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Phase 1/2 study to assess safety, tolerability, and efficacy of XmAb942 (anti-TL1A) in healthy participants and participants with ulcerative colitis Hung, K.; Aggarwal, S.; Gargosky, S.; Peterson, C.; Ramanujan, S.; Banfield, C.; Manukyan, Z.; Hassan-Zahraee, M.; Kanodia, J.; Woo, J.; Szymkowski, D.; Visonneau, S.; Burington, B.; Trout, C.; Leone, D.; Dahiyat, B.; Gujrathi, S.; Desjarlais, J. 分享 收藏
Unveiling diverse trimeric forms of STEAP1 in human prostate cancer cells: Exploring STEAP1-STEAP2 interdependence for expression and plasma membrane localization Li, Cong; Liang, Lingming; Park, Joonhee; Pryshchep, Olga; Staley, Binnaz; Li, Peng; Alba, Ben; Liu, Xuan; Li, Fei; Moore, Gregory L.; Bernett, Matthew J.; Muchhal, Umesh; Desjarlais, John; Coxon, Angela; Bailis, Julie M. 分享 收藏
Complex PK-PD of an engineered IL-15/IL-15Rα-Fc fusion protein in cynomolgus monkeys: QSP modeling of lymphocyte dynamics Lu, Dan; Yadav, Rajbharan; Holder, Patrick; Chiang, Eugene; Sanjabi, Shomyseh; Poon, Victor; Bernett, Matthew; Varma, Rajat; Liu, Ke; Leung, Irene; Bogaert, Liz; Desjarlais, John; Shivva, Vittal; Hosseini, Iraj; Ramanujan, Saroja 分享 收藏
Tumor-specific CD28 costimulatory bispecific antibodies enhance T cell activation in solid tumors Dragovich, Matthew A.; Davra, Viralkumar; Faber, Matthew S.; Kim, Yoon Kyung; Nisthal, Alex; Zeng, Veronica G.; Jacinto, Jonathan; Diaz, Juan E.; Truong, Thuy; Qi, Jing; Avery, Kendra N.; Rashid, Rumana; Lee, Sung-Hyung; Chu, Seung Y.; Bonzon, Christine; Love, Ruschelle; Bernett, Matthew J.; Ernst, James A.; Bahjat, Rena; Barlow, Norman J.; Desjarlais, John R.; Hedvat, Michael; Moore, Gregory L. 分享 收藏
LAG3-TARGETED IL15/IL15Rα-FC (LAG3 X IL15) FUSION PROTEINS FOR PREFERENTIAL TIL EXPANSION VIA CIS DELIVERY OF IL15 TO LAG3+ CELLS Bernett, Matthew; Schubbert, Suzanne; Hackett, Michael; Ochyl, Lukasz; Scott, Lizett; Bonzon, Christine; Rashid, Rumana; Avery, Kendra; Rodriguez, Nicole; Leung, Irene; Barlow, Norman; Bahjat, Rena; Muchhal, Umesh; Desjarlais, John 分享 收藏
XMAB143, AN ENGINEERED IL18 HETERODIMERIC FCFUSION, FEATURES IMPROVED STABILITY, REDUCED POTENCY, AND INSENSITIVITY TO IL18BP Nisthal, Alex; Lee, Sung-Hyung; Bonzon, Christine; Love, Ruschelle; Avery, Kendra; Rashid, Rumana; Lertkiatmongkol, Panida; Rodriguez, Nicole; Karki, Sher; Barlow, Norman; Chu, Seung; Moore, Gregory; Desjarlais, John 分享 收藏
COSTIMULATORY CD28 TRISPECIFIC ANTIBODIES TARGETING PDL1 AND PDL2 ENHANCE T CELL ACTIVATION IN SOLID TUMORS Zeng, Veronica; Diaz, Juan; Qi, Jing; Truong, Thuy; Dragovich, Matthew; Rashid, Rumana; Bonzon, Christine; Lertkiatmongkol, Panida; Love, Ruschelle; Hackett, Michael; Avery, Kendra; Barlow, Norman; Desjarlais, John; Hedvat, Michael; Moore, Gregory 分享 收藏
SYNERGISTIC COMBINATION OF NATURAL KILLER CELL ENGAGERS (NKES) WITH PROINFLAMMATORY CYTOKINES Zhang, Tian; Faber, Matthew; Pong, Erik; Liu, Ke; Bernett, Matthew; Bonzon, Christine; Diaz, Juan; Nam, Dong Hyun; Avery, Kendra; Qi, Jing; Rashid, Rumana; Bahjat, Rena; Desjarlais, John; Bykova, Katrina 分享 收藏
NATURAL KILLER CELL ENGAGERS ACTIVATE INNATE AND ADAPTIVE IMMUNITY AND SHOW SYNERGY WITH PROINFLAMMATORY CYTOKINES Bykova, Katrina; Faber, Matthew; Liu, Ke; Siddiqi, Noor; Bernett, Matthew; Bonzon, Christine; Diaz, Juan; Nam, Dong Hyun; Avery, Kendra; Qi, Jing; Rashid, Rumana; Bahjat, Rena; Desjarlais, John 分享 收藏
IL12 FC-FUSIONS ENGINEERED FOR REDUCED POTENCY AND EXTENDED HALF-LIFE EXHIBIT STRONG ANTITUMOR ACTIVITY AND IMPROVED THERAPEUTIC INDEX COMPARED TO WILD-TYPE IL12 AGENTS Bernett, Matthew; Liu, Ke; Bonzon, Christine; Hackett, Michael; Bykova, Katrina; Rashid, Rumana; Rodriguez, Nicole; Hassanzadeh-Kiabi, Nargess; Ardila, Connie; Barlow, Norman; Leung, Irene; Nguyen, Hanh; Eivazi, Araz; Avery, Kendra; Varma, Rajat; Muchhal, Umesh; Desjarlais, John 分享 收藏
