未登录Discovery and Synthesis of Heterobifunctional Degraders of Rearranged during Transfection (RET) Kinase
Qiao, Jennifer X.; Williams, David; Gill, Patrice; Li, Ling; Norris, Derek; Tokarski, John S.; Wong, Jessica; Qi, Huilin; Hafeji, Yamnah; Downes, Daniel P.; Degnen, Bill; Wang, Ying-Kai; Locke, Gregory; Fang, Hua; Yu, Fei; Xu, Songmei; Naglich, Joseph; Zhang, Jun; Nanjappa, Purushothama; Dai, Chao; Chourb, Lisa; Napoline, Jonathan; Tester, Richland; Jorge, Christine; Li, Yi-Xin; Mathur, Arvind; Barbieri, Christopher; Soars, Matthew G.; Venkatanarayan, Avinashnarayan; Lees, Emma; Borzilleri, Robert M.; Gavai, Ashvinikumar V.; Wichroski, Michael; Dhar, T. G. Murali .png)
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收藏DGKα/ζ inhibitors combine with PD-1 checkpoint therapy to promote T cell-mediated antitumor immunityWichroski, Michael; Benci, Joseph; Liu, Si-Qi; Chupak, Louis; Fang, Jie; Cao, Carolyn; Wang, Cindy; Onorato, Joelle; Qiu, Hongchen; Shan, Yongli; Banas, Dana; Powles, Ryan; Locke, Gregory; Witt, Abigail; Stromko, Caitlyn; Qi, Huilin; Zheng, Xiaofan; Martin, Scott; Ding, Min; Gentles, Robert; Meanwell, Nicholas; Velaparthi, Upender; Olson, Richard; Wee, Susan; Tenney, Daniel; Parker, Christopher G.; Cravatt, Benjamin F.; Lawrence, Michael; Borzilleri, Robert; Lees, Emma 分享 收藏 分享 收藏 分享 收藏 分享 收藏 PCA062, a P-cadherin Targeting Antibody-Drug Conjugate, Displays Potent Antitumor Activity Against P-cadherin-expressing MalignanciesPCA062是一种靶向P-钙粘蛋白的抗体-药物偶联物，对表达P-钙粘蛋白的恶性肿瘤表现出有效的抗肿瘤活性Sheng, Qing; D'Alessio, Joseph A.; Menezes, Daniel L.; Karim, Christopher; Tang, Yan; Tam, Angela; Clark, Suzanna; Ying, Chi; Connor, Anu; Mansfield, Keith G.; Rondeau, Jean-Michel; Ghoddusi, Majid; Geyer, Felipe C.; Gu, Jane; McLaughlin, Margaret E.; Newcombe, Rick; Elliot, GiNell; Tschantz, William R.; Lehmann, Sylvie; Fanton, Christie P.; Miller, Kathy; Huber, Thomas; Rendahl, Katherine G.; Jeffry, Ursula; Pryer, Nancy K.; Lees, Emma; Kwon, Paul; Abraham, Judith A.; Damiano, Jason S.; Abrams, Tinya J. 分享 收藏 Enhanced antitumor immunity by a novel small molecule HPK1 inhibitorYou, Dan; Hillerman, Stephen; Locke, Gregory; Chaudhry, Charu; Stromko, Caitlyn; Murtaza, Anwar; Fan, Yi; Koenitzer, Jennifer; Chen, Yali; Briceno, Stephanie; Bhadra, Rajarshi; Duperret, Elizabeth; Gullo-Brown, Johnni; Gao, Chan; Zhao, Dandan; Feder, John; Curtin, Joshua; Degnan, Andrew P.; Kumi, Godwin; Wittman, Mark; Johnson, Benjamin M.; Parrish, Karen E.; Gokulrangan, Giridharan; Morrison, John; Quigley, Michael; Hunt, John T.; Salter-Cid, Luisa; Lees, Emma; Sanjuan, Miguel A.; Liu, Jinqi 分享 收藏 Design and Discovery of N-(3-(2-(2-Hydroxyethoxy)-6morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the ClinicRamurthy, Savithri; Taft, Benjamin R.; Aversa, Robert J.; Barsanti, Paul A.; Burger, Matthew T.; Lou, Yan; Nishiguchi, Gisele A.; Rico, Alice; Setti, Lina; Smith, Aaron; Subramanian, Sharadha; Tamez, Victoriano; Tanner, Huw; Wan, Lifeng; Hu, Cheng; Appleton, Brent A.; Mamo, Mulugeta; Tandeske, Laura; Tellew, John E.; Huang, Shenlin; Yue, Qn; Cliaudliary, Apurva; Tian, Hung; Iyer, Raman; Hassan, A. Quamrul; Griner, Lesley A. Mathews; La Bonte, Laura R.; Cooke, Vesselina G.; Van Abbema, Anne; Merritt, Hanne; Gampa, Kalyani; Feng, Fei; Yuan, Jing; Mishina, Yuji; Wang, Yingyun; Haling, Jacob R.; Vaziri, Sepideh; Hekmat-Nejad, Mohammad; Polyakov, Valery; Zang, Richard; Sethuraman, Vijay; Amiri, Payman; Singh, Mallika; Sellers, William R.; Lees, Emma; Shao, Wenlin; Dillon, Michael P.; Stuart, Darrin D. 