未登录 Discovery of GS-2278, a Potent and Selective LPAR1 Antagonist for the Treatment of Idiopathic Pulmonary Fibrosis Tang, Doris T.; Du, Zhimin; Yang, Kin S.; Bestvater, Brian P.; Kaplan, Joshua; Neubig, Megan E.; Olen, Casey L.; Phillips, Bart; Wang, Peiyuan; Hudson, Thomas; Marchand, Bruno; Chan, Julie; Sharma, Monika; Hu, Yiding; Matles, Mike; Nejati, Elham; Chojnacka, Maja; Adams, Clifton; Pong, Cassie; Holsapple, Kevin; Budas, Grant; Tsui, Vickie; Venkataramani, Chandrasekar; Lazerwith, Scott E.; Notte, Gregory T.; Watkins, William J.; McGlinchey, Ellen; Zagorska, Anna; Farand, Julie 分享 收藏
Discovery of GS-7682, a Novel 4′-Cyano-Modified C-Nucleoside Prodrug with Broad Activity against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys Siegel, Dustin S.; Hui, Hon C.; Pitts, Jared; Vermillion, Meghan S.; Ishida, Kazuya; Rautiola, Davin; Keeney, Michael; Irshad, Hammad; Zhang, Lijun; Chun, Kwon; Chin, Gregory; Goyal, Bindu; Doerffler, Edward; Yang, Hai; Clarke, Michael O.; Palmiotti, Chris; Vijjapurapu, Arya; Riola, Nicholas C.; Stray, Kirsten; Murakami, Eisuke; Ma, Bin; Wang, Ting; Zhao, Xiaofeng; Xu, Yili; Lee, Gary; Marchand, Bruno; Seung, Minji; Nayak, Arabinda; Tomkinson, Adrian; Kadrichu, Nani; Ellis, Scott; Barauskas, Ona; Feng, Joy Y.; Perry, Jason K.; Perron, Michel; Bilello, John P.; Kuehl, Philip J.; Subramanian, Raju; Cihlar, Tomas; Mackman, Richard L. 分享 收藏
GS-4571, an Oral Small Molecule GLP-1R Agonist, Improves Glucose Tolerance and Suppresses Food Intake in Obese Diabetic Cynomolgus Monkeys Vogel, Jen; Seung, Minji; Marchand, Bruno; Bhangre, Neeraja; Mukherjee, Jit; Ammann, Stephen E.; Armstrong, Megan; Brizgys, Gediminas; Chin, Elbert; Chou, Chien-Hung; Cottell, Jeromy; Schroeder, Scott D.; Thomas-Tran, Rhiannon; Yang, Zheng-Yu; Peters, Michael; Budas, Grant; Mitchell, Michael L.; Chojnacka, Maja; Jermain, Scott; Hung, Joey; Kulkarni, Supriya; Yue, Qin; Lin, David W.; Miranda, Diego A. 分享 收藏
Preclinical characterization of a non-peptidomimetic HIV protease inhibitor with improved metabolic stability 具有改善的代谢稳定性的非肽模拟HIV蛋白酶抑制剂的临床前表征 Mulato, Andrew; Lansdon, Eric; Aoyama, Ron; Voigt, Johannes; Lee, Michael; Liclican, Albert; Lee, Gary; Singer, Eric; Stafford, Brian; Gong, Ruoyu; Murray, Bernard; Chan, Julie; Lee, Johnny; Xu, Yili; Ahmadyar, Shekeba; Gonzalez, Ana; Cho, Aesop; Stepan, George J.; Schmitz, Uli; Schultz, Brian; Marchand, Bruno; Brumshtein, Boris; Wang, Ruth; Yu, Helen; Cihlar, Tomas; Xu, Lianhong; Yant, Stephen R. 分享 收藏
Combinations of an acetyl CoA carboxylase inhibitor with hepatic lipid modulating agents do not augment antifibrotic efficacy in preclinical models of NASH and fibrosis Vijayakumar, Archana; Okesli-Armlovich, Ayse; Wang, Ting; Olson, Isabel; Seung, Minji; Kusam, Saritha; Hollenback, David; Mahadevan, Sangeetha; Marchand, Bruno; Toteva, Maria; Breckenridge, David G.; Trevaskis, James L.; Bates, Jamie 分享 收藏
Acetyl-CoA carboxylase inhibition disrupts metabolic reprogramming during hepatic stellate cell activation Bates, Jamie; Vijayakumar, Archana; Ghoshal, Sarani; Marchand, Bruno; Yi, Saili; Kornyeyev, Dmytro; Zagorska, Anna; Hollenback, David; Walker, Katie; Liu, Kathy; Pendem, Swetha; Newstrom, David; Brockett, Robert; Mikaelian, Igor; Kusam, Saritha; Ramirez, Ricardo; Lopez, David; Li, Li; Fuchs, Bryan C.; Breckenridge, David G. 分享 收藏
Hepatitis B Virus X Protein Function Requires Zinc Binding 乙型肝炎病毒X蛋白功能需要锌结合 Ramakrishnan, Dhivya; Xing, Weimei; Beran, Rudolf K.; Chemuru, Saketh; Rohrs, Henry; Niedziela-Majka, Anita; Marchand, Bruno; Mehra, Upasana; Zabransky, Ales; Dolezal, Michal; Hubalek, Martin; Pichova, Iva; Gross, Michael L.; Kwon, Hyock Joo; Fletcher, Simon P. 分享 收藏
