Jonathan D. Violin - Publications, H-index & Citations

Jonathan D. Violin

istituto superiore di sanita (iss)

45H指数

102论文数

1.2W被引数

收录论文 40

发表时间

STAR-0215 is a Novel, Long-Acting Monoclonal Antibody Inhibitor of Plasma Kallikrein for the Potential Treatment of Hereditary Angioedema

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2023-11-01

OAAI

Bedian, Vahe; Biris, Nikolaos; Omer, Charles; Chung, Jou-Ku; Fuller, James; Dagher, Rafif; Chandran, Sachin; Harwin, Peter; Kiselak, Tomas; Violin, Jonathan; Nichols, Andrew; Quellis, Pradeep Bista

TRV0109101, a G Protein-Biased Agonist of the μ-Opioid Receptor, Does Not Promote Opioid-Induced Mechanical Allodynia following Chronic Administration

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2017-08-01

OAAI

Koblish, Michael; Carr, Richard, III; Siuda, Edward R.; Rominger, David H.; Gowen-MacDonald, William; Cowan, Conrad L.; Crombie, Aimee L.; Violin, Jonathan D.; Lark, Michael W.

Assessment of Nociceptive Sensitization with TRV9101, a Novel μ, Receptor G Protein Pathway Selective Modulator (μ-GPS), versus Fentanyl, Morphine, and Oxycodone

JOURNAL OF PAIN

IF4

2017-04-01

OAAI

Wobblish, M.; Carr, R.; Cowan, C.; Crombie, A.; Gowen-MacDonald, W.; Rominger, D.; Siuda, E.; Violin, J.; Lark, M.

Biased mu-opioid receptor ligands: a promising new generation of pain therapeutics

CURRENT OPINION IN PHARMACOLOGY

IF4.2

2017-02-01

117

PREAI

Siuda, Edward R.; Carr, Richard, III; Rominger, David H.; Violin, Jonathan D.

Cardiac myosin light chain phosphorylation and inotropic effects of a biased ligand, TRV120023, in a dilated cardiomyopathy model

CARDIOVASCULAR RESEARCH

IF13.3

2015-06-04

OAAI

Tarigopula, Madhusudhan; Davis, Robert T., III; Mungai, Paul T.; Ryba, David M.; Wieczorek, David F.; Cowan, Conrad L.; Violin, Jonathan D.; Wolska, Beata M.; Solaro, R. John

Heart Failure Therapeutics on the Basis of a Biased Ligand of the Angiotensin-2 Type 1 Receptor Rationale and Design of the BLAST-AHF Study (Biased Ligand of the Angiotensin Receptor Study in Acute Heart Failure)

JACC-HEART FAILURE

IF11.8

2015-03-01

OAAI

Felker, G. Michael; Butler, Javed; Collins, Sean P.; Cotter, Gad; Davison, Beth A.; Ezekowitz, Justin A.; Filippatos, Gerasimos; Levy, Phillip D.; Metra, Marco; Ponikowski, Piotr; Soergel, David G.; Teerlink, John R.; Violin, Jonathan D.; Voors, Adriaan A.; Pang, Peter S.

Biased agonism of the μ-opioid receptor by TRV130 increases analgesia and reduces on-target adverse effects versus morphine: A randomized, double-blind, placebo-controlled, crossover study in healthy volunteers

PAIN

IF5.5

2014-09-01

260

PREAI

Soergel, David G.; Subach, Ruth Ann; Burnham, Nancy; Lark, Michael W.; James, Ian E.; Sadler, Brian M.; Skobieranda, Franck; Violin, Jonathan D.; Webster, Lynn R.

Biased ligands: pathway validation for novel GPCR therapeutics

CURRENT OPINION IN PHARMACOLOGY

IF4.2

2014-06-01

PREAI

Rominger, David H.; Cowan, Conrad L.; Gowen-MacDonald, William; Violin, Jonathan D.

Divergent Transducer-specific Molecular Efficacies Generate Biased Agonism at a G Protein-coupled Receptor ( GPCR)

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2014-05-01

111

OAAI

Strachan, Ryan T.; Sun, Jin-peng; Rominger, David H.; Violin, Jonathan D.; Ahn, Seungkirl; Thomsen, Alex Rojas Bie; Zhu, Xiao; Kleist, Andrew; Costa, Tommaso; Lefkowitz, Robert J.

