John F. Boylan - Publications, H-index & Citations

John F. Boylan

bristol-myers squibb

34H指数

151论文数

5.0K被引数

收录论文 32

发表时间

Shear stress-induced restoration of pulmonary microvascular endothelial barrier function following ischemia reperfusion injury requires VEGFR2 signaling 剪切应力诱导的缺血再灌注损伤后肺微血管内皮屏障功能的恢复需要VEGFR2信号传导

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

IF3.5

2025-03-01

PREAI

Walsh, D; Kostyunina, DS; Blake, A; Boylan, J; McLoughlin, P

Structure-Guided Optimization Provides a Series of TTK Protein Inhibitors with Potent Antitumor Activity

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2021-08-30

PREAI

Elsner, Jan; Cashion, Dan; Robinson, Dale; Bahmanyar, Sogole; Tehrani, Lida; Fultz, Kimberly E.; Narla, Rama Krishna; Peng, Xiaohui; Tran, Tam; Apuy, Julius; LeBrun, Laurie; Leftheris, Katerina; Boylan, John F.; Zhu, Dan; Riggs, Jennifer R.

Design and Optimization Leading to an Orally Active TTK Protein Kinase Inhibitor with Robust Single Agent Efficacy

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2019-04-18

PREAI

Riggs, Jennifer R.; Elsner, Jan; Cashion, Dan; Robinson, Dale; Tehrani, Lida; Nagy, Mark; Fultz, Kimberly E.; Narla, Rama Krishna; Peng, Xiaohui; Tran, Tam; Kulkarni, Ashutosh; Bahmanyar, Sogole; Condroski, Kevin; Pagarigan, Barbra; Fenalti, Gustavo; LeBrun, Laurie; Leftheris, Katerina; Zhu, Dan; Boylan, John F.

Synthetic Lethal Strategy Identifies a Potent and Selective TTK and CLK1/2 Inhibitor for Treatment of Triple-Negative Breast Cancer with a Compromised G1-S Checkpoint

MOLECULAR CANCER THERAPEUTICS

IF5.5

2018-07-31

OAAI

Zhu, Dan; Xu, Shuichan; Deyanat-Yazdi, Gordafaried; Peng, Sophie X.; Barnes, Leo A.; Narla, Rama Krishna; Tran, Tam; Mikolon, David; Ning, Yuhong; Shi, Tao; Jiang, Ning; Raymon, Heather K.; Riggs, Jennifer R.; Boylan, John F.

Synthetic lethal approach identifies potent and selective TTK and CLK inhibitor with preclinical anticancer activity in triple-negative breast cancer model

MOLECULAR CANCER THERAPEUTICS

IF5.5

2018-01-01

PREAI

Zhu, Dan; Deyanat-Yazdi, Gordafaried; Mikolon, David; Narla, Rama K.; Peng, Sophie X.; Ning, Yuhong; Riggs, Jennifer R.; Boylan, John F.

Identification of a patient enrichment strategy supporting development of a potent and selective dual TTK/CLK2 inhibitor CC-671

MOLECULAR CANCER THERAPEUTICS

IF5.5

2018-01-01

PREAI

Xu, Shuichan; Tran, Tam; Shi, Tao; Jiang, Ning; Zhu, Dan; Riggs, Jennifer R.; Boylan, John

The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2017-10-27

PREAI

Riggs, Jennifer R.; Nagy, Mark; Elsner, Jan; Erdman, Paul; Cashion, Dan; Robinson, Dale; Harris, Roy; Huang, Dehua; Tehrani, Lida; Deyanat-Yazdi, Gordafaried; Narla, Rama Krishna; Peng, Xiaohui; Tam Tran; Barnes, Leo; Miller, Terra; Katz, Jason; Tang, Yang; Chen, Ming; Moghaddam, Mehran F.; Bahmanyar, Sogole; Pagarigan, Barbra; Delker, Silvia; LeBrun, Laurie; Chamberlain, Philip P.; Calabrese, Andrew; Canan, Stacie S.; Leftheris, Katerina; Zhu, Dan; Boylan, John F.

CC-90002 (anti-CD47 antibody) in vivo anti-tumor activity is associated with an increase in M1-polarized macrophages

CANCER RESEARCH

IF16.6

2017-07-01

PREAI

Zheng, Bing; Wong, Piu; Yang, WenQing; Narla, Rama; Burgess, Michael; Escoubet, Laure; Raymon, Heather; Hariharan, Kandasamy; Boylan, John; Hege, Kristen; Sung, Victoria

The humanized anti-CD47 monclonal antibody, CC-90002, has antitumor activity in vitro and in vivo

CANCER RESEARCH

IF16.6

2017-07-01

PREAI

Narla, Rama Krishna; Modi, Hardik; Wong, Lilly; Abassian, Mahan; Bauer, Daniel; Desai, Pragnya; Gaffney, Bonny; Jackson, Pilgrim; Leisten, Jim; Liu, Jing; Lopez-Girona, Antonia; Romero, Maria; Yang, WenQing; Eckelman, Brendan P.; Deveraux, Quinn; Phillips, Laurie; Raymon, Heather K.; Escoubet, Laure; Boylan, John; Hariharan, Kandasamy

What do we treat when we treat ARDS?

