未登录 Drug-Fc conjugate CD388 targets influenza virus neuraminidase and is broadly protective in mice Drug-Fc conjugate CD388靶向流感病毒神经氨酸酶，并在小鼠中具有广泛的保护作用。 Dohrmann, Simon; Levin, James; Cole, Jason N.; Borchardt, Allen; Amundson, Karin; Almaguer, Amanda; Abelovski, Elizabeth; Grewal, Rajvir; Zuill, Douglas; Dedeic, Nicholas; Hough, Grayson; Fortier, Joanne; Donatelli, Joanna; Lam, Thanh; Chen, Zhi-Yong; Jiang, Wanlong; Haussener, Travis; Noncovich, Alain; Balkovec, James M.; Bensen, Daniel C.; Ong, Voon; Brady, Thomas P.; Locke, Jeffrey B.; Flanagan, Shawn; Hughes, Robert M.; Stein, Jeffrey L.; Tari, Leslie W. 分享 收藏
CTC-177, a novel drug-Fc conjugate, shows promise as an immunoprophylactic agent against multidrug-resistant Gram-negative bacterial infections Lovey, Arianne; Lee, Annie; Yu, Allison; Krel, Mila; Wang, Mingming; Paderu, Padmaja; Brady, Thomas; Hough, Grayson; Zhao, Qiping; Balkovec, James M.; Perlin, David S.; Zhao, Yanan 分享 收藏
Development of Novel Immunoprophylactic Agents against Multidrug-Resistant Gram-Negative Bacterial Infections 抗多药耐药革兰氏阴性菌感染的新型免疫预防剂的开发 Lovey, Arianne; Krel, Mila; Borchardt, Allen; Brady, Thomas; Cole, Jason N.; Do, Quyen-Quyen; Fortier, Joanne; Hough, Grayson; Jiang, Wanlong; Noncovich, Alain; Tari, Les; Zhao, Qiping; Balkovec, James M.; Zhao, Yanan; Perlin, David S. 分享 收藏
Bifunctional Small Molecules Enhance Neutrophil Activities Against Aspergillus fumigatus in vivo and in vitro Jones, Caroline N.; Ellett, Felix; Robertson, Anne L.; Forrest, Kevin M.; Judice, Kevin; Balkovec, James M.; Springer, Martin; Markmannm, James F.; Vyas, Jatin M.; Warren, H. Shaw; Irimia, Daniel 分享 收藏
Microscale High-Throughput Experimentation as an Enabling Technology in Drug Discovery: Application in the Discovery of (Piperidinyl)pyridinyl-1H-benzimidazole Diacylglycerol Acyltransferase 1 Inhibitors Cernak, Tim; Gesmundo, Nathan J.; Dykstra, Kevin; Yu, Yang; Wu, Zhicai; Shi, Zhi-Cai; Vachal, Petr; Sperbeck, Donald; He, Shuwen; Murphy, Beth Ann; Sonatore, Lisa; Williams, Steven; Madeira, Maria; Verras, Andreas; Reiter, Maud; Lee, Claire Heechoon; Cuff, James; Sherer, Edward C.; Kuethe, Jeffrey; Goble, Stephen; Perrotto, Nicholas; Pinto, Shirly; Shen, Dong-Ming; Nargund, Ravi; Balkovec, James; DeVita, Robert J.; Dreher, Spencer D. 分享 收藏
Preclinical Evaluation of the Stability, Safety, and Efficacy of CD101, a Novel Echinocandin Ong, Voon; Hough, Grayson; Schlosser, Michael; Bartizal, Ken; Balkovec, James M.; James, Kenneth D.; Krishnan, B. Radha 分享 收藏
Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety He, Shuwen; Hong, Qingmei; Lai, Zhong; Yang, David X.; Ting, Pauline C.; Kuethe, Jeffrey T.; Cernak, Timothy A.; Dykstra, Kevin D.; Sperbeck, Donald M.; Wu, Zhicai; Yu, Yang; Yang, Ginger X.; Jian, Tianying; Liu, Jian; Guiadeen, Deodial; Krikorian, Arto D.; Sonatore, Lisa M.; Wiltsie, Judyann; Liu, Jinqi; Gorski, Judith N.; Chung, Christine C.; Gibson, Jack T.; Lisnock, JeanMarie; Xiao, Jianying; Wolff, Michael; Tong, Sharon X.; Madeira, Maria; Karanam, Bindhu V.; Shen, Dong-Ming; Balkovec, James M.; Pinto, Shirly; Nargund, Ravi P.; DeVita, Robert J. 分享 收藏