Structural basis of HIV inhibition by translocation-defective RT inhibitor 4′-ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) Salie, Zhe Li; Kirby, Karen A.; Michailidis, Eleftherios; Marchand, Bruno; Singh, Kamalendra; Rohan, Lisa C.; Kodama, Eiichi N.; Mitsuya, Hiroaki; Parniak, Michael A.; Sarafianos, Stefan G. 分享 收藏
Structural basis of clade-specific HIV-1 neutralization by humanized anti-V3 monoclonal antibody KD-247 Kirby, Karen A.; Ong, Yee Tsuey; Hachiya, Atsuko; Laughlin, Thomas G.; Chiang, Leslie A.; Pan, Yun; Moran, Jennifer L.; Marchand, Bruno; Singh, Kamalendra; Gallazzi, Fabio; Quinn, Thomas P.; Yoshimura, Kazuhisa; Murakami, Toshio; Matsushita, Shuzo; Sarafianos, Stefan G. 分享 收藏
4′-Ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) Inhibits HIV-1 Reverse Transcriptase with Multiple Mechanisms Michailidis, Eleftherios; Huber, Andrew D.; Ryan, Emily M.; Ong, Yee T.; Leslie, Maxwell D.; Matzek, Kayla B.; Singh, Kamalendra; Marchand, Bruno; Hagedorn, Ariel N.; Kirby, Karen A.; Rohan, Lisa C.; Kodama, Eiichi N.; Mitsuya, Hiroaki; Parniak, Michael A.; Sarafianos, Stefan G. 分享 收藏
Effects of Substitutions at the 4′ and 2 Positions on the Bioactivity of 4′- Ethynyl-2-Fluoro-2′-Deoxyadenosine Kirby, Karen A.; Michailidis, Eleftherios; Fetterly, Tracy L.; Steinbach, Musetta A.; Singh, Kamalendra; Marchand, Bruno; Leslie, Maxwell D.; Hagedorn, Ariel N.; Kodama, Eiichi N.; Marquez, Victor E.; Hughes, Stephen H.; Mitsuya, Hiroaki; Parniak, Michael A.; Sarafianos, Stefan G. 分享 收藏
Evaluation of Combinations of 4′-Ethynyl-2-Fluoro-2′-Deoxyadenosine with Clinically Used Antiretroviral Drugs Hachiya, Atsuko; Reeve, Aaron B.; Marchand, Bruno; Michailidis, Eleftherios; Ong, Yee Tsuey; Kirby, Karen A.; Leslie, Maxwell D.; Oka, Shinichi; Kodama, Eiichi N.; Rohan, Lisa C.; Mitsuya, Hiroaki; Parniak, Michael A.; Sarafianos, Stefan G. 分享 收藏
Biochemical Mechanism of HIV-1 Resistance to Rilpivirine Singh, Kamalendra; Marchand, Bruno; Rai, Devendra K.; Sharma, Bechan; Michailidis, Eleftherios; Ryan, Emily M.; Matzek, Kayla B.; Leslie, Maxwell D.; Hagedorn, Ariel N.; Li, Zhe; Norden, Pieter R.; Hachiya, Atsuko; Parniak, Michael A.; Xu, Hong-Tao; Wainberg, Mark A.; Sarafianos, Stefan G. 分享 收藏
HIV-1 Reverse Transcriptase (RT) Polymorphism 172K Suppresses the Effect of Clinically Relevant Drug Resistance Mutations to Both Nucleoside and Non-nucleoside RT Inhibitors Hachiya, Atsuko; Marchand, Bruno; Kirby, Karen A.; Michailidis, Eleftherios; Tu, Xiongying; Palczewski, Krzysztof; Ong, Yee Tsuey; Li, Zhe; Griffin, Daniel T.; Schuckmann, Matthew M.; Tanuma, Junko; Oka, Shinichi; Singh, Kamalendra; Kodama, Eiichi N.; Sarafianos, Stefan G. 分享 收藏
Structural and Inhibition Studies of the RNase H Function of Xenotropic Murine Leukemia Virus-Related Virus Reverse Transcriptase Kirby, Karen A.; Marchand, Bruno; Ong, Yee Tsuey; Ndongwe, Tanyaradzwa P.; Hachiya, Atsuko; Michailidis, Eleftherios; Leslie, Maxwell D.; Sietsema, Daniel V.; Fetterly, Tracy L.; Dorst, Christopher A.; Singh, Kamalendra; Wang, Zhengqiang; Parniak, Michael A.; Sarafianos, Stefan G. 分享 收藏
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Mechanism of Inhibition of HIV-1 Reverse Transcriptase by 4′-Ethynyl-2-fluoro-2′-deoxyadenosine Triphosphate, a Translocation-defective Reverse Transcriptase Inhibitor Michailidis, Eleftherios; Marchand, Bruno; Kodama, Eiichi N.; Singh, Kamlendra; Matsuoka, Masao; Kirby, Karen A.; Ryan, Emily M.; Sawani, Ali M.; Nagy, Eva; Ashida, Noriyuki; Mitsuya, Hiroaki; Parniak, Michael A.; Sarafianos, Stefan G. 分享 收藏
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