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Christopher R. Bethel

case western reserve university

40H指数
256论文数
4.5K被引数
收录论文 90
发表时间
Structural and Kinetic Basis for the Rational Design of Next-Generation β-Lactamase Inhibitors下一代β-内酰胺酶抑制剂的理性设计:结构与动力学基础
err2026-03-16
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errOAAI
errShuang Chen; Muchen Yu; Manming Xu; Sergio Decherchi; Magdalena A. Taracila; Andrea M. Hujer; Christopher R. Bethel; Robert A. Bonomo; Shozeb Haider
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Mechanistic basis for inhibition of the extended-spectrum β-lactamase GES-1 by enmetazobactam and tazobactam广谱β-内酰胺酶GES-1被恩美他唑巴坦和他唑巴坦抑制的机制基础
err2025-09-01
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errBeer, Michael; Hinchliffe, Philip; Hanzevacki, Marko; Bethel, Christopher R.; Tooke, Catherine L.; van der Kamp, Marc W.; Papp-Wallace, Krisztina M.; Bonomo, Robert A.; Shapiro, Stuart; Mulholland, Adrian J.; Spencer, James
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Inhibitor Affinity Differs among Clinical Variants of IMP Metallo-β-Lactamases: Analysis and Implications for Inhibitor Design抑制剂亲和力在不同临床类型的IMP金属-β-内酰胺酶之间存在差异:分析与抑制剂设计的意义
err2025-07-24
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PREAI
errCaitlyn A. Thomas; John Paul Alao; Thomas Smisek; Zishuo Cheng; Christopher R. Bethel; Kundi Yang; Ikponwmosa Obaseki; Richard C. Page; Robert A. Bonomo; Peter Oelschlaeger; Walter Fast; Andrea N. Kravats; Michael W. Crowder
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Emerging Resistance to Novel β-Lactam β-Lactamase Inhibitor Combinations in Klebsiella pneumoniae bearing KPC Variants携带KPC变体的肺炎克雷伯菌对新型β-内酰胺/β-内酰胺酶抑制剂组合的耐药性出现
err2025-07-14
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errMase Hamza; German M. Traglia; Lucia Maccari; Sonia Gomez; Maria Belen Sanz; Usman Akhtar; Vyanka Mezcord; Jenny Escalante; Alejandra Corso; Cecilia Rodriguez; Christopher R. Bethel; Gauri G. Rao; Marcelo E. Tolmasky; David Paterson; Robert A. Bonomo; Fernando Pasteran; Maria Soledad Ramirez
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Durlobactam in combination with β-lactams to combat Mycobacterium abscessus
err2025-02-13
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PREAI
errShin, Eunjeong; Dousa, Khalid M.; Taracila, Magdalena A.; Bethel, Christopher R.; Nantongo, Mary; Nguyen, David C.; Akusobi, Chidiebere; Kurz, Sebastian G.; Plummer, Mark S.; Daley, Charles L.; Holland, Steven M.; Rubin, Eric J.; Bulitta, Jurgen B.; Boom, W. Henry; Kreiswirth, Barry N.; Bonomo, Robert A.
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ARGONAUT-IV: susceptibility of carbapenemase-producing Klebsiella pneumoniae to the oral bicyclic boronate β-lactamase inhibitor ledaborbactam combined with ceftibuten
err2024-12-05
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PREAI
errJacobs, Michael R.; Good, Caryn E.; Abdelhamed, Ayman M.; Mack, Andrew R.; Bethel, Christopher R.; Marshall, Steven H.; Hujer, Andrea M.; Hujer, Kristine M.; Patel, Robin; van Duin, David; Fowler, Vance G.; Rhoads, Daniel D.; Six, David A.; Moeck, Greg; Uehara, Tsuyoshi; Papp-Wallace, Krisztina M.; Bonomo, Robert A.
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ARGONAUT-III and -V: susceptibility of carbapenem-resistant Klebsiella pneumoniae and multidrug-resistant Pseudomonas aeruginosa to the bicyclic boronate β-lactamase inhibitor taniborbactam combined with cefepime
err2024-09-04
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errOAAI
errJacobs, Michael R.; Abdelhamed, Ayman M.; Good, Caryn E.; Mack, Andrew R.; Bethel, Christopher R.; Marshall, Steven; Hujer, Andrea M.; Hujer, Kristine M.; Patel, Robin; van Duin, David; Fowler, Vance G.; Rhoads, Daniel D.; Six, David A.; Moeck, Greg; Uehara, Tsuyoshi; Papp-Wallace, Krisztina M.; Bonomo, Robert A.
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The interaction of the azetidine thiazole side chain with the active site loop (ASL) 3 drives the evolution of IMP metallo-β-lactamase against tebipenem
err2024-08-07
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PREAI
errOno, Daisuke; Cmolik, Anna; Bethel, Christopher R.; Ishii, Yoshikazu; Drusin, Salvador I.; Moreno, Diego M.; Vila, Alejandro J.; Bonomo, Robert A.; Mojica, Maria F.
