logo
科言猫学术研究的AI总结
language
手机端手机端
  • Phone Feature微信小程序
简体中文简体中文
notice消息通知
博客博客
delete
arrow
返回
T

Timothy Palzkill

Baylor College of Medicine

56H指数
284论文数
8.9K被引数
收录论文 38
发表时间
logo
A β-lactamase inhibitory protein mutant displays high potency and a broad inhibition profile due to an altered binding mode with β-lactamases一种β-内酰胺酶抑制蛋白突变体因与β-内酰胺酶的配体结合模式发生改变而表现出高活性和广谱抑制谱。
errJournal of Biological Chemistry
IF3.9
err2025-10-23
err0
errOAAI
errPaola Rivera; Shuo Lu; Dignite Ngango; Banumathi Sankaran; B.V. Venkataram Prasad; Timothy Palzkill
err分享
err收藏
Conformational flexibility is a critical factor in designing broad-spectrum human norovirus protease inhibitors
errJOURNAL OF VIROLOGY
IF3.8
err2025-02-25
err0
errOAAI
errPham, Son; Zhao, Boyang; Neetu, Neetu; Sankaran, Banumathi; Patil, Ketki; Ramani, Sasirekha; Song, Yongcheng; Estes, Mary K.; Palzkill, Timothy; Prasad, B. V. Venkataram
err分享
err收藏
Norovirus replication, host interactions and vaccine advances诺如病毒复制、宿主相互作用及疫苗进展
errNATURE REVIEWS MICROBIOLOGY
IF103.3
err2025-01-17
err1
PREAI
errPrasad, B. V. Venkataram; Atmar, Robert L.; Ramani, Sasirekha; Palzkill, Timothy; Song, Yongcheng; Crawford, Sue E.; Estes, Mary K.
err分享
err收藏
Expanding Complex Morpholines Using Systematic Chemical Diversity
errORGANIC LETTERS
IF5
err2024-03-20
err1
PREAI
errTang, Sunny Ann; Fults, Afton; Boyd, Shelton R.; Gattu, Nikhil; Tran, Kevin A.; Fan, Jiayi; Mackenzie, Kevin R.; Palzkill, Timothy; Young, Damian W.; Chamakuri, Srinivas
err分享
err收藏
Network of epistatic interactions in an enzyme active site revealed by large- scale deep mutational scanning
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2024-03-14
err3
errOAAI
errJudge, Allison; Sankaran, Banumathi; Hu, Liya; Palaniappan, Murugesan; Birgy, Andre; Prasad, B. V. Venkataram; Palzkill, Timothy
err分享
err收藏
The mechanism of ceftazidime and cefiderocol hydrolysis by D179Y variants of KPC carbapenemases is similar and involves the formation of a long-lived covalent intermediate
errANTIMICROBIAL AGENTS AND CHEMOTHERAPY
IF4.5
err2024-03-06
err3
errOAAI
errBirgy, Andre; Nnabuife, Christina; Palzkill, Timothy
err分享
err收藏
Klebsiella pneumoniae carbapenemase variant 44 acquires ceftazidime-avibactam resistance by altering the conformation of active-site loops
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2024-01-01
err3
errOAAI
errSun, Zhizeng; Lin, Hanfeng; Hu, Liya; Neetu, Neetu; Sankaran, Banumathi; Wang, Jin; Prasad, B. V. Venkataram; Palzkill, Timothy
err分享
err收藏
Exploiting the Carboxylate-Binding Pocket of β-Lactamase Enzymes Using a Focused DNA-Encoded Chemical Library
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2023-12-20
err3
PREAI
errPark, Suhyeorn; Fan, Jiayi; Chamakuri, Srinivas; Palaniappan, Murugesan; Sharma, Kiran; Qin, Xuan; Wang, Jian; Tan, Zhi; Judge, Allison; Hu, Liya; Sankaran, Banumathi; Li, Feng; Prasad, B. V. Venkataram; Matzuk, Martin M.; Palzkill, Timothy
err分享
err收藏
DNA-encoded chemical libraries yield non-covalent and non-peptidic SARS-CoV-2 main protease inhibitors
errCOMMUNICATIONS CHEMISTRY
IF6.2
err2023-08-04
err8
errOAAI
errJimmidi, Ravikumar; Chamakuri, Srinivas; Lu, Shuo; Ucisik, Melek Nihan; Chen, Peng-Jen; Bohren, Kurt M.; Moghadasi, Seyed Arad; Versteeg, Leroy; Nnabuife, Christina; Li, Jian-Yuan; Qin, Xuan; Chen, Ying-Chu; Faver, John C.; Nyshadham, Pranavanand; Sharma, Kiran L.; Sankaran, Banumathi; Judge, Allison; Yu, Zhifeng; Li, Feng; Pollet, Jeroen; Harris, Reuben S.; Matzuk, Martin M.; Palzkill, Timothy; Young, Damian W.
err分享
err收藏
Mapping human norovirus antigens during infection reveals the breadth of the humoral immune response
errNPJ VACCINES
IF6.5
err2023-06-06
err2
errOAAI
errSu, Lynn; Huang, Wanzhi; Neill, Frederick H.; Estes, Mary K.; Atmar, Robert L.; Palzkill, Timothy
err分享
err收藏
