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J

Jayaraman Chandrasekhar

Gilead Sciences

47H指数
305论文数
5.7W被引数
收录论文 46
发表时间
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Discovery of an Atropisomeric PI3Kβ Selective Inhibitor through Optimization of the Hinge Binding Motif
errACS MEDICINAL CHEMISTRY LETTERS
IF4
err2020-04-13
err12
errOAAI
errPerreault, Stephane; Arjmand, Fatima; Chandrasekhar, Jayaraman; Hao, Jia; Keegan, Kathleen S.; Koditek, David; Lepist, Eve-Irene; Matson, Clinton K.; McGrath, Mary E.; Patel, Leena; Sedillo, Kassandra; Therrien, Joseph; Till, Nicholas A.; Tomkinson, Adrian; Treiberg, Jennifer; Zherebina, Yelena; Phillips, Gary
err分享
err收藏
Discovery of Lanraplenib (GS-9876): A Once-Daily Spleen Tyrosine Kinase Inhibitor for Autoimmune Diseases
errACS MEDICINAL CHEMISTRY LETTERS
IF4
err2020-02-12
err32
errOAAI
errBlomgren, Peter; Chandrasekhar, Jayaraman; Di Paolo, Julie A.; Fung, Wanchi; Geng, Guoju; Ip, Carmen; Jones, Randall; Kropf, Jeffrey E.; Lansdon, Eric B.; Lee, Seung; Lo, Jennifer R.; Mitchell, Scott A.; Murray, Bernard; Pohlmeyer, Chris; Schmitt, Aaron; Suekawa-Pirrone, Kimberly; Wise, Sarah; Xiong, Jin-Ming; Xu, Jianjun; Yu, Helen; Zhao, Zhongdong; Currie, Kevin S.
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err收藏
Atropisomerism by Design: Discovery of a Selective and Stable Phosphoinositide 3-Kinase (PI3K) β Inhibitor
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2018-07-17
err44
PREAI
errChandrasekhar, Jayaraman; Dick, Ryan; Van Veldhuizen, Joshua; Koditek, David; Lepist, Eve-Irene; McGrath, Mary E.; Patel, Leena; Phillips, Gary; Sedillo, Kassandra; Somoza, John R.; Therrien, Joseph; Till, Nicholas A.; Treiberg, Jennifer; Villasenor, Armando G.; Zherebina, Yelena; Perreault, Stephane
err分享
err收藏
Discovery of a Phosphoinositide 3-Kinase (PI3K) β/δ Inhibitor for the Treatment of Phosphatase and Tensin Homolog (PTEN) Deficient Tumors: Building PI3Kβ Potency in a PI3Kδ-Selective Template by Targeting Nonconserved Asp856
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2017-02-07
err34
PREAI
errPerreault, Stephane; Chandrasekhar, Jayaraman; Cui, Zhi-Hua; Evarts, Jerry; Hao, Jia; Kaplan, Joshua A.; Kashishian, Adam; Keegan, Kathleen S.; Kenney, Thomas; Koditek, David; Lad, Latesh; Lepist, Eve-Irene; McGrath, Mary E.; Patel, Leena; Phillips, Bart; Therrien, Joseph; Treiberg, Jennifer; Yahiaoui, Anella; Phillips, Gary
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err收藏
Discovery of Orally Efficacious Phosphoinositide 3-Kinase δ Inhibitors with Improved Metabolic Stability
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2016-10-03
err44
PREAI
errPatel, Leena; Chandrasekhar, Jayaraman; Evarts, Jerry; Forseth, Kristen; Haran, Aaron C.; Ip, Carmen; Kashishian, Adam; Kim, Musong; Koditek, David; Koppenol, Sandy; Lad, Latesh; Lepist, Eve-Irene; McGrath, Mary E.; Perreault, Stephane; Puri, Kamal D.; Villasenor, Armando G.; Somoza, John R.; Steiner, Bart H.; Therrien, Joseph; Treiberg, Jennifer; Phillips, Gary
err分享
err收藏
2,4,6-Triaminopyrimidine as a Novel Hinge Binder in a Series of PI3Kδ Selective Inhibitors
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2016-03-29
err47
PREAI
errPatel, Leena; Chandrasekhar, Jayaraman; Evarts, Jerry; Haran, Aaron C.; Ip, Carmen; Kaplan, Joshua A.; Kim, Musong; Koditek, David; Lad, Latesh; Lepist, Eve-Irene; McGrath, Mary E.; Novikov, Nikolai; Perreault, Stephane; Puri, Kamal D.; Somoza, John R.; Steiner, Bart H.; Stevens, Kirk L.; Therrien, Joseph; Treiberg, Jennifer; Villasenor, Armando G.; Yeung, Arthur; Phillips, Gary
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err收藏
Strategies and tactics for optimizing the Hit-to-Lead process and beyond - A computational chemistry perspective
errDRUG DISCOVERY TODAY
IF7.5
err2008-02-01
err47
PREAI
errManly, Charles J.; Chandrasekhar, Jayaraman; Ochterski, Joseph W.; Hammer, Jack D.; Warfield, Beniamin B.
