未登录 A phase I/IIa trial of PXS-5505, a novel pan-lysyl oxidase inhibitor, in advanced myelofibrosis PXS-5505（一种新型泛赖氨酰氧化酶抑制剂）在晚期骨髓纤维化中的I/IIa期临床试验 Vachhani, Pankit; Tan, Peter; Watson, Anne-Marie; Wu, Shang-Ju; Baker, Ross; Cheung, Stanley; Lee, Sung-Eun; Chen, Chih-Cheng; Chen, Tsai-Yun; Hsiao, Hui-Hua; Lee, Jae Hoon; Masarova, Lucia; Tan, Shuh Ying; Baskar, Jana; Charlton, Brett; Findlay, Alison; Hamprecht, Dieter; Jarolimek, Wolfgang; Leadbetter, Joanna; Miller, John; Morgan, Kristen; Zahoor, Amna; Hobbs, Gabriela 分享 收藏
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A first-in-class pan-lysyl oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer 一种一流的泛赖氨酰氧化酶抑制剂可削弱胰腺癌的基质重塑并增强吉西他滨反应和生存率 Chitty, Jessica L.; Yam, Michelle; Perryman, Lara; Parker, Amelia L.; Skhinas, Joanna N.; Setargew, Yordanos F. I.; Mok, Ellie T. Y.; Tran, Emmi; Grant, Rhiannon D.; Latham, Sharissa L.; Pereira, Brooke A.; Ritchie, Shona C.; Murphy, Kendelle J.; Trpceski, Michael; Findlay, Alison D.; Melenec, Pauline; Filipe, Elysse C.; Nadalini, Audrey; Velayuthar, Sipiththa; Major, Gretel; Wyllie, Kaitlin; Papanicolaou, Michael; Ratnaseelan, Shivanjali; Phillips, Phoebe A.; Sharbeen, George; Youkhana, Janet; Russo, Alice; Blackwell, Antonia; Hastings, Jordan F.; Lucas, Morghan C.; Chambers, Cecilia R.; Reed, Daniel A.; Stoehr, Janett; Vennin, Claire; Pidsley, Ruth; Zaratzian, Anaiis; Da Silva, Andrew M.; Tayao, Michael; Charlton, Brett; Herrmann, David; Nobis, Max; Clark, Susan J.; Biankin, Andrew V.; Johns, Amber L.; Croucher, David R.; Nagrial, Adnan; Gill, Anthony J.; Grimmond, Sean M.; Pajic, Marina; Timpson, Paul; Jarolimek, Wolfgang; Cox, Thomas R. 分享 收藏
Author Correction: Topical application of an irreversible small molecule inhibitor of lysyl oxidases ameliorates skin scarring and fibrosis( doi 10.1038/s41467-022-33148-5, 22 sep, 2022 ) Chaudhari, Nutan; Findlay, Alison D.; Stevenson, Andrew W.; Clemons, Tristan D.; Yao, Yimin; Joshi, Amar; Sayyar, Sepidar; Wallace, Gordon; Rea, Suzanne; Toshniwal, Priyanka; Deng, Zhenjun; Melton, Philip E.; Hortin, Nicole; Iyer, K. Swaminathan; Jarolimek, Wolfgang; Wood, Fiona M.; Fear, Mark W. 分享 收藏
Topical application of an irreversible small molecule inhibitor of lysyl oxidases ameliorates skin scarring and fibrosis Chaudhari, Nutan; Findlay, Alison; Stevenson, Andrew; Clemons, Tristan; Yao, Yimin; Joshi, Amar; Sayyar, Sepidar; Wallace, Gordon; Rea, Suzanne; Toshniwal, Priyanka; Deng, Zhenjun; Melton, Philip; Hortin, Nicole; Iyer, Swaminatha; Jarolimek, Wolfgang; Wood, Fiona; Fear, Mark 分享 收藏
An activity-based bioprobe differentiates a novel small molecule inhibitor from a LOXL2 antibody and provides renewed promise for anti-fibrotic therapeutic strategies Findlay, Alison; Turner, Craig; Schilter, Heidi; Deodhar, Mandar; Zhou, Wenbin; Perryman, Lara; Foot, Jonathan; Zahoor, Amna; Yao, Yimin; Hamilton, Ross; Brock, Mary; Raso, Christina; Stolp, Jessica; Galati, Marie; Hamprecht, Dieter; Charlton, Brett; Jarolimek, Wolfgang 分享 收藏
Identification and Optimization of Mechanism-Based Fluoroallylamine Inhibitors of Lysyl Oxidase-like 2/3 Findlay, Alison D.; Foot, Jonathan S.; Buson, Alberto; Deodhar, Mandar; Jarnicki, Andrew G.; Hansbro, Philip M.; Liu, Gang; Schilter, Heidi; Turner, Craig I.; Zhou, Wenbin; Jarolimek, Wolfgang 分享 收藏
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A multicentre validation of Metasin: a molecular assay for the intraoperative assessment of sentinel lymph nodes from breast cancer patients Sai-Giridhar, Priya; Al-Ramadhani, Salma; George, Dilushana; Gopinath, Preethi; Andrews, William; Jader, Samar; Brown, Shelley; Findlay, Alison; Arkoumani, Evdokia; Al-Sam, Salam; McKenzie, Jolanta G.; Bradpiece, Howard; Jenkins, Stephanie; Aylwin, Anthony; Holt, Simon; Sharaiha, Yousef; Yiangou, Constantinos; Agrawal, Avi; McDowell, Amanda; Gabriel, Francis G.; Jeffrey, Margaret; Agrawal, Neerja; Cree, Ian A.; Mansel, Robert E.; Keshtgar, Mo; McDermott, Nuala; El Sheikh, Soha; Wellsted, David; Collard, Jade; Chaplin, Hema; Landt, Olfert; Bustin, Stephen; Sundaresan, Maryse; Sundaresan, Vasi 分享 收藏
The mannose-6-phosphate analogue, PXS64, inhibits fibrosis via TGF-β1 pathway in human lung fibroblasts mannose-6-phosphate类似物PXS64通过TGF-β1途径抑制人肺成纤维细胞的纤维化 Schilter, Heidi; Cantemir-Stone, Carmen Z.; Leksa, Vladimir; Ohradanova-Repic, Anna; Findlay, Alison D.; Deodhar, Mandar; Stockinger, Hannes; Song, Xiaomin; Molloy, Mark; Marsh, Clay B.; Jarolimek, Wolfgang 分享 收藏
PXS-4681A, a Potent and Selective Mechanism-Based Inhibitor of SSAO/VAP-1 with Anti-Inflammatory Effects In Vivo Foot, Jonathan S.; Yow, Tin T.; Schilter, Heidi; Buson, Alberto; Deodhar, Mandar; Findlay, Alison D.; Guo, Lily; McDonald, Ian A.; Turner, Craig I.; Zhou, Wenbin; Jarolimek, Wolfgang 分享 收藏
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