未登录Phase 2 study of novel HER2-targeting, TLR7/8 immune-stimulating antibody conjugate (ISAC) BDC-1001+/- pertuzumab in patients with HER2-positive metastatic breast cancer (MBC) previously treated with trastuzumab deruxtecan
Pegram, Mark; Calfa, Carmen; Chen, Chris; Salgado, Alfonso Cortes; Heeke, Arielle; Kang, Irene; Pistilli, Barbara; Pohlmann, Paula; Rugo, Hope; Saura, Cristina; Vicier, Cecile; Pearson, Cecelia I.; Tapia, Coya; Yin, Ming; Yu, Tai; Alonso, Michael N.; Perez, Edith A.; Drago, Joshua .png)
分享.png)
收藏Combined MEK/MDM2 inhibition demonstrates antitumor efficacy in TP53 wild-type thyroid and colorectal cancers with MAPK alterationsPairawan, Seyed; Akcakanat, Argun; Kopetz, Scott; Tapia, Coya; Zheng, Xiaofeng; Chen, Huiqin; Ha, Min Jin; Rizvi, Yasmeen; Holla, Vijaykumar; Wang, Jing; Evans, Kurt W.; Zhao, Ming; Busaidy, Naifa; Fang, Bingliang; Roth, Jack A.; Dumbrava, Ecaterina Ileana; Meric-Bernstam, Funda 分享 收藏 Oxidative Phosphorylation Is a Metabolic Vulnerability in Chemotherapy-Resistant Triple-Negative Breast CancerEvans, Kurt W.; Yuca, Erkan; Scott, Stephen S.; Zhao, Ming; Arango, Natalia Paez; Pico, Christian X. Cruz; Saridogan, Turcin; Shariati, Maryam; Class, Caleb A.; Bristow, Christopher A.; Vellano, Christopher P.; Zheng, Xiaofeng; Gonzalez-Angulo, Ana Maria; Su, Xiaoping; Tapia, Coya; Chen, Ken; Akcakanat, Argun; Lim, Bora; Tripathy, Debu; Yap, Timothy A.; Di Francesco, Maria Emilia; Draetta, Giulio F.; Jones, Philip; Heffernan, Timothy P.; Marszalek, Joseph R.; Meric-Bernstam, Funda 分享 收藏 Combined inhibition of DDR1 and CDK4/6 induces synergistic effects in ER-positive, HER2-negative breast cancer with PIK3CA/AKT1 mutationsShariati, Maryam; Evans, Kurt W.; Zheng, Xiaofeng; Bristow, Christopher A.; Ng, Patrick Kwok-Shing; Rizvi, Yasmeen Q.; Tapia, Coya; Yang, Fei; Carugo, Alessandro; Heffernan, Timothy P.; Peoples, Michael D.; Tripathy, Debu; Meric-Bernstam, Funda 分享 收藏 First in class dual MDM2/MDMX inhibitor ALRN-6924 enhances antitumor efficacy of chemotherapy in TP53 wild-type hormone receptor-positive breast cancer models一流的双重MDM2/MDMX抑制剂ALRN-6924增强了TP53野生型激素受体阳性乳腺癌模型中化疗的抗肿瘤效果Pairawan, Seyed; Zhao, Ming; Yuca, Erkan; Annis, Allen; Evans, Kurt; Sutton, David; Carvajal, Luis; Ren, Jian-Guo; Santiago, Solimar; Guerlavais, Vincent; Akcakanat, Argun; Tapia, Coya; Yang, Fei; Bose, Priya Subash Chandra; Zheng, Xiaofeng; Dumbrava, Ecaterina Ileana; Aivado, Manuel; Meric-Bernstam, Funda 分享 收藏 Synergism of PARP inhibitor and MET inhibitor in multiple cancer types with intrinsic and acquired PARP inhibitor resistancesChen, Mei-Kuang; Xia, Weiya; Dong, Qiongzhu; Du, Yi; Wang, Hung-Ling; Tapia, Coya; Wei, Yongkun; Han, Ye; Chu, Yu-Yi; Yam, Clinton; Gao, Yuan; Wang, Yu-Han; Meric-Bernstam, Funda; Liu, Jinsong; Wang, Shao-Chun; Yu, Dihua; Hung, Mien-Chie 