err分享
err收藏
Contributions of conformational compression and preferential transition state stabilization to the rate enhancement by chorismate mutase
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2003-05-10
err78
PREAI
errGuimaraes, CRW; Repasky, MP; Chandrasekhar, J; Tirado-Rives, J; Jorgensen, WL
err分享
err收藏
Investigation of solvent effects for the Claisen rearrangement of chorismate to prephenate: Mechanistic interpretation via near attack conformations
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2003-05-08
err47
PREAI
errRepasky, MP; Guimaraes, CRW; Chandrasekhar, J; Tirado-Rives, J; Jorgensen, WL
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err收藏
Controlling chemistry with cations: photochemistry within zeolites
errCHEMICAL COMMUNICATIONS
IF4.2
err2003-01-01
err49
PREAI
errRamamurthy, V; Shailaja, J; Kaanumalle, LS; Sunoj, RB; Chandrasekhar, J
err分享
err收藏
Light-induced geometric isomerization of 1,2-diphenylcyclopropanes included within Y zeolites: Role of cation-guest binding
errJOURNAL OF ORGANIC CHEMISTRY
IF3.6
err2002-11-15
err21
PREAI
errKaanumalle, LS; Sivaguru, J; Sunoj, RB; Lakshminarasimhan, PH; Chandrasekhar, J; Ramamurthy, V
err分享
err收藏
Structural effects on the formation of proton and alkali metal ion adducts of apolar, neutral peptides: Electrospray ionization mass spectrometry and ab initio theoretical studies
errCHEMISTRY-A EUROPEAN JOURNAL
IF3.7
err2002-11-04
err13
PREAI
errSudha, R; Panda, M; Chandrasekhar, J; Balaram, P
err分享
err收藏
Direct and sensitized (energy and electron transfer) geometric isomerization of stilbene within zeolites: a comparison between solution and zeolite as reaction media
errJOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
IF4.7
err2002-11-01
err20
PREAI
errLakshminarasimhan, PH; Sunoj, RB; Karthikeyan, S; Chandrasekhar, J; Johnston, LJ; Ramamurthy, V
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err收藏
PDDG/PM3 and PDDG/MNDO: Improved semiempirical methods
errJOURNAL OF COMPUTATIONAL CHEMISTRY
IF4.8
err2002-10-18
err319
PREAI
errRepasky, MP; Chandrasekhar, J; Jorgensen, WL
err分享
err收藏
ABINITIO STUDY OF SILYLENE INSERTION INTO O-H BONDS - STABILITY OF ZWITTERIONIC INTERMEDIATES
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2002-05-01
err49
PREAI
errRAGHAVACHARI, K; CHANDRASEKHAR, J; FRISCH, MJ
err分享
err收藏
ELUSIVENESS OF BISHOMOAROMATICITY IN ANIONIC SYSTEMS - THE BICYCLO[3.2.1]OCTA-3,6-DIEN-2-YL ANION
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2002-05-01
err77
errOAAI
errKAUFMANN, E; MAYR, H; CHANDRASEKHAR, J; SCHLEYER, PV
err分享
err收藏
MAGNITUDE AND ORIGIN OF THE BETA-SILICON EFFECT ON CARBENIUM IONS
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2002-05-01
err345
PREAI
errWIERSCHKE, SG; CHANDRASEKHAR, J; JORGENSEN, WL
err分享
err收藏
ENERGY PROFILE FOR A NONCONCERTED SN2 REACTION IN SOLUTION
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2002-05-01
err211
PREAI
errCHANDRASEKHAR, J; JORGENSEN, WL
err分享
err收藏
LITHIUM-STABILIZED METHANONIUM IONS, CLI5-NHN+ - A THEORETICAL-STUDY
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2002-05-01
err67
PREAI
errSCHLEYER, PV; TIDOR, B; JEMMIS, ED; CHANDRASEKHAR, J; WURTHWEIN, EU; KOS, AJ; LUKE, BT; POPLE, JA
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CUMULATIVE ANOMERIC EFFECT - A THEORETICAL AND X-RAY-DIFFRACTION STUDY OF ORTHOCARBONATES
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2002-05-01
err40
PREAI
errNARASIMHAMURTHY, N; MANOHAR, H; SAMUELSON, AG; CHANDRASEKHAR, J
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研究方向

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合作学者
合作期刊
A
Alex K.‐Y. Jen
H 指数: 160 · 论文数: 1.3K
J
John A. Pople
H 指数: 142 · 论文数: 735
W
William L. Jorgensen
H 指数: 120 · 论文数: 781
G
George A. Olah
H 指数: 107 · 论文数: 2.2K
M
Michael J. Frisch
H 指数: 98 · 论文数: 354
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