未登录 Plasmodium falciparum Resistance to a Lead Benzoxaborole Due to Blocked Compound Activation and Altered Ubiquitination or Sumoylation Sindhe, Kirthana M., V; Wu, Wesley; Legac, Jenny; Zhang, Yong-Kang; Easom, Eric E.; Cooper, Roland A.; Plattner, Jacob J.; Freund, Yvonne R.; DeRisi, Joseph L.; Rosenthal, Philip J. 分享 收藏
In vivo efficacy of the boron-pleuromutilin AN11251 against I of the rodent filarial nematode Litomosoides sigmodontis Ehrens, Alexandra; Lunde, Christopher S.; Jacobs, Robert T.; Struever, Dominique; Koschel, Marianne; Frohberger, Stefan J.; Lenz, Franziska; Fendler, Martina; Turner, Joseph D.; Ward, Stephen A.; Taylor, Mark J.; Freund, Yvonne R.; Stefanakis, Rianna; Easom, Eric; Li, Xianfeng; Plattner, Jacob J.; Hoerauf, Achim; Huebner, Marc P. 分享 收藏
Macrofilaricidal Benzimidazole-Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness: Part 1. Amide Linked Analogs Akama, Tsutomu; Freund, Yvonne R.; Berry, Pamela W.; Carter, David S.; Easom, Eric E.; Jarnagin, Kurt; Lunde, Christopher S.; Plattner, Jacob J.; Rock, Fernando; Stefanakis, Rianna; Fischer, Chelsea; Bulman, Christina A.; Lim, Kee Chong; Suzuki, Brian M.; Tricoche, Nancy; Mansour, Abdelmoneim; DiCosty, Utami; McCall, Scott; Carson, Ben; McCall, John W.; McKerrow, James; Huebner, Marc P.; Specht, Sabine; Hoerauf, Achim; Lustigman, Sara; Sakanari, Judy A.; Jacobs, Robert T. 分享 收藏
Macrofilaricidal Benzimidazole-Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness: Part 2. Ketone Linked Analogs Carter, David S.; Jacobs, Robert T.; Freund, Yvonne R.; Berry, Pamela W.; Akama, Tsutomu; Easom, Eric E.; Lunde, Christopher S.; Rock, Fernando; Stefanakis, Rianna; McKerrow, James; Fischer, Chelsea; Bulman, Christina A.; Lim, Kee Chong; Suzuki, Brian M.; Tricoche, Nancy; Sakanari, Judy A.; Lustigman, Sara; Plattner, Jacob J. 分享 收藏
Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis Lunde, Christopher S.; Stebbins, Erin E.; Jumani, Rajiv S.; Hasan, Md Mahmudul; Miller, Peter; Barlow, John; Freund, Yvonne R.; Berry, Pamela; Stefanakis, Rianna; Gut, Jiri; Rosenthal, Philip J.; Love, Melissa S.; McNamara, Case W.; Easom, Eric; Plattner, Jacob J.; Jacobs, Robert T.; Huston, Christopher D. 分享 收藏
Boron-Pleuromutilins as Anti-Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis Jacobs, Robert T.; Lunde, Christopher S.; Freund, Yvonne R.; Hernandez, Vincent; Li, Xianfeng; Xia, Yi; Carter, David S.; Berry, Pamela W.; Halladay, Jason; Rock, Fernando; Stefanakis, Rianna; Easom, Eric; Plattner, Jacob J.; Ford, Louise; Johnston, Kelly L.; Cook, Darren A. N.; Clare, Rachel; Cassidy, Andrew; Myhill, Laura; Tyrer, Hayley; Gamble, Joanne; Guimaraes, Ana F.; Steven, Andrew; Lenz, Franziska; Ehrens, Alexandra; Frohberger, Stefan J.; Koschel, Marianne; Hoerauf, Achim; Huebner, Marc P.; McNamara, Case W.; Bakowski, Malina A.; Turner, Joseph D.; Taylor, Mark J.; Ward, Stephen A. 分享 收藏