分享 收藏 Overcoming PARP inhibitor resistance with molecularly guided rational combinations in triple-negative breast cancer patient-derived xenograft modelsPico, Christian X. Cruz; Evans, Kurt W.; Chen, Ken; Zheng, Xiaofeng; Akcakanat, Argun; Zhao, Ming; Tapia, Coya; Scott, Stephen M.; Yuca, Erkan; Meric-Bernstam, Funda 分享 收藏 Evaluation of cytotoxic T cell infiltration and clinical benefit from PD-L1 checkpoint inhibition among PIK3CA mutant microsatellite stable (MSS) metastatic adenocarcinoma patientsNusrat, Maliha; Tapia, Coya; Call, S. Greg; Hong, David S.; Piha-Paul, Sarina A.; Subbiah, Vivek; Rodon, Jordi; Tsimberidou, Apostolia M.; Adat, Abha; Wang, Yan; Meric-Bernstam, Funda; Overman, Michael J.; Kopetz, Scott; Janku, Filip 分享 收藏 Decrease in tumor content assessed in biopsies is associated with improved treatment outcome response to pembrolizumab in patients with rare tumorsTapia, Coya; Aung, Phyu P.; Roy-Chowdhuri, Sinchita; Xu, Mingxuan; Ouyang, Fengying; Alshawa, Anas; Hajjar, Joud; Singh, Gopal; Yang, Vincent; Castillo, Lilibeth; Le, Hung; Murthy, Ravi; Stephen, Bettzy; Hess, Kenneth R.; Wistuba, Ignacio; Naing, Aung 分享 收藏 Phase 2 study of pembrolizumab in patients with advanced rare cancersNaing, Aung; Meric-Bernstam, Funda; Stephen, Bettzy; Karp, Daniel D.; Hajjar, Joud; Ahnert, Jordi Rodon; Piha-Paul, Sarina A.; Colen, Rivka R.; Jimenez, Camilo; Raghav, Kanwal P.; Ferrarotto, Renata; Tu, Shi-Ming; Campbell, Matthew; Wang, Linghua; Sabir, Sarjeel H.; Tapia, Coya; Bernatchez, Chantale; Frumovitz, Michael; Tannir, Nizar; Ravi, Vinod; Khan, Saria; Painter, Jeane M.; Abonofal, Abulrahman; Gong, Jing; Alshawa, Anas; McQuinn, Lacey M.; Xu, Mingxuan; Ahmed, Sara; Subbiah, Vivek; Hong, David S.; Pant, Shubham; Yap, Timothy A.; Tsimberidou, Apostolia M.; Dumbrava, Ecaterina E. Ileana; Janku, Filip; Fu, Siqing; Simon, Richard M.; Hess, Kenneth R.; Varadhachary, Gauri R.; Habra, Mouhammed Amir 分享 收藏 Oxidative phosphorylation is a metabolic vulnerability in chemotherapy resistant triple negative breast cancerEvans, Kurt; Moulder, Stacy; Yuca, Erkan; Scott, Stephen; Arango, Natalia Paez; Shariati, Maryam; Vellano, Christopher P.; Saridogan, Turcin; Zheng, Xiaofeng; Gonzalez-Angulo, Ana Maria; Zhao, Ming; Su, Xiaoping; Tapia, Coya; Chen, Ken; Akcakanat, Argun; Perou, Charles M.; Lim, Bora; Tripathy, Debu; Yap, Timothy A.; Di Francesco, Maria E.; Draetta, Giulio; Jones, Philip; Marszalek, Joe; Meric-Bernstam, Funda 分享 收藏 分享 收藏 Early-stage endometrial cancer, CTNNB1 mutations, and the relationship between lymphovascular space invasion and recurrenceImboden, Sara; Tapia, Coya; Scheiwiller, Nadja; Kocbek, Vida; Altermatt, Hans J.; Janzen, Jan; Mueller, Michael D.; McKinnon, Brett 分享 收藏 Phase II clinical trial of pembrolizumab efficacy and