未登录 分享 收藏
分享 收藏
分享 收藏
Pharmacological characterization of GLPG1972/S201086, a potent and selective small-molecule inhibitor of ADAMTS5 Clement-Lacroix, P.; Little, C. B.; Smith, M. M.; Cottereaux, C.; Merciris, D.; Meurisse, S.; Mollat, P.; Touitou, R.; Brebion, F.; Gosmini, R.; De Ceuninck, F.; Botez, I; Lepescheux, L.; van der Aar, E.; Christophe, T.; Vandervoort, N.; Blanque, R.; Comas, D.; Deprez, P.; Amantini, D. 分享 收藏
Discovery of GLPG1972/S201086, a Potent, Selective, and Orally Bioavailable ADAMTS-5 Inhibitor for the Treatment of Osteoarthritis Brebion, Franck; Gosmini, Romain; Deprez, Pierre; Varin, Marie; Peixoto, Christophe; Alvey, Luke; Jary, Helene; Bienvenu, Natacha; Triballeau, Nicolas; Blanque, Roland; Cottereaux, Celine; Christophe, Thierry; Vandervoort, Nele; Mollat, Patrick; Touitou, Robert; Leonard, Philip; De Ceuninck, Frederic; Botez, Iuliana; Monjardet, Alain; van der Aar, Ellen; Amantini, David 分享 收藏
EBF1 drives hallmark B cell gene expression by enabling the interaction of PAX5 with the MLL H3K4 methyltransferase complex Bullerwell, Charles E.; Robichaud, Philippe Pierre; Deprez, Pierre M. L.; Joy, Andrew P.; Wajnberg, Gabriel; D'Souza, Darwin; Chacko, Simi; Fournier, Sebastien; Crapoulet, Nicolas; Barnett, David A.; Lewis, Stephen M.; Ouellette, Rodney J. 分享 收藏
Discovery of 9-Cyclopropylethynyl-2-((S)-1-[1,4]dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one (GLPG1205), a Unique GPR84 Negative Allosteric Modulator Undergoing Evaluation in a Phase II Clinical Trial Labeguere, Frederic; Dupont, Sonia; Alvey, Luke; Soulas, Florilene; Newsome, Gregory; Tirera, Amynata; Quenehen, Vanessa; Thi Thu Trang Mai; Deprez, Pierre; Blanque, Roland; Oste, Line; Le Tallec, Sandrine; De Vos, Steve; Hagers, Annick; Vandevelde, Ann; Nelles, Luc; Vandervoort, Nele; Conrath, Katja; Christophe, Thierry; van der Aar, Ellen; Wakselman, Emanuelle; Merciris, Didier; Cottereaux, Celine; da Costa, Cecile; Saniere, Laurent; Clement-Lacroix, Philippe; Jenkins, Laura; Milligan, Graeme; Fletcher, Stephen; Brys, Reginald; Gosmini, Romain 分享 收藏
Dilation or biodegradable stent placement for recurrent benign esophageal strictures: a randomized controlled trial Walter, Daisy; van den Berg, Maarten W.; Hirdes, Meike M.; Vleggaar, Frank P.; Repici, Alessandro; Deprez, Pierre H.; Viedma, Bartolome L.; Lovat, Laurence B.; Weusten, Bas L.; Bisschops, Raf; Haidry, Rehan; Ferrara, Elisa; Sanborn, Keith J.; O'Leary, Erin E.; van Hooft, Jeanin E.; Siersema, Peter D. 分享 收藏
ADAMTS-5 INHIBITION WITH THE POTENT AND HIGHLY SELECTIVE INHIBITOR GLPG1972 RESULTS IN STRONG DISEASE-MODIFYING OA DRUG EFFECTS IN THE RAT MENISCECTOMY MODEL Clement-Lacroix, P.; Meurisse, S.; Lepescheux, L.; Merciris, D.; Borgonovi, M.; Cottereaux, C.; Mollat, P.; Brebion, F.; Gosmini, R.; De Ceuninck, F.; Botez, I.; Christophe, T.; van der Aar, E. E.; Vandervoort, N.; Blanque, R.; Comas, D.; Deprez, P.; Amantini, D. 分享 收藏
GLPG1972: A POTENT, SELECTIVE, ORALLY AVAILABLE ADAMTS-5 INHIBITOR FOR THE TREATMENT OF OA Clement-Lacroix, P.; Little, C.; Meurisse, S.; Blanque, R.; Mollat, P.; Brebion, F.; Gosmini, R.; De Ceuninck, F.; Botez, I.; Lepescheux, L.; van der Aar, E.; Christophe, T.; Vandervoort, N.; Cottereaux, C.; Comas, D.; Deprez, P.; Amantini, D. 分享 收藏
