未登录Discovery of GJG057, a Potent and Highly Selective Inhibitor of Leukotriene C4 SynthaseGJG057的发现，一种强效且高选择性的白三烯C4合酶抑制剂
Thoma, Gebhard; Miltz, Wolfgang; Waelchli, Rudolf; Orain, David; Spanka, Carsten; Decoret, Odile; Wolf, Romain M.; Hurley, Brian; Cheung, Atwood K.; Sandham, David A.; Honda, Ayako; Tichkule, Ritesh; Chen, Xin; Patel, Tajesh; Labbe-Giguere, Nancy; Tan, Kian L.; Springer, Clayton; Manchester, John; Culshaw, Andrew J.; Hunt, Peter; Srinivas, Honnappa; Penno, Carlos A.; Ferrand, Sandrine; Numao, Shin; Schopfer, Ulrich; Ja''ger, Petra; Wack, Nathalie; Hasler, Franziska; Urban, Beatrice; Sindelar, Miriam; Loetscher, Pius; Kiffe, Michael; Ren, Xiaojun; Nicklin, Paul; White, Kevin; Subramanian, Khaushik; Liu, Haoyuan; Growcott, Ellena J.; Roehn, Till A. .png)
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收藏Preclinical characterization of the Toll-like receptor 7/8 antagonist MHV370 for lupus therapyHawtin, Stuart; Andre, Cedric; Collignon-Zipfel, Geraldine; Appenzeller, Simone; Bannert, Bettina; Baumgartner, Lea; Beck, Damian; Betschart, Claudia; Boulay, Thomas; Brunner, Hermine I.; Ceci, Melanie; Deane, Jonatha; Feifel, Roland; Ferrero, Enrico; Kyburz, Diego; Lafossas, Frederique; Loetscher, Pius; Merz-Stoeckle, Christina; Michellys, Pierre; Nuesslein-Hildesheim, Barbara; Raulf, Friedrich; Rush, James S.; Ruzzante, Giulia; Stein, Thomas; Zaharevitz, Samantha; Wieczorek, Grazyna; Siegel, Richard; Gergely, Peter; Shisha, Tamas; Junt, Tobias 分享 收藏 Structure-Based Optimization of a Fragment-like TLR8 Binding Screening Hit to an In Vivo Efficacious TLR7/8 AntagonistBetschart, Claudia; Faller, Michael; Zink, Florence; Hemmig, Rene; Blank, Jutta; Vangrevelinghe, Eric; Bourrel, Marjorie; Glatthar, Ralf; Behnke, Dirk; Barker, Kerstin; Heizmann, Andreas; Angst, Daniela; Nimsgern, Pierre; Jacquier, Sebastien; Junt, Tobias; Zipfel, Geraldine; Ruzzante, Giulia; Loetscher, Pius; Limonta, Sarah; Hawtin, Stuart; Andre, Cedric Bernard; Boulay, Thomas; Feifel, Roland; Knoepfel, Thomas 分享 收藏 Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A4 HydrolaseMarkert, Christian; Thoma, Gebhard; Srinivas, Honnappa; Bollbuck, Birgit; Lueoend, Rainer M.; Miltz, Wolfgang; Waelchli, Rudolf; Wolf, Romain; Hinrichs, Juergen; Bergsdorf, Christian; Azzaoui, Kamal; Penno, Carlos A.; Klein, Kai; Wack, Nathalie; Jaeger, Petra; Hasler, Franziska; Beerli, Christian; Loetscher, Pius; Dawson, Janet; Wieczorek, Grazyna; Numao, Shin; Littlewood-Evans, Amanda; Roehn, Till A. 分享 收藏 Target-Based Identification and Optimization of 5-Indazol-5-yl Pyridones as Toll-like Receptor 7 and 8 Antagonists Using a Biochemical TLR8 Antagonist Competition AssayKnoepfel, Thomas; Nimsgern, Pierre; Jacquier, Sebastien; Bourrel, Marjorie; Vangrevelinghe, Eric; Glatthar, Ralf; Behnke, Dirk; Alper, Phil B.; Michellys, Pierre-Yves; Deane, Jonathan; Junt, Tobias; Zipfel, Geraldine; Limonta, Sarah; Hawtin, Stuart; Andre, Cedric; Boulay, Thomas; Loetscher, Pius; Faller, Michael; Blank, Jutta; Feifel, Roland; Betschart, Claudia 分享 收藏 分享 收藏 分享 收藏 Design and synthesis of potent and orally active GPR4 antagonists with modulatory effects on nociception, inflammation, and angiogenesis对伤害感受，炎症和血管生成具有调节作用的有效和口服活性的GPR4拮抗剂的设计和合成Miltz, Wolfgang; Velcicky, Juraj; Dawson, Janet; Littlewood-Evans, Amanda; Ludwig, Marie-Gabrielle; Seuwen, Klaus; Feifel, Roland; Oberhauser, Berndt; Meyer, Arndt; Gabriel, Daniela; Nash, Mark; Loetscher, Pius 分享 收藏 Development of Selective, Orally Active GPR4 Antagonists with Modulatory Effects on Nociception, Inflammation, and AngiogenesisVelcicky, Juraj; Miltz, Wolfgang; Oberhauser, Berndt; Orain, David; Vaupel, Andrea; Weigand, Klaus; King, Janet Dawson; Littlewood-Evans, Amanda; Nash, Mark; Feifel, Roland; Loetscher, Pius 分享 收藏 分享 收藏 CCR1 Inhibition Ameliorates the Progression of Lupus Nephritis in NZB/W MiceBignon, Alexandre; Gaudin, Francoise; Hemon, Patrice; Tharinger, Hugo; Mayol, Katia; Walzer, Thierry; Loetscher, Pius; Peuchmaur, Michel; Berrebi, Dominique; Balabanian, Karl 分享 收藏 分享 收藏 分享 收藏 分享 收藏 分享 收藏 分享 收藏 分享 收藏 分享 收藏 分享 收藏 The ligands of CXC chemokine receptor 3, I-TAC, Mig, and IP10, are natural antagonists for CCR3Loetscher, P; Pellegrino, A; Gong, JH; Mattioli, I; Loetscher, M; Bardi, G; Baggiolini, M; Clark-Lewis, I 分享 收藏 
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