T. Kendall Harden - Publications, H-index & Citations

T. Kendall Harden

University of North Carolina Chapel Hill

68H指数

431论文数

1.4W被引数

收录论文 113

发表时间

Loss of P2Y1 receptor desensitization does not impact hemostasis or thrombosis despite increased platelet reactivity in vitro

JOURNAL OF THROMBOSIS AND HAEMOSTASIS

IF5

2023-07-01

OAAI

Paul, David S.; Blatt, Tasha N.; Schug, Wyatt J.; Clark, Emily G.; Kawano, Tomohiro; Mackman, Nigel; Murcia, Sebastian; Poe, Kathryn O.; Mwiza, Jean Marie N.; Harden, T. Kendall; Bergmeier, Wolfgang; Nicholas, Robert A.

Structural basis for the activation of PLC-γ isozymes by phosphorylation and cancerassociated mutations

ELIFE

IF0

2019-12-31

OAAI

Hajicek, Nicole; Keith, Nicholas C.; Siraliev-Perez, Edhriz; Temple, Brenda R. S.; Huang, Weigang; Zhang, Qisheng; Harden, T. Kendall; Sondek, John

A membrane-associated, fluorogenic reporter for mammalian phospholipase C isozymes 哺乳动物磷脂酶C同工酶的膜相关荧光报告基因

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2018-02-01

OAAI

Huang, Weigang; Wang, Xiaoyang; Endo-Streeter, Stuart; Barrett, Matthew; Waybright, Jarod; Wohlfeld, Christian; Hajicek, Nicole; Harden, T. Kendall; Sondek, John; Zhang, Qisheng

Potent and Selective Peptide-based Inhibition of the G Protein Gq

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2016-12-01

OAAI

Charpentier, Thomas H.; Waldo, Gary L.; Lowery-Gionta, Emily G.; Krajewski, Krzysztof; Strahl, Brian D.; Kash, Thomas L.; Harden, T. Kendall; Sondek, John

UDP-glucose promotes neutrophil recruitment in the lung

Purinergic Signalling

IF2.4

2016-07-15

OAAI

Sesma, Juliana I.; Weitzer, Clarissa D.; Livraghi-Butrico, Alessandra; Dang, Hong; Donaldson, Scott; Alexis, Neil E.; Jacobson, Kenneth A.; Harden, T. Kendall; Lazarowski, Eduardo R.

Structure-Based Design of 3-(4-Aryl-1H-1,2,3-triazol-1-yl)-Biphenyl Derivatives as P2Y14 Receptor Antagonists

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2016-06-22

OAAI

Junker, Anna; Balasubramanian, Ramachandran; Ciancetta, Antonella; Uliassi, Elisa; Kiselev, Evgeny; Martiriggiano, Chiara; Trujillo, Kevin; Mtchedlidze, Giorgi; Birdwell, Leah; Brown, Kyle A.; Harden, T. Kendall; Jacobson, Kenneth A.

The experimental power of FR900359 to study Gq-regulated biological processes

NATURE COMMUNICATIONS

IF15.7

2015-12-14

296

OAAI

Schrage, Ramona; Schmitz, Anna-Lena; Gaffal, Evelyn; Annala, Suvi; Kehraus, Stefan; Wenzel, Daniela; Buellesbach, Katrin M.; Bald, Tobias; Inoue, Asuka; Shinjo, Yuji; Galandrin, Segolene; Shridhar, Naveen; Hesse, Michael; Grundmann, Manuel; Merten, Nicole; Charpentier, Thomas H.; Martz, Matthew; Butcher, Adrian J.; Slodczyk, Tanja; Armando, Sylvain; Effern, Maike; Namkung, Yoon; Jenkins, Laura; Horn, Velten; Stoessel, Anne; Dargatz, Harald; Tietze, Daniel; Imhof, Diana; Gales, Celine; Drewke, Christel; Mueller, Christa E.; Hoelzel, Michael; Milligan, Graeme; Tobin, Andrew B.; Gomeza, Jesus; Dohlman, Henrik G.; Sondek, John; Harden, T. Kendall; Bouvier, Michel; Laporte, Stephane A.; Aoki, Junken; Fleischmann, Bernd K.; Mohr, Klaus; Koenig, Gabriele M.; Tueting, Thomas; Kostenis, Evi

The First 50 Years of Molecular Pharmacology

MOLECULAR PHARMACOLOGY

IF3

2015-07-01

OAAI

Brown, Joan Heller; Catterall, William A.; Conn, P. Jeffrey; Cull-Candy, Stuart G.; Dingledine, Ray; Harden, T. Kendall; Insel, Paul A.; Milligan, Graeme; Traynelis, Stephen F.

