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B

Bryan Laffitte

North Carolina State University
H指数:30
被引数:9,988

个人简介

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荣誉奖项

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A Dual Inhibitor of DYRK1A and GSK3β for β-Cell Proliferation: Aminopyrazine Derivative GNF4877
CHEMMEDCHEM
IF3.4
2020-07-0213
PREAI
Liu, Yahu A.; Jin, Qihui; Ding, Qiang; Hao, Xueshi; Mo, Tingting; Yan, Shanshan; Zou, Yefen; Huang, Zhihong; Zhang, Xiaoyue; Gao, Wenqi; Wu, Tom Y. -H.; Li, Chun; Bursalaya, Badry; Di Donato, Michael; Zhang, You-Qing; Deaton, Lisa; Shen, Weijun; Taylor, Brandon; Kamireddy, Anwesh; Harb, George; Li, Jing; Jia, Yong; Schumacher, Andrew M.; Laffitte, Bryan; Glynne, Richard; Pan, Shifeng; McNamara, Peter; Molteni, Valentina; Loren, Jon
Selective DYRK1A Inhibitor for the Treatment of Type 1 Diabetes: Discovery of 6-Azaindole Derivative GNF2133
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2020-02-2055
PREAI
Liu, Yahu A.; Jin, Qihui; Zou, Yefen; Ding, Qiang; Yan, Shanshan; Wang, Zhicheng; Hao, Xueshi; Bao Nguyen; Zhang, Xiaoyue; Pan, Jianfeng; Mo, Tingting; Jacobsen, Kate; Thanh Lam; Wu, Tom Y-H; Petrassi, H. Michael; Bursulaya, Badry; DiDonato, Michael; Gordon, W. Perry; Liu, Bo; Baaten, Janine; Hill, Robert; Van Nguyen-Tran; Qiu, Minhua; Zhang, You-Qing; Kamireddy, Anwesh; Espinola, Sheryll; Deaton, Lisa; Ha, Sukwon; Harb, George; Jia, Yong; Li, Jing; Shen, Weijun; Schumacher, Andrew M.; Colman, Karyn; Glynne, Richard; Pan, Shifeng; McNamara, Peter; Laffitte, Bryan; Meeusen, Shelly; Molteni, Valentina; Loren, Jon
Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis

Ndufexor (LMB763)，一种用于治疗非酒精性脂肪性肝炎的新型FXR调节剂

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2020-01-1585
OAAI
Chianelli, Donatella; Rucker, Paul, V; Roland, Jason; Tully, David C.; Nelson, John; Liu, Xiaodong; Bursulaya, Badry; Hernandez, Eloy D.; Wu, Jane; Prashad, Mahavir; Schlama, Thierry; Liu, Yugang; Chu, Alan; Schmeits, James; Huang, David J.; Hill, Robert; Bao, Dingjiu; Zoll, Jocelyn; Kim, Young; Groessl, Todd; McNamara, Peter; Liu, Bo; Richmond, Wendy; Sancho-Martinez, Ignatio; Phimister, Andrew; Seidel, H. Martin; Badman, Michael K.; Joseph, Sean B.; Laffitte, Bryan; Molteni, Valentina
Tropifexor-Mediated Abrogation of Steatohepatitis and Fibrosis Is Associated With the Antioxidative Gene Expression Profile in Rodents
HEPATOLOGY COMMUNICATIONS
IF4.6
2019-05-1780
OAAI
Hernandez, Eloy D.; Zheng, Lianxing; Kim, Young; Fang, Bin; Liu, Bo; Valdez, Reginald A.; Dietrich, William F.; Rucker, Paul V.; Chianelli, Donatella; Schmeits, James; Bao, Dingjiu; Zoll, Jocelyn; Dubois, Claire; Federe, Glenn C.; Chen, Lihao; Joseph, Sean B.; Klickstein, Lloyd B.; Walker, John; Molteni, Valentina; McNamara, Peter; Meeusen, Shelly; Tully, David C.; Badman, Michael K.; Xu, Jie; Laffitte, Bryan
Gpr68 Senses Blood Flow and is Essential for Vascular Physiology
CIRCULATION RESEARCH
IF16.2
2018-08-030
PRE
Xu, Jie; Mathur, Jayanti; Vessieres, Emilie; Hammack, Scott; Nonomura, Keiko; Favre, Julie; Grimaud, Linda; Petrus, Matt; Francisco, Allain; Li, Jingyuan; Lee, Van; Xiang, Fu-li; Mainquist, James; Cahalan, S.; Orth, A.; Walker, J.; Ma, S.; Lukacs, V.; Bordone, L.; Bandell, M.; Laffitte, B.; Xu, Y.; Chien, S.; Henrion, D.; Patapoutian, A.
Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH)
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2017-12-08209
OA
Tully, David C.; Rucker, Paul V.; Chianelli, Donatella; Williams, Jennifer; Vidal, Agnes; Alper, Phil B.; Mutnick, Daniel; Bursulaya, Badry; Schmeits, James; Wu, Xiangdong; Bao, Dingjiu; Zoll, Jocelyn; Kim, Young; Groessl, Todd; McNamara, Peter; Seidel, H. Martin; Molteni, Valentina; Liu, Bo; Phimister, Andrew; Joseph, Sean B.; Laffitte, Bryan
Inhibition of DYRK1A and GSK3B induces human β-cell proliferation
NATURE COMMUNICATIONS
IF15.7
2015-10-26188
OAAI
Shen, Weijun; Taylor, Brandon; Jin, Qihui; Nguyen-Tran, Van; Meeusen, Shelly; Zhang, You-Qing; Kamireddy, Anwesh; Swafford, Austin; Powers, Andrew F.; Walker, John; Lamb, John; Bursalaya, Badry; DiDonato, Michael; Harb, George; Qiu, Minhua; Filippi, Christophe M.; Deaton, Lisa; Turk, Carolina N.; Suarez-Pinzon, Wilma L.; Liu, Yahu; Hao, Xueshi; Mo, Tingting; Yan, Shanshan; Li, Jing; Herman, Ann E.; Hering, Bernhard J.; Wu, Tom; Seidel, H. Martin; McNamara, Peter; Glynne, Richard; Laffitte, Bryan
Small-Molecule Inducer of β Cell Proliferation Identified by High-Throughput Screening (vol 135, pg 1669, 2013)
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
2013-03-060
PREAI
Shen, Weijun; Tremblay, Matthew S.; Deshmukh, Vishal A.; Wang, Weidong; Filippi, Christophe M.; Harb, George; Zhang, You-qing; Kamireddy, Anwesh; Baaten, Janine E.; Jin, Qihui; Wu, Tom; Swoboda, Jonathan G.; Peters, Eric C.; Cho, Charles Y.; Li, Jing; Laffitte, Bryan A.; McNamara, Peter; Glynne, Richard; Wu, Xu; Herman, Ann E.; Schultz, Peter G.
Screening the mammalian extracellular proteome for regulators of embryonic human stem cell pluripotency

