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GDNF reduces fibril-induced early-stage alpha-synuclein pathology after delivery of 20S proteasome inhibitor lactacystin Er, Safak; Parkkinen, Ilmari; Trepczyk, Karolina; Seelbach, Anna; Pasculli, Maria Samuela; De Lorenzo, Francesca; Luk, Kelvin; Jankowska, Elzbieta; Chmielarz, Piotr; Domanskyi, Andrii; Airavaara, Mikko 分享 收藏
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Uptake of alpha-synuclein preformed fibrils is suppressed by inflammation and induces an aberrant phenotype in human microglia Α-突触核蛋白预制原纤维的摄取被炎症抑制，并在人小胶质细胞中诱导异常表型 Niskanen, Jonna; Peltonen, Sanni; Ohtonen, Sohvi; Fazaludeen, Mohammad Feroze; Luk, Kelvin C.; Giudice, Luca; Koistinaho, Jari; Malm, Tarja; Goldsteins, Gundars; Albert, Katrina; Lehtonen, Sarka 分享 收藏
Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of a-synuclein inclusions 快速iPSC包涵体病变模型揭示了a-突触核蛋白包涵体的形成，后果和分子亚型 Lam, Isabel; Ndayisaba, Alain; Lewis, Amanda J.; Fu, Yuhong; Sagredo, Giselle T.; Kuzkina, Anastasia; Zaccagnini, Ludovica; Celikag, Meral; Sandoe, Jackson; Sanz, Ricardo L.; Vahdatshoar, Aazam; Martin, Timothy D.; Morshed, Nader; Ichihashi, Toru; Tripathi, Arati; Ramalingam, Nagendran; Oettgen-Suazo, Charlotte; Bartels, Theresa; Boussouf, Manel; Schabinger, Max; Hallacli, Erinc; Jiang, Xin; Verma, Amrita; Tea, Challana; Wang, Zichen; Hakozaki, Hiroyuki; Yu, Xiao; Hyles, Kelly; Park, Chansaem; Wang, Xinyuan; Theunissen, Thorold W.; Wang, Haoyi; Jaenisch, Rudolf; Lindquist, Susan; Stevens, Beth; Stefanova, Nadia; Wenning, Gregor; Berg, Wilma D. J. van de; Luk, Kelvin C.; Sanchez-Pernaute, Rosario; Gomez-Esteban, Juan Carlos; Felsky, Daniel; Kiyota, Yasujiro; Sahni, Nidhi; Yi, S. Stephen; Chung, Chee Yeun; Stahlberg, Henning; Ferrer, Isidro; Schoneberg, Johannes; Elledge, Stephen J.; Dettmer, Ulf; Halliday, Glenda M.; Bartels, Tim; Khurana, Vikram 分享 收藏
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MSUT2 regulates tau spreading via adenosinergic signaling mediated ASAP1 pathway in neurons MSUT2通过腺苷酸信号介导的ASAP1通路调节神经元tau扩散 Xu, Hong; Qiu, Qi; Hu, Peng; Hoxha, Kevt'her; Jang, Elliot; O'Reilly, Mia; Kim, Christopher; He, Zhuohao; Marotta, Nicholas; Changolkar, Lakshmi; Zhang, Bin; Wu, Hao; Schellenberg, Gerard D.; Kraemer, Brian; Luk, Kelvin C.; Lee, Edward B.; Trojanowski, John Q.; Brunden, Kurt R.; Lee, Virginia M. -Y. 分享 收藏
O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology(Feb, 10.1038/s41589-024-01551-2, 2024) Balana, Aaron T.; Mahul-Mellier, Anne-Laure; Nguyen, Binh A.; Horvath, Mian; Javed, Afraah; Hard, Eldon R.; Jasiqi, Yllza; Singh, Preeti; Afrin, Shumaila; Pedretti, Rose; Singh, Virender; Lee, Virginia M. -Y.; Luk, Kelvin C.; Saelices, Lorena; Lashuel, Hilal A.; Pratt, Matthew R. 分享 收藏
O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology Balana, Aaron T.; Mahul-Mellier, Anne-Laure; Nguyen, Binh A.; Horvath, Mian; Javed, Afraah; Hard, Eldon R.; Jasiqi, Yllza; Singh, Preeti; Afrin, Shumaila; Pedretti, Rose; Singh, Virender; Lee, Virginia M. -Y.; Luk, Kelvin C.; Saelices, Lorena; Lashuel, Hilal A.; Pratt, Matthew R. 分享 收藏
Sequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons Santhosh Kumar, Saranya; Naseri, Nima N.; Pather, Sarshan R.; Hallacli, Erinc; Ndayisaba, Alain; Buenaventura, Chris; Acosta, Karen; Roof, Jennifer; Fazelinia, Hossein; Spruce, Lynn A.; Luk, Kelvin; Khurana, Vikram; Rhoades, Elizabeth; Shalem, Ophir 分享 收藏
Tau maturation in the clinicopathological spectrum of Lewy body and Alzheimer's disease Arezoumandan, Sanaz; Cousins, Katheryn A. Q.; Ohm, Daniel T.; Lowe, MaKayla; Chen, Min; Gee, James; Phillips, Jeffrey S.; McMillan, Corey T.; Luk, Kelvin C.; Deik, Andres; Spindler, Meredith A.; Tropea, Thomas F.; Weintraub, Daniel; Wolk, David A.; Grossman, Murray; Lee, Virginia; Chen-Plotkin, Alice S.; Lee, Edward B.; Irwin, David J. 分享 收藏
Transcriptomic profiling of early synucleinopathy in rats induced with preformed fibrils Patterson, Joseph R.; Kochmanski, Joseph; Stoll, Anna C.; Kubik, Michael; Kemp, Christopher J.; Duffy, Megan F.; Thompson, Kajene; Howe, Jacob W.; Cole-Strauss, Allyson; Kuhn, Nathan C.; Miller, Kathryn M.; Nelson, Seth; Onyekpe, Christopher U.; Beck, John S.; Counts, Scott E.; Bernstein, Alison I.; Steece-Collier, Kathy; Luk, Kelvin C.; Sortwell, Caryl E. 分享 收藏
α-Synuclein aggregates amplified from patient-derived Lewy bodies recapitulate Lewy body diseases in mice 从患者衍生的Lewy体扩增的 α-突触核蛋白聚集体概括了小鼠的Lewy体病 Uemura, Norihito; Marotta, Nicholas P.; Ara, Jahan; Meymand, Emily S.; Zhang, Bin; Kameda, Hiroshi; Koike, Masato; Luk, Kelvin C.; Trojanowski, John Q.; Lee, Virginia M. -Y. 分享 收藏
A Novel Brain PET Radiotracer for Imaging Alpha Synuclein Fibrils in Multiple System Atrophy 一种新型的脑PET放射性示踪剂，用于对多系统萎缩中的 α 突触核蛋白原纤维进行成像 Kim, Ho Young; Chia, Wai Kit; Hsieh, Chia-Ju; Saturnino Guarino, Dinahlee; Graham, Thomas J. A.; Lengyel-Zhand, Zsofia; Schneider, Mark; Tomita, Cosette; Lougee, Marshall G.; Kim, Hee Jong; Pagar, Vinayak V.; Lee, Hsiaoju; Hou, Catherine; Garcia, Benjamin A.; Petersson, E. James; O'Shea, Jennifer; Kotzbauer, Paul T.; Mathis, Chester A.; Lee, Virginia M. -Y.; Luk, Kelvin C.; Mach, Robert H. 分享 收藏
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