未登录 Rational design of a superior single agent active, potential best-in-class WEE1/PKMYT1 inhibitor using Acrivon Predictive Precision Proteomics (AP3) Baddour-Sousounis, J.; Pasetto, M.; Nilsson, H.; Mitsa, G.; Shi, L.; Lombardo, P.; Best, Z.; Improgo, R.; Kumar, S.; Rappard, K.; Hay, E.; Muralitharan, U.; Murshid, A.; Shipitsin, M.; Wigerup, C.; Jakobsson, M. E.; Jung, J.; Proia, D. A.; Masson, K.; Blume-Jensen, P. 分享 收藏
ACR-2316: A potentially first-in- class, potent, selective WEE1/PKMYT1 inhibitor rationally designed for superior single agent activity through synergistic disruption of cell cycle checkpoints Wigerup, Caroline; Nilsson, Helen; Shi, Lei; Jung, Joon; Baddour-Sousounis, Joelle; Cornelius, Ruban; Lipjankic, Nina; Muralitharan, Uthira; Siino, Valentina; Diez, Ignacio Arribas; Best, Zachary; Pasetto, Martina; Dahlberg, William; Rafiei, Shahrzad; Lombardo, Portia; Jakobsson, Magnus E.; Improgo, Reina; Scherer, Christina; van Duzer, John; Proia, David A.; Masson, Kristina; Blume-Jensen, Peter 分享 收藏
Evaluation of the Small-molecule BRD4 Degrader CFT-2718 in Small-cell Lung Cancer and Pancreatic Cancer Models Sun, Danlin; Nikonova, Anna S.; Zhang, Peishan; Deneka, Alexander Y.; Fitzgerald, Mark E.; Michael, Ryan E.; Lee, Linda; Lilly, Anna C.; Fisher, Stewart L.; Phillips, Andrew J.; Nasveschuk, Christopher G.; Proia, David A.; Tu, Zhigang; Golemis, Erica A. 分享 收藏
In vivo profiling of BET degraders establishes optimal pharmacological properties that showcase distinct biological differences from BET inhibitors Ladd, Brendon; Cocozziello, David; Fitzgerald, Mark E.; Michael, Ryan E.; Vieux, Ellen F.; Lee, Linda; Issa, Marta; Feala, Jacob D.; Agafonov, Roman, V; Park, Eun Sun; Nasveschuk, Christopher G.; Proia, David A. 分享 收藏
Consecutive Day HSP90 Inhibitor Administration Improves Efficacy in Murine Models of KIT-Driven Malignancies and Canine Mast Cell Tumors London, Cheryl A.; Acquaviva, Jaime; Smith, Donald L.; Sequeira, Manuel; Ogawa, Luisa Shin; Gardner, Heather L.; Bernabe, Louis Feo; Bear, Misty D.; Bechtel, Sandra A.; Proia, David A. 分享 收藏
High-throughput screens identify HSP90 inhibitors as potent therapeutics that target inter-related growth and survival pathways in advanced prostate cancer Jansson, Keith H.; Tucker, John B.; Stahl, Lauren E.; Simmons, John K.; Fuller, Caitlyn; Beshiri, Michael L.; Agarwal, Supreet; Fang, Lei; Hynes, Paul G.; Alilin, Aian Neil; Lake, Ross; Abbey, Yasmine C.; Cawley, Jacob; Tice, Caitlin M.; Yin, JuanJuan; McKnight, Crystal; Klummp-Thomas, Carleen; Zhang, Xiaohu; Guha, Rajarshi; Hoover, Shelley; Simpson, R. Mark; Nguyen, Holly M.; Corey, Eva; Thomas, Craig J.; Proia, David A.; Kelly, Kathleen 分享 收藏
A high-throughput screen identifies HSP90 inhibitors as potent therapeutics across multiple clinically representative organoid models of advanced prostate cancer Jansson, Keith H.; Tucker, John B.; Stahl, Lauren E.; Simmons, John K.; Fuller, Caitlyn; Beshiri, Michael L.; Agarwal, Supreet; Abbey, Yasmine; Fang, Lei; Hynes, Paul G.; Neil, Alilin Aian; Cawley, Jacob; Lake, Ross; Tran, Crystal; Tice, Caitlin M.; Yin, JuanJuan; Zhang, Xiahu; Guha, Rajarshi; Hoover, Shelley; Simpson, R. Mark; Nguyen, Holly; Corey, Eva; Thomas, Craig J.; Proia, David; Kelly, Kathleen 分享 收藏
Ganetespib limits ciliation and cystogenesis in autosomal-dominant polycystic kidney disease (ADPKD) Nikonova, Anna S.; Deneka, Alexander Y.; Kiseleva, Anna A.; Korobeynikov, Vladislav; Gaponova, Anna; Serebriiskii, Ilya G.; Kopp, Meghan C.; Hensley, Harvey H.; Seeger-Nukpezah, Tamina N.; Somlo, Stefan; Proia, David A.; Golemis, Erica A. 分享 收藏
HSP90 inhibition enhances cancer immunotherapy by upregulating interferon response genes Mbofung, Rina M.; McKenzie, Jodi A.; Malu, Shruti; Zhang, Min; Peng, Weiyi; Liu, Chengwen; Kuiatse, Isere; Tieu, Trang; Williams, Leila; Devi, Seram; Ashkin, Emily; Xu, Chunyu; Huang, Lu; Zhang, Minying; Talukder, Amjad H.; Tripathi, Satyendra C.; Khong, Hiep; Satani, Nikunj; Muller, Florian L.; Roszik, Jason; Heffernan, Timothy; Allison, James P.; Lizee, Gregory; Hanash, Sam M.; Proia, David; Amaria, Rodabe; Davis, R. Eric; Hwu, Patrick 分享 收藏
