未登录 NLRP10 maintains epidermal homeostasis by promoting keratinocyte survival and P63-dependent differentiation and barrier function Cho, Yeonhee; Cao, Zhongzheng; Luo, Xin; Tian, Jennifer J.; Hukkanen, Renee R.; Hussien, Rajaa; Cancilla, Belinda; Chowdhury, Priyanka; Li, Fei; Ma, Shining; LaGory, Edward L.; Schroeder, Mark; Dusenberry, Amanda; Marshall, Leslie; Hawkins, Jenn; van Lookeren Campagne, Menno; Zhou, Yi 分享 收藏
Anti-TIGIT biomarker study: Inhibition of TIGIT induces loss of Tregs from tumors and requires effector function for tumor growth inhibition Argast, Gretchen M.; Cancilla, Belinda; Cattaruzza, Fiore; Yeung, Pete; le Scolan, Erwan; Harris, Rose; Lahmy, Reyhaneh; Brunner, Alayne; Wang, Min; O'Young, Gilbert; Lowe, Earth Light; Axelrod, Fumiko; Monteon, Jorge; Elechko, Jennifer; Lam, Andrew; Xie, MingHong; Gurney, Austin; Lewicki, John; Kapoun, Ann 分享 收藏
GITRL-Fc biomarker and mechanism study: GITRL-Fc reduces Treg frequency in tumors and requires effector function for inhibition of tumor growth Gitrl-fc生物标志物和机制研究: gitrl-fc降低肿瘤中Treg频率，并需要效应子功能来抑制肿瘤生长 Argast, Gretchen M.; Cancilla, Belinda; Cattaruzza, Fiore; Yeung, Pete; Lahmy, Reyhaneh; Le Scolan, Erwan; Harris, Rose; Brunner, Alayne; Wang, Min; Axelrod, Fumiko; Monteon, Jorge; Elechko, Jennifer; Lam, Andrew; Xie, MingHong; Lowe, Earth Light; O'Young, Gilbert; Gurney, Austin; Kapoun, Ann M. 分享 收藏
RSPO3 antagonism inhibits growth and tumorigenicity in colorectal tumors harboring common Wnt pathway mutations Fischer, Marcus M.; Yeung, V. Pete; Cattaruzza, Fiore; Hussein, Rajaa; Yen, Wan-Ching; Murriel, Christopher; Evans, James W.; O'Young, Gilbert; Brunner, Alayne L.; Wang, Min; Cain, Jennifer; Cancilla, Belinda; Kapoun, Ann; Hoey, Timothy 分享 收藏
Prevalence of GITR expression and pharmacodynamic (PD) biomarkers in syngeneic tumor models treated by a GITR agonist (GITRL-Fc) Wang, Min; Cattaruzza, Fiore; Yeung, Pete; Brunner, Alayne; LeScolan, Erwan; Liu, Yuwang; Cain, Jennifer; OYoung, Gilbert; Lowe, Earth Light; Cancilla, Belinda; Harris, Rose; Hoey, Tim; Gurney, Austin; Lewicki, John; Argast, Gretchen; Kapoun, Ann M. 分享 收藏
Pharmacodynamic biomarkers for anti-TIGIT treatment and prevalence of TIGIT expression in multiple solid tumor types Cattaruzza, Fiore; Yeung, Pete; Wang, Min; Brunner, Alayne; Le Scolan, Erwan; Cain, Jennifer; Argast, Gretechen; O'Young, Gilbert; Liu, YuWang; Cancilla, Belinda; Gurney, Austin; Hoey, Tim; Lewicki, John; Kapoun, Ann 分享 收藏
R-SPONDIN3 antagonism sensitizes colorectal cancer to taxane treatment Fischer, Marcus M.; Yeung, V. Pete; Cattaruzza, Fiore; Murriel, Christopher; Evans, James W.; O'Young, Gilbert; Brunner, Alayne; Wang, Min; Cancilla, Belinda; Kapoun, Ann; Hoey, Timothy 分享 收藏
WNT antagonists exhibit unique combinatorial antitumor activity with taxanes by potentiating mitotic cell death Fischer, Marcus M.; Cancilla, Belinda; Yeung, V. Pete; Cattaruzza, Fiore; Chartier, Cecile; Murriel, Christopher L.; Cain, Jennifer; Tam, Raymond; Cheng, Chieh-Yang; Evans, James W.; O'Young, Gilbert; Song, Xiaomei; Lewicki, John; Kapoun, Ann M.; Gurney, Austin; Yen, Wan-Ching; Hoey, Timothy 分享 收藏
Predictive biomarker identification for response to vantictumab (OMP-18R5; anti-Frizzled) using primary patient-derived human pancreatic tumor xenografts Zhang, Chun; Cattaruzza, Fiore; Yeung, Pete; Yen, Wan-Ching; Fischer, Marcus; Guo, Claire; Brunner, Alayne; Wang, Min; Cancilla, Belinda; Gurney, Austin; Brachmann, Rainer; Lewicki, John; Hoey, Tim; Kapoun, Ann M. 分享 收藏
Effects of anti-DLL4 treatment on non-small cell lung cancer (NSCLC) human xenograft tumors Brunner, Alayne; Cattaruzza, Fiore; Yen, Wan-Ching; Yeung, Pete; Fischer, Marcus; Cancilla, Belinda; O'Young, Gilbert; Tam, Raymond; Liu, Yu-Wang; Gurney, Austin; Lewicki, John; Hoey, Tim; Wang, Min; Kapoun, Ann M. 分享 收藏
