未登录Structure-Based Design and Preclinical Characterization of Selective and Orally Bioavailable Factor XIa Inhibitors: Demonstrating the Power of an Integrated S1 Protease Family Approach
Lorthiois, Edwige; Roache, James; Barnes-Seeman, David; Altmann, Eva; Hassiepen, Ulrich; Turner, Gordon; Duvadie, Rohit; Hornak, Viktor; Karki, Rajeshri G.; Schiering, Nikolaus; Weihofen, Wilhelm A.; Perruccio, Francesca; Calhoun, Amy; Fazal, Tanzina; Dedic, Darija; Durand, Corinne; Dussauge, Solene; Fettis, Kamal; Tritsch, Fabien; Dentel, Celine; Druet, Adelaide; Liu, Donglei; Kirman, Louise; Lachal, Julie; Namoto, Kenji; Bevan, Douglas; Mo, Rose; Monnet, Gabriela; Muller, Lionel; Zessis, Richard; Huang, Xueming; Lindsley, Loren; Currie, Treeve; Chiu, Yu-Hsin; Fridrich, Cary; Delgado, Peter; Wang, Shuangxi; Hollis-Symynkywicz, Micah; Berghausen, Joerg; Williams, Eric; Liu, Hong; Liang, Guiqing; Kim, Hyungchul; Hoffmann, Peter; Hein, Andreas; Ramage, Paul; D'Arcy, Allan; Harlfinger, Stefanie; Renatus, Martin; Ruedisser, Simon; Feldman, David; Elliott, Jason; Sedrani, Richard; Maibaum, Juergen; Adams, Christopher M. .png)
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收藏Structure-Guided Design of Substituted Biphenyl Butanoic Acid Derivatives as Neprilysin InhibitorsKawanami, Toshio; Karki, Rajeshri G.; Cody, Emma; Liu, Qian; Liang, Guiqing; Ksander, Gary M.; Rigel, Dean F.; Schiering, Nikolaus; Gong, Yongjin; Coppola, Gary M.; Iwaki, Yuki; Sun, Robert; Neubert, Alan; Fan, Li; Ingles, Sara; D'Arcy, Allan; Villard, Frederic; Ramage, Paul; Jeng, Arco Y.; Leung-Chu, Jennifer; Liu, Jing; Beil, Michael; Fu, Fumin; Chen, Wei; Cumin, Frederic; Wiesmann, Christian; Mogi, Muneto 分享 收藏 Structure of neprilysin in complex with the active metabolite of sacubitrilSchiering, Nikolaus; D'Arcy, Allan; Villard, Frederic; Ramage, Paul; Logel, Claude; Cumin, Frederic; Ksander, Gary M.; Wiesmann, Christian; Karki, Rajeshri G.; Mogi, Muneto 分享 收藏 A macrocyclic HCV NS3/4A protease inhibitor interacts with protease and helicase residues in the complex with its full-length targetSchiering, Nikolaus; D'Arcy, Allan; Villard, Frederic; Simic, Oliver; Kamke, Marion; Monnet, Gaby; Hassiepen, Ulrich; Svergun, Dmitri I.; Pulfer, Ruth; Eder, Joerg; Raman, Prakash; Bodendorf, Ursula 分享 收藏 分享 收藏 Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virusErbel, P; Schiering, N; D'Arcy, A; Renatus, M; Kroemer, M; Lim, SP; Yin, Z; Keller, TH; Vasudevan, SG; Hommel, U 分享 收藏 Crystal structures of Staphylococcus aureus methionine aminopeptidase complexed with keto heterocycle and aminoketone inhibitors reveal the formation of a tetrahedral intermediate (vol 47, pg1325, 2004)Douangamath, A; Dale, GE; D'Arcy, A; Almstetter, M; Eckl, R; Frutos-Hoener, A; Henkel, B; Illgen, K; Nerdinger, S; Schulz, H; Mac Sweeney, A; Thormann, M; Treml, A; Pierau, S; Wadman, S; Oefner, C 分享 收藏 Crystal structures of Staphylococcus aureus methionine aminopeptidase complexed with keto heterocycle and aminoketone inhibitors reveal the formation of a tetrahedral intermediateDouangamath, A; Dale, GE; D'Arcy, A; Almstetter, M; Eckl, R; Frutos-Hoener, A; Henkel, B; Illgen, K; Nerdinger, S; Schulz, H; MacSweeney, A; Thormann, M; Treml, A; Pierau, S; Wadman, S; Oefner, C 分享 收藏 分享 收藏 
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