分享 收藏 Preclinical Antitumor Activity of a Novel Anti-c-KIT Antibody-Drug Conjugate against Mutant and Wild-type c-KIT-Positive Solid TumorsAbrams, Tinya; Connor, Anu; Fanton, Christie; Cohen, Steven B.; Huber, Thomas; Miller, Kathy; Hong, E. Erica; Niu, Xiaohong; Kline, Janine; Ison-Dugenny, Marjorie; Harris, Sarah; Walker, Dana; Krauser, Klaus; Galimi, Francesco; Wang, Zhen; Ghoddusi, Majid; Mansfield, Keith; Lee-Hoeflich, Si Tuen; Holash, Jocelyn; Pryer, Nancy; Kluwe, William; Ettenberg, Seth A.; Sellers, William R.; Lees, Emma; Kwon, Paul; Abraham, Judith A.; Schleyer, Siew C. 分享 收藏 Mechanistic Insights of an Immunological Adverse Event Induced by an Anti-KIT Antibody Drug Conjugate and Mitigation StrategiesL'Italien, Lawrence; Orozco, Olivia; Abrams, Tinya; Cantagallo, Lisa; Connor, Anu; Desai, Jayesh; Ebersbach, Hilmar; Gelderblom, Hans; Hoffmaster, Keith; Lees, Emma; Maacke, Heiko; Schleyer, Siew; Skegro, Darko; Lee-Hoeflich, Si Tuen 分享 收藏 Pharmacological profile and anti-tumor properties of LXH254, a highly selective RAF kinase inhibitorStuart, Darrin D.; Shao, Wenlin; Mishina, Yuji; Feng, Yun; Caponigro, Giordano; Cooke, Vesselina G.; Rivera, Stacey; Shen, Fang; Korn, Joshua; Griner, Lesley A. Mathews; Nishiguchi, Giselle; Taft, Benjamin; Wan, Lifeng; Subramanian, Sharadha; Lou, Yan; Setti, Lina; Burger, Matthew; Tamez, Victor; Rico, Alice; Aversa, Robert; Tellew, John; Haling, Jacob R.; Polyakov, Valery; Lambert, Amy; Zang, Richard; Van Abbema, Ann; Hekmat-Nejad, Mohamad; Amiri, Payman; Singh, Mallika; Keen, Nicholas; Dillon, Michael P.; Lees, Emma; Sellers, William R.; Ramurthy, Savithri 分享 收藏 Design and Discovery of N-(2-Methyl-5′-morpholino-6′-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3′-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant CancersNishiguchi, Gisele A.; Rico, Alice; Tanner, Huw; Aversa, Robert J.; Taft, Benjamin R.; Subramanian, Sharadha; Setti, Lina; Burger, Matthew T.; Wan, Lifeng; Tamez, Victoriano; Smith, Aaron; Lou, Yan; Barsanti, Paul A.; Appleton, Brent A.; Mamo, Mulugeta; Tandeske, Laura; Dix, Ina; Tellew, John E.; Huang, Shenlin; Griner, Lesley A. Mathews; Cooke, Vesselina G.; Van Abbema, Anne; Merritt, Hanne; Ma, Sylvia; Gampa, Kalyani; Feng, Fei; Yuan, Jing; Wang, Yingyun; Haling, Jacob R.; Vaziri, Sepideh; Hekmat-Nejad, Mohammad; Jansen, Johanna M.; Polyakov, Valery; Zang, Richard; Sethuraman, Vijay; Amiri, Payman; Singh, Mallika; Lees, Emma; Shao, Wenlin; Stuart, Darrin D.; Dillon, Michael P.; Ramurthy, Savithri 分享 收藏 Targeting cadherin-6 (CDH6) with an antibody-drug conjugate for the treatment of ovarian and renal cancerCollins, Scott D.; Saxena, Parmita; Li, Xiao Y.; Shim, Yeonju; Ostrom, Lance; Yoder, Nicholas C.; Catcott, Kalli C.; McShea, Molly A.; Sun, Xiuxia; Bilic, Sanela; Tschantz, William R.; Flaherty, Meghan; Mansfield, Keith; Hu, Tiancen; Capka, Vladimir; Kurz, Markus; Rajlic, Ivana Liric; London, Anne Serdakowski; Duc Nguyen; Mosher, Rebecca; Meyer, Matthew J.; Bourret, Aaron; Saeh, Jamal; Cameron, Scott; Lees, Emma; Bialucha, Carl U. 分享 收藏 Structure-guided discovery of cyclin-dependent kinase inhibitorsFischmann, Thierry O.; Hruza, Alan; Duca, Jose S.; Ramanathan, Lata; Mayhood, Todd; Windsor, William T.; Le, Hung V.; Guzi, Thimothy J.; Dwyer, Michael P.; Paruch, Kamil; Doll, Ronald J.; Lees, Emma; Parry, David; Seghezzi, Wolfgang; Madison, Vincent 分享 收藏 分享 收藏 分享 收藏 分享 收藏 分享 收藏 分享 收藏 
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