safety in advanced adrenocortical carcinomaHabra, Mouhammed Amir; Stephen, Bettzy; Campbell, Matthew; Hess, Kenneth; Tapia, Coya; Xu, Mingxuan; Ahnert, Jordi Rodon; Jimenez, Camilo; Lee, Jeffrey E.; Perrier, Nancy D.; Boraddus, Russell R.; Pant, Shubham; Subbiah, Vivek; Hong, David S.; Zarifa, Abdulrazzak; Fu, Siqing; Karp, Daniel D.; Meric-Bernstam, Funda; Naing, Aung 分享 收藏 Patient-derived xenografts of central nervous system metastasis reveal expansion of aggressive minor clonesTew, Ben Yi; Legendre, Christophe; Schroeder, Mark A.; Triche, Tim, Jr.; Gooden, Gerald C.; Huang, Yizhou; Butry, Loren; Ma, Daniel J.; Johnson, Kyle; Martinez, Rae Anne; Pierobon, Mariaelena; Petricoin, Emanuel F.; O'Shaughnessy, Joyce; Osborne, Cindy; Tapia, Coya; Buckley, David N.; Glen, Jennifer; Bernstein, Mark; Sarkaria, Jann N.; Toms, Steven A.; Salhia, Bodour 分享 收藏 Atypical plant homeodomain of UBR7 functions as an H2BK120Ub ligase and breast tumor suppressorAdhikary, Santanu; Chakravarti, Deepavali; Terranova, Christopher; Sengupta, Isha; Maitituoheti, Mayinuer; Dasgupta, Anirban; Srivastava, Dushyant Kumar; Ma, Junsheng; Raman, Ayush T.; Tarco, Emily; Sahin, Aysegul A.; Bassett, Roland; Yang, Fei; Tapia, Coya; Roy, Siddhartha; Rai, Kunal; Das, Chandrima 分享 收藏 Molecular determinants of post-mastectomy breast cancer recurrenceKeene, Kimberly S.; King, Tari; Hwang, E. Shelley; Peng, Bo; McGuire, Kandace P.; Tapia, Coya; Zhang, Hong; Bae, Sejong; Nakhlis, Faina; Klauber-Demore, Nancy; Meszoely, Ingrid; Sabel, Michael S.; Willey, Shawna C.; Eterovic, Agda Karina; Hudis, Cliff; Wolff, Antonio C.; De Los Santos, Jennifer; Thompson, Alastair; Mills, Gordon B.; Meric-Bernstam, Funda 分享 收藏 分享 收藏 Phase II study of the PARP inhibitor talazoparib in advanced cancer patients with somatic alterations in BRCA1/2, mutations/deletions in PTEN or PTEN loss, aberrations in other BRCA pathway genes, and germline mutations in BRCA1/2 (not breast or ovarian cancer)Piha-Paul, Sarina A.; Xiong, Wendy Wen; Moss, Tyler; Mostorino, Rosa M.; Sedelmeier, Shelby; Hess, Kenneth; Fu, Siqing; Hong, David; Janku, Filip; Karp, Daniel; Naing, Aung; Pant, Shubham; Rodon, Jordi; Subbiah, Vivek; Tsimberidou, A. M.; Yap, Timothy; Javle, Milind; Tapia, Coya; Shaw, Kenna R.; Eterovic, Karina; Mills, Gordon B.; Meric-Bernstam, Funda 分享 收藏 A Population of Heterogeneous Breast Cancer Patient-Derived Xenografts Demonstrate Broad Activity of PARP Inhibitor in BRCA1/2 Wild-Type TumorsEvans, Kurt W.; Yuca, Erkan; Akcakanat, Argun; Scott, Stephen M.; Arango, Natalia Paez; Zheng, Xiaofeng; Chen, Ken; Tapia, Coya; Tarco, Emily; Eterovic, Agda K.; Black, Dalliah M.; Litton, Jennifer K.; Yap, Timothy A.; Tripathy, Debu; Mills, Gordon B.; Meric-Bernstam, Funda 分享 收藏 
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