筛选哺乳动物细胞外蛋白质组的人胚胎干细胞多能性调节因子

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2010-02-2391
OAAI
Gonzalez, Rodolfo; Jennings, Lori L.; Knuth, Mark; Orth, Anthony P.; Klock, Heath E.; Ou, Weija; Feuerhelm, Julie; Hull, Mitchell V.; Koesema, Eric; Wang, Yuping; Zhang, Jia; Wu, Chunlei; Cho, Charles Y.; Su, Andrew I.; Batalov, Serge; Chen, Hong; Johnson, Kristen; Laffitte, Bryan; Nguyen, Deborah G.; Snyder, Evan Y.; Schultz, Peter G.; Harris, Jennifer L.; Lesley, Scott A.
Structure-guided design of N-phenyl tertiary Amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2008-08-2349
PREAI
Chao, Esther Y.; Caravella, Justin A.; Watson, Mike A.; Campobasso, Nino; Ghisletti, Serena; Billin, Andrew N.; Galardi, Cristin; Wang, Ping; Laffitte, Bryan A.; Lannone, Marie A.; Goodwin, Bryan J.; Nichols, Jason A.; Parks, Derek J.; Stewart, Eugene; Wiethe, Robert W.; Williams, Shawn P.; Smallwood, Angela; Pearce, Kenneth H.; Glass, Christopher K.; Willson, Timothy M.; Zuercher, William J.; Collins, Jon L.
Discovery of substituted maleimides as liver X receptor agonists and determination of a ligand-bound crystal structure
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2005-08-0447
PREAI
Jaye, MC; Krawiec, JA; Campobasso, N; Smallwood, A; Qiu, CY; Lu, Q; Kerrigan, JJ; Alvaro, MDL; Laffitte, B; Liu, WS; Marino, JP; Meyer, CR; Nichols, JA; Parks, DJ; Perez, P; Sarov-Blat, L; Seepersaud, SD; Steplewski, KM; Thompson, SK; Wang, P; Watson, MA; Webb, CL; Haigh, D; Caravella, JA; Macphee, CH; Willson, TM; Collins, JL

研究方向

暂未获取到该数据
P
Peter McNamara
H 指数:49论文数:193被引数:1.2万
W
Weijun Shen
H 指数:29论文数:95被引数:3,016
T
Tom Wu
H 指数:19论文数:36被引数:1,836
V
Valentina Molteni
H 指数:30论文数:66被引数:3,328
Q
Qihui Jin
H 指数:14论文数:21被引数:712
R
Richard Glynne
H 指数:39论文数:104被引数:7,370
G
George Harb
H 指数:21论文数:69被引数:3,040
M
Michael K. Badman
H 指数:25论文数:69被引数:6,163
A
Anwesh Kamireddy
H 指数:6论文数:17被引数:735
P
Paul V. Rucker
H 指数:16论文数:39被引数:898