Michael R. Waterman - Publications, H-index & Citations

Michael R. Waterman

vanderbilt university

81H指数

460论文数

2.7W被引数

收录论文 49

发表时间

Concerning P450 Evolution: Structural Analyses Support Bacterial Origin of Sterol 14α-Demethylases

MOLECULAR BIOLOGY AND EVOLUTION

IF5.3

2020-10-08

OAAI

Lamb, David C.; Hargrove, Tatiana Y.; Zhao, Bin; Wawrzak, Zdzislaw; Goldstone, Jared, V; Nes, William David; Kelly, Steven L.; Waterman, Michael R.; Stegeman, John J.; Lepesheva, Galina, I

Binding of a physiological substrate causes large-scale conformational reorganization in cytochrome P450 51

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2018-12-01

OAAI

Hargrove, Tatiana Y.; Wawrzak, Zdzislaw; Fisher, Paxtyn M.; Child, Stella A.; Nes, W. David; Guengerich, F. Peter; Waterman, Michael R.; Lepesheva, Galina I.

Functional analysis of human cytochrome P450 21A2 variants involved in congenital adrenal hyperplasia

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2017-06-01

OAAI

Wang, Chunxue; Pallan, Pradeep S.; Zhang, Wei; Lei, Li; Yoshimoto, Francis K.; Waterman, Michael R.; Egli, Martin; Guengerich, F. Peter

Recent Structural Insights into Cytochrome P450 Function 细胞色素P450功能的最新结构见解

TRENDS IN PHARMACOLOGICAL SCIENCES

IF19.9

2016-08-01

287

OAAI

Guengerich, F. Peter; Waterman, Michael R.; Egli, Martin

Human sterol 14α-demethylase as a target for anticancer chemotherapy: towards structure-aided drug design

JOURNAL OF LIPID RESEARCH

IF4.1

2016-08-01

OAAI

Hargrove, Tatiana Y.; Friggeri, Laura; Wawrzak, Zdzislaw; Sivakumaran, Suneethi; Yazlovitskaya, Eugenia M.; Hiebert, Scott W.; Guengerich, F. Peter; Waterman, Michael R.; Lepesheva, Galina I.

Genetic and structural analyses of cytochrome P450 hydroxylases in sex hormone biosynthesis: Sequential origin and subsequent coevolution 性激素生物合成中细胞色素P450羟化酶的遗传和结构分析: 顺序起源和随后的进化

MOLECULAR PHYLOGENETICS AND EVOLUTION

IF3.6

2016-01-01

OAAI

Goldstone, Jared V.; Sundaramoorthy, Munirathinam; Zhao, Bin; Waterman, Michael R.; Stegeman, John J.; Lamb, David C.

Human Cytochrome P450 21A2, the Major Steroid 21-Hydroxylase STRUCTURE OF THE ENZYME.PROGESTERONE SUBSTRATE COMPLEX AND RATE-LIMITING C-H BOND CLEAVAGE

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2015-05-01

OAAI

Pallan, Pradeep S.; Wang, Chunxue; Lei, Li; Yoshimoto, Francis K.; Auchus, Richard J.; Waterman, Michael R.; Guengerich, F. Peter; Egli, Martin

VFV as a New Effective CYP51 Structure-Derived Drug Candidate for Chagas Disease and Visceral Leishmaniasis

JOURNAL OF INFECTIOUS DISEASES

IF4.5

2015-04-15

OAAI

Lepesheva, Galina I.; Hargrove, Tatiana Y.; Rachakonda, Girish; Wawrzak, Zdzislaw; Pomel, Sebastien; Cojean, Sandrine; Nde, Pius N.; Nes, W. David; Locuson, Charles W.; Calcutt, M. Wade; Waterman, Michael R.; Daniels, J. Scott; Loiseau, Philippe M.; Villalta, Fernando

Structural and Kinetic Basis of Steroid 17α,20-Lyase Activity in Teleost Fish Cytochrome P450 17A1 and Its Absence in Cytochrome P450 17A2

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2015-02-01

OAAI

Pallan, Pradeep S.; Nagy, Leslie D.; Lei, Li; Gonzalez, Eric; Kramlinger, Valerie M.; Azumaya, Caleigh M.; Wawrzak, Zdzislaw; Waterman, Michael R.; Guengerich, F. Peter; Egli, Martin

Structural Basis for Rational Design of Inhibitors Targeting Trypanosoma cruzi Sterol 14α-Demethylase: Two Regions of the Enzyme Molecule Potentiate Its Inhibition

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2014-07-29

OAAI

Friggeri, Laura; Hargrove, Tatiana Y.; Rachakonda, Girish; Williams, Amanda D.; Wawrzak, Zdzislaw; Di Santo, Roberto; De Vita, Daniela; Waterman, Michael R.; Tortorella, Silvano; Villalta, Fernando; Lepesheva, Galina I.

