未登录 Structural basis for GPR40 allosteric agonism and incretin stimulation Ho, Joseph D.; Chau, Betty; Rodgers, Logan; Lu, Frances; Wilbur, Kelly L.; Otto, Keith A.; Chen, Yanyun; Song, Min; Riley, Jonathan P.; Yang, Hsiu-Chiung; Reynolds, Nichole A.; Kahl, Steven D.; Lewis, Anjana Patel; Groshong, Christopher; Madsen, Russell E.; Conners, Kris; Lineswala, Jayana P.; Gheyi, Tarun; Saflor, Melbert-Brian Decipulo; Lee, Matthew R.; Benach, Jordi; Baker, Kenton A.; Montrose-Rafizadeh, Chahrzad; Genin, Michael J.; Miller, Anne R.; Hamdouchi, Chafiq 分享 收藏
Discovery of LY3104607: A Potent and Selective G Protein-Coupled Receptor 40 (GPR40) Agonist with Optimized Pharmacokinetic Properties to Support Once Daily Oral Treatment in Patients with Type 2 Diabetes Mellitus Hamdouchi, Chafiq; Maiti, Pranab; Warshawsky, Alan M.; DeBaillie, Amy C.; Otto, Keith A.; Wilbur, Kelly L.; Kahl, Steven D.; Lewis, Anjana Patel; Cardona, Guemalli R.; Zink, Richard W.; Chen, Keyue; Siddaramaiah, C. R.; Lineswala, Jayana P.; Neathery, Grace L.; Bouaichi, Cecilia; Diseroad, Benjamin A.; Campbell, Alison N.; Sweetana, Stephanie A.; Adams, Lisa A.; Cabrera, Over; Ma, Xiaosu; Yumibe, Nathan P.; Montrose-Rafizadeh, Chahrzad; Chen, Yanyun; Miller, Anne Reifel 分享 收藏
A Novel Aldosterone Antagonist Limits Renal Injury in 5/6 Nephrectomy Fujihara, Clarice K.; Kowala, M. C.; Breyer, M. D.; Sena, Claudia R.; Rodrigues, Mariliza V.; Arias, Simone C. A.; Fanelli, Camilla; Malheiros, Denise M.; Jadhav, P. K.; Montrose-Rafizadeh, Chahrzad; Krieger, Jose E.; Zatz, Roberto 分享 收藏
The Discovery, Preclinical, and Early Clinical Development of Potent and Selective GPR40 Agonists for the Treatment of Type 2 Diabetes Mellitus (LY2881835, LY2922083, and LY2922470) Hamdouchi, Chafiq; Kahl, Steven D.; Lewis, Anjana Patel; Cardona, Guemalli R.; Zink, Richard W.; Chen, Keyue; Eessalu, Thomas E.; Ficorilli, James V.; Marcelo, Marialuisa C.; Otto, Keith A.; Wilbur, Kelly L.; Lineswala, Jayana P.; Piper, Jared L.; Coffey, D. Scott; Sweetana, Stephanie A.; Haas, Joseph V.; Brooks, Dawn A.; Pratt, Edward J.; Belin, Ruth M.; Deeg, Mark A.; Ma, Xiaosu; Cannady, Ellen A.; Johnson, Jason T.; Yumibe, Nathan P.; Chen, Qi; Maiti, Pranab; Montrose-Rafizadeh, Chahrzad; Chen, Yanyun; Miller, Anne Reifel 分享 收藏
Discovery of 6-(4-{[5-Cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl]methoxy}piperidin-1-yl)-1-methyl-1H-indole-3-carboxylic Acid: A Novel FXR Agonist for the Treatment of Dyslipidemia 发现6-(4-{[5-环丙基-3-(2，6-二氯苯基) isoxazol-4-yl] 甲氧基} piperidin-1-yl)-1-甲基-1h-吲哚-3-羧酸: 一种用于治疗血脂异常的新型FXR激动剂 Genin, Michael J.; Bueno, Ana B.; Francisco, Javier Agejas; Manninen, Peter R.; Bocchinfuso, Wayne P.; Montrose-Rafizadeh, Chahrzad; Cannady, Ellen A.; Jones, Timothy M.; Stille, John R.; Raddad, Eyas; Reidy, Charles; Cox, Amy; Michael, M. Dodson; Michael, Laura F. 分享 收藏
Novel 3-Aryl Indoles as Progesterone Receptor Antagonists for Uterine Fibroids Richardson, Timothy I.; Clarke, Christian A.; Yu, Kuo-Long; Yee, Ying K.; Bleisch, Thomas J.; Lopez, Jose E.; Jones, Scott A.; Hughes, Norman E.; Muehl, Brian S.; Lugar, Charles W.; Moore, Terry L.; Shetler, Pamela K.; Zink, Richard W.; Osborne, John J.; Montrose-Rafizadeh, Chahrzad; Patel, Nita; Geiser, Andrew G.; Galvin, Rachelle J. Sells; Dodge, Jeffrey A. 分享 收藏
