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Luminal breast epithelial cells of BRCA1 or BRCA2 mutation carriers and noncarriers harbor common breast cancer copy number alterations Williams, Marc J.; Oliphant, Michael U. J.; Au, Vinci; Liu, Cathy; Baril, Caroline; O'Flanagan, Ciara; Lai, Daniel; Beatty, Sean; Van Vliet, Michael; Yiu, Jacky C. H.; O'Connor, Lauren; Goh, Walter L.; Pollaci, Alicia; Weiner, Adam C.; Grewal, Diljot; Mcpherson, Andrew; Norton, Klarisa; Moore, Mckenna; Prabhakar, Vikas; Agarwal, Shailesh; Garber, Judy E.; Dillon, Deborah A.; Shah, Sohrab P.; Brugge, Joan S.; Aparicio, Samuel 分享 收藏
Brca1 haploinsufficiency promotes early tumor onset and epigenetic alterations in a mouse model of hereditary breast cancer (11 Nov, 10.1038/s41588-024-01958-6, 2024) Brca1单倍体不足在遗传性乳腺癌小鼠模型中促进早期肿瘤发作和表观遗传改变 (11月11日，10.1038/s41588-024-01958-6，2024) Li, Carman Man-Chung; Cordes, Alyssa; Oliphant, Michael U. J.; Quinn, S. Aidan; Thomas, Mayura; Selfors, Laura M.; Silvestri, Francesca; Girnius, Nomeda; Rinaldi, Gianmarco; Zoeller, Jason J.; Shapiro, Hana; Tsiobikas, Christina; Gupta, Kushali P.; Pathania, Shailja; Regev, Aviv; Kadoch, Cigall; Muthuswamy, Senthil K.; Brugge, Joan S. 分享 收藏
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EYA2 tyrosine phosphatase inhibition reduces MYC and prevents medulloblastoma progression Wolin, Arthur R.; Vincent, Melanie Y.; Hotz, Taylor; Purdy, Stephen C.; Rosenbaum, Sheera R.; Hughes, Connor J.; Hsu, Jessica Y.; Oliphant, Michael U. J.; Armstrong, Brock; Wessells, Veronica; Varella-Garcia, Marileila; Galbraith, Matthew D.; Pierce, Angela; Wang, Dong; Venkataraman, Sujatha; Danis, Etienne; Veo, Bethany; Serkova, Natalie; Espinosa, Joaquin M.; Gustafson, Daniel L.; Vibhakar, Rajeev; Ford, Heide L. 分享 收藏
Parallelized multidimensional analytic framework applied to mammary epithelial cells uncovers regulatory principles in EMT Paul, Indranil; Bolzan, Dante; Youssef, Ahmed; Gagnon, Keith A.; Hook, Heather; Karemore, Gopal; Oliphant, Michael U. J.; Lin, Weiwei; Liu, Qian; Phanse, Sadhna; White, Carl; Padhorny, Dzmitry; Kotelnikov, Sergei; Chen, Christopher S.; Hu, Pingzhao; Denis, Gerald V.; Kozakov, Dima; Raught, Brian; Siggers, Trevor; Wuchty, Stefan; Muthuswamy, Senthil K.; Emili, Andrew 分享 收藏
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Identification of a Small-Molecule Inhibitor That Disrupts the SIX1/EYA2 Complex, EMT, and Metastasis Zhou, Hengbo; Blevins, Melanie A.; Hsu, Jessica Y.; Kong, Deguang; Galbraith, Matthew D.; Goodspeed, Andrew; Culp-Hill, Rachel; Oliphant, Michael U. J.; Ramirez, Dominique; Zhang, Lingdi; Trinidad-Pineiro, Jennyvette; Griner, Lesley Mathews; King, Rebecca; Barnaeva, Elena; Hu, Xin; Southall, Noel T.; Ferrer, Marc; Gustafson, Daniel L.; Regan, Daniel P.; D'Alessandro, Angelo; Costello, James C.; Patnaik, Samarjit; Marugan, Juan; Zhao, Rui; Ford, Heide L. 分享 收藏
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Novel Small Molecule Compound disrupts the SIX1/EYA2 Complex and Inhibits Breast Cancer Metastasis Zhou, Hengbo; Blevins, Melanie; Kong, Deguang; Hsu, Jessica; Galbraith, Matthew; Goodspeed, Andrew; Culp-Hill, Rachel; Oliphant, Michael; Ramirez, Dominique; Gustafson, Dan; D'Alessandro, Angelo; Costello, James; Patnaik, Samarjit; Marugan, Juan; Zhao, Rui; Ford, Heide 分享 收藏
Identification of a novel small molecule inhibitor of the Six1/Eya2 complex and in vivo metastasis Zhou, Hengbo; Blevins, Melanie; Zhang, Lingdi; Kong, Deguang; Oliphant, Michael; Gustafson, Daniel L.; Patnaik, Samarjit; Marugan, Juan; Zhao, Rui; Ford, Heide L. 分享 收藏
SIX2 Mediates Late-Stage Metastasis via Direct Regulation of SOX2 and Induction of a Cancer Stem Cell Program Oliphant, Michael U. J.; Vincent, Melanie Y.; Galbraith, Matthew D.; Pandey, Ahwan; Zaberezhnyy, Vadym; Rudra, Pratyaydipta; Johnson, Katherine R.; Costello, James C.; Ghosh, Debashis; DeGregori, James; Espinosa, Joaquin M.; Ford, Heide L. 分享 收藏
EMT cells increase breast cancer metastasis via paracrine GLI activation in neighbouring tumour cells (vol 8, 15773, 2017) Neelakantan, Deepika; Zhou, Hengbo; Oliphant, Michael U. J.; Zhang, Xiaomei; Simon, Lukas M.; Henke, David M.; Shaw, Chad A.; Wu, Meng-Fen; Hilsenbeck, Susan G.; White, Lisa D.; Lewis, Michael T.; Ford, Heide L. 分享 收藏
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The miR-106b-25 cluster mediates breast tumor initiation through activation of NOTCH1 via direct repression of NEDD4L Guarnieri, A. L.; Towers, C. G.; Drasin, D. J.; Oliphant, M. U. J.; Andrysik, Z.; Hotz, T. J.; Vartuli, R. L.; Linklater, E. S.; Pandey, A.; Khanal, S.; Espinosa, J. M.; Ford, H. L. 分享 收藏
EMT cells increase breast cancer metastasis via paracrine GLI activation in neighbouring tumour cells Neelakantan, Deepika; Zhou, Hengbo; Oliphant, Michael U. J.; Zhang, Xiaomei; Simon, Lukas M.; Henke, David M.; Shaw, Chad A.; Wu, Meng-Fen; Hilsenbeck, Susan G.; White, Lisa D.; Lewis, Michael T.; Ford, Heide L. 分享 收藏
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The Six1 oncoprotein downregulates p53 via concomitant regulation of RPL26 and microRNA-27a-3p Towers, Christina G.; Guarnieri, Anna L.; Micalizzi, Doug S.; Harrell, J. Chuck; Gillen, Austin E.; Kim, Jihye; Wang, Chu-An; Oliphant, Michael U. J.; Drasin, David J.; Guney, Michelle A.; Kabos, Peter; Sartorius, Carol A.; Tan, Aik-Choon; Perou, Charles M.; Espinosa, Joaquin M.; Ford, Heide L. 分享 收藏
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