未登录 Targeted disruption of the Wnt regulator Kremen induces limb defects and high bone density Ellwanger, Kristina; Saito, Hiroaki; Clement-Lacroix, Philippe; Maltry, Nicole; Niedermeyer, Joachim; Lee, Woon Kyu; Baron, Roland; Rawadi, Georges; Westphal, Heiner; Niehrs, Christof 分享 收藏
IRAK4 inhibition dampens pathogenic processes driving inflammatory skin diseases IRAK4抑制抑制驱动炎症性皮肤病的致病过程 Lavazais, Stephanie; Jargosch, Manja; Dupont, Sonia; Labeguere, Frederic; Menet, Christel; Jagerschmidt, Catherine; Ohm, Frenz; Kupcsik, Laszlo; Parent, Isabelle; Cottereaux, Celine; Marsais, Florence; Oste, Line; Van de Water, An; Christophe, Thierry; De Vos, Steve; Fallon, Padraic; Lauffer, Felix; Clement-Lacroix, Philippe; Eyerich, Kilian; Brys, Reginald 分享 收藏
Discovery of the S1P2 Antagonist GLPG2938 (1-[2-Ethoxy-6-(trifluoromethyl)-4-pyridyl]-3-[[5-methyl-6-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyridazin-3-yl]methyl]urea), a Preclinical Candidate for the Treatment of Idiopathic Pulmonary Fibrosis Mammoliti, Oscar; Palisse, Adeline; Joannesse, Caroline; El Bkassiny, Sandy; Allart, Brigitte; Jaunet, Alex; Menet, Christel; Coornaert, Beatrice; Sonck, Kathleen; Duys, Inge; Clement-Lacroix, Philippe; Oste, Line; Borgonovi, Monica; Wakselman, Emanuelle; Christophe, Thierry; Houvenaghel, Nicolas; Jans, Mia; Heckmann, Bertrand; Saniere, Laurent; Brys, Reginald 分享 收藏
Discovery of 9-Cyclopropylethynyl-2-((S)-1-[1,4]dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one (GLPG1205), a Unique GPR84 Negative Allosteric Modulator Undergoing Evaluation in a Phase II Clinical Trial Labeguere, Frederic; Dupont, Sonia; Alvey, Luke; Soulas, Florilene; Newsome, Gregory; Tirera, Amynata; Quenehen, Vanessa; Thi Thu Trang Mai; Deprez, Pierre; Blanque, Roland; Oste, Line; Le Tallec, Sandrine; De Vos, Steve; Hagers, Annick; Vandevelde, Ann; Nelles, Luc; Vandervoort, Nele; Conrath, Katja; Christophe, Thierry; van der Aar, Ellen; Wakselman, Emanuelle; Merciris, Didier; Cottereaux, Celine; da Costa, Cecile; Saniere, Laurent; Clement-Lacroix, Philippe; Jenkins, Laura; Milligan, Graeme; Fletcher, Stephen; Brys, Reginald; Gosmini, Romain 分享 收藏
The Medium-Chain Fatty Acid Receptor GPR84 Mediates Myeloid Cell Infiltration Promoting Steatohepatitis and Fibrosis Puengel, Tobias; De Vos, Steve; Hundertmark, Jana; Kohlhepp, Marlene; Guldiken, Nurdan; Pujuguet, Philippe; Auberval, Marielle; Marsais, Florence; Shoji, Kenji F.; Saniere, Laurent; Trautwein, Christian; Luedde, Tom; Strnad, Pavel; Brys, Reginald; Clement-Lacroix, Philippe; Tacke, Frank 分享 收藏
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Triazolopyridines as Selective JAK1 Inhibitors: From Hit Identification to GLPG0634 Menet, Christel J.; Fletcher, Stephen R.; Van Lommen, Guy; Geney, Raphael; Blanc, Javier; Smits, Koen; Jouannigot, Nolwenn; Deprez, Pierre; van der Aar, Ellen M.; Clement-Lacroix, Philippe; Lepescheux, Lien; Galien, Rene; Vayssiere, Beatrice; Nelles, Luc; Christophe, Thierry; Brys, Reginald; Uhring, Muriel; Ciesieski, Fabrice; Van Rompaey, Luc 分享 收藏