High-throughput screen identifies HSP90 as a potential therapeutic target in models of advanced CRPC Jansson, Keith H.; Tucker, John; Stahl, Lauren; Fuller, Caitlyn; Beshiri, Michael; Simmons, John K.; Agarwal, Supreet; Fang, Lei; Alilin, Aian Neil; Lake, Ross; Tran, Crystal; Hynes, Paul G.; Cawley, Jacob; Yin, JuanJuan; Zhang, Xiaohu; Guha, Rajarshi; Hoover, Shelley; Simpson, R. Mark; Nguyen, Holly; Corey, Eva; Thomas, Craig; Proia, David; Kelly, Kathleen 分享 收藏
Hsp90 Inhibitor Ganetespib Sensitizes Non-Small Cell Lung Cancer to Radiation but Has Variable Effects with Chemoradiation Wang, Yifan; Liu, Hui; Diao, Lixia; Potter, Adam; Zhang, Jianhu; Qiao, Yawei; Wang, Jing; Proia, David A.; Tailor, Ramesh; Komaki, Ritsuko; Lin, Steven H. 分享 收藏
A Novel HSP90 Inhibitor-Drug Conjugate to SN38 Is Highly Effective in Small Cell Lung Cancer Gaponova, Anna V.; Nikonova, Anna S.; Deneka, Alexander Y.; Kopp, Meghan C.; Kudinov, Alexander E.; Skobeleva, Natalia; Khazak, Vladimir; Ogawa, Luisa S.; Cai, Kathy Q.; Duncan, Kelly E.; Duncan, James S.; Egleston, Brian L.; Proia, David A.; Boumber, Yanis; Golemis, Erica A. 分享 收藏
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Anti-Mullerian Hormone Signaling Regulates Epithelial Plasticity and Chemoresistance in Lung Cancer Beck, Tim N.; Korobeynikov, Vladislav A.; Kudinov, Alexander E.; Georgopoulos, Rachel; Solanki, Nehal R.; Andrews-Hoke, Magda; Kistner, Timothy M.; Pepin, David; Donahoe, Patricia K.; Nicolas, Emmanuelle; Einarson, Margret B.; Zhou, Yan; Boumber, Yanis; Proia, David A.; Serebriiskii, Ilya G.; Golemis, Erica A. 分享 收藏
Anti-Mullerian hormone (AMH) supports epithelial identity and survival signaling in lung cancer Beck, Tim N.; Korobeynikov, Vladislav; Kudinov, Alexander; Georgeopoulos, Rachel; Nicolas, Emmanuelle; Einarson, Margret B.; Zhou, Yan; Boumber, Yanis; Proia, David A.; Serebriiskii, Ilya G.; Golemis, Erica A. 分享 收藏
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Ganetespib radiosensitization for liver cancer therapy Chettiar, Sivarajan T.; Malek, Reem; Annadanam, Anvesh; Nugent, Katriana M.; Kato, Yoshinori; Wang, Hailun; Cades, Jessica A.; Taparra, Kekoa; Belcaid, Zineb; Ballew, Matthew; Manmiller, Sarah; Proia, David; Lim, Michael; Anders, Robert A.; Herman, Joseph M.; Tran, Phuoc T. 分享 收藏
HSP90 Inhibitor-SN-38 Conjugate Strategy for Targeted Delivery of Topoisomerase I Inhibitor to Tumors Proia, David A.; Smith, Donald L.; Zhang, Junyi; Jimenez, John-Paul; Sang, Jim; Ogawa, Luisa Shin; Sequeira, Manuel; Acquaviva, Jaime; He, Suqin; Zhang, Chaohua; Khazak, Vladimir; Astsaturov, Igor; Inoue, Takayo; Tatsuta, Noriaki; Osman, Sami; Bates, Richard C.; Chimmanamada, Dinesh; Ying, Weiwen 分享 收藏
Repeated PD-1/PD-L1 monoclonal antibody administration induces fatal xenogeneic hypersensitivity reactions in a murine model of breast cancer Mall, Christine; Sckisel, Gail D.; Proia, David A.; Mirsoian, Annie; Grossenbacher, Steven K.; Pai, Chien-Chun Steven; Chen, Mingyi; Monjazeb, Arta M.; Kelly, Karen; Blazar, Bruce R.; Murphy, William J. 分享 收藏
STA-12-8666: a first-in-class HSP90 inhibitor drug conjugate (HDC) designed to selectively deliver chemotherapy to tumors Proia, David A.; Smith, Donald L.; Zhang, Junyi; Zhou, Dan; Jimenez, John-Paul; Sang, Jim; Rippy, Sarah; London, Cheryl; Ogawa, Luisa S.; Jiang, Jun; Przewloka, Teresa; Sequeira, Manuel; Acquaviva, Jaime; He, Suqin; Chu, John; Zhang, Chaohua; Liu, Yuan; Ye, Josephine; Khazak, Vladimir; Astsaturov, Igor; Inoue, Takayo; Tatsuta, Noriaki; Bates, Richard C.; Sonderfan, Andrew; Chimmanamada, Dinesh; Ying, Weiwen 分享 收藏
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