Tzuling Cheng - Publications, H-index & Citations

Tzuling Cheng

arcus biosciences, hayward, california, usa

13H指数

43论文数

5.8K被引数

收录论文 15

发表时间

Pharmacokinetics, pharmacodynamics and safety of casdatifan, a novel hypoxia-inducible factor-2α inhibitor, in healthy participants 卡萨地芬（casdatifan）的药代动力学、药效动力学和安全性研究，该药物是一种新型缺氧诱导因子-2α抑制剂，研究对象为健康受试者。

British Journal of Clinical Pharmacology

IF3

2025-07-27

OAAI

Mohammad Ghasemi; Ji Yun Kim; Lisa Seitz; Lixia Jin; Paul G. Foster; Kai H. Liao; Tzuling Cheng; Elaine Paterson; Maria Velinova; Nicole Rivera Rosario; Reza Khosravan; Balaji Agoram

Discovery and characterization of Casdatifan (AB521), a clinical-stage, potent, and selective Hypoxia-Inducible Factor (HIF)-2α inhibitor

MOLECULAR CANCER THERAPEUTICS

IF5.5

2024-12-09

PREAI

Lawson, Kenneth V.; Mailyan, Artur; Mata, Guillaume; Beatty, Joel W.; Drew, Samuel L.; Fournier, Jeremy T. A.; Kalisiak, Jaroslaw; Tran, Ahn T.; Yu, Kai; Rosen, Brandon R.; Hardman, Clayton; Epplin, Matthew; Sivick, Kelsey E.; Piovesan, Dana; Liu, Suan; Ginn, Elain; Meleza, Cesar A.; Seitz, Lisa; Cheng, Tzuling; Pham, Amber; Ghasemi, Mohammad; Foster, Paul G.; Walters, Matthew J.; Leleti, Manmohan; Powers, Jay P.

Targeting hypoxia inducible factor (HIF)-2α with AB521, a novel and potent small molecule HIF-2α inhibitor, for the treatment of clear cell renal cell carcinoma

CANCER RESEARCH

IF16.6

2023-08-15

PREAI

Piovesan, Dana; Cho, Soonweng; Lawson, Kenneth V.; Liao, Kai H.; Foster, Paul G.; Cheng, Tzuling; Walters, Matthew J.; Gauthier, Kelsey E. Sivick

Glutaminase isoforms expression switches microRNA levels and oxidative status in glioblastoma cells

JOURNAL OF BIOMEDICAL SCIENCE

IF12.1

2021-02-20

OAAI

de los Santos-jimenez, Juan; Campos-Sandoval, Jose A.; Marquez-Torres, Clara; Urbano-Polo, Nieves; Brondegaard, David; Martin-Rufian, Mercedes; Lobo, Carolina; Penalver, Ana; Gomez-Garcia, Maria C.; Martin-Campos, Janet; Cardona, Carolina; Castilla, Laura; da Costa Souza, Felipe; Cheng, Tzuling; Segura, Juan A.; Alonso, Francisco J.; Curi, Rui; Colquhoun, Alison; DeBerardinis, Ralph J.; Marquez, Javier; Mates, Jose M.

Listen Before Receive (LBR) Assisted Network Access in LAA and WiFi Heterogeneous Networks

IEEE ACCESS

IF3.6

2021-01-01

OAAI

Huang, Chin-Ya; Chen, Hsueh-Yi; Huang, Chen-Hao; Sheu, Shiann-Tsong; Chiang, Te-Wei; Cheng, Tzu-Ling; Chang, Chen-Chi

Design and Activity of Specific Hypoxia-Inducible Factor-2α (HIF-2α) Inhibitors for the Treatment of Clear Cell Renal Cell Carcinoma: Discovery of Clinical Candidate (S)-3-((2,2-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile (PT2385)

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2018-10-05

PREAI

Wehn, Paul M.; Rizzi, James P.; Dixon, Darryl D.; Grina, Jonas A.; Schlachter, Stephen T.; Wang, Bin; Xu, Rui; Yang, Hanbiao; Du, Xinlin; Han, Guangzhou; Wang, Keshi; Cao, Zhaodan; Cheng, Tzuling; Czerwinski, Robert M.; Goggin, Barry S.; Huang, Heli; Halfmann, Megan M.; Maddie, Melissa A.; Morton, Emily L.; Olive, Sarah R.; Tan, Huiling; Xie, Shanhai; Wong, Tai; Josey, John A.; Wallace, Eli M.