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Preclinical Characterization of GLPG0634, a Selective Inhibitor of JAK1, for the Treatment of Inflammatory Diseases Van Rompaey, Luc; Galien, Rene; van der Aar, Ellen M.; Clement-Lacroix, Philippe; Nelles, Luc; Smets, Bart; Lepescheux, Lien; Christophe, Thierry; Conrath, Katja; Vandeghinste, Nick; Vayssiere, Beatrice; De Vos, Steve; Fletcher, Stephen; Brys, Reginald; van 't Klooster, Gerben; Feyen, Jean H. M.; Menet, Christel 分享 收藏
Discovery of Diarylhydantoins as New Selective Androgen Receptor Modulators Nique, Francois; Hebbe, Severine; Peixoto, Christophe; Annoot, Denis; Lefrancois, Jean-Michel; Duval, Eric; Michoux, Laurence; Triballeau, Nicolas; Lemoullec, Jean-Michel; Mollat, Patrick; Thauvin, Maxime; Prange, Thierry; Minet, Dominique; Clement-Lacroix, Philippe; Robin-Jagerschmidt, Catherine; Fleury, Damien; Guedin, Denis; Deprez, Pierre 分享 收藏
Increased Expression of a Set of Genes Enriched in Oxygen Binding Function Discloses a Predisposition of Breast Cancer Bone Metastases to Generate Metastasis Spread in Multiple Organs Capulli, Mattia; Angelucci, Adriano; Driouch, Keltouma; Garcia, Teresa; Clement-Lacroix, Philippe; Martella, Francesco; Ventura, Luca; Bologna, Mauro; Flamini, Stefano; Moreschini, Oreste; Lidereau, Rosette; Ricevuto, Enrico; Muraca, Maurizio; Teti, Anna; Rucci, Nadia 分享 收藏
Molecular imaging demonstrates GLPG0187, a small-molecule integrin antagonist, binds to RGD-integrin receptors in vivo and is efficacious in tumor and metastasis models Pujuguet, P.; Berrocal, E.; Heckmann, B.; Wigerinck, P.; Lorenzon, G.; Clement-Lacroix, P.; Bormans, G.; Deroose, C. 分享 收藏
Targeting of αv-Integrins in Stem/Progenitor Cells and Supportive Microenvironment Impairs Bone Metastasis in Human Prostate Cancer van der Horst, Geertje; van den Hoogen, Christel; Buijs, Jeroen T.; Cheung, Henry; Bloys, Henny; Pelger, Rob C. M.; Lorenzon, Giocondo; Heckmann, Bertrand; Feyen, Jean; Pujuguet, Philippe; Blanque, Roland; Clement-Lacroix, Philippe; van der Pluijm, Gabri 分享 收藏
Up-regulation of a set of genes in breast cancer bone metastases discloses predisposition to generate metastases also in visceral organs Rucci, N.; Capulli, M.; Angelucci, A.; Martella, F.; Bologna, M.; Ventura, L.; Moreschini, O.; Driouch, K.; Landemaine, T.; Lidereau, R.; Clement-Lacroix, P.; Garcia, T.; Ricevuto, E.; Teti, A. 分享 收藏
Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass Morvan, Frederic; Boulukos, Kim; Clement-Lacroix, Philippe; Roman, Sergio Roman; Suc-Royer, Isabelle; Vayssiere, Batrice; Ammann, Patrick; Martin, Patrick; Pinho, Sonia; Pognonec, Philippe; Mollat, Patrick; Niehrs, Christof; Baron, Roland; Rawadi, Georges 分享 收藏
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Anti-rheumatic activities of histone deacetylase (HDAC) inhibitors in vivo in collagen-induced arthritis in rodents Lin, H-S; Hu, C-Y; Chan, H-Y; Liew, Y-Y; Huang, H-P; Lepescheux, L.; Bastianelli, E.; Baron, R.; Rawadi, G.; Clement-Lacroix, P. 分享 收藏
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