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D

David P. Humphreys

ucb pharma sa
H指数:26
被引数:2,118

个人简介

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教育背景

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工作经历

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荣誉奖项

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Impact of antibody Fc engineering on translational pharmacology, and safety: insights from industry case studies

抗体Fc段工程对转化药理学及安全性的影响：来自工业案例研究的见解

mAbs
IF7.3
2025-07-070
OAAI
Frank R. Brennan; J. Ryan Polli; Jean Sathish; Melissa Ramones; Babette Wolf; Tilman Schlothauer; Shirley J. Peters; Curtis C. Maier; Changhua Ji; David L. Wensel; Derrick Witcher; Patricia C. Ryan; T. Scott Manetz; Adriano Flora; Brian Soper; Birgit Fogal; Lindsey Dzielak; Xiaoting Wang; Prathap Nagaraja Shastri; Karen Price; Michael Doyle; Nidhi Sharda; Mary Struthers; Maximilian Brinkhaus; Bianca Balbino; Eric Stefanich; Masaki Honda; Jan Terje Andersen; Shermaine Mitchell-Ryan; David P. Humphreys
Interactions of the anti-FcRn monoclonal antibody, rozanolixizumab, with Fcγ receptors and functional impact on immune cells in vitro

抗FcRn单克隆抗体rozanolixizumab与fc γ 受体的相互作用及其对免疫细胞的功能影响

MABS
IF7.3
2024-01-191
OAAI
Qureshi, Omar S.; Sutton, Emma J.; Bithell, Rosemary F.; West, Shauna M.; Cutler, Rona M.; Mccluskey, Gillian; Craggs, Graham; Maroof, Asher; Barnes, Nicholas M.; Humphreys, David P.; Rapecki, Stephen; Smith, Bryan J.; Shock, Anthony
Antibodies as drugs-a Keystone Symposia report
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
IF4.8
2022-11-163
OA
Cable, Jennifer; Saphire, Erica Ollmann; Hayday, Adrian C.; Wiltshire, Timothy D.; Mousa, Jarrod J.; Humphreys, David P.; Breij, Esther C. W.; Bruhns, Pierre; Broketa, Matteo; Furuya, Genta; Hauser, Blake M.; Mahevas, Matthieu; Carfi, Andrea; Cantaert, Tineke; Kwong, Peter D.; Tripathi, Prabhanshu; Davis, Jonathan H.; Brewis, Neil; Keyt, Bruce A.; Fennemann, Felix L.; Dussupt, Vincent; Sivasubramanian, Arvind; Kim, Philip M.; Rawi, Reda; Richardson, Eve; Leventhal, Daniel; Wolters, Rachael M.; Geuijen, Cecile A. W.; Sleeman, Matthew A.; Pengo, Niccolo; Donnellan, Francesca Rose
Microbial protein cell factories fight back?
TRENDS IN BIOTECHNOLOGY
IF14.9
2022-05-0128
OA
Rettenbacher, Lukas A.; Arauzo-Aguilera, Klaudia; Buscajoni, Luisa; Castillo-Corujo, Angel; Ferrero-Bordera, Borja; Kostopoulou, Aliki; Moran-Torres, Rafael; Nunez-Nepomuceno, David; OEktem, Ayseguel; Palma, Arianna; Pisent, Beatrice; Puricelli, Martina; Schilling, Tobias; Tungekar, Aatir A.; Walgraeve, Jonathan; Humphreys, David; Haar, Tobias von der; Gasser, Brigitte; Mattanovich, Diethard; Ruddock, Lloyd; Dijl, Jan Maarten van
Engineered hexavalent Fc proteins with enhanced Fc-gamma receptor avidity provide insights into immune-complex interactions
COMMUNICATIONS BIOLOGY
IF5.1
2018-09-1429
OAAI
Rowley, Tania F.; Peters, Shirley J.; Aylott, Mike; Griffin, Robert; Davies, Nicola L.; Healy, Louise J.; Cutler, Rona M.; Eddleston, Alison; Pither, Thomas L.; Sopp, Joshua M.; Zaccheo, Oliver; Fossati, Gianluca; Cain, Katharine; Ventom, Andrew M.; Hailu, Hanna; Ward, Eleanor J.; Sherington, John; Brennan, Frank R.; Fallah-Arani, Farnaz; Humphreys, David P.
Multivalent Fcγ-receptor engagement by a hexameric Fc-fusion protein triggers Fcγ-receptor internalisation and modulation of Fcγ-receptor functions
SCIENTIFIC REPORTS
IF3.9
2017-12-0644
OAAI
Qureshi, O. S.; Rowley, T. F.; Junker, F.; Peters, S. J.; Crilly, S.; Compson, J.; Eddleston, A.; Bjoerkelund, H.; Greenslade, K.; Parkinson, M.; Davies, N. L.; Griffin, R.; Pither, T. L.; Cain, K.; Christodoulou, L.; Staelens, L.; Ward, E.; Tibbitts, J.; Kiessling, A.; Smith, B.; Brennan, F. R.; Malmqvist, M.; Fallah-Arani, F.; Humphreys, D. P.
Fab-dsFv: A bispecific antibody format with extended serum half-life through albumin binding
MABS
IF7.3
2016-08-1743
OAAI
Dave, Emma; Adams, Ralph; Zaccheo, Oliver; Carrington, Bruce; Compson, Joanne E.; Dugdale, Sarah; Airey, Michael; Malcolm, Sarah; Hailu, Hanna; Wild, Gavin; Turner, Alison; Heads, James; Sarkar, Kaushik; Ventom, Andrew; Marshall, Diane; Jairaj, Mark; Kopotsha, Tim; Christodoulou, Louis; Zamacona, Miren; Lawson, Alastair D.; Heywood, Sam; Humphreys, David P.

研究方向

暂未获取到该数据
S
Shirley J. Peters
H 指数:9论文数:19被引数:376
T
Tania F. Rowley
H 指数:14论文数:19被引数:1,111
M
Mark Ellis
H 指数:23论文数:43被引数:1,443
J
Joanne Compson
H 指数:9论文数:17被引数:608
H 指数:0论文数:32被引数:0
H 指数:0论文数:76被引数:0
E
Emma Davé
H 指数:7论文数:17被引数:240
M
Matthew Hinchliffe
H 指数:3论文数:15被引数:79
C
C. Mark Smales
H 指数:35论文数:151被引数:4,350
J
Joshua M. Sopp
H 指数:3论文数:3被引数:76