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Discovery of a Myeloid Cell Leukemia 1 (Mcl-1) Inhibitor That Demonstrates Potent In Vivo Activities in Mouse Models of Hematological and Solid Tumors Tarr, James C.; Salovich, James M.; Aichinger, Martin; Jeon, Kyuok; Veerasamy, Nagarathanam; Sensintaffar, John L.; Arnhof, Heribert; Samwer, Matthias; Christov, Plamen P.; Kim, Kwangho; Wunberg, Tobias; Schweifer, Norbert; Trapani, Francesca; Arnold, Allison; Martin, Florian; Zhao, Bin; Miriyala, Nagaraju; Sgubin, Danielle; Fogarty, Stuart; Moore, William J.; Stott, Gordon M.; Olejniczak, Edward T.; Engelhardt, Harald; Rudolph, Dorothea; Lee, Taekyu; Mcconnell, Darryl B.; Fesik, Stephen W. 分享 收藏
Impact of WIN site inhibitor on the WDR5 interactome Guarnaccia, Alissa D.; Rose, Kristie L.; Wang, Jing; Zhao, Bin; Popay, Tessa M.; Wang, Christina E.; Guerrazzi, Kiana; Hill, Salisha; Woodley, Chase M.; Hansen, Tyler J.; Lorey, Shelly L.; Shaw, J. Grace; Payne, William G.; Weissmiller, April M.; Olejniczak, Edward T.; Fesik, Stephen W.; Liu, Qi; Tansey, William P. 分享 收藏
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Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design Simon, Selena Chacon; Wang, Feng; Thomas, Lance R.; Phan, Jason; Zhao, Bin; Olejniczak, Edward T.; Macdonald, Jonathan D.; Shaw, J. Grace; Schlund, Caden; Payne, William; Creighton, Joy; Stauffer, Shaun R.; Waterson, Alex G.; Tansey, William P.; Fesik, Stephen W. 分享 收藏
Predicting MCL1 inhibitor sensitivity in large cell line panels using a gene expression signature Wemitznig, Andreas; Rudolph, Dorothea; Samwer, Matthias; Schweifer, Norbert; Trapani, Francesca; Wunberg, Tobias; Arnhof, Heribert; Lee, Teakyu; Sensintaffar, John L.; Olejniczak, Edward T.; Benes, Cyril H.; Fesik, Stephen W.; Kraut, Norbert 分享 收藏
Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer Lee, Taekyu; Christov, Plamen P.; Shaw, Subrata; Tarr, James C.; Zhao, Bin; Veerasamy, Nagarathanam; Jeon, Kyu Ok; Mills, Jonathan J.; Bian, Zhiguo; Sensintaffar, John L.; Arnold, Allison L.; Fogarty, Stuart A.; Perry, Evan; Ramsey, Haley E.; Cook, Rebecca S.; Hollingshead, Melinda; Millin, Myrtle Davis; Lee, Kyung-min; Koss, Brian; Budhraja, Amit; Opferman, Joseph T.; Kim, Kwangho; Arteaga, Carlos L.; Moore, William J.; Olejniczak, Edward T.; Savona, Michael R.; Fesik, Stephen W. 分享 收藏
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A Novel MCL1 Inhibitor Combined with Venetoclax Rescues Venetoclax-Resistant Acute Myelogenous Leukemia 一种新型MCL1抑制剂联合维尼托克治疗维尼托克耐药急性髓系白血病 Ramsey, Haley E.; Fischer, Melissa A.; Lee, Taekyu; Gorskal, Agnieszka E.; Arratel, Maria Pia; Fuller, Londa; Boyd, Kelli L.; Strickland, Stephen A.; Sensintaffar, John; Hogdal, Leah J.; Ayerss, Gregory D.; Olejniczak, Edward T.; Fesik, Stephen W.; Savona, Michael R. 分享 收藏
Discovery of Potent 2-Aryl-6,7-dihydro-5H-pyrrolo[1,2-a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design Wang, Feng; Jeon, Kyu Ok; Salovich, James M.; Macdonald, Jonathan D.; Alvarado, Joseph H.; Gogliotti, Rocco D.; Phan, Jason; Olejniczak, Edward T.; Sun, Qi; Wang, Shidong; Camper, DeMarco; Yuh, Joannes P.; Shaw, J. Grace; Sai, Jiqing; Rossanese, Olivia W.; Tansey, William P.; Stauffer, Shaun R.; Fesik, Stephen W. 分享 收藏
