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Substituted Azabicyclo[2.2.1]heptanes as Selective Orexin-1 Antagonists: Discovery of JNJ-54717793 Preville, Cathy; Bonaventure, Pascal; Koudriakova, Tatiana; Lord, Brian; Nepomuceno, Diane; Rizzolio, Michele; Mani, Neelakandha; Coe, Kevin J.; Ndifor, Anthony; Dugovic, Christine; Dvorak, Curt A.; Coate, Heather; Pippel, Daniel J.; Fitzgerald, Anne; Allison, Brett; Lovenberg, Timothy W.; Carruthers, Nicholas, I; Shireman, Brock T. 分享 收藏
Pharmacologic Characterization of JNJ-42226314, [1-(4-Fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl) piperazin-1-yl]azetidin-1-yl]methanone, a Reversible, Selective, and Potent Monoacylglycerol Lipase Inhibitor Wyatt, Ryan M.; Fraser, Ian; Welty, Natalie; Lord, Brian; Wennerholm, Michelle; Sutton, Steven; Ameriks, Michael K.; Dugovic, Christine; Yun, Sujin; White, Allison; Nguyen, Leslie; Koudriakova, Tatiana; Tian, Gaochao; Suarez, Javier; Szewczuk, Lawrence; Bonnette, William; Ahn, Kay; Ghosh, Brahma; Flores, Christopher M.; Connolly, Peter J.; Zhu, Bin; Macielag, Mark J.; Brandt, Michael R.; Chevalier, Kristen; Zhang, Sui-Po; Lovenberg, Timothy; Bonaventure, Pascal 分享 收藏
Pharmacology of JNJ-28583113: A novel TRPM2 antagonist Fourgeaud, Lawrence; Dvorak, Curt; Faouzi, Malika; Starkus, John; Sandeo, Sunil; Wang, Qi; Lord, Brian; Coate, Heather; Taylor, Natalie; He, Yingbo; Qin, Ning; Wickenden, Alan; Carruthers, Nicholas; Lovenberg, Timothy W.; Penner, Reinhold; Bhattacharya, Anindya 分享 收藏
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Discovery of Imidazo[1,2-a]pyrazines and Pyrazolo[1,5-c]pyrimidines as TARP γ-8 Selective AMPAR Negative Modulators Sayall, Brad M.; Wu, Dongpei; Swanson, Devin M.; Seierstad, Mark; Wu, Nyantsz; Vives Martinez, Jorge; Garcia Olmos, Beatriz; Lord, Brian; Coe, Kevin; Koudriakova, Tatiana; Lovenberg, Timothy W.; Carruthers, Nicholas I.; Maher, Michael P.; Ameriks, Michael K. 分享 收藏
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Lead Optimization of 5-Aryl Benzimidazolone- and Oxindole-Based AMPA Receptor Modulators Selective for TARP γ-8 Ravula, Suchitra; Savall, Brad M.; Wu, Nyantsz; Lord, Brian; Coe, Kevin; Wang, Kai; Seierstad, Mark; Swanson, Devin M.; Ziff, Jeannie; Minh Nguyen; Leung, Perry; Rynberg, Ray; La, David; Pippel, Daniel J.; Koudriakova, Tatiana; Lovenberg, Timothy W.; Carruthers, Nicholas, I; Maher, Michael P.; Ameriks, Michael K. 分享 收藏
Neuropsychopharmacology of JNJ-55308942: evaluation of a clinical candidate targeting P2X7 ion channels in animal models of neuroinflammation and anhedonia Bhattacharya, Anindya; Lord, Brian; Grigoleit, Jan-Sebastian; He, Yingbo; Fraser, Ian; Campbell, Shannon N.; Taylor, Natalie; Aluisio, Leah; O'Connor, Jason C.; Papp, Mariusz; Chrovian, Christa; Carruthers, Nicholas; Lovenberg, Timothy W.; Letavic, Michael A. 分享 收藏
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4-Methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate Letavic, Michael A.; Savall, Brad M.; Allison, Brett D.; Aluisio, Leah; Andres, Jose Ignacio; De Angelis, Meri; Ao, Hong; Beauchamp, Derek A.; Bonaventure, Pascal; Bryan, Stewart; CarruthersT, Nicholas I.; Ceusters, Marc; Coe, Kevin J.; Dvorak, Curt A.; Fraser, Ian C.; Gelin, Christine F.; Koudriakova, Tatiana; Liang, Jimmy; Lord, Brian; Lovenberg, Timothy W.; Otieno, Monicah A.; Schoetens, Freddy; Swanson, Devin M.; Wang, Qi; Wickenden, Alan D.; Bhattacharyat, Anindya 分享 收藏
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Identification of (R)-(2-Chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyridin-2-yl)-4-methyl-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)methanone (JNJ 54166060), a Small Molecule Antagonist of the P2X7 receptor Swanson, Devin M.; Savall, Brad M.; Coe, Kevin J.; Schoetens, Freddy; Koudriakova, Tatiana; Skaptason, Judith; Wall, Jessica; Rech, Jason; Deng, Xiahou; De Angelis, Meri; Everson, Anita; Lord, Brian; Wang, Qi; Ao, Hong; Scott, Brian; Sepassi, Kia; Lovenberg, Timothy W.; Carruthers, Nicholas I.; Bhattacharya, Anindya; Letavic, Michael A. 分享 收藏
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Discovery and Characterization of AMPA Receptor Modulators Selective for TARP-γ8 Maher, Michael P.; Wu, Nyantsz; Ravula, Suchitra; Ameriks, Michael K.; Savall, Brad M.; Liu, Changlu; Lord, Brian; Wyatt, Ryan M.; Matta, Jose A.; Dugovic, Christine; Yun, Sujin; Donck, Luc Ver; Steckler, Thomas; Wickenden, Alan D.; Carruthers, Nicholas I.; Lovenberg, Timothy W. 分享 收藏