L Nelles - Publications, H-index & Citations

L Nelles

galapagos nv

32H指数

97论文数

4.1K被引数

收录论文 15

发表时间

Discovery of 9-Cyclopropylethynyl-2-((S)-1-[1,4]dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one (GLPG1205), a Unique GPR84 Negative Allosteric Modulator Undergoing Evaluation in a Phase II Clinical Trial

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2020-09-09

OAAI

Labeguere, Frederic; Dupont, Sonia; Alvey, Luke; Soulas, Florilene; Newsome, Gregory; Tirera, Amynata; Quenehen, Vanessa; Thi Thu Trang Mai; Deprez, Pierre; Blanque, Roland; Oste, Line; Le Tallec, Sandrine; De Vos, Steve; Hagers, Annick; Vandevelde, Ann; Nelles, Luc; Vandervoort, Nele; Conrath, Katja; Christophe, Thierry; van der Aar, Ellen; Wakselman, Emanuelle; Merciris, Didier; Cottereaux, Celine; da Costa, Cecile; Saniere, Laurent; Clement-Lacroix, Philippe; Jenkins, Laura; Milligan, Graeme; Fletcher, Stephen; Brys, Reginald; Gosmini, Romain

Discovery of N-(3-Carbamoyl-5,5,7,7-tetramethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-2-yl)-lH-pyrazole-5-carboxamide (GLPG1837), a Novel Potentiator Which Can Open Class III Mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Channels to a High Extent

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2018-01-10

PREAI

Van der Plas, Steven E.; Kelgtermans, Hans; De Munck, Tom; Martina, Sebastien L. X.; Dropsit, Sebastien; Quinton, Evelyne; De Blieck, Ann; Joannesse, Caroline; Tomaskovic, Linda; Jans, Mia; Christophe, Thierry; van der Aar, Ellen; Borgonovi, Monica; Nelles, Luc; Gees, Maarten; Stouten, Pieter; Van Der Schueren, Jan; Mammoliti, Oscar; Conrath, Katja; Andrews, Martin

Discovery and Optimization of an Azetidine Chemical Series As a Free Fatty Acid Receptor 2 (FFA2) Antagonist: From Hit to Clinic

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2014-12-01

PREAI

Pizzonero, Mathieu; Dupont, Sonia; Babel, Marielle; Beaumont, Stephane; Bienvenu, Natacha; Blanque, Roland; Cherel, Laetitia; Christophe, Thierry; Crescenzi, Benedetta; De Lemos, Elsa; Delerive, Philippe; Deprez, Pierre; De Vos, Steve; Djata, Fatoumata; Fletcher, Stephen; Kopiejewski, Sabrina; L'Ebraly, Christelle; Lefrancois, Jean-Michel; Lavazais, Stephanie; Manioc, Murielle; Nelles, Luc; Oste, Line; Polancec, Denis; Quenehen, Vanessa; Soulas, Florilene; Triballeau, Nicolas; van der Aar, Ellen M.; Vandeghinste, Nick; Wakselman, Emanuelle; Brys, Reginald; Saniere, Laurent

Triazolopyridines as Selective JAK1 Inhibitors: From Hit Identification to GLPG0634

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2014-11-17

116

PREAI

Menet, Christel J.; Fletcher, Stephen R.; Van Lommen, Guy; Geney, Raphael; Blanc, Javier; Smits, Koen; Jouannigot, Nolwenn; Deprez, Pierre; van der Aar, Ellen M.; Clement-Lacroix, Philippe; Lepescheux, Lien; Galien, Rene; Vayssiere, Beatrice; Nelles, Luc; Christophe, Thierry; Brys, Reginald; Uhring, Muriel; Ciesieski, Fabrice; Van Rompaey, Luc

Preclinical Characterization of GLPG0634, a Selective Inhibitor of JAK1, for the Treatment of Inflammatory Diseases

JOURNAL OF IMMUNOLOGY

IF3.4

2013-10-01

208

PREAI

Van Rompaey, Luc; Galien, Rene; van der Aar, Ellen M.; Clement-Lacroix, Philippe; Nelles, Luc; Smets, Bart; Lepescheux, Lien; Christophe, Thierry; Conrath, Katja; Vandeghinste, Nick; Vayssiere, Beatrice; De Vos, Steve; Fletcher, Stephen; Brys, Reginald; van 't Klooster, Gerben; Feyen, Jean H. M.; Menet, Christel

Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination

DEVELOPMENT

IF3.6

2007-12-15

OAAI

Esguerra, Camila V.; Nelles, Luc; Vermeire, Liesbeth; Ibrahimi, Abdelilah; Crawford, Alexander D.; Derua, Rita; Janssens, Els; Waelkens, Etienne; Carmeliet, Peter; Collen, Desire; Huylebroeck, Danny

Activation of NF-κB by Akt upregulates Snail expression and induces epithelium mesenchyme transition Akt激活nf-κb上调Snail表达并诱导上皮间质转化

ONCOGENE

IF7.3

2007-06-11

466

OAAI

Julien, S.; Puig, I.; Caretti, E.; Bonaventure, J.; Nelles, L.; van Roy, F.; Dargemont, C.; Garcia de Herreros, A.; Bellacosa, A.; Larue, L.

Neural crest-specific removal of Zfhx1b in mouse leads to a wide range of neurocristopathies reminiscent of Mowat-Wilson syndrome

HUMAN MOLECULAR GENETICS

IF3.2

2007-05-03

OAAI