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Potent DGAT1 Inhibitors in the Benzimidazole Class with a Pyridyl-oxy-cyclohexanecarboxylic Acid Moiety He, Shuwen; Hong, Qingmei; Lai, Zhong; Wu, Zhicai; Yu, Yang; Kim, David W.; Ting, Pauline C.; Kuethe, Jeffrey T.; Yang, Ginger X.; Jian, Tianying; Liu, Jian; Guiadeen, Deodial; Krikorian, Arto D.; Sperbeck, Donald M.; Sonatore, Lisa M.; Wiltsie, Judyann; Chung, Christine C.; Gibson, Jack T.; Lisnock, JeanMarie; Murphy, Beth A.; Gorski, Judith N.; Liu, Jinqi; Chen, Dunlu; Chen, Xiaoli; Wolff, Michael; Tong, Sharon X.; Madeira, Maria; Karanam, Bindhu V.; Shen, Dong-Ming; Balkovec, James M.; Pinto, Shiny; Nargund, Ravi P.; DeVita, Robert J. 分享 收藏
Pharmacological Inhibition of Diacylglycerol Acyltransferase 1 Reduces Body Weight and Modulates Gut Peptide Release-Potential Insight into Mechanism of Action Liu, Jinqi; Gorski, Judith N.; Gold, Stephen J.; Chen, Dunlu; Chen, Shirley; Forrest, Gail; Itoh, Yoshiki; Marsh, Donald J.; McLaren, David G.; Shen, Zhu; Sonatore, Lisa; Carballo-Jane, Ester; Craw, Stephanie; Guan, Xiaoming; Karanam, Bindhu; Sakaki, Junichi; Szeto, Daphne; Tong, Xinchun; Xiao, Jianying; Yoshimoto, Ryo; Yu, Hong; Roddy, Thomas P.; Balkovec, James; Pinto, Shirly 分享 收藏
The use of stable-isotopically labeled oleic acid to interrogate lipid assembly in vivo: assessing pharmacological effects in preclinical species McLaren, David G.; He, Timothy; Wang, Sheng-Ping; Mendoza, Vivienne; Rosa, Raymond; Gagen, Karen; Bhat, Gowri; Herath, Kithsiri; Miller, Paul L.; Stribling, Sloan; Taggart, Andrew; Imbriglio, Jason; Liu, Jinqi; Chen, Dunlu; Pinto, Shirly; Balkovec, James M.; DeVita, Robert J.; Marsh, Donald J.; Castro-Perez, Jose M.; Strack, Alison; Johns, Douglas G.; Previs, Stephen F.; Hubbard, Brian K.; Roddy, Thomas P. 分享 收藏
Discovery of betamethasone 17α-carbamates as dissociated glucocorticoid receptor modulators in the rat Ali, Amjad; Balkovec, James M.; Greenlee, Mark; Hammond, Milton L.; Rouen, Greg; Taylor, Gayle; Einstein, Monica; Ge, Lan; Harris, Georgianna; Kelly, Terri M.; Mazur, Paul; Pandit, Shilpa; Santoro, Joseph; Sitlani, Ayesha; Wang, Chuanlin; Williamson, Joann; Forrest, Michael J.; Carballo-Jane, Ester; Luell, Silvi; Lowitz, Karen; Visco, Denise 分享 收藏
11β-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice Hermanowski-Vosatka, A; Balkovec, JM; Cheng, K; Chen, HY; Hernandez, M; Koo, GC; Le Grand, CB; Li, ZH; Metzger, JM; Mundt, SS; Noonan, H; Nunes, CN; Olson, SH; Pikounis, B; Ren, N; Robertson, N; Schaeffer, JM; Shah, K; Springer, MS; Strack, AM; Strowski, M; Wu, K; Wu, TJ; Xiao, JY; Zhang, BB; Wright, SD; Thieringer, R 分享 收藏
Novel N-arylpyrazolo[3,2-c]-based ligands for the glucocorticoid receptor:: Receptor binding and in vivo activity Ali, A; Thompson, CF; Balkovec, JM; Graham, DW; Hammond, ML; Quraishi, N; Tata, JR; Einstein, M; Ge, L; Harris, G; Kelly, TM; Mazur, P; Pandit, S; Santoro, J; Sitlani, A; Wang, CL; Williamson, J; Miller, DK; Thompson, CM; Zaller, DM; Forrest, MJ; Carballo-Jane, E; Luell, S 分享 收藏
SYNTHESIS AND ANTIFUNGAL ACTIVITY OF NOVEL CATIONIC PNEUMOCANDIN B-O DERIVATIVES BOUFFARD, FA; ZAMBIAS, RA; DROPINSKI, JF; BALKOVEC, JM; HAMMOND, ML; ABRUZZO, GK; BARTIZAL, KF; MARRINAN, JA; KURTZ, MB; MCFADDEN, DC; NOLLSTADT, KH; POWLES, MA; SCHMATZ, DM 分享 收藏
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Succinic acids as potent inhibitors of plasmid-borne IMP-1 metallo-β-lactamase Toney, JH; Hammond, GG; Fitzgerald, PMD; Sharma, N; Balkovec, JM; Rouen, GP; Olson, SH; Hammond, ML; Greenlee, ML; Gao, YD 分享 收藏
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