Fred W. van Leeuwen - Publications, H-index & Citations

Fred W. van Leeuwen

Maastricht University

33H指数

115论文数

4.0K被引数

收录论文 28

发表时间

Altered ubiquitin signaling induces Alzheimer's disease-like hallmarks in a three-dimensional human neural cell culture model

NATURE COMMUNICATIONS

IF15.7

2023-09-22

OAAI

Maniv, Inbal; Sarji, Mahasen; Bdarneh, Anwar; Feldman, Alona; Ankawa, Roi; Koren, Elle; Magid-Gold, Inbar; Reis, Noa; Soteriou, Despina; Salomon-Zimri, Shiran; Lavy, Tali; Kesselman, Ellina; Koifman, Naama; Kurz, Thimo; Kleifeld, Oded; Michaelson, Daniel; van Leeuwen, Fred W.; Verheijen, Bert M.; Fuchs, Yaron; Glickman, Michael H.

Expression of Mutant Ubiquitin and Proteostasis Impairment in Kii Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex Brains

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

IF3

2020-08-06

OAAI

Verheijen, Bert M.; Morimoto, Satoru; Sasaki, Ryogen; Oyanagi, Kiyomitsu; Kokubo, Yasumasa; Kuzuhara, Shigeki; van Leeuwen, Fred W.

Somatic mutations in neurons during aging and neurodegeneration (vol 135, pg 811, 2018)

ACTA NEUROPATHOLOGICA

IF9.3

2020-07-06

OAAI

Verheijen, Bert M.; Vermulst, Marc; van Leeuwen, Fred W.

Activation of the Unfolded Protein Response and Proteostasis Disturbance in Parkinsonism-Dementia of Guam

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

IF3

2019-10-22

OAAI

Verheijen, Bert M.; Lussier, Celina; Mueller-Huebers, Cora; Garruto, Ralph M.; Oyanagi, Kiyomitsu; Braun, Ralf J.; van Leeuwen, Fred W.

Paradoxical effects of mutant ubiquitin on Aβ plaque formation in an Alzheimer mouse model

NEUROBIOLOGY OF AGING

IF3.5

2018-12-01

OAAI

Verheijen, Bert M.; Stevens, Jo A. A.; Gentier, Romina J. G.; van't Hekke, Christian D.; van den Hove, Daniel L. A.; Hermes, Denise J. H. P.; Steinbusch, Harry W. M.; Ruijter, Jan M.; Grimm, Marcus O. W.; Haupenthal, Viola J.; Annaert, Wim; Hartmann, Tobias; van Leeuwen, Fred W.

Mutant ubiquitin reduces Aβ plaques

AGING-US

IF3.9

2018-10-15

OAAI

Verheijen, Bert M.; van Leeuwen, Fred W.

Somatic mutations in neurons during aging and neurodegeneration

ACTA NEUROPATHOLOGICA

IF9.3

2018-04-28

OAAI

Verheijen, Bert M.; Vermulst, Marc; van Leeuwen, Fred W.

Deposition of mutant ubiquitin in parkinsonism-dementia complex of Guam 关岛帕金森病-痴呆复合体中突变泛素的沉积

ACTA NEUROPATHOLOGICA COMMUNICATIONS

IF5.7

2017-11-09

OAAI

Verheijen, Bert M.; Hashimoto, Tomoyo; Oyanagi, Kiyomitsu; van Leeuwen, Fred W.

The cerebellum in Alzheimer's disease: evaluating its role in cognitive decline 阿尔茨海默病的小脑: 评估其在认知能力下降中的作用

BRAIN

IF11.7

2017-07-28

226

OAAI

Jacobs, Heidi I. L.; Hopkins, David A.; Mayrhofer, Helen C.; Bruner, Emiliano; van Leeuwen, Fred W.; Raaijmakers, Wijnand; Schmahmann, Jeremy D.

Editorial: Ubiquitin and the Brain: Roles of Proteolysis in the Normal and Abnormal Nervous System

FRONTIERS IN MOLECULAR NEUROSCIENCE

IF3.8

2017-07-18

OAAI

Hegde, Ashok N.; van Leeuwen, Fred W.

Fluoxetine Treatment Induces Seizure Behavior and Premature Death in APPswe/PS1dE9 Mice 氟西汀治疗可诱导APPswe/PS1dE9小鼠的癫痫发作行为和过早死亡

JOURNAL OF ALZHEIMERS DISEASE

IF3.1

2016-03-30

PREAI

Sierksma, Annerieke S. R.; de Nijs, Laurence; Hoogland, Govert; Vanmierlo, Tim; van Leeuwen, Fred W.; Rutten, Bart P. F.; Steinbusch, Harry W. M.; Prickaerts, Jos; van den Hove, Daniel L. A.

