Michael W. Lark - Publications, H-index & Citations

Michael W. Lark

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61H指数

195论文数

1.4W被引数

收录论文 45

发表时间

TRV0109101, a G Protein-Biased Agonist of the μ-Opioid Receptor, Does Not Promote Opioid-Induced Mechanical Allodynia following Chronic Administration

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2017-08-01

OAAI

Koblish, Michael; Carr, Richard, III; Siuda, Edward R.; Rominger, David H.; Gowen-MacDonald, William; Cowan, Conrad L.; Crombie, Aimee L.; Violin, Jonathan D.; Lark, Michael W.

Biased agonism of the μ-opioid receptor by TRV130 increases analgesia and reduces on-target adverse effects versus morphine: A randomized, double-blind, placebo-controlled, crossover study in healthy volunteers

PAIN

IF5.5

2014-09-01

260

PREAI

Soergel, David G.; Subach, Ruth Ann; Burnham, Nancy; Lark, Michael W.; James, Ian E.; Sadler, Brian M.; Skobieranda, Franck; Violin, Jonathan D.; Webster, Lynn R.

TRV130, a novel biased opioid ligand, elicits increased analgesia with reduced adverse effects compared to morphine in healthy volunteers

JOURNAL OF PAIN

IF4

2014-04-01

OAAI

Soergel, D.; Subach, R.; James, I.; Violin, I.; Skobieranda, F.; Sadler, B.; Burnham, N.; Theisen, T.; Lark, M.; Webster, L.

GPCR biased ligands as novel heart failure therapeutics

TRENDS IN CARDIOVASCULAR MEDICINE

IF9

2013-10-01

PREAI

Violin, Jonathan D.; Soergel, David G.; Boerrigter, Guido; Burnett, John C., Jr.; Lark, Michael W.

An orally available mu-opioid receptor biased ligand is analgesic with reduced constipation in rodents

JOURNAL OF PAIN

IF4

2013-04-01

OAAI

Violin, J.; DeWire, S.; Koblish, M.; Chen, D.; Crombie, A.; Yamashita, D.; Soergel, D.; Lark, M.

A G Protein-Biased Ligand at the μ-Opioid Receptor Is Potently Analgesic with Reduced Gastrointestinal and Respiratory Dysfunction Compared with Morphines

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2013-03-01

577

PREAI

DeWire, Scott M.; Yamashita, Dennis S.; Rominger, David H.; Liu, Guodong; Cowan, Conrad L.; Graczyk, Thomas M.; Chen, Xiao-Tao; Pitis, Philip M.; Gotchev, Dimitar; Yuan, Catherine; Koblish, Michael; Lark, Michael W.; Violin, Jonathan D.

TRV120027, a Novel β-Arrestin Biased Ligand at the Angiotensin II Type I Receptor, Unloads the Heart and Maintains Renal Function When Added to Furosemide in Experimental Heart Failure

jacc heart failure

IF8.4

2012-09-01

117

OAAI

Boerrigter, Guido; Soergel, David G.; Violin, Jonathan D.; Lark, Michael W.; Burnett, John C., Jr.

First Human Dosing Experience With TRV027, a Novel Therapy for Acute Heart Failure

JOURNAL OF CARDIAC FAILURE

IF8.2

2012-08-01

OAAI

Soergel, David G.; Subach, Ruth Ann; Violin, Jonathan D.; Yamashita, Dennis; Gowen, Maxine; Lark, Michael W.

Cardiorenal Actions of TRV120027, a Novel β-Arrestin-Biased Ligand at the Angiotensin II Type I Receptor, in Healthy and Heart Failure Canines A Novel Therapeutic Strategy for Acute Heart Failure

jacc heart failure

IF8.4

2011-11-01

139

OAAI

Boerrigter, Guido; Lark, Michael W.; Whalen, Erin J.; Soergel, David G.; Violin, Jonathan D.; Burnett, John C., Jr.

TRV120027, a Novel Beta-Arrestin Biased Ligand at the Angiotensin II Type I Receptor, Unloads the Heart and Maintains Renal Function When Added to Furosemide in Experimental Heart Failure

JOURNAL OF CARDIAC FAILURE

IF8.2

2011-08-01

PREAI

Boerrigter, Guido; Soergel, David G.; Lark, Michael W.; Burnett, John C., Jr.

Selectively Engaging β-Arrestins at the Angiotensin II Type 1 Receptor Reduces Blood Pressure and Increases Cardiac Performance

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2010-12-01

335

PREAI

Violin, Jonathan D.; DeWire, Scott M.; Yamashita, Dennis; Rominger, David H.; Nguyen, Lisa; Schiller, Kevin; Whalen, Erin J.; Gowen, Maxine; Lark, Michael W.

