未登录Loss of Socs2 improves molecular responses to IFNα in a mouse model of myeloproliferative neoplasms driven by JAK2-V617F在由JAK2-V617F驱动的骨髓增殖性肿瘤小鼠模型中，Socs2的缺失改善了IFNα的分子应答。
Usart, Marc; Kimmerlin, Quentin; Stetka, Jan; Stoll, Cedric; Rai, Shivam; Fonseca, Tiago Almeida; Karjalainen, Riikka; Hao-Shen, Hui; Roux, Julien; El Taher, Athimed; Lynch, Dylan; Makukhin, Nikolai; Ciulli, Alessio; Skoda, Radek C. .png)
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收藏Precision systems medicine in acute myeloid leukemia: real-time translation of tailored therapeutic opportunities arising from ex-vivo drug sensitivity testing and molecular profilingMalani, Disha; Kumar, Ashwni; Yadav, Bhagwan; Kontro, Mika; Potdar, Swapnil; Bruck, Oscar; Kytola, Sari; Saarela, Jani; Eldfors, Samuli; Karjalainen, Riikka; Majumder, Muntasir M.; Vastrik, Imre; Ellonen, Pekka; Kankainen, Matti; Suvela, Minna; Knappila, Siv; Parson, Alun; Palva, Aino; Mattila, Pirkko; Kulesskiy, Evgeny; Turunen, Laura; Laamanen, Karoliina; Lehtinen, Elina; Nurmi, Maria; Suomi, Katja; Muruimagi, Astrid; Gjertsen, Bjorn T.; Mustjoki, Satu; Anders, Simon; Wolf, Maija; Aittokallio, Tero; Wennerberg, Krister; Heckman, Caroline; Porkka, Kimmo; Kallioniemi, Olli 分享 收藏 Elevated expression of S100A8 and S100A9 correlates with resistance to the BCL-2 inhibitor venetoclax in AMLKarjalainen, Riikka; Liu, Minxia; Kumar, Ashwini; He, Liye; Malani, Disha; Parsons, Alun; Kontro, Mika; Kallioniemi, Olli; Porkka, Kimmo; Heckman, Caroline A. 分享 收藏 Discovery and clinical implementation of individualized therapies in acute myeloid leukemia based on ex vivo drug sensitivity testing and multi-omics profilingMalani, Disha; Kumar, Ashwini; Yadav, Bhagwan; Kontro, Mika; Potdar, Swapnil; Bruck, Oscar; Kytola, Sari; Saarela, Jani; Eldfors, Samuli; Ojamies, Poojitha; Riikka, Karjalainen; Majumder, Muntasir Mamun; Vastrik, Imre; Ellonen, Pekka; Kankainen, Matti; Suvela, Minna; Knappila, Siv; Parson, Alun; Palva, Aino; Mattila, Pirkko; Kulesskiy, Evgeny; Turunen, Laura; Laamanen, Karoliina; Lehtinen, Elina; Mikkonen, Piia; Nurmi, Maria; Timonen, Sanna; Murumagi, Astrid; Gjersten, Bjorn Tore; Mustjoki, Satu; Aittokallio, Tero; Wennerberg, Krister; Anders, Simon; Wolf, Maija; Heckman, Caroline; Porkka, Kimmo; Kallioniemi, Olli 分享 收藏 Enhanced sensitivity to glucocorticoids in cytarabine-resistant AMLMalani, D.; Murumagi, A.; Yadav, B.; Kontro, M.; Eldfors, S.; Kumar, A.; Karjalainen, R.; Majumder, M. M.; Ojamies, P.; Pemovska, T.; Wennerberg, K.; Heckman, C.; Porkka, K.; Wolf, M.; Aittokallio, T.; Kallioniemi, O. 分享 收藏 分享 收藏 Identification of the genes regulated by Wnt-4, a critical signal for commitment of the ovaryNaillat, Florence; Yan, Wenying; Karjalainen, Riikka; Liakhovitskaia, Anna; Samoylenko, Anatoly; Xu, Qi; Sun, Zhandong; Shen, Bairong; Medvinsky, Alexander; Quaggin, Susan; Vainio, Seppo J. 分享 收藏 分享 收藏 分享 收藏 Quantitative scoring of differential drug sensitivity for individually optimized anticancer therapiesYadav, Bhagwan; Pemovska, Tea; Szwajda, Agnieszka; Kulesskiy, Evgeny; Kontro, Mika; Karjalainen, Riikka; Majumder, Muntasir Mamun; Malani, Disha; Murumagi, Astrid; Knowles, Jonathan; Porkka, Kimmo; Heckman, Caroline; Kallioniemi, Olli; Wennerberg, Krister; Aittokallio, Tero 分享 收藏 Individualized Systems Medicine Strategy to Tailor Treatments for Patients with Chemorefractory Acute Myeloid LeukemiaPemovska, Tea; Kontro, Mika; Yadav, Bhagwan; Edgren, Henrik; Eldfors, Samuli; Szwajda, Agnieszka; Almusa, Henrikki; Bespalov, Maxim M.; Ellonen, Pekka; Elonen, Erkki; Gjertsen, Bjorn T.; Karjalainen, Riikka; Kulesskiy, Evgeny; Lagstrom, Sonja; Lehto, Anna; Lepisto, Maija; Lundan, Tuija; Majumder, Muntasir Mamun; Marti, Jesus