Paul Polakis - Publications, H-index & Citations

Antibody-Drug Conjugates Derived from Cytotoxic seco-CBI-Dimer Payloads Are Highly Efficacious in Xenograft Models and Form Protein Adducts In Vivo

IF5.5

2019-11-01

OAAI

Bhakta, Sunil; Crocker, Lisa M.; Chen, Yvonne; Hazen, Meredith; Schutten, Melissa M.; Li, Dongwei; Kuijl, Coenraad; Ohri, Rachana; Zhong, Fiona; Poon, Kirsten A.; Go, Mary Ann T.; Cheng, Eric; Piskol, Robert; Firestein, Ron; Fourie-O'Donohue, Aimee; Kozak, Katherine R.; Raab, Helga; Hongo, Jo-Anne; Sampath, Deepak; Dennis, Mark S.; Scheller, Richard H.; Polakis, Paul; Junutula, Jagath R.

BIOCONJUGATE CHEMISTRY

IF3.9

2019-04-10

PREAI

Su, Dian; Chen, Jinhua; Cosino, Ely; dela Cruz-Chuh, Josefa; Davis, Helen; Del Rosario, Geoffrey; Figueroa, Isabel; Goon, Leanne; He, Jintang; Kamath, Amrita V.; Kaur, Surinder; Kozak, Katherine R.; Lau, Jeffrey; Lee, Donna; Lee, M. Violet; Leipold, Douglas; Liu, Luna; Liu, Peter; Lu, Guo-Liang; Nelson, Chris; Ng, Carl; Pillow, Thomas H.; Polakis, Paul; Polson, Andrew G.; Rowntree, Rebecca K.; Saad, Ola; Safina, Brian; Stagg, Nicola J.; Tercel, Moana; Vandlen, Richard; Vollmar, Breanna S.; Wai, John; Wang, Tao; Wei, BinQing; Xu, Keyang; Xue, Juanjuan; Xu, Zijin; Yan, Gang; Yao, Hui; Yu, Shang-Fan; Zhang, Donglu; Zhong, Fiona; Dragovich, Peter S.

An Anti-GDNF Family Receptor Alpha 1 (GFRA1) Antibody-Drug Conjugate for the Treatment of Hormone Receptor-Positive Breast Cancer

High-Throughput Cysteine Scanning To Identify Stable Antibody Conjugation Sites for Maleimide- and Disulfide-Based Linkers

IF5.5

2018-02-28

OAAI

BIOCONJUGATE CHEMISTRY

IF3.9

2018-02-09

102

PREAI

Ohri, Rachana; Bhakta, Sunil; Fourie-O'Donohue, Aimee; dela Cruz-Chuh, Josefa; Tsai, Siao Ping; Cook, Ryan; Wei, Binqing; Ng, Carl; Wong, Athena W.; Bos, Aaron B.; Farahi, Farzam; Bhakta, Jiten; Pillow, Thomas H.; Raab, Helga; Vandlen, Richard; Polakis, Paul; Liu, Yichin; Erickson, Hans; Junutula, Jagath R.; Kozak, Katherine R.

Modulating Therapeutic Activity and Toxicity of Pyrrolobenzodiazepine Antibody-Drug Conjugates with Self-Immolative Disulfide Linkers

Targeting LGR5+ cells with an antibody-drug conjugate for the treatment of colon cancer

IF5.5

2017-05-02

OAAI

Pillow, Thomas H.; Schutten, Melissa; Yu, Shang-Fan; Ohri, Rachana; Sadowsky, Jack; Poon, Kirsten Achilles; Solis, Willy; Zhong, Fiona; Del Rosario, Geoffrey; Go, Mary Ann T.; Lau, Jeffrey; Yee, Sharon; He, Jintang; Liu, Luna; Ng, Carl; Xu, Keyang; Leipold, Douglas D.; Kamath, Amrita V.; Zhang, Donglu; Masterson, Luke; Gregson, Stephen J.; Howard, Philip W.; Fang, Fan; Chen, Jinhua; Gunzner-Toste, Janet; Kozak, Katherine K.; Spencer, Susan; Polakis, Paul; Polson, Andrew G.; Flygare, John A.; Junutula, Jagath R.

SCIENCE TRANSLATIONAL MEDICINE

IF14.6

2015-11-18

139

PREAI

Junttila, Melissa R.; Mao, Weiguang; Wang, Xi; Wang, Bu-Er; Thinh Pham; Flygare, John; Yu, Shang-Fan; Yee, Sharon; Goldenberg, David; Fields, Carter; Eastham-Anderson, Jeffrey; Singh, Mallika; Vij, Rajesh; Hongo, Jo-Anne; Firestein, Ron; Schutten, Melissa; Flagella, Kelly; Polakis, Paul; Polson, Andrew G.