Obituary for Dr Estabrook

DRUG METABOLISM REVIEWS

IF3.8

2013-11-18

OAAI

Prough, Russell; Waterman, Michael

Complexes of Trypanosoma cruzi Sterol 14α-Demethylase (CYP51) with Two Pyridine-based Drug Candidates for Chagas Disease STRUCTURAL BASIS FOR PATHOGEN SELECTIVITY

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2013-11-01

OAAI

Hargrove, Tatiana Y.; Wawrzak, Zdzislaw; Alexander, Paul W.; Chaplin, Jason H.; Keenan, Martine; Charman, Susan A.; Perez, Catherine J.; Waterman, Michael R.; Chatelain, Eric; Lepesheva, Galina I.

In Vitro and In Vivo Studies of the Antiparasitic Activity of Sterol 14α-Demethylase (CYP51) Inhibitor VNI against Drug-Resistant Strains of Trypanosoma cruzi

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2013-09-01

OAAI

Correia Soeiro, Maria de Nazare; de Souza, Elen Mello; da Silva, Cristiane Franca; Jaen Batista, Denise da Gama; Batista, Marcos Meuser; Pavao, Beatriz Philot; Araujo, Julianna Siciliano; Fortes Aiub, Claudia Alessandra; da Silva, Patricia Bernardino; Lionel, Jessica; Britto, Constanca; Kim, Kwangho; Sulikowski, Gary; Hargrove, Tatiana Y.; Waterman, Michael R.; Lepesheva, Galina I.

Streptomyces cytochromes P450: applications in drug metabolism 链霉菌细胞色素P450: 在药物代谢中的应用

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY

IF3.4

2013-06-06

PREAI

Lamb, David C.; Waterman, Michael R.; Zhao, Bin

Cytochromes P450: Roles in Diseases

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2013-06-01

OAAI

Pikuleva, Irina A.; Waterman, Michael R.

Unusual properties of the cytochrome P450 superfamily 细胞色素P450超家族的异常性质

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

IF4.7

2013-02-19

OAAI

Lamb, David C.; Waterman, Michael R.

VNI Cures Acute and Chronic Experimental Chagas Disease

JOURNAL OF INFECTIOUS DISEASES

IF4.5

2013-01-31

OAAI

Villalta, Fernando; Dobish, Mark C.; Nde, Pius N.; Kleshchenko, Yulia Y.; Hargrove, Tatiana Y.; Johnson, Candice A.; Waterman, Michael R.; Johnston, Jeffrey N.; Lepesheva, Galina I.

Organocatalytic, Enantioselective Synthesis of VNI: A Robust Therapeutic Development Platform for Chagas, a Neglected Tropical Disease

ORGANIC LETTERS

IF5

2012-12-07

OAAI

Dobish, Mark C.; Villalta, Fernando; Waterman, Michael R.; Lepesheva, Galina I.; Johnston, Jeffrey N.

CYP51 structures and structure-based development of novel, pathogen-specific inhibitory scaffolds

INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE

IF3.4

2012-12-01

OAAI

Hargrove, Tatiana Y.; Kim, Kwangho; Correia Soeiro, Maria de Nazare; da Silva, Cristiane Franca; Jaen Batista, Denise da Gama; Batista, Marcos Meuser; Yazlovitskaya, Eugenia M.; Waterman, Michael R.; Sulikowski, Gary A.; Lepesheva, Galina I.

Novel sterol metabolic network of Trypanosoma brucei procyclic and bloodstream forms

BIOCHEMICAL JOURNAL

IF4.3

2012-03-14

OAAI

Nes, Craigen R.; Singha, Ujjal K.; Liu, Jialin; Ganapathy, Kulothungan; Villalta, Fernando; Waterman, Michael R.; Lepesheva, Galina I.; Chaudhuri, Minu; Nes, W. David

研究方向