Mutagenesis and structural analysis reveal the CTX-M β-lactamase active site is optimized for cephalosporin catalysis and drug resistance
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2023-05-01
err4
errOAAI
errLu, Shuo; Montoya, Miranda; Hu, Liya; Neetu, Neetu; Sankaran, Banumathi; Prasad, B. V. Venkataram; Palzkill, Timothy
err分享
err收藏
Mapping the determinants of catalysis and substrate specificity of the antibiotic resistance enzyme CTX-M β-lactamase
errCOMMUNICATIONS BIOLOGY
IF5.1
err2023-01-12
err11
errOAAI
errJudge, Allison; Hu, Liya; Sankaran, Banumathi; Van Riper, Justin; Venkataram Prasad, B. V.; Palzkill, Timothy
err分享
err收藏
An active site loop toggles between conformations to control antibiotic hydrolysis and inhibition potency for CTX-M β-lactamase drug-resistance enzymes
errNATURE COMMUNICATIONS
IF15.7
err2022-11-07
err6
errOAAI
errLu, Shuo; Hu, Liya; Lin, Hanfeng; Judge, Allison; Rivera, Paola; Palaniappan, Murugesan; Sankaran, Banumathi; Wang, Jin; Prasad, B. V. Venkataram; Palzkill, Timothy
err分享
err收藏
Slow Protein Dynamics Elicits New Enzymatic Functions by Means of Epistatic Interactions
errMOLECULAR BIOLOGY AND EVOLUTION
IF5.3
err2022-09-22
err4
errOAAI
errRossi, Maria-Agustina; Palzkill, Timothy; Almeida, Fabio C. L.; Vila, Alejandro J.
err分享
err收藏
Evaluation of Tebipenem Hydrolysis by β-Lactamases Prevalent in Complicated Urinary Tract Infections
errANTIMICROBIAL AGENTS AND CHEMOTHERAPY
IF4.5
err2022-05-17
err10
errOAAI
errSun, Zhizeng; Su, Lynn; Cotroneo, Nicole; Critchley, Ian; Pucci, Michael; Jain, Akash; Palzkill, Timothy
err分享
err收藏
Consensus on β-Lactamase Nomenclature
errANTIMICROBIAL AGENTS AND CHEMOTHERAPY
IF4.5
err2022-04-19
err18
errOAAI
errBradford, Patricia A.; Bonomo, Robert A.; Bush, Karen; Carattoli, Alessandra; Feldgarden, Michael; Haft, Daniel H.; Ishii, Yoshikazu; Jacoby, George A.; Klimke, William; Palzkill, Timothy; Poirel, Laurent; Rossolini, Gian Maria; Tamma, Pranita D.; Arias, Cesar A.
err分享
err收藏
Unique Diacidic Fragments Inhibit the OXA-48 Carbapenemase and Enhance the Killing of Escherichia coli Producing OXA-48独特的二酸片段抑制OXA-48碳青霉烯酶并增强对大肠杆菌产生OXA-48的杀灭作用
errACS INFECTIOUS DISEASES
IF3.8
err2021-11-24
err5
errOAAI
errTaylor, Doris Mia; Anglin, Justin; Hu, Liya; Wang, Lingfei; Sankaran, Banumathi; Wang, Jin; Matzuk, Martin M.; Prasad, B. V. Venkataram; Palzkill, Timothy
err分享
err收藏
DNA-encoded chemistry technology yields expedient access to SARS-CoV-2 Mpro inhibitors
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2021-08-23
err45
errOAAI
errChamakuri, Srinivas; Lu, Shuo; Ucisik, Melek Nihan; Bohren, Kurt M.; Chen, Ying-Chu; Du, Huang-Chi; Faver, John C.; Jimmidi, Ravikumar; Li, Feng; Li, Jian-Yuan; Nyshadham, Pranavanand; Palmer, Stephen S.; Pollet, Jeroen; Qin, Xuan; Ronca, Shannon E.; Sankaran, Banumathi; Sharma, Kiran L.; Tan, Zhi; Versteeg, Leroy; Yu, Zhifeng; Matzuk, Martin M.; Palzkill, Timothy; Young, Damian W.
err分享
err收藏
A Test for the Rapid Detection of the cefazolin Inoculum Effect in Methicillin-Susceptible Staphylococcus aureus
errJOURNAL OF CLINICAL MICROBIOLOGY
IF5.4
err2021-03-19
err11
errOAAI
errRincon, Sandra; Carvajal, Lina P.; Gomez-Villegas, Sara, I; Echeverri, Aura M.; Rios, Rafael; An Dinh; Pedroza, Claudia; Ordonez, Karen M.; Nannini, Esteban; Sun, Zhizeng; Fowler, Vance G.; Murray, Barbara E.; Miller, William R.; Palzkill, Timothy; Diaz, Lorena; Arias, Cesar A.; Reyes, Jinnethe
err分享
err收藏
Mechanistic Basis of OXA-48-like β-Lactamases' Hydrolysis of Carbapenems
errACS INFECTIOUS DISEASES
IF3.8
err2021-01-25
err21
errOAAI
errStojanoski, Vlatko; Hu, Liya; Sankaran, Banumathi; Wang, Feng; Tao, Peng; Prasad, B. V. Venkataram; Palzkill, Timothy
err分享
err收藏

研究方向

暂时未获取到该数据
合作学者
合作期刊
P
Patrice Nordmann
H 指数: 140 · 论文数: 974
H
Huda Y. Zoghbi
H 指数: 135 · 论文数: 566
G
George M. Weinstock
H 指数: 133 · 论文数: 622
L
Laurent Poirel
H 指数: 127 · 论文数: 746
J
James M. Musser
H 指数: 125 · 论文数: 572
查看更多