Structure Activity Relationships and Discovery of a G Protein Biased μ Opioid Receptor Ligand, [(3-Methoxythiophen-2-yl)methyl]a2[(9R)-9-(pyridin-2-y1)-6-oxaspiro-[4.5]clecan-9-yl]ethylpamine (TRV130), for the Treatment of Acute Severe Pain

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2013-10-14

192

PREAI

Chen, Xiao-Tao; Pitis, Philip; Liu, Guodong; Yuan, Catherine; Gotchev, Dimitar; Cowan, Conrad L.; Rominger, David H.; Koblish, Michael; DeWire, Scott M.; Crombie, Aimee L.; Violin, Jonathan D.; Yamashita, Dennis S.

GPCR biased ligands as novel heart failure therapeutics

TRENDS IN CARDIOVASCULAR MEDICINE

IF9

2013-10-01

PREAI

Violin, Jonathan D.; Soergel, David G.; Boerrigter, Guido; Burnett, John C., Jr.; Lark, Michael W.

An orally available mu-opioid receptor biased ligand is analgesic with reduced constipation in rodents

JOURNAL OF PAIN

IF4

2013-04-01

OAAI

Violin, J.; DeWire, S.; Koblish, M.; Chen, D.; Crombie, A.; Yamashita, D.; Soergel, D.; Lark, M.

A G Protein-Biased Ligand at the μ-Opioid Receptor Is Potently Analgesic with Reduced Gastrointestinal and Respiratory Dysfunction Compared with Morphines

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2013-03-01

577

PREAI

DeWire, Scott M.; Yamashita, Dennis S.; Rominger, David H.; Liu, Guodong; Cowan, Conrad L.; Graczyk, Thomas M.; Chen, Xiao-Tao; Pitis, Philip M.; Gotchev, Dimitar; Yuan, Catherine; Koblish, Michael; Lark, Michael W.; Violin, Jonathan D.

TRV120027, a Novel β-Arrestin Biased Ligand at the Angiotensin II Type I Receptor, Unloads the Heart and Maintains Renal Function When Added to Furosemide in Experimental Heart Failure

jacc heart failure

IF8.4

2012-09-01

117

OAAI

Boerrigter, Guido; Soergel, David G.; Violin, Jonathan D.; Lark, Michael W.; Burnett, John C., Jr.

First Human Dosing Experience With TRV027, a Novel Therapy for Acute Heart Failure

JOURNAL OF CARDIAC FAILURE

IF8.2

2012-08-01

OAAI

Soergel, David G.; Subach, Ruth Ann; Violin, Jonathan D.; Yamashita, Dennis; Gowen, Maxine; Lark, Michael W.

Competing G protein-coupled receptor kinases balance G protein and β-arrestin signaling

MOLECULAR SYSTEMS BIOLOGY

IF7.7

2012-06-26

OAAI

Heitzler, Domitille; Durand, Guillaume; Gallay, Nathalie; Rizk, Aurelien; Ahn, Seungkirl; Kim, Jihee; Violin, Jonathan D.; Dupuy, Laurence; Gauthier, Christophe; Piketty, Vincent; Crepieux, Pascale; Poupon, Anne; Clement, Frederique; Fages, Francois; Lefkowitz, Robert J.; Reiter, Eric

Cardiorenal Actions of TRV120027, a Novel β-Arrestin-Biased Ligand at the Angiotensin II Type I Receptor, in Healthy and Heart Failure Canines A Novel Therapeutic Strategy for Acute Heart Failure

jacc heart failure

IF8.4

2011-11-01

139

OAAI

Boerrigter, Guido; Lark, Michael W.; Whalen, Erin J.; Soergel, David G.; Violin, Jonathan D.; Burnett, John C., Jr.

Quantifying Ligand Bias at Seven-Transmembrane Receptors

MOLECULAR PHARMACOLOGY

IF3

2011-09-01

345

OAAI

Rajagopal, Sudarshan; Ahn, Seungkirl; Rominger, David H.; Gowen-MacDonald, William; Lam, Christopher M.; DeWire, Scott M.; Violin, Jonathan D.; Lefkowitz, Robert J.

Biased Ligands for Better Cardiovascular Drugs Dissecting G-Protein-Coupled Receptor Pharmacology

CIRCULATION RESEARCH

IF16.2

2011-07-08

120

OAAI

DeWire, Scott M.; Violin, Jonathan D.

Selectively Engaging β-Arrestins at the Angiotensin II Type 1 Receptor Reduces Blood Pressure and Increases Cardiac Performance

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2010-12-01

335

PREAI

Violin, Jonathan D.; DeWire, Scott M.; Yamashita, Dennis; Rominger, David H.; Nguyen, Lisa; Schiller, Kevin; Whalen, Erin J.; Gowen, Maxine; Lark, Michael W.

研究方向