UDP-Sugars as Extracellular Signaling Molecules: Cellular and Physiologic Consequences of P2Y14 Receptor Activation

MOLECULAR PHARMACOLOGY

IF3

2015-07-01

OAAI

Lazarowski, Eduardo R.; Harden, T. Kendall

Exploring a 2-Naphthoic Acid Template for the Structure-Based Design of P2Y14 Receptor Antagonist Molecular Probes

ACS CHEMICAL BIOLOGY

IF3.8

2014-10-20

OAAI

Kiselev, Evgeny; Barrett, Matthew O.; Katritch, Vsevolod; Paoletta, Silvia; Weitzer, Clarissa D.; Brown, Kyle A.; Hammes, Eva; Yin, Andrew L.; Zhao, Qiang; Stevens, Raymond C.; Harden, T. Kendall; Jacobson, Kenneth A.

Membrane-induced Allosteric Control of Phospholipase C-β Isozymes 膜诱导的磷脂酶c-β 同工酶的变构控制

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2014-10-01

OAAI

Charpentier, Thomas H.; Waldo, Gary L.; Barrett, Matthew O.; Huang, Weigang; Zhang, Qisheng; Harden, T. Kendall; Sondek, John

4-Alkyloxyimino Derivatives of Uridine-5′-triphosphate: Distal Modification of Potent Agonists as a Strategy for Molecular Probes of P2Y2, P2Y4, and P2Y6 Receptors

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2014-04-18

OAAI

Jayasekara, P. Suresh; Barrett, Matthew O.; Ball, Christopher B.; Brown, Kyle A.; Hammes, Eva; Balasubramanian, Ramachandran; Harden, T. Kendall; Jacobson, Kenneth A.

Is GPR17 a P2Y/Leukotriene Receptor? Examination of Uracil Nucleotides, Nucleotide Sugars, and Cysteinyl Leukotrienes as Agonists of GPR17

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2013-10-01

OAAI

Qi, Ai-Dong; Harden, T. Kendall; Nicholas, Robert A.

A Selective High-Affinity Antagonist of the P2Y14 Receptor Inhibits UDP-Glucose-Stimulated Chemotaxis of Human Neutrophils

MOLECULAR PHARMACOLOGY

IF3

2013-07-01

OAAI

Barrett, Matthew O.; Sesma, Juliana I.; Ball, Christopher B.; Jayasekara, P. Suresh; Jacobson, Kenneth A.; Lazarowski, Eduardo R.; Harden, T. Kendall

Small Molecule Inhibitors of Phospholipase C from a Novel High-throughput Screen

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2013-02-01

OAAI

Huang, Weigang; Barrett, Matthew; Hajicek, Nicole; Hicks, Stephanie; Harden, T. Kendall; Sondek, John; Zhang, Qisheng

CELL BIOLOGY G Protein-Coupled Receptor-Mediated Activation of p110β by Gβγ Is Required for Cellular Transformation and Invasiveness

SCIENCE SIGNALING

IF6.6

2012-12-04

144

OAAI

Dbouk, Hashem A.; Vadas, Oscar; Shymanets, Aliaksei; Burke, John E.; Salamon, Rachel S.; Khalil, Bassem D.; Barrett, Mathew O.; Waldo, Gary L.; Surve, Chinmay; Hsueh, Christine; Perisic, Olga; Harteneck, Christian; Shepherd, Peter R.; Harden, T. Kendall; Smrcka, Alan V.; Taussig, Ronald; Bresnick, Anne R.; Nuernberg, Bernd; Williams, Roger L.; Backer, Jonathan M.

Virtual screening leads to the discovery of novel non-nucleotide P2Y1 receptor antagonists

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2012-09-01

OAAI

Costanzi, Stefano; Kumar, T. Santhosh; Balasubramanian, Ramachandran; Harden, T. Kendall; Jacobson, Kenneth A.

The UDP-sugar-sensing P2Y14 receptor promotes Rho-mediated signaling and chemotaxis in human neutrophils

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

IF4.7

2012-09-01

OAAI

Sesma, Juliana I.; Kreda, Silvia M.; Steinckwich-Besancon, Natacha; Dang, Hong; Garcia-Mata, Rafael; Harden, T. Kendall; Lazarowski, Eduardo R.