A European survey of perendoscopic treatment of biliary complications in patients with alveolar echinococcosis Ambregna, Sylvain; Koch, Stephane; Sulz, Michael C.; Gruener, Beate; Oeztuerk, Suemeyra; Chevaux, Jean-Baptiste; Sulima, Malgorzata; de Gottardi, Andrea; Napoleon, Bertrand; Abergel, Armand; Bichard, Philippe; Boytchev, Isabelle; Deprez, Pierre; Dumortier, Jerome; Frossard, Jean-Louis; Kull, Eric; Meny, Bernard; Moradpour, Darius; Prat, Frederic; Vanbiervliet, Geoffroy; Thevenot, Thierry; Vuitton, Dominique Angele; Bresson-Hadni, Solange; Vuitton, Lucine 分享 收藏
NEW CARTILAGE QUALITY EVALUATION USING BIO-INDENTATION: EFFECT OF A TOOL DMOAD COMPOUND ACTIVE IN THE RAT MNX MODEL Lavet, C.; Clement-Lacroix, P.; Merciris, D.; Meurisse, S.; Lepescheux, L.; Gaillard, V.; Pastoureau, P.; Deprez, P.; Amantini, D.; Ammann, P. 分享 收藏
Endoscopic submucosal dissection: European Society of Gastrointestinal Endoscopy (ESGE) Guideline Pimentel-Nunes, Pedro; Dinis-Ribeiro, Mario; Ponchon, Thierry; Repici, Alessandro; Vieth, Michael; De Ceglie, Antonella; Amato, Arnaldo; Berr, Frieder; Bhandari, Pradeep; Bialek, Andrzej; Conio, Massimo; Haringsma, Jelle; Langner, Cord; Meisner, Soren; Messmann, Helmut; Morino, Mario; Neuhaus, Horst; Piessevaux, Hubert; Rugge, Massimo; Saunders, Brian P.; Robaszkiewicz, Michel; Seewald, Stefan; Kashin, Sergey; Dumonceau, Jean-Marc; Hassan, Cesare; Deprez, Pierre H. 分享 收藏
Discovery and Optimization of an Azetidine Chemical Series As a Free Fatty Acid Receptor 2 (FFA2) Antagonist: From Hit to Clinic Pizzonero, Mathieu; Dupont, Sonia; Babel, Marielle; Beaumont, Stephane; Bienvenu, Natacha; Blanque, Roland; Cherel, Laetitia; Christophe, Thierry; Crescenzi, Benedetta; De Lemos, Elsa; Delerive, Philippe; Deprez, Pierre; De Vos, Steve; Djata, Fatoumata; Fletcher, Stephen; Kopiejewski, Sabrina; L'Ebraly, Christelle; Lefrancois, Jean-Michel; Lavazais, Stephanie; Manioc, Murielle; Nelles, Luc; Oste, Line; Polancec, Denis; Quenehen, Vanessa; Soulas, Florilene; Triballeau, Nicolas; van der Aar, Ellen M.; Vandeghinste, Nick; Wakselman, Emanuelle; Brys, Reginald; Saniere, Laurent 分享 收藏
Triazolopyridines as Selective JAK1 Inhibitors: From Hit Identification to GLPG0634 Menet, Christel J.; Fletcher, Stephen R.; Van Lommen, Guy; Geney, Raphael; Blanc, Javier; Smits, Koen; Jouannigot, Nolwenn; Deprez, Pierre; van der Aar, Ellen M.; Clement-Lacroix, Philippe; Lepescheux, Lien; Galien, Rene; Vayssiere, Beatrice; Nelles, Luc; Christophe, Thierry; Brys, Reginald; Uhring, Muriel; Ciesieski, Fabrice; Van Rompaey, Luc 分享 收藏
Discovery of Diarylhydantoins as New Selective Androgen Receptor Modulators Nique, Francois; Hebbe, Severine; Peixoto, Christophe; Annoot, Denis; Lefrancois, Jean-Michel; Duval, Eric; Michoux, Laurence; Triballeau, Nicolas; Lemoullec, Jean-Michel; Mollat, Patrick; Thauvin, Maxime; Prange, Thierry; Minet, Dominique; Clement-Lacroix, Philippe; Robin-Jagerschmidt, Catherine; Fleury, Damien; Guedin, Denis; Deprez, Pierre 分享 收藏
Identification of a 4-(Hydroxymethyl)diarylhydantoin as a Selective Androgen Receptor Modulator Nique, Francois; Hebbe, Severine; Triballeau, Nicolas; Peixoto, Christophe; Lefrancois, Jean-Michel; Jary, Helene; Alvey, Luke; Manioc, Murielle; Housseman, Christopher; Klaassen, Hugo; Van Beeck, Kris; Guedin, Denis; Namour, Florence; Minet, Dominque; Van der Aar, Ellen; Feyen, Jean; Fletcher, Stephen; Blanque, Roland; Robin-Jagerschmidt, Catherine; Deprez, Pierre 分享 收藏
Efficacy of Endoscopic Closure of Acute Perforations of the Gastrointestinal Tract Voermans, Rogier P.; Le Moine, Olivier; von Renteln, Daniel; Ponchon, Thierry; Giovannini, Marc; Bruno, Marco; Weusten, Bas; Seewald, Stefan; Costamagna, Guido; Deprez, Pierre; Fockens, Paul 分享 收藏
分享 收藏
分享 收藏
.png){kind=icon}
未登录.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