A Nonsecosteroidal Vitamin D Receptor Ligand with Improved Therapeutic Window of Bone Efficacy over Hypercalcemia Sato, Masahiko; Lu, Jianliang; Iturria, Stephen; Stayrook, Keith R.; Burris, Lorri L.; Zeng, Qing Qiang; Schmidt, Allen; Barr, Robert J.; Montrose-Rafizadeh, Chahrzad; Bryant, Henry U.; Ma, Yanfei L. 分享 收藏
Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical method Dai, Susie Y.; Chalmers, Michael J.; Bruning, John; Bramlett, Kelli S.; Osborne, Harold E.; Montrose-Rafizadeh, Chahrzad; Barr, Robert J.; Wang, Yong; Wang, Minmin; Burris, Thomas P.; Dodge, Jeffrey A.; Griffin, Patrick R. 分享 收藏
Benzopyrans are selective estrogen receptor β agonists with novel activity in models of benign prostatic hyperplasia Norman, Bryan H.; Dodge, Jeffrey A.; Richardson, Timothy I.; Borromeo, Peter S.; Lugar, Charles W.; Jones, Scott A.; Chen, Keyue; Wang, Yong; Durst, Gregory L.; Barr, Robert J.; Montrose-Rafizadeh, Chahrzad; Osborne, Harold E.; Amos, Robert M.; Guo, Sherry; Boodhoo, Amechand; Krishnan, Venkatesh 分享 收藏
Design and synthesis of dual peroxisome proliferator-activated receptors γ and δ Agonists as novel euglycemic agents with a reduced weight gain profile Xu, Yanping; Etgen, Garret J.; Broderick, Carol L.; Canada, Emily; Gonzalez, Isabel; Lamar, Jason; Montrose-Rafizadeh, Chahrzad; Oldham, Brian A.; Osborne, John J.; Xie, Chaoyu; Shi, Qing; Winneroski, Leonard L.; York, Jeremy; Yumibe, Nathan; Zink, Richard; Mantlo, Nathan 分享 收藏
Biological characterization of a heterodimer-selective retinoid X receptor modulator: Potential benefits for the treatment of type 2 diabetes Leibowitz, MD; Ardecky, RJ; Boehm, MF; Broderick, CL; Carfagna, MA; Crombie, DL; D'Arrigo, J; Etgen, GJ; Faul, MM; Grese, TA; Havel, H; Hein, NI; Heyman, RA; Jolley, D; Klausing, K; Liu, S; Mais, DE; Mapes, CM; Marschke, KB; Michellys, PV; Montrose-Rafizadeh, C; Ogilvie, KM; Pascual, B; Rungta, D; Tyhonas, JS; Urcan, MS; Wardlow, M; Yumibe, N; Reifel-Miller, A 分享 收藏
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Design and synthesis of α-aryloxy-α-methylhydrocinnamic acids:: A novel class of dual peroxisome proliferator-activated receptor α/γ agonists Xu, YP; Rito, CJ; Etgen, GJ; Ardecky, RJ; Bean, JS; Bensch, WR; Bosley, JR; Broderick, CL; Brooks, DA; Dominianni, SJ; Hahn, PJ; Liu, S; Mais, DE; Montrose-Rafizadeh, C; Ogilvie, KM; Oldham, BA; Peters, M; Rungta, DK; Shuker, AJ; Stephenson, GA; Tripp, AE; Wilson, S; Winneroski, LL; Zink, R; Kauffman, RF; McCarthy, JR 分享 收藏
Design and synthesis of a potent and selective triazolone-based peroxisome proliferator-activated receptor α agonist Xu, YP; Mayhugh, D; Saeed, A; Wang, XD; Thompson, RC; Dominianni, SJ; Kauffman, RF; Singh, J; Bean, JS; Bensch, WR; Barr, RJ; Osborne, J; Montrose-Rafizadeh, C; Zink, RW; Yumibe, NP; Huang, NJ; Luffer-Atlas, D; Rungta, D; Maise, DE; Mantlo, NB 分享 收藏
Design, synthesis, and structure-activity relationship studies of novel 6,7-locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic acids Michellys, PY; Ardecky, RJ; Chen, JH; D'Arrigo, J; Grese, TA; Karanewsky, DS; Leibowitz, MD; Liu, S; Mais, DA; Mapes, CM; Montrose-Rafizadeh, C; Ogilvie, KM; Reifel-Miller, A; Rungta, D; Thompson, AW; Tyhonas, JS; Boehm, MF 分享 收藏
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