John P. Mathias - Publications, H-index & Citations

John P. Mathias

pfizer usa

26H指数

87论文数

6.9K被引数

收录论文 13

发表时间

Discovery of a Series of Pyrimidine Carboxamides as Inhibitors of Vanin-1 一系列嘧啶甲酰胺类Vanin-1抑制剂的发现

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2021-12-30

PREAI

Casimiro-Garcia, Agustin; Allais, Christophe; Brennan, Agnes; Choi, Chulho; Dower, Gabriela; Farley, Kathleen A.; Fleming, Margaret; Flick, Andrew; Frisbie, Richard K.; Hall, Justin; Hepworth, David; Jones, Hannah; Knafels, John D.; Kortum, Steve; Lovering, Frank E.; Mathias, John P.; Mohan, Sashi; Morgan, Paul M.; Parng, Chuenlei; Parris, Kevin; Pullen, Nick; Schlerman, Franklin; Stansfield, John; Strohbach, Joseph W.; Vajdos, Felix F.; Vincent, Fabien; Wang, Hong; Wang, Xiaolun; Webster, Robert; Wright, Stephen W.

Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment -Based Drug Design

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2017-06-14

125

PREAI

Lee, Katherine L.; Ambler, Catherine M.; Anderson, David R.; Boscoe, Brian P.; Bree, Andrea G.; Brodfuehrer, Joanne I.; Chang, Jeanne S.; Choi, Chulho; Chung, Seungwon; Curran, Kevin J.; Day, Jacqueline E.; Dehnhardt, Christoph M.; Dower, Ken; Drozda, Susan E.; Frisbie, Richard K.; Gavrin, Lori K.; Goldberg, Joel A.; Han, Seungil; Hegen, Martin; Hepworth, David; Hope, Heidi R.; Kamtekar, Satwik; Kilty, Iain C.; Lee, Arthur; Ling, Lih-Ling; Lovering, Frank E.; Lowe, Michael D.; Mathias, John P.; Morgan, Heidi M.; Murphy, Elizabeth A.; Papaioannou, Nikolaos; Patny, Akshay; Pierce, Betsy S.; Rao, Vikram R.; Saiah, Eddine; Samardjiev, Ivan J.; Samas, Brian M.; Shen, Marina W. H.; Shin, Julia H.; Soutter, Holly H.; Strohbach, Joseph W.; Symanowicz, Peter T.; Thomason, Jennifer R.; Trzupek, John D.; Vargas, Richard; Vincent, Fabien; Yan, Jiangli; Zapf, Christoph W.; Wright, Stephen W.

Selectively targeting an inactive conformation of interleukin-2-inducible T-cell kinase by allosteric inhibitors 变构抑制剂选择性靶向interleukin-2-inducible T细胞激酶的非活性构象

BIOCHEMICAL JOURNAL

IF4.3

2014-05-13

PREAI

Han, Seungil; Czerwinski, Robert M.; Caspers, Nicole L.; Limburg, David C.; Ding, WeiDong; Wang, Hong; Ohren, Jeffrey F.; Rajamohan, Francis; McLellan, Thomas J.; Unwalla, Ray; Choi, Chulho; Parikh, Mihir D.; Seth, Nilufer; Edmonds, Jason; Phillips, Chris; Shakya, Subarna; Li, Xin; Spaulding, Vikki; Hughes, Samantha; Cook, Andrew; Robinson, Colin; Mathias, John P.; Navratilova, Iva; Medley, Quintus G.; Anderson, David R.; Kurumbail, Ravi G.; Aulabaugh, Ann

Plate-based diversity subset screening: an efficient paradigm for high throughput screening of a large screening file

MOLECULAR DIVERSITY

IF3.8

2013-04-05

PREAI

Bell, Andrew S.; Bradley, Joseph; Everett, Jeremy R.; Knight, Michelle; Loesel, Jens; Mathias, John; McLoughlin, David; Mills, James; Sharp, Robert E.; Williams, Christine; Wood, Terence P.

Shaping a Screening File for Maximal. Lead Discovery Efficiency and Effectiveness: Elimination of Molecular Redundancy

JOURNAL OF CHEMICAL INFORMATION AND MODELING

IF5.3

2012-10-31

OAAI

Bakken, Gregory A.; Bell, Andrew S.; Boehm, Markus; Everett, Jeremy R.; Gonzales, Rosalia; Hepworth, David; Klug-McLeod, Jacquelyn L.; Lanfear, Jeremy; Loesel, Jens; Mathias, John; Wood, Terence P.

The discovery of UK-369003, a novel PDE5 inhibitor with the potential for oral bioavailability and dose-proportional pharmacokinetics

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2012-01-01

PREAI

Rawson, David J.; Ballard, Stephen; Barber, Christopher; Barker, Laura; Beaumont, Kevin; Bunnage, Mark; Cole, Susan; Corless, Martin; Denton, Stephen; Ellis, David; Floc'h, Marion; Foster, Laura; Gosset, James; Holmwood, Frances; Lane, Charlotte; Leahy, David; Mathias, John; Maw, Graham; Million, William; Poinsard, Cedric; Price, Jenny; Russel, Rachel; Street, Stephen; Watson, Lesa

Design and Synthesis of Inhaled p38 Inhibitors for the Treatment of Chronic Obstructive Pulmonary Disease

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2011-10-28

115

PREAI

Millan, David S.; Bunnage, Mark E.; Burrows, Jane L.; Butcher, Kenneth J.; Dodd, Peter G.; Evans, Timothy J.; Fairman, David A.; Hughes, Samantha J.; Kilty, Iain C.; Lemaitre, Arnaud; Lewthwaite, Russell A.; Mahnke, Axel; Mathias, John P.; Philip, James; Smith, Robert T.; Stefaniak, Mark H.; Yeadon, Michael; Phillips, Christopher

SELF-ASSEMBLY THROUGH HYDROGEN-BONDING - PREPARATION AND CHARACTERIZATION OF 3 NEW TYPES OF SUPRAMOLECULAR AGGREGATES BASED ON PARALLEL CYCLIC CA3.M3 ROSETTES

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2002-05-01

144

PREAI

MATHIAS, JP; SETO, CT; SIMANEK, EE; WHITESIDES, GM

MOLECULAR LEGO .1. SUBSTRATE-DIRECTED SYNTHESIS VIA STEREOREGULAR DIELS-ALDER OLIGOMERIZATIONS

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2002-05-01

198