TRV120027, a β-Arrestin Biased Ligand at the Angiotensin II Type 1 Receptor, Produces Unique Pharmacology and Is a Novel Potential Therapy for Heart Failure

JOURNAL OF CARDIAC FAILURE

IF8.2

2010-08-01

PREAI

Violin, Jonathan D.; Soergel, David G.; DeWire, Scott M.; Yamashita, Dennis; Rominger, David; Whalen, Erin J.; Gowen, Maxine; Lark, Michael W.

Cardiorenal Actions of TRV120027, a Novel, β-Arrestin-Biased Ligand at the Angiotensin II Type I Receptor, in Healthy and Heart Failure Canines: A Novel Therapeutic Strategy for Acute Heart Failure

JOURNAL OF CARDIAC FAILURE

IF8.2

2010-08-01

OAAI

Boerrigter, Guido; Whalen, Erin J.; Lark, Michael; Burnett, John C.

Antagonism of the osteoclast vitronectin receptor with an orally active nonpeptide inhibitor prevents cancellous bone loss in the ovariectomized rat

JOURNAL OF BONE AND MINERAL RESEARCH

IF5.9

2009-12-02

OAAI

Lark, MW; Stroup, GB; Dodds, RA; Kapadia, R; Hoffman, SJ; Hwang, SM; James, IE; Lechowska, B; Liang, XG; Rieman, DJ; Salyers, KL; Ward, K; Smith, BR; Miller, WH; Huffman, WF; Gowen, M

Human osteoclast cathepsin K is processed intracellularly prior to attachment and bone resorption

JOURNAL OF BONE AND MINERAL RESEARCH

IF5.9

2009-12-02

PREAI

Dodds, RA; James, IE; Rieman, D; Ahern, R; Hwang, SM; Connor, JR; Thompson, SD; Veber, DF; Drake, FH; Holmes, S; Lark, MW; Gowen, M

Potent and selective inhibition of human cathepsin K leads to inhibition of bone resorption in vivo in a nonhuman primate 人组织蛋白酶K的有效和选择性抑制导致非人灵长类动物体内骨吸收的抑制

JOURNAL OF BONE AND MINERAL RESEARCH

IF5.9

2009-12-02

161

PREAI

Stroup, GB; Lark, MW; Veber, DF; Bhattacharyya, A; Blake, S; Dare, LC; Erhard, KF; Hoffman, SJ; James, IE; Marquis, RW; Ru, Y; Vasko-Moser, JA; Smith, BR; Tomaszek, T; Gowen, M

Interference with tissue factor prolongs intrahepatic islet allograft survival in a nonhuman primate marginal mass model

TRANSPLANTATION

IF5

2007-08-15

OAAI

Berman, Dora M.; Cabrera, Over; Kenyon, Norman M.; Miller, Joshua; Tam, Susan H.; Khandekar, Vrinda S.; Picha, Kristen M.; Soderman, Avery R.; Jordan, Robert E.; Bugelski, Peter J.; Horninger, Denison; Lark, Michael; Davis, Janet E.; Alejandro, Rodolfo; Berggren, Per-Olof; Zimmerman, Mark; O'Neil, John J.; Ricordi, Camillo; Kenyon, Norma S.

A highly potent inhibitor of cathepsin K (relacatib) reduces biomarkers of bone resorption both in vitro and in an acute model of elevated bone turnover in vivo in monkeys 组织蛋白酶K的高效抑制剂 (relacatib) 在体外和猴子体内骨转换升高的急性模型中均降低了骨吸收的生物标志物

BONE

IF3.6

2007-01-01

120

PREAI

Kumar, S.; Dare, L.; Vasko-Moser, J. A.; James, I. E.; Blake, S. M.; Rickard, D. J.; Hwang, S. -M.; Tomaszek, T.; Yamashita, D. S.; Marquis, R. W.; Oh, H.; Jeong, J. U.; Veber, D. F.; Gowen, M.; Lark, M. W.; Stroup, G.

Structure activity relationships of 5-, 6-, and 7-methyl -substituted azepan-3-one cathepsin K inhibitors

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2006-02-15

PREAI

Yamashita, DS; Marquis, RW; Xie, R; Nidamarthy, SD; Oh, HJ; Jeong, JU; Erhard, KF; Ward, KW; Roethke, TJ; Smith, BR; Cheng, HY; Geng, XL; Lin, F; Offen, PH; Wang, B; Nevins, N; Head, MS; Haltiwanger, RC; Sarjeant, AAN; Liable-Sands, LM; Zhao, BG; Smith, WW; Janson, CA; Gao, E; Tomaszek, T; McQueney, M; Jarnes, IE; Gress, CJ; Zembryki, DL; Lark, MW; Veber, DF

Human osteoarthritis synovial fluid and joint cartilage contain both aggrecanase- and matrix metalloproteinase-generated aggrecan fragments

OSTEOARTHRITIS AND CARTILAGE

IF9

2006-02-01

188

OAAI

Struglics, A; Larsson, S; Pratta, MA; Kumar, S; Lark, MW; Lohmander, LS

研究方向