PARG inhibitors exhibit synthetic lethality with XRCC1 deficiency and a cellular mechanism of action that is distinct from PARP inhibition

CANCER RESEARCH

IF16.6

2018-07-01

PREAI

Martin, Leenus; Cheng, Tzuling; James, Dominic I.; Begum, Habiba; Smith, Kate M.; Jordan, Allan; Waddell, Ian; Vaidya, Kedar; Fischer, Marcus; Yao, Bing; Drummond, Jason; Cleary, Leah; Martinez, Ruben; Sutton, James; Ravindran, Nandini; Joseph, James; Venetsanakos, Eleni; Dillon, Michael; Hager, Jeffrey H.; Belmont, Lisa D.

PT2977, a novel HIF-2a antagonist, has potent antitumor activity and remodels the immunosuppressive tumor microenvironment in clear cell renal cell cancer

MOLECULAR CANCER THERAPEUTICS

IF5.5

2018-01-01

PREAI

Wong, Tai W.; Shrimali, Rajeev; Contreras, Cristina; Cheng, Tzuling; Czerwinski, Robert M.; Dixon, Daryl D.; Du, Xinlin; Fett, Craig; Goree, Jessica; Grina, Jonas A.; Han, Guangzhou; Huang, Heli; Rizzi, Jim; Schlachter, Stephen T.; Wang, Bin; Wang, Keshi; Wehn, Paul M.; Xie, Shanhai; Xu, Rui; Yang, Hanbiao; Josey, John A.; Wallace, Eli M.

A Small-Molecule Antagonist of HIF2α Is Efficacious in Preclinical Models of Renal Cell Carcinoma

CANCER RESEARCH

IF16.6

2016-09-15

253

OAAI

Wallace, Eli M.; Rizzi, James P.; Han, Guangzhou; Wehn, Paul M.; Cao, Zhaodan; Du, Xinlin; Cheng, Tzuling; Czerwinski, Robert M.; Dixon, Darryl D.; Goggin, Barry S.; Grina, Jonas A.; Halfmann, Megan M.; Maddie, Melissa A.; Olive, Sarah R.; Schlachter, Stephen T.; Tan, Huiling; Wang, Bin; Wang, Keshi; Xie, Shanhai; Xu, Rui; Yang, Hanbiao; Josey, John A.

PT2385: First-in-class HIF-2α antagonist for the treatment of renal cell carcinoma

CANCER RESEARCH

IF16.6

2015-08-01

PREAI

Wallace, Eli M.; Cao, Zhaodan; Cheng, Tzuling; Czerwinski, Robert; Dixon, Darryl D.; Du, Xinlin; Goggin, Barry; Grina, Jonas; Halfmann, Megan; Han, Guangzhou; Huang, Heli; Josey, John A.; Maddie, Melissa A.; Olive, Sarah; Rizzi, James; Schlachter, Stephen T.; Tan, Hui-Ling; Wang, Bin; Wang, Keshi; Wehn, Paul M.; Xie, Shanhai; Xu, Rui; Yang, Hanbiao

Pyruvate carboxylase is required for glutamine-independent growth of tumor cells 肿瘤细胞的谷氨酰胺非依赖性生长需要丙酮酸羧化酶

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2011-05-09

417

OAAI

Cheng, Tzuling; Sudderth, Jessica; Yang, Chendong; Mullen, Andrew R.; Jin, Eunsook S.; Mates, Jose M.; DeBerardinis, Ralph J.

TBK1 Directly Engages Akt/PKB Survival Signaling to Support Oncogenic Transformation

MOLECULAR CELL

IF16.6

2011-02-01

214

OAAI

Ou, Yi-Hung; Torres, Michael; Ram, Rosalyn; Formstecher, Etienne; Roland, Christina; Cheng, Tzuling; Brekken, Rolf; Wurz, Ryan; Tasker, Andrew; Polverino, Tony; Tan, Seng-Lai; White, Michael A.

Comprehensive Mapping of the Human Kinome to Epidermal Growth Factor Receptor Signaling

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2010-07-01

OAAI

Komurov, Kakajan; Padron, David; Cheng, Tzuling; Roth, Michael; Rosenblatt, Kevin P.; White, Michael A.

Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer Q的下一个: 谷氨酰胺在代谢，细胞生物学和癌症中的多种功能

ONCOGENE

IF7.3

2009-11-02

1.2K

OAAI

DeBerardinis, R. J.; Cheng, T.

Substrate and functional diversity of lysine acetylation revealed by a proteomics survey

MOLECULAR CELL

IF16.6

2006-08-01

1.5K

OAAI

Kim, Sung Chan; Sprung, Robert; Chen, Yue; Xu, Yingda; Ball, Haydn; Pei, Jimin; Cheng, Tzuling; Kho, Yoonjung; Xiao, Hao; Xiao, Lin; Grishin, Nick V.; White, Michael; Yang, Xiang-Jiao; Zhao, Yingming

研究方向