Optimization of Potent and Selective Tricyclic Indole Diazepinone Myeloid Cell Leukemia-1 Inhibitors Using Structure-Based Design Shaw, Subrata; Bian, Zhiguo; Zhao, Bin; Tarr, James C.; Veerasamy, Nagarathanam; Jeon, Kyu Ok; Belmar, Johannes; Arnold, Allison L.; Fogarty, Stuart A.; Perry, Evan; Sensintaffar, John L.; Camper, DeMarco V.; Rossanese, Olivia W.; Lee, Taekyu; Olejniczak, Edward T.; Fesik, Stephen W. 分享 收藏
MCL-1 inhibition ameliorates the expansion of human leukemia in a dose dependent fashion Ramsey, Haley E.; Fischer, Melissa A.; Lee, Taekyu; Gorska, Agnieszka E.; Arrate, Pia; Sensintaffer, John; Hogdal, Leah; Olejniczak, Edward; Fesik, Stephen; Savona, Michael R. 分享 收藏
Mitochondrial MCL1 maintains triple negative breast cancer stem cells and contributes to chemotherapy resistance Lee, Kyung-min; Giltnane, Jennifer; Balko, Justin; Schwarz, Luis; Guerrero, Angel; Hutchinson, Katie; Hicks, Mellissa; Sanchez, Violeta; Sanders, Melinda; Lee, Taekyu; Olejniczak, Edward; Fesik, Stephen; Arteaga, Carlos 分享 收藏
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Discovery and biological characterization of potent myeloid cell leukemia-1 inhibitors Lee, Taekyu; Bian, Zhiguo; Zhao, Bin; Hogdal, Leah J.; Sensintaffar, John L.; Goodwin, Craig M.; Belmar, Johannes; Shaw, Subrata; Tarr, James C.; Veerasamy, Nagarathanam; Matulis, Shannon M.; Koss, Brian; Fischer, Melissa A.; Arnold, Allison L.; Camper, DeMarco V.; Browning, Carrie F.; Rossanese, Olivia W.; Budhraja, Amit; Opferman, Joseph; Boise, Lawrence H.; Savona, Michael R.; Letai, Anthony; Olejniczak, Edward T.; Fesik, Stephen W. 分享 收藏
Predicting cellular response to small molecule Mcl-1 antagonists Hogdal, Leah; Sensintaffar, John; Arnold, Allison; Goodwin, Craig; Bian, Zhiguo; Shaw, Subrata; Tarr, Chris; Lee, Taekyu; Olejniczak, Edward; Fesik, Stephen 分享 收藏
Discovery of potent 2-Indole-acylsulfonamide Mcl-1 inhibitors using structure guided fragment-based methods Shaw, Subrata; Tarr, James Chris; Pelz, Nicholas; Bian, Zhiguo; Belmar, Johannes; Zhao, Bin; Goodwin, Craig; Arnold, Allison; Sensintaffar, John; Rossanese, Olivia; Lee, Taekyu; Olejniczak, Edward; Fesik, Stephen 分享 收藏
Discovery of orally bioavailable novel Mcl-1 inhibitors that exhibit selective anti-proliferative activity in Mcl-1 sensitive cancer cell lines Lee, Taekyu; Bian, Zhiguo; Belmar, Johannes; Shaw, Subrata; Tarr, James C.; Zhao, Bin; Pelz, Nick; Camper, DeMarco; Goodwin, Craig M.; Arnold, Allison L.; Sensintaffar, John L.; Browning, Carrie F.; Rossanese, Olivia W.; Olejniczak, Edward T.; Fesik, Stephen W. 分享 收藏
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Discovery of 2-Indole-acylsulfonamide Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods 使用基于片段的方法发现2-吲哚-酰基磺酰胺髓细胞白血病1 (Mcl-1) 抑制剂 Pelz, Nicholas F.; Bian, Zhiguo; Zhao, Bin; Shaw, Subrata; Tarr, James C.; Belmar, Johannes; Gregg, Claire; Camper, DeMarco V.; Goodwin, Craig M.; Arnold, Allison L.; Sensintaffar, John L.; Friberg, Anders; Rossanese, Olivia W.; Lee, Taekyu; Olejniczak, Edward T.; Fesik, Stephen W. 分享 收藏
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