未登录In Vitro and In Vivo Activity of AMG 337, a Potent and Selective MET Kinase Inhibitor, in MET-Dependent Cancer Models
Hughes, Paul E.; Rex, Karen; Caenepeel, Sean; Yang, Yajing; Zhang, Yihong; Broome, Martin A.; Kha, Hue T.; Burgess, Teresa L.; Amore, Benny; Kaplan-Lefko, Paula J.; Moriguchi, Jodi; Werner, Jonathan; Damore, Michael A.; Baker, Daniel; Choquette, Deborah M.; Harmange, Jean-Christophe; Radinsky, Robert; Kendall, Richard; Dussault, Isabelle; Coxon, Angela .png)
分享.png)
收藏Antibody-mediated neutralization of autocrine Gas6 inhibits the growth of pancreatic ductal adenocarcinoma tumors in vivoMoody, Gordon; Belmontes, Brian; Masterman, Stephanie; Wang, Wei; King, Chadwick; Murawsky, Chris; Tsuruda, Trace; Liu, Shuying; Radinsky, Robert; Beltran, Pedro J. 分享 收藏 A novel covalent inhibitor of mutant but not wild-type (WT) epidermal growth factor receptor (EGFR) has activity in vitro and in vivo in non-small cell lung cancer (NSCLC) modelsBeltran, Pedro J.; Zhan, Jinghui; Mitchell, Petia; Wurz, Ryan P.; Pettus, Liping; Wu, Tian; Chaves, Mary; Reid, Darren L.; Radinsky, Robert; Cooke, Keegan; Tasker, Andrew 分享 收藏 Oxopyrido[2,3-d]pyrimidines as Covalent L858R/T790M Mutant Selective Epidermal Growth Factor Receptor (EGFR) InhibitorsWurz, Ryan P.; Pettus, Liping H.; Ashton, Kate; Brown, James; Chen, Jian Jeffrey; Herberich, Brad; Hong, Fang-Tsao; Hu-Harrington, Essa; Nguyen, Tom; St Jean, David J., Jr.; Tadesse, Seifu; Bauer, David; Kubryk, Michele; Zhan, Jinghui; Cooke, Keegan; Mitchell, Petia; Andrews, Kristin L.; Hsieh, Faye; Hickman, Dean; Kalyanaraman, Nataraj; Wu, Tian; Reid, Darren L.; Lobenhofer, Edward K.; Andrews, Dina A.; Everds, Nancy; Guzman, Roberto; Parsons, Andrew T.; Hedley, Simon J.; Tedrow, Jason; Thiel, Oliver R.; Potter, Matthew; Radinsky, Robert; Beltran, Pedro J.; Tasker, Andrew S. 分享 收藏 Discovery of N-(4-(3-(2-Aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine (AMG 900), A Highly Selective, Orally Bioavailable Inhibitor of Aurora Kinases with Activity against Multidrug-Resistant Cancer Cell LinesGeuns-Meyer, Stephanie; Cee, Victor J.; Deak, Holly L.; Du, Bingfan; Hodous, Brian L.; Hanh Nho Nguyen; Olivieri, Philip R.; Schenkel, Laurie B.; Vaida, Karina R.; Andrews, Paul; Bak, Annette; Be, Xuhai; Beltran, Pedro J.; Bush, Tammy L.; Chaves, Mary K.; Chung, Grace; Dai, Yang; Eden, Patrick; Hanested, Kelly; Huang, Liyue; Lin, Min-Hwa Jasmin; Tang, Jin; Ziegler, Beth; Radinsky, Robert; Kendall, Richard; Patel, Vinod F.; Payton, Marc 分享 收藏 The MDM2 Inhibitor AMG 232 Demonstrates Robust Antitumor Efficacy and Potentiates the Activity of p53-Inducing Cytotoxic AgentsMDM2抑制剂AMG 232显示出强大的抗肿瘤功效，并增强了p53-Inducing细胞毒性剂的活性Canon, Jude; Osgood, Tao; Olson, Steven H.; Saiki, Anne Y.; Robertson, Rebecca; Yu, Dongyin; Eksterowicz, John; Ye, Qiuping; Jin, Lixia; Chen, Ada; Zhou, Jing; Cordover, David; kaufman, Stephen; Kendall, Richard; Oliner, Jonathan D.; Coxon, Angela; Radinsky, Robert 分享 收藏 AMG 900, a potent inhibitor of aurora kinases causes pharmacodynamic changes in p-Histone H3 immunoreactivity in human tumor xenografts and proliferating mouse tissuesJuan, Gloria; Bush, Tammy L.; Ma, Connie; Manoukian, Raffi; Chung, Grace; Hawkins, Jennifer M.; Zoog, Stephen; Kendall, Richard; Radinsky, Robert; Loberg, Robert; Friberg, Greg; Payton, Marc 分享 收藏 Antagonism of Ang-Tie2 and DII4-Notch signaling has opposing effects on tumor endothelial cell proliferation, evidenced by a new flow cytometry