Development of a RSPO3 CLIA-validated assay as a predictive biomarker for response to anti-RSPO3 antibody treatment in patients with solid tumors Zhang, Chun; Liu, Yuwang; Wang, Min; OYoung, Gilbert; Kavanagh, Joy; McFarlane, Cheryl; Cattaruzza, Fiore; Yeung, Pete; Cain, Jennifer; Yen, Wan-Ching; Fischer, Marcus; Cancilla, Belinda; Dobbin, Edwina; McCarthy, Michelle; Gurney, Austin; Faoro, Leonardo; Lewicki, John; Hoey, Tim; Kapoun, Ann M. 分享 收藏
Therapeutic Targeting of Tumor-Derived R-Spondin Attenuates β-Catenin Signaling and Tumorigenesis in Multiple Cancer Types Chartier, Cecile; Raval, Janak; Axelrod, Fumiko; Bond, Chris; Cain, Jennifer; Dee-Hoskins, Cristina; Ma, Shirley; Fischer, Marcus M.; Shah, Jalpa; Wei, Jie; Ji, May; Lam, Andrew; Stroud, Michelle; Yen, Wan-Ching; Yeung, Pete; Cancilla, Belinda; O'Young, Gilbert; Wang, Min; Kapoun, Ann M.; Lewicki, John; Hoey, Timothy; Gurney, Austin 分享 收藏
Development and validation of a biomarker for prospective selection of Notch1 activation in patients with certain advanced solid tumors in a first-in-human phase1 study of the cancer stem cell targeting antibody OMP-52M51 (anti-Notch1) Cancilla, Belinda; Tam, Raymond; Zhang, Chun; Anderson, Steve; Lewicki, John; Hoey, Tim; McCune, Bryan; Johnson, Lori; Idusogie, Esohe; Kapoun, Ann M. 分享 收藏
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Tarextumab (Anti-NOTCH2/3) reverses NOTCH2 and NOTCH3-dependent tumorigenicity and metastases in small cell lung cancer Shah, Jalpa; O'Young, Gilbert; Wei, Jie; Fischer, Marcus; Yen, Wan-Ching; Cancilla, Belinda; Kapoun, Ann; Lewicki, John; Cain, Jennifer; Hoey, Timothy 分享 收藏
Dual targeting of Delta-like ligand 4 (DLL4) and programmed death 1(PD1) inhibits tumor growth and generates enhanced long-term immunological memory Srivastava, Minu; Murriel, Christopher L.; Rods, Julie; Jie, Hyun-Bae; Axelrod, Fumiko; Xie, Ming-Hong; Yun, Rui; Mayes, Erin; Bentley, Trevor; Cancilla, Belinda; Tam, Raymond; Tang, Tracy; Kapoun, Ann; Lewicki, John; Hoey, Tim; Gurney, Austin; Park, Angie Inkyung 分享 收藏
Targeting Notch Signaling with a Notch2/Notch3 Antagonist (Tarextumab) Inhibits Tumor Growth and Decreases Tumor-Initiating Cell Frequency Yen, Wan-Ching; Fischer, Marcus M.; Axelrod, Fumiko; Bond, Christopher; Cain, Jennifer; Cancilla, Belinda; Henner, William R.; Meisner, Rene; Sato, Aaron; Shah, Jalpa; Tang, Tracy; Wallace, Breanna; Wang, Min; Zhang, Chun; Kapoun, Ann M.; Lewicki, John; Gurney, Austin; Hoey, Timothy 分享 收藏
Combined therapy of a novel anti-NOTCH2/3 antibody with paclitaxel inhibits tumor growth in a patient-derived breast tumor xenograft Wei, Jie; Cain, Jennifer; Shah, Jalpa; Wallace, Breanna; Tang, Tracy; Wang, Min; Murriel, Christopher; Belinda, Cancilla; Gurney, Austin; Sato, Aaron; Lewicki, John; Kapoun, Ann; Hoey, Tim 分享 收藏
Biomarker analysis in Phase 1b study of anti-cancer stem cell antibody Tarextumab (TAR) in combination with nab-paclitaxel and gemcitabine (Nab-P plus Gem) demonstrates pharmacodynamic (PD) modulation of the Notch pathway in patients (pts) with untreated metastatic pancreatic cancer (mPC) Kapoun, A.; O'Reilly, E.; Cohn, A.; Bendell, J. C.; Smith, L.; Strickler, J. H.; Gluck, W.; Liu, Y. W.; Wallace, B.; Tam, R.; Cancilla, B.; Brunner, A.; Hill, D.; Zhou, L.; Dupont, J.; Zhang, C.; Wang, M. 分享 收藏
Wnt pathway antagonist OMP-54F28 (FZD8-Fc) inhibits tumor growth and reduces tumor-initiating cell frequency in patient-derived hepatocellular carcinoma and ovarian cancer xenograft models Yeung, Pete; Beviglia, Lucia; Cancilla, Belinda; Dee-Hoskins, Cristina; Evans, James W.; Fischer, Marcus M.; Yen, Wan-Ching; Gurney, Austin; Lewicki, John; Hoey, Timothy; Kapoun, Ann M. 分享 收藏
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