未登录 Real-world experience with CPX-351 for secondary acute myeloid leukaemia: Comparison with FLAG-IDA in a propensity score matching analysis CPX-351治疗继发性急性髓系白血病的真实世界经验：与FLAG-IDA的倾向性评分匹配分析 Perusini, Maria Agustina; Patino, Ana Flavia; Andrews, Claire; Assouline, Sarit E.; Brandwein, Joseph M.; Chow, Signy; Popradi, Gizelle; Sanford, David; Savoie, Lynn; Saini, Lalit; Nadia, Bambace; Khalaf, Dina; Schuh, Andre C.; Yee, Karen; Gupta, Vikas; Maze, Dawn; Chan, Steven M.; Schimmer, Aaron D.; Sabry, Waleed; Sibai, Hassan 分享 收藏
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Mechanism of allosteric activation in human mitochondrial ClpP protease 人源线粒体ClpP蛋白酶的别构激活机制 Goncalves, Monica M.; Uday, Adwaith B.; Forrester, Taylor J. B.; Currie, S. Quinn W.; Kim, Angelina S.; Feng, Yue; Jitkova, Yulia; Velyvis, Algirdas; Harkness, Robert W.; Kimber, Matthew S.; Schimmer, Aaron D.; Zeytuni, Natalie; Vahidi, Siavash 分享 收藏
Serine phosphorylation facilitates protein degradation by the human mitochondrial ClpXP protease 丝氨酸磷酸化促进人类线粒体ClpXP蛋白酶的蛋白质降解 Goncalves, Monica M.; Jitkova, Yulia; Keszei, Alexander F. A.; Yan, Yongran; Sarathy, Chaitra; St-Germain, Jonathan; Kenney, Tristan M. G.; Tcheng, Matthew; Mancini, Ross S.; Upadhyay, Rahul; Hurren, Rose; Gronda, Marcela; Schultz, Matthew; Soriano, Kaylen; Lees, Kaitlin; Pomroy, Neil C.; Currie, S. Quinn W.; Prive, Gilbert G.; Reed, Mark A.; Yudin, Andrei K.; Penn, Linda Z.; Arrowsmith, Cheryl H.; Raught, Brian; Mazhab-jafari, Mohammad T.; Vahidi, Siavash; Schimmer, Aaron D. 分享 收藏
The Mitochondrial Unfolded Protein Response (UPRmt) Is Upregulated in Acute Myeloid Leukemia (AML) and Inhibiting the UPRmt Protease, LONP1, Leads to Mitochondrial Protein Aggregation and Cell Death Selectively in AML 线粒体未折叠蛋白反应（UPRmt）在急性髓系白血病（AML）中上调，并且抑制UPRmt蛋白酶LONP1会导致线粒体蛋白质聚集，并选择性地在AML中引起细胞死亡。 Tcheng, Matthew; Voisin, Veronique; Gronda, Marcela; Hurren, Rose; Ling, Dakai; Yan, Yongran; Zhang, Lan Xin; Feng, Yue; Mamai, Zaynab; Jitkova, Yulia; Sarathy, Chaitra; Arruda, Andrea; Kornblau, Steven M.; Minden, Mark D.; Schimmer, Aaron 分享 收藏
AML Cells Have Increased Mitochondrial RNA Degradation and Inhibiting This Degradation Promotes Cell Differentiation, Decreases Viability, and Increases Sensitivity to Immune-Mediated Killing AML Cells具有增强的线粒体RNA降解，抑制这种降解可促进细胞分化，降低细胞活力，并增加对免疫介导杀伤的敏感性。 Thomas, Geethu Emily; Nouri, Kazem; Hurren, Rose; Lee, JongBok; Voisin, Veronique; Yan, Yongran; Maclean, Neil; Gronda, Marcela; Jitkova, Yulia; Barbieri, Taylor; Ma, Li; Wang, Xiaoming; Arruda, Andrea; Minden, Mark D.; Zhang, Li; Schimmer, Aaron 分享 收藏
FLAG-IDA Plus Venetoclax in High-Risk Newly Diagnosed and Relapsed or Refractory Acute Myeloid Leukemia: The Princess Margaret Cancer Center Experience FLAG-IDA Plus Venetoclax 在高风险初诊及复发或难治性急性髓系白血病中的疗效：玛格丽特公主癌症中心的经验 Al-Shaibani, Eshrak; Davidson, Marta Beata; Bankar, Aniket; Chan, Steven M.; Sibai, Hassan; Maze, Dawn C.; Schimmer, Aaron; Minden, Mark D.; Yee, Karen; Gupta, Vikas; Schuh, Andre C.; Richard-Carpentier, Guillaume 分享 收藏