Topical Treatment for Cutaneous Leishmaniasis: Dermato-Pharmacokinetic Lead Optimization of Benzoxaboroles 皮肤利什曼病的局部治疗: 苯并氧杂硼的皮肤药代动力学铅优化 Van Bocxlaer, Katrien; Gaukel, Eric; Hauser, Deirdre; Park, Seong Hee; Schock, Sara; Yardley, Vanessa; Randolph, Ryan; Plattner, Jacob J.; Merchant, Tejal; Croft, Simon L.; Jacobs, Robert T.; Wring, Stephen A. 分享 收藏
Discovery of a Potent and Specific M-tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)-3-(Aminomethyl)-4-chloro-7-(2hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol (GSK656) Li, Xianfeng; Hernandez, Vincent; Rock, Fernando L.; Choi, Wai; Mak, Yvonne S. L.; Mohan, Manisha; Mao, Weimin; Zhou, Yasheen; Easom, Eric E.; Plattner, Jacob J.; Zou, Wuxin; Perez-Herran, Esther; Giordano, Ilaria; Mendoza-Losana, Alfonso; Alemparte, Carlos; Rullas, Joaquin; Angulo-Barturen, Inigo; Crouch, Sabrinia; Ortega, Fatima; Barros, David; Alley, M. R. K. 分享 收藏
Benzoxaborole Antimalarial Agents. Part 5. Lead Optimization of Novel Amide Pyrazinyloxy Benzoxaboroles and Identification of a Preclinical Candidate Zhang, Yong-Kang; Plattner, Jacob J.; Easom, Eric E.; Jacobs, Robert T.; Guo, Denghui; Freund, Yvonne R.; Berry, Pamela; Ciaravino, Vic; Erve, John C. L.; Rosenthal, Philip J.; Campo, Brice; Gamo, Francisco-Javier; Sanz, Laura M.; Cao, Jianxin 分享 收藏
Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase Palencia, Andres; Li, Xianfeng; Bu, Wei; Choi, Wai; Ding, Charles Z.; Easom, Eric E.; Feng, Lisa; Hernandez, Vincent; Houston, Paul; Liu, Liang; Meewan, Maliwan; Mohan, Manisha; Rock, Fernando L.; Sexton, Holly; Zhang, Suoming; Zhou, Yasheen; Wan, Baojie; Wang, Yuehong; Franzblau, Scott G.; Woolhiser, Lisa; Gruppo, Veronica; Lenaerts, Anne J.; O'Malley, Theresa; Parish, Tanya; Cooper, Christopher B.; Waters, M. Gerard; Ma, Zhenkun; Ioerger, Thomas R.; Sacchettini, James C.; Rullas, Joaquin; Angulo-Barturen, Inigo; Perez-Herran, Esther; Mendoza, Alfonso; Barros, David; Cusack, Stephen; Plattner, Jacob J.; Alley, M. R. K. 分享 收藏
Benzoxaborole Antimalarial Agents. Part 4. Discovery of Potent 6-(2-(Alkoxycarbonyl)pyrazinyl-5-oxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles Zhang, Yong-Kang; Plattner, Jacob J.; Easom, Eric E.; Jacobs, Robert T.; Guo, Denghui; Sanders, Virginia; Freund, Yvonne R.; Campo, Brice; Rosenthal, Philip J.; Bu, Wei; Gamo, Francisco-Javier; Sanz, Laura M.; Ge, Min; Li, Liang; Ding, Jie; Yang, Yin 分享 收藏
Discovery of a Novel Class of Boron-Based Antibacterials with Activity against Gram-Negative Bacteria Hernandez, Vincent; Crepin, Thibaut; Palencia, Andres; Cusack, Stephen; Akama, Tsutomu; Baker, Stephen J.; Bu, Wei; Feng, Lisa; Freund, Yvonne R.; Liu, Liang; Meewan, Maliwan; Mohan, Manisha; Mao, Weimin; Rock, Fernando L.; Sexton, Holly; Sheoran, Anita; Zhang, Yanchen; Zhang, Yong-Kang; Zhou, Yasheen; Nieman, James A.; Anugula, Mahipal Reddy; Keramane, El Mehdi; Savariraj, Kingsley; Reddy, D. Shekhar; Sharma, Rashmi; Subedi, Rajendra; Singh, Rajeshwar; O'Leary, Ann; Simon, Nerissa L.; De Marsh, Peter L.; Mushtaq, Shazad; Warner, Marina; Livermore, David M.; Alley, M. R. K.; Plattner, Jacob J. 分享 收藏