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Crystal structure of the class A extended-spectrum β-lactamase CTX-M-96 in complex with relebactam at 1.03 Angstrom resolution
err2024-08-07
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PREAI
errGhiglione, Barbara; Rodriguez, Maria Margarita; Penzotti, Pedro; Bethel, Christopher R.; Gutkind, Gabriel; Bonomo, Robert A.; Klinke, Sebastian; Power, Pablo
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Synergistic effects of sulopenem in combination with cefuroxime or durlobactam against Mycobacterium abscessus
errMBIO
IF4.7
err2024-06-12
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errDousa, Khalid M.; Shin, Eunjeong; Kurz, Sebastian G.; Plummer, Mark; Nantongo, Mary; Bethel, Christopher R.; Taracila, Magdalena A.; Nguyen, David C.; Kreiswith, Barry N.; Daley, Charles L.; Remy, Kenneth E.; Holland, Steven M.; Bonomo, Robert A.
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Machine Learning Models Identify Inhibitors of New Delhi Metallo-β-lactamase
err2024-05-10
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errOAAI
errCheng, Zishuo; Aitha, Mahesh; Thomas, Caitlyn A.; Sturgill, Aidan; Fairweather, Mitch; Hu, Amy; Bethel, Christopher R.; Rivera, Dann D.; Dranchak, Patricia; Thomas, Pei W.; Li, Han; Feng, Qi; Tao, Kaicheng; Song, Minshuai; Sun, Na; Wang, Shuo; Silwal, Surendra Bikram; Page, Richard C.; Fast, Walt; Bonomo, Robert A.; Weese, Maria; Martinez, Waldyn; Inglese, James; Crowder, Michael W.
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Durlobactam, a Diazabicyclooctane β-Lactamase Inhibitor, Inhibits BlaC and Peptidoglycan Transpeptidases of Mycobacterium tuberculosis
err2024-04-15
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errNantongo, Mary; Nguyen, David C.; Bethel, Christopher R.; Taracila, Magdalena A.; Li, Qing; Dousa, Khalid M.; Shin, Eunjeong; Kurz, Sebastian G.; Nguyen, Liem; Kreiswirth, Barry N.; Boom, W. Henry; Plummer, Mark S.; Bonomo, Robert A.
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The Structural Role of N170 in Substrate-Assisted Deacylation in KPC-2 β-Lactamase
err2024-02-12
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errParwana, Diksha; Gu, Jing; Chen, Shuang; Bethel, Christopher R.; Marshall, Emma; Hujer, Andrea M.; Bonomo, Robert A.; Haider, Shozeb
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Structural role of K224 in taniborbactam inhibition of NDM-1
err2024-02-07
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errOno, Daisuke; Mojica, Maria F.; Bethel, Christopher R.; Ishii, Yoshikazu; Drusin, Salvador I.; Moreno, Diego M.; Vila, Alejandro J.; Bonomo, Robert A.
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The directed evolution of NDM-1NDM-1的定向进化
err2023-11-15
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errThomas, Caitlyn A.; Cheng, Zishuo; Bethel, Christopher R.; Hujer, Andrea M.; Sturgill, Aidan M.; Onuoha, Kelechi; Page, Richard C.; Bonomo, Robert A.; Crowder, Michael W.; Tamma, Pranita D.
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Collateral Changes in Cell Physiology Associated with ADC-7 β-Lactamase Expression in Acinetobacter baumannii
err2023-06-15
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errColquhoun, Jennifer M. M.; Farokhyfar, Marjan; Anderson, Alexander C. C.; Bethel, Christopher R. R.; Bonomo, Robert A. A.; Clarke, Anthony J. J.; Rather, Philip N. N.
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The Effectiveness of Imipenem-Relebactam against Ceftazidime-Avibactam Resistant Variants of the KPC-2 β-Lactamase亚胺培南-Relebactam对KPC-2 β-内酰胺酶的头孢他啶-阿维巴坦耐药变体的有效性
err2023-05-11
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errPapp-Wallace, Krisztina M.; Barnes, Melissa D.; Taracila, Magdalena A.; Bethel, Christopher R.; Rutter, Joseph D.; Zeiser, Elise T.; Young, Katherine; Bonomo, Robert A.
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Boronic Acid Transition State Inhibitors as Potent Inactivators of KPC and CTX-M β-Lactamases: Biochemical and Structural Analyses
err2023-01-24
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errAlsenani, Tahani A. A.; Rodriguez, Maria Margarita; Ghiglione, Barbara; Taracila, Magdalena A. A.; Mojica, Maria F. F.; Rojas, Laura J. J.; Hujer, Andrea M. M.; Gutkind, Gabriel; Bethel, Christopher R. R.; Rather, Philip N. N.; Introvigne, Maria Luisa; Prati, Fabio; Caselli, Emilia; Power, Pablo; van den Akker, Focco; Bonomo, Robert A. A.
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Penicillanic Acid Sulfones Inactivate the Extended-Spectrum β-Lactamase CTX-M-15 through Formation of a Serine-Lysine Cross-Link: an Alternative Mechanism of β-Lactamase Inhibition
errMBIO
IF4.7
err2022-06-28
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errOAAI
errHinchliffe, Philip; Tooke, Catherine L.; Bethel, Christopher R.; Wang, Benlian; Arthur, Christopher; Heesom, Kate J.; Shapiro, Stuart; Schlatzer, Daniela M.; Papp-Wallace, Krisztina M.; Bonomo, Robert A.; Spencer, James
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