Accumulation of Basic Amino Acids at Mitochondria Dictates the Cytotoxicity of Aberrant Ubiquitin

CELL REPORTS

IF6.9

2015-03-01

OAAI

Braun, Ralf J.; Sommer, Cornelia; Leibiger, Christine; Gentier, Romina J. G.; Dumit, Veronica I.; Paduch, Katrin; Eisenberg, Tobias; Habernig, Lukas; Trausinger, Gert; Magnes, Christoph; Pieber, Thomas; Sinner, Frank; Dengjel, Joern; van Leeuwen, Fred W.; Kroemer, Guido; Madeo, Frank

Expression of progerin in aging mouse brains reveals structural nuclear abnormalities without detectible significant alterations in gene expression, hippocampal stem cells or behavior

HUMAN MOLECULAR GENETICS

IF3.2

2014-10-24

OAAI

Baek, Jean-Ha; Schmidt, Eva; Viceconte, Nikenza; Strandgren, Charlotte; Pernold, Karin; Richard, Thibaud J. C.; Van Leeuwen, Fred W.; Dantuma, Nico P.; Damberg, Peter; Hultenby, Kjell; Ulfhake, Brun; Mugnaini, Enrico; Rozell, Bjorn; Eriksson, Maria

The lectin OS-9 delivers mutant neuroserpin to endoplasmic reticulum associated degradation in familial encephalopathy with neuroserpin inclusion bodies

NEUROBIOLOGY OF AGING

IF3.5

2014-10-01

PREAI

Schipanski, Angela; Oberhauser, Felix; Neumann, Melanie; Lange, Sascha; Szalay, Beata; Krasemann, Susanne; van Leeuwen, Fred W.; Galliciotti, Giovanna; Glatzel, Markus

Identification and characterization of RING-finger ubiquitin ligase UBR7 in mammalian spermatozoa

CELL AND TISSUE RESEARCH

IF2.9

2014-03-25

PREAI

Zimmerman, Shawn W.; Yi, Young-Joo; Sutovsky, Miriam; van Leeuwen, Fred W.; Conant, Gavin; Sutovsky, Peter

Mutant ubiquitin decreases amyloid β plaque formation in a transgenic mouse model of Alzheimer's disease

NEUROCHEMISTRY INTERNATIONAL

IF4

2012-10-01

PREAI

van Tijn, Paula; Dennissen, Frank J. A.; Gentier, Romina J. G.; Hobo, Barbara; Hermes, Denise; Steinbusch, Harry W. M.; Van Leeuwen, Fred W.; Fischer, David F.

Long-term proteasomal inhibition in transgenic mice by UBB+1 expression results in dysfunction of central respiration control reminiscent of brainstem neuropathology in Alzheimer patients

ACTA NEUROPATHOLOGICA

IF9.3

2012-06-23

OAAI

Irmler, Martin; Gentier, Romina J. G.; Dennissen, Frank J. A.; Schulz, Holger; Bolle, Ines; Hoelter, Sabine M.; Kallnik, Magdalena; Cheng, Jing Jun; Klingenspor, Martin; Rozman, Jan; Ehrhardt, Nicole; Hermes, Denise J. H. P.; Gailus-Durner, Valerie; Fuchs, Helmut; de Angelis, Martin Hrabe; Meyer, Helmut E.; Hopkins, David A.; Van Leeuwen, Fred W.; Beckers, Johannes

Mutant ubiquitin (UBB+1) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH-L3)

FEBS LETTERS

IF3

2011-07-06

OAAI

Dennissen, Frank J. A.; Kholod, Natalia; Hermes, Denise J. H. P.; Kemmerling, Nadja; Steinbusch, Harry W. M.; Dantuma, Nico P.; van Leeuwen, Fred W.

Ubiquitin over-expression phenotypes and ubiquitin gene molecular misreading during aging in Drosophila melanogaster

AGING-US

IF3.9

2011-03-12

OAAI

Hoe, Nicholas; Huang, Chung M.; Landis, Gary; Verhage, Marian; Ford, Daniel; Yang, Junsheng; van Leeuwen, Fred W.; Tower, John

A Novel PRNP Y218N Mutation in Gerstmann-Straussler-Scheinker Disease With Neurofibrillary Degeneration

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

IF3

2010-08-01

PREAI

Alzualde, Ainhoa; Indakoetxea, Begona; Ferrer, Isidre; Moreno, Fermin; Barandiaran, Myriam; Gorostidi, Ana; Estanga, Ainara; Ruiz, Irune; Calero, Miguel; van Leeuwen, Fred W.; Atares, Begona; Juste, Ramon; Belen Rodriguez-Martinez, Ana; Lopez de Munain, Adolfo

研究方向