Preclinical Development of an Anti-NaPi2b (SLC34A2) Antibody-Drug Conjugate as a Therapeutic for Non-Small Cell Lung and Ovarian Cancers

Biomarker evaluation of phase 1 clinical trials of antibody-drug conjugates (ADCs) in platinum resistant ovarian cancer

IF10.2

2015-11-12

PREAI

Lin, Kedan; Rubinfeld, Bonnee; Zhang, Crystal; Firestein, Ron; Harstad, Eric; Roth, Leslie; Tsai, Siao Ping; Schutten, Melissa; Xu, Keyang; Hristopoulos, Maria; Polakis, Paul

An antibody drug conjugate (ADC) directed to lymphocyte antigen 6 complex, locus E (LY6E) delivers targeted chemotherapy to a wide range of solid tumor malignancies

IF10.2

2015-08-15

PREAI

Wang, Yulei; Firestein, Ron; Ryner, Lisa; Darbonne, Walter; Guan, Yinghui; Lu, Shan; Choi, Y. J.; Xiao, Yuanyuan; Polakis, Paul; Suttmann, Becky; Desai, Rupal; Fu, Ling; Saad, Ola; Poon, Kirsten Achilles; Denker, Mitch; Leveque, Vincent; Sumiyoshi, Teiko; Lackner, Mark; Shames, David; Humke, Eric; Mayslar, Daniel

A Novel Anti-CD22 Anthracycline-Based Antibody-Drug Conjugate (ADC) That Overcomes Resistance to Auristatin-Based ADCs

IF16.6

2015-08-01

PREAI

Asundi, Jyoti; Crocker, Lisa; Tremayne, Jarrod; Polakis, Paul; Firestein, Ron

An Antibody-Drug Conjugate Directed against Lymphocyte Antigen 6 Complex, Locus E (LY6E) Provides Robust Tumor Killing in a Wide Range of Solid Tumor Malignancies

IF10.2

2015-07-14

129

OAAI

Yu, Shang-Fan; Zheng, Bing; Go, MaryAnn; Lau, Jeff; Spencer, Susan; Raab, Helga; Soriano, Robert; Jhunjhunwala, Suchit; Cohen, Robert; Caruso, Michele; Polakis, Paul; Flygare, John; Polson, Andrew G.

MAPK pathway inhibition enhances the efficacy of an anti-endothelin B receptor drug conjugate by inducing target expression in melanoma

IF10.2

2015-07-14

OAAI

Asundi, Jyoti; Crocker, Lisa; Tremayne, Jarrod; Chang, Peter; Sakanaka, Chie; Tanguay, Josh; Spencer, Susan; Chalasani, Sreedevi; Luis, Elizabeth; Gascoigne, Karen; Desai, Rupal; Raja, Rajiv; Friedman, Brad A.; Haverty, Peter M.; Polakis, Paul; Firestein, Ron

Site-Specific Trastuzumab Maytansinoid Antibody-Drug Conjugates with Improved Therapeutic Activity through Linker and Antibody Engineering

IF16.6

2014-10-01

PREAI

Asundi, Jyoti; Polakis, Paul; Lacap, Jennifer A.; Nannini, Michelle

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2014-09-18

111

PREAI

Pillow, Thomas H.; Tien, Janet; Parsons-Reponte, Kathryn L.; Bhakta, Sunil; Li, Hao; Staben, Leanna R.; Li, Guangmin; Chuh, Josefa; Fourie-O'Donohue, Aimee; Darwish, Martine; Yip, Victor; Liu, Luna; Leipold, Douglas D.; Su, Dian; Wu, Elmer; Spencer, Susan D.; Shen, Ben-Quan; Xu, Keyang; Kozak, Katherine R.; Raab, Helga; Vandlen, Richard; Phillips, Gail D. Lewis; Scheller, Richard H.; Polakis, Paul; Sliwkowski, Mark X.; Flygare, John A.; Junutula, Jagath R.

MAPK Pathway Inhibition Enhances the Efficacy of an Anti-Endothelin B Receptor Drug Conjugate by Inducing Target Expression in Melanoma

Site-specific antibody drug conjugates for cancer therapy

IF5.5

2014-06-04

OAAI

Asundi, Jyoti; Lacap, Jennifer A.; Clark, Suzanna; Nannini, Michelle; Roth, Leslie; Polakis, Paul

MABS

IF7.3

2013-11-01

620

OAAI

Panowski, Siler; Bhakta, Sunil; Raab, Helga; Polakis, Paul; Junutula, Jagath R.

An improved and robust DNA immunization method to develop antibodies against extra-cellular loops of multi-transmembrane proteins

MABS

IF7.3

2013-10-11

OAAI

Hazen, Meredith; Bhakta, Sunil; Vij, Rajesh; Randle, Steven; Kallop, Dara; Chiang, Vicki; Hoetzel, Isidro; Jaiswal, Bijay S.; Ervin, Karen E.; Li, Bing; Weimer, Robby M.; Polakis, Paul; Scheller, Richard H.; Junutula, Jagath R.; Hongo, Jo-Anne S.

A Novel Tankyrase Small-Molecule Inhibitor Suppresses APC Mutation-Driven Colorectal Tumor Growth

Anthracycline based antibody-drug conjugates (ADCs) for the treatment of non-Hodgkin's lymphoma are effective in cell lines resistant to auristatin based ADCs.

IF16.6

2013-05-12

303

OAAI

Lau, Ted; Chan, Emily; Callow, Marinella; Waaler, Jo; Boggs, Jason; Blake, Robert A.; Magnuson, Steven; Sambrone, Amy; Schutten, Melissa; Firestein, Ron; Machon, Ondrej; Korinek, Vladimir; Choo, Edna; Diaz, Dolores; Merchant, Mark; Polakis, Paul; Holsworth, Daniel D.; Krauss, Stefan; Costa, Mike

Preclinical development of anti-SLC34A2 antibody drug conjugate as a therapeutic for non-small cell lung and ovarian cancers.

IF16.6

2013-04-01

PREAI

Polson, Andrew G.; Zheng, Bing; Go, MaryAnn; Lau, Jeffery; Yu, Shang-Fan; Spencer, Susan; Cohen, Robert; Caruso, Michele; Flygare, John; Polakis, Paul