INTENSIVE CARE MEDICINE

IF21.2

2015-12-14

OAAI

Yoshida, Takeshi; Boylan, John F.; Kavanagh, Brian P.

Discovery of siRNA Lipid Nanoparticles to Transfect Suspension Leukemia Cells and Provide In Vivo Delivery Capability

MOLECULAR THERAPY

IF12

2014-02-01

OAAI

He, Wei; Bennett, Michael J.; Luistro, Leopoldo; Carvajal, Daisy; Nevins, Thomas; Smith, Melissa; Tyagi, Gaurav; Cai, James; Wei, Xin; Lin, Tai-An; Heimbrook, David C.; Packman, Kathryn; Boylan, John F.

Development of a 3-dimensional synthetic lethality screening approach targeting KRasmut cells

CANCER RESEARCH

IF16.6

2013-04-01

PREAI

Tsuji, Toshiya; Sapinoso, Lisa M.; Lin, I-Lin; Xu, Shuichan; Boylan, John F.

Hypoxia-Induced Inflammation in the Lung A Potential Therapeutic Target in Acute Lung Injury?

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

IF5.3

2013-03-01

PREAI

Froehlich, Stephen; Boylan, John; McLoughlin, Paul

Inactivation of Mirk/Dyrk1b Kinase Targets Quiescent Pancreatic Cancer Cells Mirk/Dyrk1b激酶的失活靶向静止的胰腺癌细胞

MOLECULAR CANCER THERAPEUTICS

IF5.5

2011-11-08

OAAI

Ewton, Daina Z.; Hu, Jing; Vilenchik, Maria; Deng, Xiaobing; Luk, Kin-chun; Polonskaia, Ann; Hoffman, Ann F.; Zipf, Karen; Boylan, John F.; Friedman, Eileen A.

Identification of the MEK1(F129L) Activating Mutation as a Potential Mechanism of Acquired Resistance to MEK Inhibition in Human Cancers Carrying the B-Raf V600E Mutation

CANCER RESEARCH

IF16.6

2011-08-11

OAAI

Wang, Huisheng; Daouti, Sherif; Li, Wen-hui; Wen, Yang; Rizzo, Christine; Higgins, Brian; Packman, Kathryn; Rosen, Neal; Boylan, John F.; Heimbrook, David; Niu, Huifeng

Activating MEK1(F129L) mutation as a potential mechanism of acquired resistance to MEK inhibition in human cancers carrying the B-RafV600E mutation

CANCER RESEARCH

IF16.6

2011-04-01

PREAI

Niu, Huifeng; Wang, Huisheng; Daouti, Sherif; Li, Wen-Hui; Wen, Yang; Rizzo, Christine; Higgins, Brian; Packman, Kathryn; Rosen, Neal; Boylan, John F.; Heimbrook, David

Mirk/dyrk1B kinase inactivation increases gemcitabine efficacy towards quiescent pancreatic cancer cells

CANCER RESEARCH

IF16.6

2011-04-01

PREAI

Ewton, Daina Z.; Vilenchik, Maria; Polonskaia, Ann; Hoffman, Ann; Zipf, Karen; Boylan, John F.; Heimbrook, Dave; Hu, Jing; Friedman, Eileen A.

Biomarkers for sensitivity to gamma secretase inhibitors in mouse models of pancreatic adenocarcinoma

CANCER RESEARCH

IF16.6

2011-04-01

PREAI

Dasari, Arvind; Powell, Rebecca W.; Puls, Lauren; Quackenbush, Kevin; Tan, Aik Choon; Messersmith, Wells; Boylan, John; Arcaroli, John

High tumor levels of IL6 and IL8 abrogate preclinical efficacy of the γ-secretase inhibitor, RO4929097

MOLECULAR ONCOLOGY

IF4.5

2011-01-21

OAAI

He, Wei; Luistro, Leopoldo; Carvajal, Daisy; Smith, Melissa; Nevins, Tom; Yin, Xuefeng; Cai, James; Higgins, Brian; Kolinsky, Kenneth; Rizzo, Christine; Packman, Kathryn; Heimbrook, David; Boylan, John F.

Hypercapnic Acidosis Reduces Oxidative Reactions in Endotoxin-induced Lung Injury

ANESTHESIOLOGY

IF9.1

2010-07-01

OAAI

Nichol, Alistair D.; O'Cronin, Donall F.; Naughton, Finola; Hopkins, Natalie; Boylan, John; McLoughlin, Paul

研究方向