Bruno Alicke - Publications, H-index & Citations

Bruno Alicke

roche holding

27H指数

127论文数

3.3K被引数

收录论文 26

发表时间

IAP antagonist GDC-0917 is more potent than Debio1143 in promoting cell death, c-IAP1 degradation and tumor growth inhibition

CELL DEATH & DISEASE

IF9.6

2022-09-28

OAAI

Alicke, Bruno; Varfolomeev, Eugene; Lee, Shi Hui Kaylee; Frommlet, Alexandra; Ubhayakar, Savita; Quinn, John G.; Fairbrother, Wayne J.; Jones, Robert; Gould, Stephen E.; Vucic, Domagoj

Growth-rate model predicts in vivo tumor response from in vitro data

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY

IF3

2022-07-04

OAAI

Diegmiller, Rocky; Salphati, Laurent; Alicke, Bruno; Wilson, Timothy R.; Stout, Thomas J.; Hafner, Marc

Generalized Additive Mixed Modeling of Longitudinal Tumor Growth Reduces Bias and Improves Decision Making in Translational Oncology

CANCER RESEARCH

IF16.6

2020-11-13

PREAI

Forrest, William F.; Alicke, Bruno; Mayba, Oleg; Osinska, Magdalena; Jakubczak, Michal; Piatkowski, Pawel; Choniawko, Lech; Starr, Alice; Gould, Stephen E.

Immunization associated with primary tumor growth leads to rejection of commonly used syngeneic tumors upon tumor rechallenge

JOURNAL FOR IMMUNOTHERAPY OF CANCER

IF10.6

2020-07-15

OAAI

Alicke, Bruno; Totpal, Klara; Schartner, Jill M.; Berkley, Amy M.; Lehar, Sophie M.; Capietto, Aude-Helene; Cubas, Rafael A.; Gould, Stephen E.

PRC2-mediated repression of SMARCA2 predicts EZH2 inhibitor activity in SWI/SNF mutant tumors

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2017-10-30

OAAI

Januario, Thomas; Ye, Xiaofen; Bainer, Russell; Alicke, Bruno; Smith, Tunde; Haley, Benjamin; Modrusan, Zora; Gould, Stephen; Yauch, Robert L.

PRC2 mediated repression of SMARCA2 predicts for EZH2 inhibitor activity in tumors with SWI/SNF mutations

CANCER RESEARCH

IF16.6

2017-07-01

PREAI

Januario, Thomas; Ye, Xiaofen; Bainer, Russell; Alicke, Bruno; Solon, Margaret; Haley, Benjamin; Modrusan, Zora; Gould, Stephen; Koeppen, Hartmut; Yauch, Robert L.

Characterization of residual Basal Cell Carcinoma after vismodegib treatment

CANCER RESEARCH

IF16.6

2017-07-01

PREAI

Biehs, Brian; Dijkgraaf, Gerrit J.; Alicke, Bruno; Peale, Franklin; Gould, Stephen E.; de Sauvage, Frederic J.

Stem cell plasticity enables hair regeneration following Lgr5+ cell loss

NATURE CELL BIOLOGY

IF19.1

2017-05-29

PREAI

Hoeck, Joerg D.; Biehs, Brian; Kurtova, Antonia V.; Kljavin, Noelyn M.; de Sousa e Melo, Felipe; Alicke, Bruno; Koeppen, Hartmut; Modrusan, Zora; Piskol, Robert; de Sauvage, Frederic J.

Discovery of Clinical Development Candidate GDC-0084, a Brain Penetrant Inhibitor of PI3K and mTOR

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2016-02-17

OAAI

Heffron, Timothy P.; Ndubaku, Chudi O.; Salphati, Laurent; Alicke, Bruno; Cheong, Jonathan; Drobnick, Joy; Edgar, Kyle; Gould, Stephen E.; Lee, Leslie B.; Lesnick, John D.; Lewis, Cristina; Nonomiya, Jim; Pang, Jodie; Plise, Emile G.; Sideris, Steve; Wallin, Jeffrey; Wang, Lan; Zhang, Xiaolin; Olivero, Alan G.

PTEN Loss Mitigates the Response of Medulloblastoma to Hedgehog Pathway Inhibition

CANCER RESEARCH

IF16.6

2013-12-01

OAAI

Metcalfe, Ciara; Alicke, Bruno; Crow, Ailey; Lamoureux, Marlea; Dijkgraaf, Gerrit J. P.; Peale, Franklin; Gould, Stephen E.; de Sauvage, Frederic J.

Determination of clinically therapeutic endoxifen concentrations based on efficacy from human MCF7 breast cancer xenografts

BREAST CANCER RESEARCH AND TREATMENT

IF3

2013-04-19

PREAI

Gong, Inna Y.; Teft, Wendy A.; Ly, Justin; Chen, Yung-Hsiang; Alicke, Bruno; Kim, Richard B.; Choo, Edna F.

Targeting the PI3K Pathway in the Brain-Efficacy of a PI3K Inhibitor Optimized to Cross the Blood-Brain Barrier

CLINICAL CANCER RESEARCH

IF10.2

2012-11-14

OAAI

Salphati, Laurent; Heffron, Timothy P.; Alicke, Bruno; Nishimura, Merry; Barck, Kai; Carano, Richard A.; Cheong, Jonathan; Edgar, Kyle A.; Greve, Joan; Kharbanda, Samir; Koeppen, Hartmut; Lau, Shari; Lee, Leslie B.; Pang, Jodie; Plise, Emile G.; Pokorny, Jenny L.; Reslan, Hani Bou; Sarkaria, Jann N.; Wallin, Jeffrey J.; Zhang, Xiaolin; Gould, Stephen E.; Olivero, Alan G.; Phillips, Heidi S.

