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P

Peter D. J. Grootenhuis

vertex pharmaceuticals

36H指数
203论文数
7.7K被引数
收录论文 24
发表时间
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Insights into regioselective metabolism of mefenamic acid by Cytochrome P450 BM3 mutants through crystallography, docking, molecular dynamics, and free energy calculations
errPROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
IF2.8
err2016-02-03
err31
PREAI
errCapoferri, Luigi; Leth, Rasmus; ter Haar, Ernst; Mohanty, Arun K.; Grootenhuis, Peter D. J.; Vottero, Eduardo; Commandeur, Jan N. M.; Vermeulen, Nico P. E.; Jorgensen, Flemming Steen; Olsen, Lars; Geerke, Daan P.
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Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2011-10-05
err975
errOAAI
errVan Goor, Fredrick; Hadida, Sabine; Grootenhuis, Peter D. J.; Burton, Bill; Stack, Jeffrey H.; Straley, Kimberly S.; Decker, Caroline J.; Miller, Mark; McCartney, Jason; Olson, Eric R.; Wine, Jeffrey J.; Frizzell, Ray A.; Ashlock, Melissa; Negulescu, Paul A.
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Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2009-11-03
err1.1K
errOAAI
errVan Goor, Fredrick; Hadida, Sabine; Grootenhuis, Peter D. J.; Burton, Bill; Cao, Dong; Neuberger, Tim; Turnbull, Amanda; Singh, Ashvani; Joubran, John; Hazlewood, Anna; Zhou, Jinglan; McCartney, Jason; Arumugam, Vijayalaksmi; Decker, Caroline; Yang, Jennifer; Young, Chris; Olson, Eric R.; Wine, Jeffery J.; Frizzell, Raymond A.; Ashlock, Melissa; Negulescu, Paul
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Rescue of ΔF508-CFTR trafficking and gating in human cystic fibrosis airway primary cultures by small molecules
errAMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
IF3.5
err2006-06-01
err529
PREAI
errVan Goor, F; Straley, KS; Cao, D; González, J; Hadida, S; Hazlewood, A; Joubran, J; Knapp, T; Makings, LR; Miller, M; Neuberger, T; Olson, E; Panchenko, V; Rader, J; Singh, A; Stack, JH; Tung, R; Grootenhuis, PDJ; Negulescu, P
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Synthesis and biological evaluation of a backbone-modified phytoalexin elicitor
errCHEMISTRY-A EUROPEAN JOURNAL
IF3.7
err2006-01-20
err42
PREAI
errTimmers, CM; Turner, JJ; Ward, CM; vanderMarel, GA; Kouwijzer, MLCE; Grootenhuis, PDJ; vanBoom, JH
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Water-soluble molecular capsules: Self-assembly and binding properties
errCHEMISTRY-A EUROPEAN JOURNAL
IF3.7
err2004-12-15
err88
PREAI
errCorbellini, F; Knegtel, RMA; Grootenhuis, PDJ; Crego-Calama, M; Reinhoudt, DN
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N-phenylphenylglycines as novel corticotropin releasing factor receptor antagonists
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2004-04-10
err21
PREAI
errMolteni, V; Penzotti, J; Wilson, DM; Termin, AP; Mao, L; Crane, CM; Hassman, F; Wang, T; Wong, H; Miller, KJ; Grossman, S; Grootenhuis, PDJ
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Performance of 3D-database molecular docking studies into homology models
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2004-01-03
err97
PREAI
errOshiro, C; Bradley, EK; Eksterowicz, J; Evensen, E; Lamb, ML; Lanctot, JK; Putta, S; Stanton, R; Grootenhuis, PDJ
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Comparing performance of computational tools for combinatorial library design
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2003-10-18
err17
PREAI
errEvensen, E; Eksterowicz, JE; Stanton, RV; Oshiro, C; Grootenhuis, PDJ; Bradley, EK
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Informative library design as an efficient strategy to identify and optimize leads: Application to cyclin-dependent kinase 2 antagonists
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2003-08-30
err32
PREAI
errBradley, EK; Miller, JL; Saiah, E; Grootenhuis, PDJ