M. Lopez; Mattila, Pirkko; Murumagi, Astrid; Mustjoki, Satu; Palva, Aino; Parsons, Alun; Pirttinen, Tero; Ramet, Maria E.; Suvela, Minna; Turunen, Laura; Vastrik, Imre; Wolf, Maija; Knowles, Jonathan; Aittokallio, Tero; Heckman, Caroline A.; Porkka, Kimmo; Kallioniemi, Olli; Wennerberg, Krister 分享 收藏 Functional drug sensitivity and resistance profiling of AML patient cells defines a disease-specific combination of druggable signal addictionsPemovska, Tea; Yadav, Bhagwan; Karjalainen, Riikka; Kulesskiy, Evgeny; Kontro, Mika; Majumder, Muntasir Mamun; Turunen, Laura; Lindenschmidt, Ida; Lehto, Anna; Knowles, Jonathan; Heckman, Caroline; Porkka, Kimmo; Aittokallio, Tero; Kallioniemi, Olli; Wennerberg, Krister 分享 收藏 Exome sequencing reveals both DNA sequence and copy number changes in AML: Potential driver changes and mechanisms of drug resistance revealed from serial samples from the same patientsKarjalainen, Riikka; Eldfors, Samuli; Edgren, Henrik; Venkata, Naga Poojitha Kota; Kontro, Mika; Majumder, Muntasir Mamun; Murumagi, Astrid; Parsons, Alun; Almusa, Henrikki; Ellonen, Pekka; Lepisto, Maija; Mattila, Pirkko; Hannula, Sari; Lagstrom, Sonja; Suvela, Minna; Wolf, Maija; Wennerberg, Krister; Knowles, Jonathan K. C.; Mustjoki, Satu; Saarela, Janna; Porkka, Kimmo; Kallioniemi, Olli; Heckman, Caroline A. 分享 收藏 Quantitative drug sensitivity and resistance testing (DSRT) of primary ex vivo AML blasts highlights mTOR and MEK as potential key molecular driver signals of therapeutic significancePemovska, Tea; Kylesskiy, Evgeny; Kontro, Mika; Szwajda, Agnieszka; Karjalainen, Riikka; Majumder, Muntasir M.; Malani, Disha; Bespalov, Maxim M.; Eldfors, Samuli; Elonen, Erkki; Knowles, Jonathan; Murumagi, Astrid; Mpindi, John P.; Edgren, Henrik; Venkata, Naga Poojitha Kota; Turunen, Laura; Mustjoki, Satu; Wolf, Maija; Yadav, Bhagwan; Aittokallio, Tero; Heckman, Caroline A.; Porkka, Kimmo; Kallioniemi, Olli; Wennerberg, Krister 分享 收藏 Personalized treatment selection for therapy-resistant AML by integrating ex-vivo drug sensitivity and resistance testing (DSRT) as well as serial genomic, transcriptomic and phosphoproteomic profilingVenkata, Naga Poojitha Kota; Kontro, Mika; Edgren, Henrik; Eldfors, Samuli; Pemovska, Tea; Kulesskiy, Evgeny; Majumder, Muntasir Mamun; Murumagi, Astrid; Nicorici, Daniel; Almusa, Henrikki; Mattila, Pirkko; Ellonen, Pekka; Lepisto, Maija; Mpindi, John Patrick; Karjalainen, Riikka; Parsons, Alun; Knowles, Jonathan K. C.; Saarela, Janna; Wolf, Maija; Wennerberg, Krister; Heckman, Caroline A.; Porkka, Kimmo; Kallioniemi, Olli 分享 收藏 Development of a cancer pharmacopeia-wide ex-vivo drug sensitivity and resistance testing (DSRT) platform for AML: Towards individually optimized therapy and improved understanding of drug resistance patternsMalani, Disha; Pemovska, Tea; Kontro, Mika; Murumagi, Astrid; Kulesskiy, Evgeny; Yadav, Bhagwan; Bespalov, Maxim; Eldfors, Samuli; Elonen, Erkki; Karjalainen, Riikka; Knowles, Jonathan K. C.; Majumder, Muntasir Mamun; Mpindi, John Patrick; Edgren, Henrik; Szwajda, Agnieszka; Venkata, Naga Poojitha Kota; Turunen, Laura; Mustjoki, Satu; Wolf, Maija; Aittokallio, Tero; Heckman, Caroline A.; Porkka, Kimmo; Wennerberg, Krister; Kallioniemi, Olli 分享 收藏 Genomic and transcriptomic data integration in chronic myelomonocytic leukemia reveals a novel fusion gene involving onco-miR-125b-2Majumder, Muntasir M.; Kontro, Mika; Edgren, Henrik; Nicorici, Daniel; Parsons, Alun; Karjalainen, Riikka; Eldfors, Samuli; Mattila, Pirkko; Lepisto, Maija; Ellonen, Pekka; Almusa, Henrikki; Rintala, Hannele; Knowles, Jonathan K. C.; Saarela, Janna; Wennerberg, Krister; Mustjoki, Satu; Wolf, Maija; Kallioniemi, Olli; Porkka, Kimmo; Heckman, Caroline A. 分享 收藏 分享 收藏 
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