methodPayton, Marc; Jun, Toni; Wayne, William; Yu, Dongyin; Manoukian, Raffi; Chung, Grace; Zhang, Nancy; Sun, Ji-Rang; Kaplan-Lefko, Paula; Scully, Sheila; Van, Gwyneth; Radinsky, Robert; Kendall, Richard; Oliner, Jonathan; Coxon, Angela 分享 收藏 AMG 337, a novel, potent and selective MET kinase inhibitor, has robust growth inhibitory activity in MET-dependent cancer modelsHughes, Paul E.; Yang, Yajing; Rex, Karen; Zhang, Yihong; Kaplan-Lefko, Paula J.; Caenepeel, Sean; Moriguchi, Jodi; Broome, Martin; Choquette, Deborah; Radinsky, Robert; Kendall, Richard; Coxon, Angela; Dussault, Isabelle 分享 收藏 IGF1R blockade with ganitumab results in systemic effects on the GH-IGF axis in miceMoody, Gordon; Beltran, Pedro J.; Mitchell, Petia; Cajulis, Elaina; Chung, Young-Ah; Hwang, David; Kendall, Richard; Radinsky, Robert; Cohen, Pinchas; Calzone, Frank J. 分享 收藏 AMG 900, a Small-Molecule Inhibitor of Aurora Kinases, Potentiates the Activity of Microtubule-Targeting Agents in Human Metastatic Breast Cancer ModelsBush, Tammy L.; Payton, Marc; Heller, Scott; Chung, Grace; Hanestad, Kelly; Rottman, James B.; Loberg, Robert; Friberg, Gregory; Kendall, Richard L.; Saffran, Douglas; Radinsky, Robert 分享 收藏 分享 收藏 Generation of a fully human Gas6 neutralizing antibody with anti-tumor activity in vivoMoody, Gordon E.; Belmontes, Brian; King, Chadwick; Liu, Shuying; Masterman, Stephanie; Murawsky, Chris; Tsuruda, Trace; Wang, Wei; Radinsky, Robert; Beltran, Pedro J. 分享 收藏 分享 收藏 Tumor penetration and epidermal growth factor receptor saturation by panitumumab correlate with antitumor activity in a preclinical model of human cancerFreeman, Daniel J.; McDorman, Kevin; Ogbagabriel, Selam; Kozlosky, Carl; Yang, Bing-Bing; Doshi, Sameer; Perez-Ruxio, Juan Jose; Fanslow, William; Starnes, Charlie; Radinsky, Robert 分享 收藏 AMG 511, a potent and selective class I PI3K inhibitor, demonstrates anti-tumor activity in multiple xenograft modelsZhang, Nancy; Caenepeel, Sean; Wang, Ling; Norman, Mark; Kendall, Richard; Burgess, Terri; Radinsky, Robert; Hughes, Paul; Freeman, Daniel J. 分享 收藏 In vitro characterization of AMG 511, a potent and selective class I PI3K inhibitor for the treatment of cancerCaenepeel, Sean; Zhang, Nancy; Wang, Ling; Norman, Mark H.; Burgess, Terri; Radinsky, Robert; Kendall, Rick; Freeman, Daniel; Hughes, Paul E. 分享 收藏 Efficacy of Ganitumab (AMG 479), Alone and in Combination with Rapamycin, in Ewing's and Osteogenic Sarcoma ModelsBeltran, Pedro J.; Chung, Young-Ah; Moody, Gordon; Mitchell, Petia; Cajulis, Elaina; Vonderfecht, Steven; Kendall, Richard; Radinsky, Robert; Calzone, Frank J. 分享 收藏 Characterization of 64Cu-DOTA-Conatumumab: A PET Tracer for In Vivo Imaging of Death Receptor 5Rossin, Raffaella; Kohno, Tadahiko; Hagooly, Aviv; Sharp, Terry; Gliniak, Brian; Arroll, Thomas; Chen, Qing; Hewig, Art; Kaplan-Lefko, Paula; Friberg, Greg; Radinsky, Robert; Evelhoch, Jeffrey L.; Welch, Michael J.; Hwang, Dah-Ren 分享 收藏 Preclinical Evaluation of AMG 900, a Novel Potent and Highly Selective Pan-Aurora Kinase Inhibitor with Activity in Taxane-Resistant Tumor Cell LinesPayton, Marc; Bush, Tammy L.; Chung, Grace; Ziegler, Beth; Eden, Patrick; McElroy, Patricia; Ross, Sandra; Cee, Victor J.; Deak, Holly L.; Hodous, Brian L.; Nguyen, Hanh Nho; Olivieri, Philip R.; Romero, Karina; Schenkel, Laurie B.; Bak, Annette; Stanton, Mary; Dussault, Isabelle; Patel, Vinod F.; Geuns-Meyer, Stephanie; Radinsky, Robert; Kendall, Richard L. 分享 收藏 
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
