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High target binding affinity with long lasting cellular target engagement and high dose intermittent schedule of PI3K inhibitor copanlisib contribute to the potent anti-tumor activity and good safety profile Fernandez-Montalvan, Amaury E.; Georgi, Victoria; Vasta, James; Glaeske, Sarah; Puetter, Vera; Robers, Matthew B.; Moenning, Ursula; Sturz, Andrea; Lefranc, Julien; Ziegelbauer, Karl; Brands, Michael; Stegmann, Christian; Scott, William J.; Liu, Ningshu 分享 收藏
BAY 1125976, a selective allosteric AKT1/2 inhibitor, exhibits high efficacy on AKT signaling-dependent tumor growth in mouse models Politz, Oliver; Siegel, Franziska; Baerfacker, Lars; Boemer, Ulf; Haegebarth, Andrea; Scott, William J.; Michels, Martin; Ince, Stuart; Neuhaus, Roland; Meyer, Kirstin; Fernandez-Montalvan, Amaury Ernesto; Liu, Ningshu; von Nussbaum, Franz; Mumberg, Dominik; Ziegelbauer, Karl 分享 收藏
Second generation 2,3-dihydroimidazo[1,2-c]quinazoline P13K inhibitors: development of BAY 1082439, a novel balanced PI3Ka/PI3Ka inhibitor Scott, William J.; Liu, Ningshu; Hagebarth, Andreas; Mowes, Manfred; Monning, Ursula; Bonner, Ulf; Mumberg, Dominik; von Nussbaum, Franz; Brands, Michael; Lafranc, Julien 分享 收藏
Discovery and SAR of Novel 2,3-Dihydroimidazo[1,2-c]-quinazoline PI3K Inhibitors: Identification of Copanlisib (BAY 80-6946) 新型2，3-二氢咪唑并 [1，2-c]-喹唑啉PI3K抑制剂的发现和SAR: Copanlisib (BAY 80-6946) 的鉴定 Scott, William J.; Hentemann, Martin F.; Rowley, R. Bruce; Bull, Cathy O.; Jenkins, Susan; Bullion, Ann M.; Johnson, Jeffrey; Redman, Aniko; Robbins, Arthur H.; Esler, William; Fracasso, R. Paul; Garrison, Timothy; Hamilton, Mark; Michels, Martin; Wood, Jill E.; Wilkie, Dean P.; Xiao, Hong; Levy, Joan; Stasik, Enrico; Liu, Ningshu; Schaefer, Martina; Brands, Michael; Lefranc, Julien 分享 收藏
BAY 80-6946 Is a Highly Selective Intravenous PI3K Inhibitor with Potent p110α and p110δ Activities in Tumor Cell Lines and Xenograft Models BAY 80-6946是一种高度选择性的静脉内PI3K抑制剂，在肿瘤细胞系和异种移植模型中具有有效的p110α 和p110δ 活性 Liu, Ningshu; Rowley, Bruce R.; Bull, Cathy O.; Schneider, Claudia; Haegebarth, Andrea; Schatz, Christoph A.; Fracasso, Paul R.; Wilkie, Dean P.; Hentemann, Martin; Wilhelm, Scott M.; Scott, William J.; Mumberg, Dominik; Ziegelbauer, Karl 分享 收藏
BAY 1082439, a highly selective and balanced PI3Kα/β inhibitor demonstrated potent activity in tumors with activated PI3Kα and loss-of-function of PTEN Liu, Ningshu; Scott, William J.; Haegebarth, Andrea; Moenning, Ursula; Fricke, Robert; Boemer, Ulf; Bruening, Michael; Mumberg, Dominik; Brands, Michael; Ziegelbauer, Karl 分享 收藏
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Replicated anterior zeugopod (raz):: a polydactylous mouse mutant with lowered Shh signaling in the limb bud Krebs, O; Schreiner, CM; Scott, WJ; Bell, SM; Robbins, DJ; Goetz, JA; Alt, H; Hawes, N; Wolf, E; Favor, J 分享 收藏
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