PD-L1 TARGETED CD28 COSTIMULATORY BISPECIFIC ANTIBODIES ENHANCE T CELL ACTIVATION IN SOLID TUMORS Zeng, Veronica; Moore, Gregory; Diaz, Juan; Bonzon, Christine; Avery, Kendra; Love, Ruschelle; Dragovich, Matthew; Rashid, Rumana; Leung, Irene; Hackett, Michael; Qi, Jing; Bakhit, Charles; Muchhal, Umesh; Barlow, Norman; Desjarlais, John; Hedvat, Michael 分享 收藏
PD1 X TGFBR2 AND CD5 X TGFBR2 BISPECIFICS SELECTIVELY BLOCK TGFBR2 ON TARGET-POSITIVE T CELLS, PROMOTE T CELL ACTIVATION, AND ELICIT AN ANTI-TUMOR RESPONSE IN SOLID TUMORS Moore, Gregory; Schubbert, Suzanne; Bonzon, Christine; Avery, Kendra; Rashid, Rumana; Pong, Erik; Ochyl, Lukasz; Nisthal, Alex; Chu, Seung; Ernst, James; Desjarlais, John 分享 收藏
Dissecting strategies to tune the therapeutic potential of SARS-CoV-2-specific monoclonal antibody CR3022 Atyeo, Caroline; Slein, Matthew D.; Fischinger, Stephanie; Burke, John; Schafer, Alexandra; Leist, Sarah R.; Kuzmina, Natalia A.; Mire, Chad; Honko, Anna; Johnson, Rebecca; Storm, Nadia; Bernett, Matthew; Tong, Pei; Zuo, Teng; Lin, Junrui; Zuiani, Adam; Linde, Caitlyn; Suscovich, Todd; Wesemann, Duane R.; Griffiths, Anthony; Desjarlais, John R.; Juelg, Boris D.; Goudsmit, Jaap; Bukreyev, Alexander; Baric, Ralph; Alter, Galit 分享 收藏
AMG 509, A STEAP1 X CD3 BISPECIFIC XMAB® 2+1 IMMUNE THERAPY, EXHIBITS AVIDITY-DRIVEN BINDING AND PREFERENTIAL KILLING OF HIGH STEAP1-EXPRESSING PROSTATE AND EWING SARCOMA CANCER CELLS Li, Cong; Fort, Madeline; Liang, Lingming; Moore, Gregory; Bernett, Matthew; Muchhal, Umesh; Osgood, Tao; Yabut, Rodolfo; Kaliyaperumal, Sarav; Harrold, John; Canon, Jude; Rogojina, Anna; Kurmasheva, Raushan; Desjarlais, John; Houghton, Peter; Nolan-Stevaux, Olivier 分享 收藏
PD1 X TGFβR2 BISPECIFICS SELECTIVELY BLOCK TGFβR2 ON PD1-POSITIVE T CELLS, PROMOTE T CELL ACTIVATION, AND ELICIT AN ANTI-TUMOR RESPONSE IN SOLID TUMORS Moore, Gregory; Schubbert, Suzanne; Bonzon, Christine; Avery, Kendra; Rashid, Rumana; Pong, Erik; Ochyl, Lukasz; Nisthal, Alex; Chu, Seung; Ernst, James; Desjarlais, John 分享 收藏
POTENCY-REDUCED AND EXTENDED HALF-LIFE IL12 HETERODIMERIC FC-FUSIONS EXHIBIT STRONG ANTI-TUMOR ACTIVITY WITH POTENTIALLY IMPROVED THERAPEUTIC INDEX COMPARED TO NATIVE IL12 AGENTS Bernett, Matthew; Varma, Rajat; Liu, Ke; Bonzon, Christine; Rashid, Rumana; Rodriguez, Nicole; Hassanzadeh-Kiabi, Nargess; Ardila, Connie; Chu, Seung; Muchhal, Umesh; Desjarlais, John 分享 收藏
XmAb30819, an XmAb®2+1 ENPP3 x CD3 bispecific antibody for RCC, demonstrates safety and efficacy in in vivo preclinical studies Nisthal, Alex; Lee, Sung-Hyung; Kim, Yoon Kyung; Bonzon, Christine; Rashid, Rumana; Avery, Kendra N.; Bogaert, Liz; Ardila, Connie; Leung, Irene W.; Rodriguez, Nicole; Muchhal, Umesh S.; Moore, Gregory L.; Chu, Seung Y.; Desjarlais, John R. 分享 收藏
Affinity tuned Xmab®2+1 anti-mesothelin x anti-CD3 bispecific antibody induces selective T cell-dependent cellular cytotoxicity of human ovarian cancer cells Zeng, Veronica G.; Faber, Matthew S.; Bernett, Matthew J.; Avery, Kendra N.; Zeytounian, John L.; Rashid, Rumana; Muchhal, Umesh S.; Moore, Gregory L.; Desjarlais, John R.; Hedvat, Michael 分享 收藏
Affinity tuned XmAb®2+1 PSMA x CD3 bispecific antibodies demonstrate selective activity in prostate cancer models Nisthal, Alex; Dragovich, Matthew; Pong, Erik W.; Zeng, Veronica; Hedvat, Michael; Bonzon, Christine; Avery, Kendra; Rashid, Rumana; Ardila, Connie; Muchhal, Umesh S.; Moore, Gregory L.; Chu, Seung Y.; Desjarlais, John R. 分享 收藏
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