; Hoffman, Paul S.; Macdonald, Timothy L.

Neutrophil- and Myeloperoxidase-Mediated Metabolism of Reduced Nimesulide: Evidence for Bioactivation

CHEMICAL RESEARCH IN TOXICOLOGY

IF3.8

2010-10-12

PREAI

Yang, Min; Chordia, Mahendra D.; Li, Fengping; Huang, Tao; Linden, Joel; Macdonald, Timothy L.

Nitazoxanide Inhibits Biofilm Formation by Staphylococcus epidermidis by Blocking Accumulation on Surfaces

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2010-07-01

OAAI

Tchouaffi-Nana, Florence; Ballard, T. Eric; Cary, Christine H.; Macdonald, Timothy L.; Sifri, Costi D.; Hoffman, Paul S.

FTY720 Promotes Local Microvascular Network Formation and Regeneration of Cranial Bone Defects

TISSUE ENGINEERING PART A

IF2.9

2010-06-01

OAAI

Aronin, Caren E. Petrie; Sefcik, Lauren S.; Tholpady, Sunil S.; Tholpady, Ashok; Sadik, Karim W.; Macdonald, Timothy L.; Peirce, Shayn M.; Wamhoff, Brian R.; Lynch, Kevin R.; Ogle, Roy C.; Botchwey, Edward A.

Activation of Sphingosine-1-Phosphate 1 Receptor in the Proximal Tubule Protects Against Ischemia-Reperfusion Injury

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

IF9.4

2010-06-01

109

OAAI

Bajwa, Amandeep; Jo, Sang-Kyung; Ye, Hong; Huang, Liping; Dondeti, Krishna R.; Rosin, Diane L.; Haase, Volker H.; Macdonald, Timothy L.; Lynch, Kevin R.; Okusa, Mark D.

Discovery, Biological Evaluation, and Structure-Activity Relationship of Amidine Based Sphingosine Kinase Inhibitors

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2010-04-08

OAAI

Mathews, Thomas P.; Kennedy, Andrew J.; Kharel, Yugesh; Kennedy, Perry C.; Nicoara, Oana; Sunkara, Manjula; Morris, Andrew J.; Wamhoff, Brian R.; Lynch, Kevin R.; Macdonald, Timothy L.

Antimalarial Asexual Stage-Specific and Gametocytocidal Activities of HIV Protease Inhibitors

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2010-03-01

OAAI

Peatey, Christopher L.; Andrews, Katherine T.; Eickel, Nina; MacDonald, Timothy; Butterworth, Alice S.; Trenholme, Katharine R.; Gardiner, Donald L.; McCarthy, James S.; Skinner-Adams, Tina S.

Nutrient isothiocyanates covalently modify and inhibit the inflammatory cytokine macrophage migration inhibitory factor (MIF)

BIOCHEMICAL JOURNAL

IF4.3

2009-10-12

OAAI

Cross, Janet V.; Rady, Joshua M.; Foss, Frank W., Jr.; Lyons, Charles E.; MacDonald, Timothy L.; Templeton, Dennis J.

Synthesis and biological evaluation of sphingosine kinase substrates as sphingosine-1-phosphate receptor prodrugs

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2009-08-01

OAAI

Foss, Frank W.; Mathews, Thomas P.; Kharel, Yugesh; Kennedy, Perry C.; Snyder, Ashley H.; Davis, Michael D.; Lynch, Kevin R.; MacDonald, Timothy L.