Efficacy of a Brain-penetrant PI3K/mTOR Inhibitor in Orthotopic Models of Glioblastoma

EUROPEAN JOURNAL OF CANCER

IF7.1

2012-11-01

PREAI

Salphati, L.; Heffron, T. P.; Alicke, B.; Barck, K.; Carano, R. A.; Kharbanda, S.; Lee, L. B.; Nishimura, M.; Olivero, A. G.; Phillips, H. S.

The Design and Identification of Brain Penetrant Inhibitors of Phosphoinositide 3-Kinase α

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2012-09-11

PREAI

Heffron, Timothy P.; Salphati, Laurent; Alicke, Bruno; Cheong, Jonathan; Dotson, Jennafer; Edgar, Kyle; Goldsmith, Richard; Gould, Stephen E.; Lee, Leslie B.; Lesnick, John D.; Lewis, Cristina; Ndubaku, Chudi; Nonomiya, Jim; Olivero, Alan G.; Pang, Jodie; Plise, Emile G.; Sideris, Steve; Trapp, Sean; Wallin, Jeffrey; Wang, Lan; Zhang, Xiaolin

Antitumor Activity of Targeted and Cytotoxic Agents in Murine Subcutaneous Tumor Models Correlates with Clinical Response

CLINICAL CANCER RESEARCH

IF10.2

2012-07-15

109

OAAI

Wong, Harvey; Choo, Edna F.; Alicke, Bruno; Ding, Xiao; La, Hank; McNamara, Erin; Theil, Frank-Peter; Tibbitts, Jay; Friedman, Lori S.; Hop, Cornelis E. C. A.; Gould, Stephen E.

Potent and Selective Aminopyrimidine-Based B-Raf Inhibitors with Favorable Physicochemical and Pharmacokinetic Properties

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2012-02-29

PREAI

Mathieu, Simon; Gradl, Stefan N.; Ren, Li; Wen, Zhaoyang; Aliagas, Ignacio; Gunzner-Toste, Janet; Lee, Wendy; Pulk, Rebecca; Zhao, Guiling; Alicke, Bruno; Boggs, Jason W.; Buckmelter, Alex J.; Choo, Edna F.; Dinkel, Victoria; Gloor, Susan L.; Gould, Stephen E.; Hansen, Joshua D.; Hastings, Gregg; Hatzivassiliou, Georgia; Laird, Ellen R.; Moreno, David; Ran, Yingqing; Voegtli, Walter C.; Wenglowsky, Steve; Grina, Jonas; Rudolph, Joachim

Pharmacokinetic-Pharmacodynamic Analysis of Vismodegib in Preclinical Models of Mutational and Ligand-Dependent Hedgehog Pathway Activation

CLINICAL CANCER RESEARCH

IF10.2

2011-07-17

105

OAAI

Wong, Harvey; Alicke, Bruno; West, Kristina A.; Pacheco, Patricia; La, Hank; Januario, Tom; Yauch, Robert L.; de Sauvage, Frederic J.; Gould, Stephen E.

Canonical hedgehog signaling augments tumor angiogenesis by induction of VEGF-A in stromal perivascular cells

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2011-05-19

111

OAAI

Chen, Weiwei; Tang, Tracy; Eastham-Anderson, Jeff; Dunlap, Debra; Alicke, Bruno; Nannini, Michelle; Gould, Stephen; Yauch, Robert; Modrusan, Zora; DuPree, Kelly J.; Darbonne, Walter C.; Plowman, Greg; de Sauvage, Frederic J.; Callahan, Christopher A.

Pyrazolopyridine Inhibitors of B-RafV600E. Part 1: The Development of Selective, Orally Bioavailable, and Efficacious Inhibitors

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2011-03-08

OAAI

Wenglowsky, Steve; Ren, Li; Ahrendt, Kateri A.; Laird, Ellen R.; Aliagas, Ignacio; Alicke, Bruno; Buckmelter, Alex J.; Choo, Edna F.; Dinkel, Victoria; Feng, Bainian; Gloor, Susan L.; Gould, Stephen E.; Gross, Stefan; Gunzner-Toste, Janet; Hansen, Joshua D.; Hatzivassiliou, Georgia; Liu, Bonnie; Malesky, Kim; Mathieu, Simon; Newhouse, Brad; Raddatz, Nicholas J.; Ran, Yingqing; Rana, Sumeet; Randolph, Nikole; Risom, Tyler; Rudolph, Joachim; Savage, Scott; Selby, LeAnn T.; Shrag, Michael; Song, Kyung; Sturgis, Hillary L.; Voegtli, Walter C.; Wen, Zhaoyang; Willis, Brandon S.; Woessner, Richard D.; Wu, Wen-I; Young, Wendy B.; Grina, Jonas

Small Molecule Inhibition of GDC-0449 Refractory Smoothened Mutants and Downstream Mechanisms of Drug Resistance

CANCER RESEARCH

IF16.6

2011-01-13

349

OAAI

Dijkgraaf, Gerrit J. P.; Alicke, Bruno; Weinmann, Lasse; Januario, Thomas; West, Kristina; Modrusan, Zora; Burdick, Dan; Goldsmith, Richard; Robarge, Kirk; Sutherlin, Dan; Scales, Suzie J.; Gould, Stephen E.; Yauch, Robert L.; de Sauvage, Frederic J.

研究方向