Discovery of Novel Urea-Based Hepatitis C Protease Inhibitors with High Potency against Protease-Inhibitor-Resistant Mutants Kazmierski, Wieslaw M.; Hamatake, Robert; Duan, Maosheng; Wright, Lois L.; Smith, Gary K.; Jarvest, Richard L.; Ji, Jing-Jing; Copper, Joel P.; Tallant, Matthew D.; Crosby, Renae M.; Creech, Katrina; Wang, Amy; Li, Xianfeng; Zhang, Suoming; Zhang, Yong-Kang; Liu, Yang; Ding, Charles Z.; Zhou, Yasheen; Plattner, Jacob J.; Baker, Stephen J.; Bu, Wei; Liu, Liang 分享 收藏
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Benzoxaboroles: a new class of potential drugs for human African trypanosomiasis Jacobs, Robert T.; Plattner, Jacob J.; Nare, Bakela; Wring, Stephen A.; Chen, Daitao; Freund, Yvonne; Gaukel, Eric G.; Orr, Matthew D.; Perales, Joe B.; Jenks, Matthew; Noe, Robert A.; Sligar, Jessica M.; Zhang, Yong-Kang; Bacchi, Cyrus J.; Yarlett, Nigel; Don, Robert 分享 收藏
SCYX-7158, an Orally-Active Benzoxaborole for the Treatment of Stage 2 Human African Trypanosomiasis Jacobs, Robert T.; Nare, Bakela; Wring, Stephen A.; Orr, Matthew D.; Chen, Daitao; Sligar, Jessica M.; Jenks, Matthew X.; Noe, Robert A.; Bowling, Tana S.; Mercer, Luke T.; Rewerts, Cindy; Gaukel, Eric; Owens, Jennifer; Parham, Robin; Randolph, Ryan; Beaudet, Beth; Bacchi, Cyrus J.; Yarlett, Nigel; Plattner, Jacob J.; Freund, Yvonne; Ding, Charles; Akama, Tsutomu; Zhang, Y. -K.; Brun, Reto; Kaiser, Marcel; Scandale, Ivan; Don, Robert 分享 收藏
Design, Synthesis, and Structure-Activity Relationship of Trypanosoma brucei Leucyl-tRNA Synthetase Inhibitors as Antitrypanosomal Agents Ding, Dazhong; Meng, Qingqing; Gao, Guangwei; Zhao, Yaxue; Wang, Qing; Nare, Bakela; Jacobs, Robert; Rock, Fernando; Alley, Michael R. K.; Plattner, Jacob J.; Chen, Guoqiang; Li, Dawei; Zhou, Huchen 分享 收藏
Discovery of Novel Orally Bioavailable Oxaborole 6-Carboxamides That Demonstrate Cure in a Murine Model of Late-Stage Central Nervous System African Trypanosomiasis Nare, Bakela; Wring, Stephen; Bacchi, Cyrus; Beaudet, Beth; Bowling, Tana; Brun, Reto; Chen, Daitao; Ding, Charles; Freund, Yvonne; Gaukel, Eric; Hussain, Ali; Jarnagin, Kurt; Jenks, Matthew; Kaiser, Marcel; Mercer, Luke; Mejia, Elena; Noe, Andy; Orr, Matt; Parham, Robin; Plattner, Jacob; Randolph, Ryan; Rattendi, Donna; Rewerts, Cindy; Sligar, Jessica; Yarlett, Nigel; Don, Robert; Jacobs, Robert 分享 收藏
Discovery of Novel Benzoxaborole-Based Potent Antitrypanosomal Agents Ding, Dazhong; Zhao, Yaxue; Meng, Qingqing; Xie, Dongsheng; Nare, Bakela; Chen, Daitao; Bacchi, Cyrus J.; Yarlett, Nigel; Zhang, Yong-Kang; Hernandez, Vincent; Xia, Yi; Freund, Yvonne; Abdulla, Maha; Ang, Kean-Hooi; Ratnam, Joseline; McKerrow, James H.; Jacobs, Robert T.; Zhou, Huchen; Plattner, Jacob J. 分享 收藏
In vitro penetration of a novel oxaborole antifungal (AN2690) into the human nail plate Hui, Xiaoying; Baker, Stephen J.; Wester, Ronald C.; Barbadillo, Sherry; Cashmore, Anne K.; Sanders, Virginia; Hold, Karin M.; Akama, Tsutomu; Zhang, Yong-Kang; Plattner, Jacob J.; Maibach, Howard I. 分享 收藏
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