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Unique overlap in the prerequisites for thrombin inhibition and oral Bioavailability resulting in potent oral antithrombotics
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2002-08-30
err40
PREAI
errAdang, AEP; de Man, APA; Vogel, GMT; Grootenhuis, PDJ; Smit, MJ; Peters, CAM; Visser, A; Rewinkel, JBM; van Dinther, T; Lucas, H; Kelder, J; van Aelst, S; Meuleman, DG; van Boeckel, CAA
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Evaluation of a novel shape-based computational filter for lead evolution: Application to thrombin inhibitors
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2002-05-07
err37
PREAI
errSrinivasan, J; Castellino, A; Bradley, EK; Eksterowicz, JE; Grootenhuis, PDJ; Putta, S; Stanton, RV
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CONSTRUCTING A MOLECULAR-MODEL OF THE INTERACTION BETWEEN ANTITHROMBIN-III AND A POTENT HEPARIN ANALOG
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2002-05-01
err94
PREAI
errGROOTENHUIS, PDJ; VANBOECKEL, CAA
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COMPUTATIONAL STUDY OF THE STRUCTURAL, ENERGETICAL, AND ACID-BASE PROPERTIES OF CALIX[4]ARENES
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2002-05-01
err325
PREAI
errGROOTENHUIS, PDJ; KOLLMAN, PA; GROENEN, LC; REINHOUDT, DN; VANHUMMEL, GJ; UGOZZOLI, F; ANDREETTI, GD
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COMPLEXES OF MACROCYCLIC POLYETHERS AND NEUTRAL GUEST MOLECULES - A SYSTEMATIC-APPROACH TO THE COMPLEXATION OF WATER-MOLECULES BY 2,6-PYRIDINIUM CROWN ETHERS
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2002-05-01
err79
PREAI
errGROOTENHUIS, PDJ; UITERWIJK, JWHM; REINHOUDT, DN; VANSTAVEREN, CJ; SUDHOLTER, EJR; BOS, M; VANEERDEN, J; KLOOSTER, WT; KRUISE, L; HARKEMA, S
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PATHWAYS FOR CONFORMATIONAL INTERCONVERSION OF CALIX[4]ARENES
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2002-05-01
err112
errOAAI
errFISCHER, S; GROOTENHUIS, PDJ; GROENEN, LC; VANHOORN, WP; VANVEGGEL, FCJM; REINHOUDT, DN; KARPLUS, M
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COMPLEXATION OF NEUTRAL MOLECULES BY PREORGANIZED MACROCYCLIC HOSTS
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2002-05-01
err29
PREAI
errGROOTENHUIS, PDJ; VANEERDEN, J; DIJKSTRA, PJ; HARKEMA, S; REINHOUDT, DN
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Arylamidrazones as novel corticotropin releasing factor receptor antagonists
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2002-04-26
err25
PREAI
errWilson, DM; Termin, AP; Mao, L; Ramirez-Weinhouse, MM; Molteni, V; Grootenhuis, PDJ; Miller, K; Keim, S; Wise, G
err分享
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A computational ensemble pharmacophore model for identifying substrates of P-glycoprotein
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2002-03-26
err179
PREAI
errPenzotti, JE; Lamb, ML; Evensen, E; Grootenhuis, PDJ
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A rapid computational method for lead evolution:: Description and application to α1-adrenergic antagonists
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2000-06-21
err61
PREAI
errBradley, EK; Beroza, P; Penzotti, JE; Grootenhuis, PDJ; Spellmeyer, DC; Miller, JL
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研究方向

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合作学者
合作期刊
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Martin Karplus
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B
Ben L. Feringa
H 指数: 147 · 论文数: 1.7K
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David N. Reinhoudt
H 指数: 116 · 论文数: 1.9K
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Peter A. Kollman
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M
Mark A. Miller
H 指数: 78 · 论文数: 356
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