What Is the Prognostic Relevance of Responses Less Than a CR(Sub-CR) to Initial AML Treatment? 小于完全缓解（Sub-CR）的初始AML治疗反应的预后相关性是什么？ Rajendra, Akhil; Smith, Elliot; Atenafu, Eshetu; Bankar, Aniket; Chan, Steven M.; Davidson, Marta Beata; Gupta, Vikas; Minden, Mark D.; Perusini, Maria Agustina; Richard-Carpentier, Guillaume; Schimmer, Aaron; Schuh, Andre C.; Sibai, Hassan; Yee, Karen; Maze, Dawn C. 分享 收藏
Genomic profiles and outcomes in de novo versus therapy-related core binding factor AML Chiu, May; Schimmer, Aaron D.; Schuh, Andre C.; Bankar, Aniket; Richard-Carpentier, Guillaume; Sibai, Hassan; Yee, Karen; Davidson, Marta; Chan, Steven M.; Gupta, Vikas; Maze, Dawn 分享 收藏
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Long-term survival and functional outcomes of critically ill patients with hematologic malignancies: a Canadian multicenter prospective study Munshi, Laveena; Dumas, Guillaume; Rochwerg, Bram; Shoukat, Farah; Detsky, Michael; Fergusson, Dean A.; Ferreyro, Bruno L.; Heffernan, Paul; Herridge, Margaret; Magder, Sheldon; Minden, Mark; Patel, Rakesh; Qureshi, Salman; Schimmer, Aaron; Thyagu, Santhosh; Wang, Han Ting; Mehta, Sangeeta 分享 收藏
Mitochondrial regulation of GPX4 inhibition-mediated ferroptosis in acute myeloid leukemia(Dec, 10.1038/s41375-023-02117-2, 2023) Akiyama, Hiroki; Zhao, Ran; Ostermann, Lauren B.; Li, Ziyi; Tcheng, Matthew; Yazdani, Samar J.; Moayed, Arman; Pryor, Malcolm L.; Slngh, Sandeep; Baran, Natalia; Ayoub, Edward; Nishida, Yuki; Mak, Po Yee; Ruvolo, Vivian R.; Carter, Bing Z.; Schimmer, Aaron D.; Andreeff, Michael; Ishizawa, Jo 分享 收藏
Outcomes of intensive and nonintensive blast-reduction strategies in accelerated and blast-phase MPN 在加速和爆炸阶段MPN中强化和非强化爆炸减少策略的结果 Davidson, Marta B.; Kennedy, James A.; Capo-Chichi, Jose-Mario; Shi, Yuliang; Xu, Wei; Cheung, Verna; Arruda, Andrea; Ankar, Aniket B.; Richard-Carpentier, Guillaume; Chan, Steven; Maze, Dawn; Minden, Mark D.; Schimmer, Aaron D.; Schuh, Andre C.; Sibai, Hassan; Yee, Karen; Tierens, Anne; Viswabandya, Auro; Gupta, Vikas 分享 收藏
Asparaginase completion among adults including older patients with acute lymphoblastic leukemia treated with a modified DFCI protocol Perusini, Maria Agustina; Andrews, Claire; Eshetu, Atenafu G.; Gupta, Vikas; Maze, Dawn; Yee, Karen W. L.; Bankar, Aniket; Davidson, Marta B.; Richard-Carpentier, Guillaume; Chan, Steven M.; Schimmer, Aaron D.; Sibai, Jad; Alharbi, Salman; Lucero, Josephine A.; Linn, Swe Mar; Minden, Mark D.; Schuh, Andre C.; Sibai, Hassan 分享 收藏
The Imipridone ONC213 Targets α-Ketoglutarate Dehydrogenase to Induce Mitochondrial Stress and Suppress Oxidative Phosphorylation in Acute Myeloid Leukemia Su, Yongwei; Carter, Jenna L.; Li, Xinyu; Fukuda, Yu; Gray, Ashley; Lynch, John; Edwards, Holly; Ma, Jun; Schreiner, Patrick; Polin, Lisa; Kushner, Juiwanna; Dzinic, Sijana H.; Buck, Steven A.; Pruett-Miller, Shondra M.; Hege-Hurrish, Katie; Robinson, Camenzind; Qiao, Xinan; Liu, Shuang; Wu, Shuangshuang; Wang, Guan; Li, Jing; Allen, Joshua E.; Prabhu, Varun V.; Schimmer, Aaron D.; Joshi, Dhananjay; Kalhor-Monfared, Shiva; Watson, Iain D. G.; Marcellus, Richard; Isaac, Methvin B.; Al-awar, Rima; Taub, Jeffrey W.; Lin, Hai; Schuetz, John D.; Ge, Yubin 分享 收藏
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